Yana R. Panikratova

Mental Health Research Center · Laboratory of Neuroimaging and Multimodal analysis

The theory of systemic and dynamic localization of higher mental functions by Lev Vygotsky and Alexander Luria was based on the data obtained via an original method, syndrome analysis of deficits of higher mental functions in patients with local brain injury. When this theory was being constructed, technical methods for brain investigation were onl...

Schizotypy, a set of behavioral traits related to an enhanced risk for mental disorders, is an informative model for the investigation of early predisposition markers. We aimed to analyze correlations between the characteristics of functional brain organization and schizotypy in mentally healthy individuals. Mentally healthy participants (n = 80 in...

To date, cerebellar contribution to language is well established via clinical and neuroimaging studies. However, the particular functional role of the cerebellum in language remains to be clarified. In this study, we present the first systematic review of the diverse language symptoms in spoken language after cerebellar lesion that were reported in...

Introduction Schizotypy is associated with increased vulnerability to schizophrenia spectrum disorders. Therefore, investigation of its brain correlates seems prominent for better understanding of schizophrenia-spectrum continuum as well as for development of biological treatments for schizotypal personality disorder. Functional alterations of pref...

Introduction Schizophrenia is heterogeneous in terms of symptoms and outcome, but neurobiology of this heterogeneity is not well-studied. Local correlation analysis of fMRI data provides a measure of local coherence, i.e., average correlation between BOLD-signal in a voxel and its neighbours. Local correlation is a promising approach, and it seems...

Шизотипия как совокупность поведенческих черт, ассоциированных с риском психических заболеваний, является информативной моделью для изучения ранних маркеров предрасположения к заболеванию. Целью исследования являлся поиск корреляций между особенностями функциональной организации головного мозга и выраженностью шизотипии у психически здоровых испыту...

Recent studies at the interface between psychiatry and neuroscience demonstrate a trend towards the investigation of single significant clinical characteristics of mental disorders in contrast to the analysis of a mental disorder as a homogeneous nosological unit. Thus, a large body of studies is focused on auditory verbal hallucinations (AVH) in s...

Presurgical brain mapping of language-eloquent cortex aims to minimize its injury during neurosurgery in patients with brain tumors and drug-resistant epilepsy, and thereby, to preserve their quality of life. Two main goals of language mapping are to identify the localization and lateralization of brain regions involved in language. Gold standards...

Neuroscience became to integrate with psychiatry more than half a century ago. Today there is a rich pool of neuroimaging techniques which allow to gain a deeper understanding of pathophysiological mechanisms of schizophrenia. The aim of the current article is to review some examples of fMRI studies of auditory verbal hallucinations in schizophreni...

The analysis of heterogeneity in cognition and brain functioning in patients with schizophrenia seems promising for a deeper understanding of the disorder as well as treatment individualization. As language production and its executive control are disturbed in schizophrenia but may be heterogeneous in severity across patients and related to outcome...

Introduction. Schizophrenia patients with auditory verbal hallucinations (AVH) demonstrate impaired functional connectivity (FC) between brain regions, involved in executive functions and language. However, as most studies compare patients to healthy controls, the specificity of these findings either for schizophrenia in general or for AVH is uncle...

Impaired communication is one of the key features of schizophrenia. Therefore, an investigation of the disease’s nature calls for a better understanding of the neural underpinnings of not only verbal communication but also the lesser-studied non-verbal communication. Spontaneous gestures accompanying oral speech are one of the most important channe...

Introduction. Heterogeneity of clinical and functional outcomes is a prominent feature of schizophrenia, however, their cognitive markers remain understudied. The aim of this study was to define cognitive characteristics which differentiate schizophrenia patients with different types of long-term outcome (favorable, intermediate, and poor) and to r...

The main aim of the study was to compare cognitive and neurophysiological characteristics in two groups of chronic schizophrenia patients with diverse clinical and functional status. We examined 39 patients with schizophrenia spectrum disorders (age 41.5 ± 5.5 years) and 18 healthy controls (age 38.8 ± 8.22 years), all males. Participants underwent...

