Yana IlievaMedical University of Sofia · Department of Pharmacognosy and Pharmaceutical Botany
Yana Ilieva
Doctor of Pharmacy
About
18
Publications
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115
Citations
Citations since 2017
Introduction
Additional affiliations
March 2014 - present
Publications
Publications (18)
Microbial infections are by no means a health problem from a past era due to the increasing antimicrobial resistance of infectious strains. Medicine is in constant need of new drugs and, recently, plant products have had a deserved renaissance and garnered scientific recognition. The aim of this work was to assess the antimicrobial activity of ten...
Cutaneous T-cell lymphoma (CTCL) is a rare form of cancer with local as well as systemic manifestations. Concomitant bacterial infections increase morbidity and mortality rates due to impaired skin barrier and immune deficiency. In the current study, we demonstrated that the in vitro anti-lymphoma potential of erufosine is diminished by TWIST1 expr...
The wastewater after rose oil distillation is usually discharged into the drainage systems and it represents a serious environmental problem. While being rich in polyphenols, which have beneficial biological activity and application in the pharmaceutical industry, limited research has been carried out about the biological activity of the specific w...
Small-scale photobioreactors (PBRs) in the inoculum stage were designed with internal (red or green) and external white LED light as an initial step of a larger-scale installation aimed at fulfilling the integral biorefinery concept for maximum utilization of microalgal biomass in a multifunctional laboratory. The specific growth rate of Scenedesmu...
The wastewater from the distillation of rose oils is discharged directly into the soil because it has a limited potential for future applications. The aim of the present study was to determine in vitro the chromatographic profile, redox-modulating capacity, and antineoplastic activity of wastewater obtained by distillation of essential oils from th...
![Antiproliferative activity presented as IC 50 values [µg/mL] of the...](profile/Alexander-Tashev/publication/354223716/figure/tbl3/AS:1062619645501440@1630359674194/Antiproliferative-activity-presented-as-IC-50-values-g-mL-of-the-corresponding_Q320.jpg)
Juniper representatives are natural sources of plenty of bioactive metabolites and have been used since ancient times as folk remedies against tapeworms, warts, cancer, etc. The antiproliferative activities of junipers are attributed to podophyllotoxin (PPT), which is a precursor for the synthesis of efficient anticancer drugs. However, the natural...
Antimicrobial resistance (AMR) is a worldwide health problem affecting humans, animals, and the environment within the framework of the “One Health” concept. The aim of our study was to evaluate the prevalence of pathogenic strains of the species Escherichia coli (E. coli), their AMR profile, and biofilm-forming potential. The isolated strains from...
The cytotoxicity and microbicidal capacity of seven organic solvents commonly applied for studying plant extracts and bioactive compounds were systematically investigated based on international standards. Four cell lines of normal (CCL-1, HaCaT) or tumor (A-375, A-431) tissue origin, seven bacterial and one fungal strain were used. The impact of th...
Plants from the Rosacea family are rich in natural molecules with beneficial biological properties, and they are widely appreciated and used in the food industry, perfumery, and cosmetics. In this review, we are considering Rosa damascena Mill., Rosa alba L., Rosa centifolia L., and Rosa gallica L. as raw materials important for producing commercia...
The present study is aimed at identification of antioxidant and antiproliferative compounds in extracts of conifers originating from the Windsor Great Park (WGP), UK, and other arboretums. Species of the genera Juniperus, Cupressus, Chamaecyparis and Taxus were studied. Rare representatives of J. indica, J. squamata, J. pingii, J. recurva, J. davur...
Natural deep eutectic solvents (NADES) are a new alternative to toxic organic solvents. Their constituents are primary metabolites, non-toxic, biocompatible and sustainable. In this study four selected NADES were applied for the extraction of two medicinal plants: Sideritis scardica, and Plantago major as an alternative to water-alcohol mixtures, a...
Three new prenyloxy chromanone derivatives, aucherine A-C (6, 7 and 9) as well as six known prenylated phloroglucinols (1-5 and 8) were isolated from the aerial parts of Hypericum aucheri Jaub. Et Spach. The structures of the isolated compounds were established by means of spectral techniques (HRESIMS, 1D and 2D NMR). The new compounds were tested...
Eight polyprenylated acylphloroglucinols, isolated from Hypericum annulatum Moris subsp. annulatum, and characterized as cytotoxic agents against human cancer cells, were subjected to computational ADME, pharmacokinetic and drug-likeness evaluation, using the web tool SwissADME. The physicochemical parameters assessment shows significant lipophilic...
A phytochemical investigation of the aerial parts of Hypericum annulatum Moris led to the isolation of five new prenylated acylphloroglucinol derivatives hyperannulatins A-E (1-3, 5 and 7) in addition to the known hypercalyxone A (4) and 3-geranyl-1-(2'-methylpropanoyl)phloroglucinol (6). The structures were determined by 1D and 2D NMR and MS spect...
The genus Juniperus L. (Cupressaceae) comprises more than 50 species in the world. Widely distributed junipers are evergreen plants that are easy for cultivation, produce a considerable amount of biomass all the year round and are rich of biologically active compounds, including antioxidants and anticancer substances. This study is pointed out at a...
The genus Juniperus L. (Cupressaceae) comprises more than 50 species in the world. Widely distributed junipers are evergreen plants that are easy for cultivation, produce a considerable amount of biomass all the year round and are rich of biologically active compounds, including antioxidants and anticancer substances. This study is pointed out at a...
The genus Hypericum L. (Hypericaceae) includes more than 480 species that are found in every continent of the world, except Antarctica [1]. Hypericum annulatum Moris is a perennial herb distributed in Sardinia, Balkans, East Africa and Saudi Arabia [2]. A phytochemical investigation of the hexane extract of the aerial parts of the titled species le...
Questions
Questions (3)
After getting them out of the freezer (-20) and melting them in the fridge how long can the buffers (which contain skimmed milk) be stored there before use?
Thanks!
Does that mean that there`s apoptosis where an increase is found (in the means of western blot after treating ) and vice versa? Or can I speculate that the decrease is due to cellular resistance against apoptosis?
Projects
Projects (2)
The project is an interdisciplinary investigation, aimed at the activity-guided analysis of unstudied (in the aspect of anticancer activities) species from the Bulgarian flora and certified foreign hybrids of genus Juniperus in order to identify and isolate (by means of modern technologies) anticancer secondary metabolites, incl. new substances, as potential chemotherapeutic agents.
To extract and assess the cytotoxic activity of acylphloroglucinols from Hypericum annulatum, Hypericum cerastioides and Hypericum olympicum
