Yang-Hsin Shih

Taipei Veterans General Hospital

Objective: Cerebral cavernous malformations (CCMs) present variably and epileptic seizures are the most common symptom. The factors contributing to cavernoma-related epilepsy (CRE) and drug resistance remain inconclusive. The outcomes of CRE after different treatment modalities have not yet been fully addressed. This study aimed to characterize th...

Multi-view stereo reconstruction relies on object's surface feature，and thus occurred data deficiency in dealing with low-texture regions，the polarization characteristics of the reflection light con be fused to observe completely surface under different light surroundings，which can reconstruct depth map of objects by calculating polarization parame...

In recommendation systems, practitioners observed that increase in the number of embedding tables and their sizes often leads to significant improvement in model performances. Given this and the business importance of these models to major internet companies, embedding tables for personalization tasks have grown to terabyte scale and continue to gr...

Rationale: Macrophages play critical roles in the pathogenesis of type 1 diabetes mellitus (T1DM). Circular RNAs (circRNAs) are a novel class of endogenous RNAs with covalently closed loop structures, implicated in various disease processes. However, their impact on macrophage activation and T1DM pathogenesis remains elusive. Methods: circRNA expre...

The Tangle-based structure becomes one of the most promising solutions when designing DAG-based blockchain systems. The approach improves the scalability by directly confirming multiple transactions in parallel instead of single blocks in linear. However, the performance gain may bring potential security risks. In this paper, we construct three typ...

This article collectively addresses the issues of optimizing the sailing speed of containerships and fleet deployment in intercontinental container liner shipping, taking cargo time values into consideration. A mixed-integer nonlinear programming model is developed to maximize the gross profits of a container shipping line. The sailing speed is div...

Objective: The semiology of cingulate gyrus epilepsy is varied and may involve the paracentral area, the adjacent limbic system, and/or the orbitofrontal gyrus. Invasive electroencephalography (iEEG) recording is usually required for patients with deeply located epileptogenic foci. This paper reports on the authors' experiences in the diagnosis an...

High citric acid content in kiwifruit wine would lead to bad sensory experience and quality deterioration. It is opportune and crucial to develop an appropriate and feasible method to degrade citric acid for kiwifruit wine. The non-Saccharomyces yeasts confirmed to have the ability to degrade citric acid were screened and used in kiwifruit wine fer...

This work was motivated by a study of particle size effects on pyrolysis kinetics and models of polystyrene particle. Micro-size polystyrene particles with four different diameters, 5, 10, 15, and 50 µm, were selected as experimental materials. Activation energies were obtained by isoconversional methods, and pyrolysis model of each particle size a...

The evolution of interfaces for underwater gas jets is the main morphological manifestation of two-phase unstable interaction. The high-speed transient photographic recording and image post-processing methods are used to obtain the interfacial change in a submerged gaseous jet at different stages after its ejection from the Laval nozzle exit. The r...

Sweet cherry (Prunus avium L.) is a delicious nutrient-rich fruit widely cultivated in countries such as China, America, Chile, and Italy. However, the yield often drops severely due to the frequently-abnormal fruitlet abscission, and few studies on the metabolism during its ripening process at the proteomic level have been executed so far. To get...

Anthocyanin contributes to the coloration of pear fruit and enhances plant defenses. Members of the ethylene response factor (ERF) family play vital roles in hormone and stress signaling and are involved in anthocyanin biosynthesis. Here, PbERF22 was identified from the lanolin-induced red fruit of ‘Zaosu’ pear (Pyrus bretschneideri Rehd.) using a...

Aggregation-caused quenching (ACQ) effect, known as the main cause to restrain solid-state luminescence of carbon quantum dots (CQDs), hinders further application of CQDs in white light-emitting diodes (WLED). Here, a complex of CQDs and phthalimide crystals (CQDs/PC) was prepared through a one-step solvothermal method. CQDs/PC prevented CQDs from...

