Yanara A. Bernal- Doctor of Philosophy
- Researcher at Universidad del Desarrollo
Yanara A. Bernal
- Doctor of Philosophy
- Researcher at Universidad del Desarrollo
Cancer Genomics | Biostatistical analysis | Biomedical Research
About
17
Publications
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Introduction
• My doctoral focuses on investigating effect of RNA edition and clinical variables that contribute to drug resistance in cancer | www.cancergenomics.cl |
• My other interest is, through analysis of large public databases, to study chronic diseases and cancer.
Current institution
Publications
Publications (17)
Background: The integration of conventional omics data such as genomics and transcriptomics data into artificial intelligence models has advanced significantly in recent years; however, their low applicability in clinical contexts, due to the high complexity of models, has been limited in their direct use inpatients. We integrated classic omics, in...
Background
Tobacco use is one of the main risk factors for Lung Cancer (LC) development. However, about 10–20% of those diagnosed with the disease are never-smokers. For Non-Small Cell Lung Cancer (NSCLC) there are clear differences in both the clinical presentation and the tumor genomic profiles between smokers and never-smokers. For example, the...
Background
Tobacco use is one of the main risk factors for Lung Cancer (LC) development. However, about 10–20% of those diagnosed with the disease are never-smokers. For Non-Small Cell Lung Cancer (NSCLC) there are clear differences in both the clinical presentation and the tumor genomic profiles between smokers and never-smokers. For example, the...
Epitranscriptomics is a field that delves into post-transcriptional changes. Among these modifications, the conversion of adenosine to inosine, traduced as guanosine (A>I(G)), is one of the known RNA-editing mechanisms, catalyzed by ADARs. This type of RNA editing is the most common type of editing in mammals and contributes to biological diversity...
Dysregulated A>I(G) RNA editing, which is mainly catalyzed by ADAR1 and is a type of post-transcriptional modification, has been linked to cancer. A low response to therapy in breast cancer (BC) is a significant contributor to mortality. However, it remains unclear if there is an association between A>I(G) RNA-edited sites and sensitivity to genoto...
Background
Multimorbidity, the presence of two or more chronic diseases in one individual, affects an increasing number of patients worldwide, creating one of the main challenges in global public health. Multimorbidity results in higher mortality, lower quality of life, and individual risks, such as polypharmacy and exposure to complex therapeutic...
Stress is known to be associated with adverse health outcomes. The COVID-19 pandemic and its associated lockdowns are examples of chronic stressors. Lockdown measures inadvertently caused significant psychological distress and became a powerful source of anxiety/stress, sleep disturbances, nutritional changes and weight gain. Stress is known to imp...
A nivel mundial existe amplio desconocimiento de la salud reproductiva masculina en comparación a la femenina, 1,2 lo cual es preocupante ya que muchas patologías del varón tienen un origen endocrino aso-ciado a comorbilidades metabólicas frecuentes-por ejemplo, la resistencia insulínica 3. Se ha reportado que es necesario mejorar el conocimiento s...
Background
An instrument to help clinicians to evaluate the oral glucose tolerance test (OGTT) at-a-glance is lacking.
Aim
To generate a program written in HTML squeezing relevant information from the OGTT with glucose and insulin measurements.
Material and Methods
We reanalyzed a database comprising 90 subjects. All of them had both an OGTT and...
Digital game-based learning and the testing effect have been shown to be effective in improving learning. The use of screens offers the opportunity to test innovative learning strategies in the classroom. Here, we report the impact of implementing a game and testing effect-based learning tool in a histology course. Seventy nine students participate...
La legalización del uso medicinal y recreativo de la marihuana (Cannabis sativa) es un tema de controversia mundial. Un artículo en Nature Reviews Neuroscience 1 destaca que el uso de Cannabis es cada vez más impor-tante para la medicina moderna, especialmente en el tratamiento del dolor y de trastornos motores. Sin embargo , su uso más extendido e...
Purpose
To evaluate the diagnostic performance of several biochemical predictors of insulin resistance (IR).
Methods
90 non-diabetic subjects were tested with both the Pancreatic Suppression Test (PST) and the Oral Glucose Tolerance Test (OGTT). Of them, 53 were non-insulin-resistant (NIR subjects) and the remainder 37 were insulin-resistant (IR s...
