Yan Li

University of California, Irvine | UCI · Department of Obstetrics & Gynecology

We propose and demonstrate an experiment to explore the optical reception performance of an on-chip spatial optical receiver based on an inverse design under three distinct turbulent conditions. Experimental results demonstrate that the receiver achieved a maximum emission efficiency of 81% at 1530 nm, with fluctuations of less than 2 dB over the w...

We propose a dual-wavelength scheme for a clipping-avoidance photonic analog-to-digital converter (PADC) operating at the sub-Nyquist sampling rate. The scheme utilizes two characteristics, the phase-wrapping feature of a PADC and the wavelength-sensitive feature of a phase modulator, equivalently performing a dual-modulus (DM) modulo operation to...

We propose a method to improve the performance of N × N(N $\geqslant$ ⩾ 3) multimode interference couplers (MMIs) by suppressing propagation constant errors through controlling excited guided modes and the width of MMI, without increasing their fabrication complexity. 5 × 5 MMIs were fabricated on a commercial 220-nm silicon-on-insulator (SOI) plat...

Main conclusion BcERF98 is induced by ethylene signaling and inhibits the expression of BcFT by interacting with BcNF-YA2 and BcEIP9, thereby inhibiting plant flowering. Abstract Several stresses trigger the accumulation of ethylene, which then transmits the signal to ethylene response factors (ERFs) to participate in the regulation of plant devel...

This Letter presents a real-time coherent receiver using digital signal processing (DSP)-assisted automatic frequency control (AFC) to compensate for the Doppler frequency shift (DFS). DFS compensation range of ±8 GHz and the frequency shifting rate of 33 MHz/s are demonstrated in an FPGA-based 2.5 Gbaud QPSK coherent optical system. The experiment...

Key message Two major-effect QTL GlcA07.1 and GlcA09.1 for green leaf color were fine mapped into 170.25 kb and 191.41 kb intervals on chromosomes A07 and A09, respectively, and were validated by transcriptome analysis. Abstract Non-heading Chinese cabbage (NHCC) is a leafy vegetable with a wide range of green colors. Understanding the genetic mec...

Importance The safety of exogenous gonadotropin treatment, based on its effect on embryos and pregnancy outcomes, remains inconclusive. Objective To evaluate the associations of different doses and durations of gonadotropins with embryonic genetic status and pregnancy outcomes after euploid embryo transfer in couples with infertility. Design, Set...

APETALA2/ethylene-responsive factors respond to ethylene and participate in many biological and physiological processes, such as plant morphogenesis, stress resistance, and hormone signal transduction. Ethylene responsive factor 070 （BcERF070）is important in flowering. However, the underlying molecular mechanisms of BcERF070 in floral transition in...

Background During human early placentation, a proportion of extravillous trophoblasts (EVTs) migrate to the maternal decidua, differentiating into endovascular EVTs to remodel spiral arteries and ensure the establishment of blood circulation at the maternal-fetal interface. Inadequate EVT migration and endovascular differentiation are closely assoc...

Background Repeated implantation failure (RIF) leads to a waste of high-quality embryos and remains a challenge in assisted reproductive technology. During early human placentation, the invasion of trophoblast cells into the decidua is an essential step for the establishment of maternal-fetal interactions and subsequent successful pregnancy. Bone m...

Reactions of o-carborane-fused bis-silylene 1 with isocyanate/isothiocyanate molecules furnished a series of SiN/SiS-heterocycles, which show distinct styles of cyclization and were theoretically studied.

The real-time CCDM and inverse CCDM were realized in an FPGA. The DM and inverse DM achieved a throughput of 16.8GBaud and supported on-line reconfiguration to realize different entropies with fine granularity.

In this paper, a detuned distribution enabled polar coded probabilistic shaped 64-QAM is proposed and experimentally investigated over a 36-Tb/s (45×800-Gb/s) 2100-km transmission system at the spectral efficiency of 8-bit/s/Hz.

We experimentally demonstrate an on-chip coherent combiner utilizing the COBYLA algorithm, resulting in a 3.15 dB enhancement in synthesis power. A 36-Gbit/s quadrature phase-shift-keying communication link carried by the combiner is demonstrated.

We propose a dual-wavelength scheme for a high-dynamic-range photonic ADC without necessitating a high oversampling rate. Utilizing a CRT-based algorithm, a 1GHz signal at an oversampling ratio of 5 was experimentally reconstructed.

The cover image is based on the Original Article Insufficient GDF15 expression predisposes women to unexplained recurrent pregnancy loss by impairing extravillous trophoblast invasion by Chunzi Lyu et al., https://doi.org/10.1111/cpr.13514 . image

A novel diversity combining scheme, in conjunction with the complex-valued decision-directed least mean square (CV-DD-LMS) algorithm, is evaluated, and a real-time experimental validation is presented. This proposed scheme employs the CV-DD-LMS algorithm to concurrently perform beam combination and carrier phase recovery (CPR), thereby effectively...