TiO2 membranes were prepared on porous Ti supports through the in situ oxidation method. The effects of oxygen concentration, oxidation temperature, and oxidation time on the thickness, pore size, and microstructure of the prepared TiO2 membrane were investigated. The results showed that with increasing oxygen concentration, oxidation temperature,...

Trueperella pyogenes (T. pyogenes) is an important opportunistic pathogen in livestock and wild animals. However, only one commercial T. pyogenes vaccine is currently available, and its immunoprotective effect is not ideal. Pyolysin (PLO) is one of the important virulence factors expressed by T. pyogenes and one of the targets for the development o...

Two random conjugated polymers (CPs), namely, PIDTT-TBT and PIDTT-TFBT, in which indacenodithieno[3,2-b]thiophene (IDTT), 3-octylthiophene, and benzothiadiazole (BT) were in turn utilized as electron-donor (D), π-bridge, and electron-acceptor (A) units, were synthesized to comprehensively analyze the impact of reducing thiophene π-bridge and furthe...

AlGaN/GaN lateral Schottky barrier diodes (SBDs) with three different anode geometries (stripe, circular, and the conventional plane one) and different rows of anode trenches are fabricated and electrically characterized to study the influence of anode trench geometries. The SBDs with anode trenches exhibit the lower on-state resistance (RON) than...

Glioblastoma (GBM) is characterized by severe hypoxic and acidic stress in an abnormal microenvironment. Monocarboxylate transporter (MCT)4, a pH-regulating protein, plays an important role in pH homeostasis of the glycolytic metabolic pathways in cancer cells. The present study showed that GBM exposure to hypoxic conditions increased MCT4 expressi...

Air pollution (mainly PM2.5) is one of the main environmental problems about air quality. Air pollution prediction and early warning is a prerequisite for air pollution prevention and control. However, it is not easy to accurately predict the long-term trend because the collected PM2.5 data have complex nonlinearity with multiple components of diff...

Low temperature (LT) is an important abiotic factor affecting plant survival, growth and distribution. The response of Cryptomeria fortunei (Chinese cedar) to LT is not well known, limiting its application in production and ornamental value. In this study, we first screened ten clones (#3, #25, #32, #42, #54, #57, #68, #66, #74, #X1), originating f...

In order to explore effects of low levels of continuous microcystin-LR (MC-LR) (a cyanotoxin) exposure on hepatic lipid metabolism on the basis of the endoplasmic reticulum stress (ERS) pathway, we exposed adult male zebrafish to MC-LR (0, 1, 5, and 25 μg/L) for 60 days, and hepatic histopathology as well as lipid metabolic parameters were determin...

Histone deacetylases (HDACs) have been proved to be promising targets for the treatment of cancer, and five histone deacetylase inhibitors (HDACis) have been approved on the market for the treatment of different lymphomas. In our previous work, we designed a series of novel coumarin-containing hydroxamate HDACis, among which compounds 6 and 7 displ...

Dexamethasone (Dex) has been widely used as a potent anti-inflammatory, antishock, and immunosuppressive agent. However, high dose or long-term use of Dex is accompanied by side effects including skeletal muscle atrophy, whose underlying mechanisms remain incompletely understood. A number of microRNAs (miRNAs) have been shown to play key roles in s...

Bovine mastitis is the most important infectious disease, causing significant losses in the dairy industry, in which Streptococcus agalactiae is a major pathogen. In this study, lysin CHAPk, derived from bacteriophage K, was expressed heterogeneously, and its antimicrobial and anti-biofilm effects against S. agalactiae isolated from bovine mastitis...

The increasing concern about noise pollution has accelerated the development of acoustic absorption and damping devices. However, conventional subtractive manufacturing can only fabricate absorption devices with simple geometric shapes that are unable to achieve high absorption coefficients in wide frequency ranges. In this paper, novel multi-layer...

The regenerative braking system of electric vehicles can not only achieve the task of braking but also recover the braking energy. However, due to the lack of in-depth analysis of the energy loss mechanism in electric braking, the energy cannot be fully recovered. In this study, the energy recovery problem of regenerative braking using the independ...