Objective: To test the general hypothesis that schizophrenia patients have an executive deficit in speech production and the more specific hypothesis that this deficit is more severe when there is a greater demand on executive functions. Materials and methods: The study included 25 patients with schizophrenia and 27 healthy subjects (control group)...

P300 wave is associated with working memory update, allocation of attention resources, and decision making. Numerous studies have consistently revealed P300 abnormalities in schizophrenia making it a promising neurophysiological state and trait marker. The aim of the current paper was to revalidate P300 meaning in schizophrenia as well as to analyz...

Speech disfluencies are a notable component of natural discourse production and comprehension that may play a role of signals that control the flow of communication. Using task-based functional MRI, we examined how brain functional connectivity changes when listeners encounter a disfluency. Participants listened to fragments of audio recordings of...

Introduction Schizophrenia patients with auditory verbal hallucinations (AVH) demonstrate impaired functional connectivity (FC) between brain regions, involved in executive functions and language. However, as most studies compare patients to healthy controls, the specificity of these findings either for schizophrenia in general or for AVH is unclea...

Introduction According to the literature, cognition may be more preserved in late-onset schizophrenia (LOS) compared to early-onset schizophrenia (EOS), but data are limited. Objectives To compare performance on cognitive tests in LOS and EOS. Methods LOS patients (n=14, mean age 58.1±8.2, 13 females, illness duration 1.07±1.5 years) and age-comp...

Although working memory (WM) is crucial for intellectual abilities, not much is known about its brain underpinnings, especially the structural connectivity. We used diffusion tensor imaging (DTI) to look across the whole brain for the white matter integrity correlates of the individual differences in the reading span (verbal WM capacity during read...

Although working memory (WM) is crucial for intellectual abilities, not much is known about its brain underpinnings, especially the structural connectivity. We used diffusion tensor imaging (DTI) to look across the whole brain for the white matter integrity correlates of the individual differences in the reading span (verbal WM capacity during read...

Deficits of executive functions and language are considered to be among the basic cognitive impairments of schizophrenia associated with positive, negative, and disorganization symptoms. Despite the close interrelationship between these functions, studies of schizophrenia seem to lack holistic approach to the investigation of their systemic breakdo...

The article describes the results of our first series of studies regarding structural and functional brain characteristics in unaffected relatives of patients with affective spectrum disorders (RA) and schizophrenia (RS). The studies were conducted by the laboratory of neuroimaging and multimodal analysis of Mental Health Research Center. The aim o...

In modern linguistics and psycholinguistics speech disfluencies in real fluent speech are a well-known phenomenon. But it's not still clear which components of brain systems are involved into its comprehension in a listener's brain. In this paper we provide a pilot neuroimaging study of the possible neural correlates of speech disfluencies percepti...

Objective The dorsolateral prefrontal cortex (DLPFC) orchestrates other brain regions and plays a vital role for “the most uniquely human” executive functions (EFs), which are divided into distinct components. Components of EFs have been localized to different brain regions and at the same time the DLPFC was found to be involved in a majority of EF...

Objective: Goldberg, the author of the “novelty-routinization” framework, suggested a new pair of cognitive styles for agent-centered decision-making (DM), context-dependency/independency (CD/CI), quantified by the Cognitive Bias Task (CBT) and supposedly reflecting functional brain hemispheric specialization. To date, there are only three lesion...

The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants. The ROIs included amygdala (one of the key regions for the regulation of anxiety) and dorsolateral prefrontal...

According to the large body of literature data, patients with schizophrenia demonstrate altered (decreased) functional connectivity (FC) between the brain regions involved in executive functions and language (in particular, dorsolateral prefrontal cortex (DLPFC) and left temporal regions). However, the analysis of similar FC in the genetic risk gro...