A real-time low-complexity pilot-assisted decision-based cycle slip elimination (PAD-CSE) scheme is investigated over an FPGA-based coherent optical communication system, which exhibits an enhanced 1.4 dB improvement in ROP sensitivity under 15GBaud QPSK OBTB systems.

Metro transmissions requiring high capacity with low complexity are becoming more appealing. Aiming to cope with the increasing traffic of metro transmissions, high-order quadrature amplitude modulation (QAM) formats requiring high optical signal-to-noise ratio (OSNR) are candidates owing to the high spectral efficiency. Although the distribution m...

The impacts of limited bandwidth on the nonlinear transmission performance are investigated by employing a truncated probabilistic shaped 64-ary quadrature amplitude modulation (TPS-64QAM) and a uniformly distributed 16-ary quadrature amplitude modulation (UD-16QAM) over a bandwidth-limited 75-GHz spaced 25-Tb/s (60 × 416.7 Gb/s) 6300-km transmissi...

Bis(1-adamantyl)phosphanylsilylene ( 1 ) was reacted with ArC≡CR (Ar = Ph, 4- i Pr-C 6 H 4 , 3-F-C 6 H 4 ; R = H, Ph) at 80 o C under microwave to afford fluorescence active SiP-heterocycles 3 a-d , which may undergo unique isomerizations...

Insufficient extravillous trophoblast (EVT) invasion during early placentation has been shown to contribute to recurrent pregnancy loss (RPL). However, the regulatory factors involved and their involvement in RPL pathogenesis remain unknown. Here, we found aberrantly decreased growth differentiation factor 15 (GDF15) levels in both first-trimester...

β-caryophyllene has physiological activities such as antibacterial, antiedemic, anti-inflammatory, antitumor, and fungicidal. Previous research has focused on the synthesis of β-caryophyllene, however little information is available about its involvement in β-caryophyllene transport. ATP-binding cassette (ABC) transporters are involved in the trans...

The reactivities of o-carborane-fused silylenes toward molecules with C≡E (E = C, P) bonds are reported. The reactions of bis(silylene) [(LSi:)C]2B10H10 (1a, L = PhC(NtBu)2) with arylalkynes afforded bis(silylium) carborane adducts 2 and 3, showing a Si(μ-C2)Si structure with an open-cage nido-carborane backbone. In contrast, the reaction of 1a wit...

In this paper, a polar coded truncated probabilistic shaped 64-QAM (PTPS-64QAM) scheme is proposed and investigated over the G.654E fiber. Results show that about 2000-km transmission could be achieved aided by the novel proposed scheme.

Objective: To investigate the characteristics of gene mutation, clinical characteristics and significance in acute leukemia (AL) patients. Methods: The clinical data of 102 AL patients in Hebei General Hospital from September 2016 to September 2020 were collected and analyzed retrospectively, including the characteristics of gene mutation, age,...

Nanotheranostics facilitates personalized treatment by providing imaging capabilities for nucleic acid drug vectors. However, available nanotheranostics are not yet capable of indicating the release behavior of nucleic acid drugs. Herein, four guidelines for the design of nanotheranostics are proposed. Under the guidance, transformable nanotheranos...

Sesquiterpenes are important defensive secondary metabolites and aroma components. However, limited information is available on the mechanism of sesquiterpene formation and composition in the non-heading Chinese cabbage (NHCC) leaf. Therefore, headspace solid-phase microextraction/gas chromatography–mass spectrometry (HS-SPME/GC–MS) combined with t...

We demonstrate a real-time coherent optical receiver based on a single field programmable gate array (FPGA) chip. To strike the balance between the performance and hardware resources, we use a clock recovery scheme using the optimal interpolation (OI). The performance and complexity of the OI-based scheme and the traditional schemes are compared an...

Two heterometallic tetranuclear clusters [Dy2Zn2(bipy)2(nb)10] (1) and [Dy2Zn2(bipy)2(μ−OH)2(nb)8] (2) (bipy = 2,2′-bipyridine, Hnb = m-nitrobenzoic acid) were hydrothermally prepared by the reactions of same mixed-ligands with different dysprosium sources. Structurally, the coordination environment, configuration, and the binding modes of the mixe...

In this paper, for the first time, a probability-aided maximum-likelihood sequence detector (PMLSD) is experimentally investigated through a 64-GBaud probabilistic shaped 16-ary quadrature amplitude modulation (PS-16QAM) transmission experiment. In order to relax the impacts of PS technology on the decision module, a PMLSD decision scheme is invest...

0.5 mol% of the amidinato disilyne [LSi:]2 (1, L=PhC(NtBu)2) and 1 mol% of B(C6F5)3 cooperatively polymerized methyl methacrylate (MMA) to form poly(MMA) with the H and CH2C(=CH2)COMe end groups (P1, Mn=3.1×10³ gmol⁻¹; repeating unit, n=31; polydispersity index, Đ: 1.55). The catalytic mechanism is proposed, where compound 1 could react with MMA an...