Insulator missing fault is a serious accident of high-voltage transmission lines, which can cause abnormal energy supply. Recently, a lot of vision-based methods are proposed for detecting an insulator missing fault in aerial images. However, these methods usually lack efficiency and robustness due to the effect of the complex background interferen...

Studies of the gene and miRNA expression profiles associated with the postnatal late growth, development, and aging of skeletal muscle are lacking in sika deer. To understand the molecular mechanisms of the growth and development of sika deer skeletal muscle, we used de novo RNA sequencing (RNA-seq) and microRNA sequencing (miRNA-seq) analyses to d...

Neutrophils play an essential role in the control of inflammatory diseases. However, whether cannabinoid receptors (CBs) play a role in neutrophil chemotaxis and NETosis in sterile liver inflammation remains unknown. The expression of marker genes on neutrophils was characterized by FACS, immunofluorescence, qRT-PCR, and Western blot. The amount of...

The forthcoming implementation of the China VI emission regulations, which are currently the most stringent around the world targeted at light-duty gasoline engine vehicles, will not only further restrict the emissions of gaseous pollutants, but also put forward, for the first time, the requirements of particulate number (PN) emissions with a limit...

s: In this paper, the guided wave propagation behavior in damaged 30CrMo steel curved plates was investigated experimentally and numerically. The effects of the notch orientation, depth in the curved plate, as well as its radius, on the wave propagation characteristics were mainly analyzed by the amplitude distribution curves and the directivity di...

The electronic structures and optical characteristics of yttrium (Y)-doped ZnO monolayers (MLs) with vacancy (zinc vacancy, oxygen vacancy) were investigated by the first-principles density functional theory. Calculations were performed with the GGA+U (generalized gradient approximation plus U) approach, which can accurately estimate the energy of...

The compound parabolic concentrator (CPC) is a highly interesting solar collector technology for different low-concentration applications due to no tracking requirement. The CPC with a tubular absorber is the most common type of CPC. Here, a comprehensive state-of-the-art review of this CPC type is presented, including design features, structure, a...

With an increasing demand for green and environmentally friendly products, configuring a customized product from modular product design to satisfy both individualized customer requirements and environment restrictions has become a vital task for mass customization. In this paper, we addressed a module-based product configuration problem under carbo...

The comparative molecular similarity index analysis (CoMSIA) model of double-activity quinolones targeting green algae toxicity and bacterial genotoxicity (8:2) was constructed in this paper on the basis of the comprehensive index method. The contour maps of the model were analyzed for molecular modifications with high toxicities. In the CoMSIA mod...

As traditional automobiles develop towards new energy vehicles, the noise, vibration and harshness (NVH) performance of automobiles is facing new challenges. Without the cover of the traditional engine noise and inlet and exhaust noise, the high-speed wind noise becomes more prominent. Thus, research on the calculation method of vehicle interior no...

Waste concrete was recycled and crushed into fine aggregate to prepare a high ductility cementitious composite (HDCC) in this study, for helping dispose the massive amount of construction waste and for reserving natural resources. Firstly, the features of recycled fine aggregate (RFA) were analyzed in detail and compared with natural fine aggregate...

The LACE index and HOSPITAL score models are the two most commonly used prediction models identifying patients at high risk of readmission with limited information for home care patients. This study compares the effectiveness of these two models in predicting 30-day readmission following acute hospitalization of such patients in Taiwan. A cohort of...

Super-resolution (SR) technology has shown great potential for improving the performance of the mapping and classification of multispectral satellite images. However, it is very challenging to solve ill-conditioned problems such as mapping for remote sensing images due to the presence of complicated ground features. In this paper, we address this p...

In order to significantly enhance the absorption capability of solar energy absorbers in the visible wavelength region, a novel monolayer molybdenum disulfide (MoS2)-based nanostructure was proposed. Local surface plasmon resonances (LSPRs) supported by Au nanocubes (NCs) can improve the absorption of monolayer MoS2. A theoretical simulation by a f...