Anterior cingulate cortex (ACC), being a key node of salience network, is involved in conflict monitoring and detection along with response inhibition, as well as self-monitoring in inner speech. Numerous studies revealed that altered functional connectivity (FC) of ACC in schizophrenia is associated with auditory verbal hallucinations and poor inh...

Numerous studies have revealed impairment of verbal abstract reasoning (VAR) in average-age onset schizophrenia (AOS). However, in late-onset schizophrenia (LOS) it remains understudied. Thus, we compared VAR in LOS, AOS, and controls.

A deficit of verbal abstract reasoning (VAR) in average-onset schizophrenia (AOS) has been revealed in a large body of research. Due to the lack of such studies in late-onset schizophrenia (LOS), we investigated VAR in AOS and LOS patients as well as in two age-comparable control groups. Study participants included ten patients with AOS (mean age 4...

The aim of the study was to analyze the understanding of reversible active and passive grammatical constructions (GCs) in first-, second- and third-graders in comparison with prepositional and instrumental GCs, as well as picture-based story creation. Two hundred forty-nine children underwent a test of understanding GCs and neuropsychological asses...

Background and Aims: One of the approaches to studying neurobiological markers of schizophrenia, its traits or so-called endophenotypes, is an examination of unaffected first-degree relatives. Patients with schizophrenia with auditory verbal hallucinations have demonstrated altered (decreased) functional connectivity (FC) between regions of the bra...

Background and Aims: One of the approaches to studying neurobiological markers of schizophrenia, its traits or so-called endophenotypes, is an examination of unaffected first-degree relatives. Patients with schizophrenia with auditory verbal hallucinations have demonstrated altered (decreased) functional connectivity (FC) between regions of the bra...

Background. The background of the present study includes analysis of the understanding of active and passive grammatical constructions (GCs) in Russianspeaking aphasic patients and in children aged 3, 4 and 5 years (Akhutina, 1989; Akhutina, Velichkovskiy, & Kempe, 1988). Data regarding the reorganization of the children’s strategies are further co...

The aim of this study was to investigate the associations between parameters of executive functions and characteristics of underlying structural (parameters of the main brain tracts) and functional (fronto-parietal control network) brain mechanisms in young healthy adults via multimodal approach. The study comprised 16 right-handed subjects, 8 men...

The effects of nootropic drug Semax on the neuronal network of the brain were studied by the resting state functional magnetic-resonance imaging (resting state fMRI). The study was carried out on two groups of healthy volunteers (11 men and 13 women aged 43.9±9.5 years). Resting state fMRI was carried out 3 times: directly before and 5 and 20 min a...

Мягким когнитивным снижением (mild cognitive impairment; MCI) называют состояние когнитивных функций, пограничное между нормальным старением и деменцией и связанное с повышенным риском развития болезни Альцгеймера (Гаврилова, 2005). По характеру нейропсихологического дефицита выделяют различные варианты MCI: с нарушениями памяти, речи, регуляторных...

In this article we analyze neuropsychology’s theoretical background, rooted in the ideas of Vygotsky and Luria, with respect to such criterion for distinguishing between scientific rationality types as characteristics of research object systemic organization. We describe the key milestones of their ideas development and distinguish the signs of pos...

Considering the fragmentary nature of previous fMRI studies of executive functions (EF), in the current study we implemented a more holistic approach to the brain mechanisms of EF. For this purpose, we combined information about the neuropsychological profiles of different components of EF from a neuropsychological assessment with information abou...

Considering the fragmentary nature of previous fMRI studies of executive functions (EF), in the current study we implemented a more holistic approach to the brain mechanisms of EF. For this purpose, we combined information about the neuropsychological profiles of different components of EF from a neuropsychological assessment with information about...

Целью исследования была проверка гипотезы о том, что метод фМРТ покоя позволяет картировать регуляторные функции индивидуально для каждого пациента с той же успешностью, что и метод фМРТ, связанной с задачей.