For minimizing the transport of antibiotics to groundwater, the migration of antibiotics in soils should be investigated. Soil organic matter can affect the migration of antibiotics. To date, the influence of aromatics and aliphatic content of organic matter on the adsorption of antibiotics has been controversial. To better understand the reaction...

As a kind of intelligent instrument, an electronic tongue (E-tongue) realizes liquid analysis with an electrode-sensor array and certain machine learning methods. The large amplitude pulse voltammetry (LAPV) is a regular E-tongue type that prefers to collect a large amount of response data at a high sampling frequency within a short time. Therefore...

The popularity of social networks provides people with many conveniences, but their rapid growth has also attracted many attackers. In recent years, the malicious behavior of social network spammers has seriously threatened the information security of ordinary users. To reduce this threat, many researchers have mined the behavior characteristics of...

The battery industry has been growing fast because of strong demand from electric vehicle and power storage applications.Laser welding is a key process in battery manufacturing. To control the production quality, the industry has a great desire for defect inspection of automated laser welding. Recently, Convolutional Neural Networks (CNNs) have bee...

Alginate extracted from widely cultured brown seaweed can be hydrolyzed by alginate lyase to produce alginate oligosaccharides (AOS) with intriguing biological activities. Herein, a novel alginate lyase Aly1281 was cloned from marine bacterium Pseudoalteromonas carrageenovora ASY5 isolated from mangrove soil and found to belong to polysaccharide ly...

Farfarae Flos (FF) is the dried flower bud of Tussilago farfara L, which has antitussive, expectorant, and anti-inflammatory effects. However, little research on the main active composition of FF has been reported. The purpose of this study is to find the main active compounds responsible for the three pharmacological effects (i.e., antitussive, ex...

Photoacoustic (PA) imaging is a hybrid imaging technique that can provide both structural and functional information of biological tissues. Due to limited permissible laser energy deposited on tissues, highly sensitive PA imaging is required. Here, we developed a 20 MHz lead zirconium titanate (PZT) transducer (1.5 mm × 3 mm) with front-end amplifi...

The phase stability of epsomite under a high temperature and high pressure were explored through Raman spectroscopy and electrical conductivity measurements in a diamond anvil cell up to ~623 K and ~12.8 GPa. Our results verified that the epsomite underwent a pressure-induced phase transition at ~5.1 GPa and room temperature, which was well charact...

This study seeks to investigate the endogenous relationship between financial leverage, economic growth and environmental degradation in China by employing a the generalized moments method (GMM) panel vector autoregressive (PVAR) approach with a panel of data from China’s 30 provinces over the period 1997–2016. Three key results arise. First, finan...

Background: Little evidence is available about the risk of sudden sensorineural hearing loss (SSNHL) in patients with thyroid diseases. We assessed whether a diagnosis of thyroid disease, particularly hyperthyroidism or hypothyroidism, is associated with SSNHL risk in an Asian population. Material and Methods: This case-control study was conducted...

In order to provide a convenient way to strengthen the rotator cuff muscles and prevent rotator cuff injury, this study designed an innovative strength trainer specifically for shoulder rotator cuff based on oscillating hydraulic damping. We carried out a myoelectric testing experiment to evaluate the shoulder rotation training effect and compared...

Polycyclic aromatic hydrocarbons (PAHs) and nitro-PAHs (NPAHs) in PM2.5 samples were collected at a roadside monitoring station in Kanazawa, Japan, in every season from 2017 to 2018. Nine PAHs and five NPAHs were determined using high-performance liquid chromatography with fluorescence detection and chemiluminescence detection, respectively. The me...

Cucurbitacin E (CuE), a highly oxygenated tetracyclic triterpene from Cucurbitaceae, has shown to exhibit potent cytotoxic and anti-proliferative properties against several human cancer cells. However, the underlying effects and mechanisms of CuE regarding hepatocellular carcinoma (HCC) have not been well understood. In the current study, unbiased...