The plant IQD gene family is responsive to a variety of stresses. In this study, we studied the structural features and functions of the gene BrIQD35 in Chinese cabbage, a member of the IQD gene family. BrIQD35 was cloned and shown to contain an IQ motif. Transient expression of BrIQD35 indicated that it was localized on the plasma membrane and was...

Fragrances are widely used in everyday life. However, too fast volatilization rates and poor adhesion on substrates limit their applications. In this study, reactive nano-fragrance based on cyanuric chloride (CYC)-modified chitosan (CSCYC) were prepared by a solvent evaporation method. First, CS-CYC was synthesized. Subsequently, CS and CS-CYC were...

Severe fever with thrombocytopenia syndrome virus (SFTSV) and Rift Valley fever virus (RVFV) are two arthropod-borne phlebovi-ruses in the Bunyaviridae family, which cause severe illness in humans and animals. Glycoprotein N (Gn) is one of the envelope proteins on the virus surface and is a major antigenic component. Despite its importance for viru...

Alzheimer's disease (AD) remains an incurable disease due to the intricate pathogenesis. The neuropathological hallmarks include extracellular amyloid‐β (Aβ) plaques, tau phosphorylation and extensive oxidative stress in neurons, which facilitate the progression of AD. Based on the complex etiology, a spatiotemporally “cascaded rocket” delivery sys...

Copper is a mineral element, which is necessary for the normal growth and development of plants, but high levels of copper will seriously damage plants. Studies have shown that AtGR1 improves the tolerance of Arabidopsis to aluminum and cadmium stress. However, the role of GR in the copper stress response of plants is still unclear. Here, we identi...

Local feature description is the fundamental research topic for 3D rigid data matching. However, how to achieve a good balanced performance of the local shape descriptor among descriptiveness, robustness, compactness and efficiency remains a challenging task. For this purpose, we propose a novel feature representation of 3D local surface called mul...

Peptide drugs play an important role in diabetes mellitus treatment. Oral administration of peptide drugs is a promising strategy for diabetes mellitus because of its convenience and high patient compliance compared to parenteral administration routes. However, there are a series of formidable unfavorable conditions present in the gastrointestinal...

Most of the PAM4 receivers eliminate the linear and nonlinear distortion by equalization and use independent symbols for decision. In this work, to remove the residual correlation between adjacent symbols after equalization, the enhanced hard decision (HD) based on multi-dimensional basis expansion is theoretically investigated and experimentally d...

During injury, monocytes are recruited from the circulation to inflamed tissues and differentiate locally into mature macrophages, with prior reports showing that cavity macrophages of the peritoneum and pericardium invade deeply into the respective organs to promote repair. Here we report a dual recombinase-mediated genetic system designed to trac...

Multiplier-free adaptive equalizers are significant for improving utilization, reducing costs, and ensuring robustness in real-time hardware implementation. In this paper, we demonstrate that using only one bit shift and one XOR operation to replace a real multiplier is a feasible and low-complexity way to obtain a multiplier-free parallel fixed-po...

In this paper, a polar coded probabilistic shaping (PS) 8-ary pulse amplitude modulation (PAM8) based on many-to-one (MTO) mapping is investigated for short-reach optical interconnection. By ingeniously assigning parity bits to ambiguities positions, no extra PS redundancy and no complex distribution matcher are required in the scheme comparing to...

We investigate the parallelized performance of the conventional Kramers-Kronig (KK) and without the digital up-sampling KK (WDU-KK) receivers in a 112-Gbit/s 16-ary quadrature amplitude modulation (16-QAM) system over a 1440-km standard single-mode fiber (SSMF). A joint overlap approach and bandwidth compensation filter (OLA-BC) architecture is pre...

The use of the dual recombinase-mediated intersectional genetic approach involving Cre-loxP and Dre-rox has significantly enhanced the precision of in vivo lineage tracing, as well as gene manipulation. However, this approach is limited by the small number of Dre recombinase driver constructs available. Here, we developed more than 70 new intersect...

A new single-ended BOTDA technique based on far-end modulation is proposed and demonstrated. 80-km-long sensing range and 1.8 MHz frequency accuracy are achieved with 2 m spatial resolution.

We propose a mode mismatching photonic lantern (MMPL) with a large taper ratio and short taper length that can satisfy adiabatic condition easily. The MMPL can effectively couple power from hundreds multi-mode to several single-modes.

Small interfering RNA (siRNA) has great potential for the treatment of various diseases. However, its intrinsic deficiencies seriously limit its application. Herein, pH-sensitive zwitterionic polymer polycarboxybetaine (PCB) was developed as a non-viral vector for siRNA. The PCB could be protonated in an acidic environment and become positively cha...

Astronauts are under high stress for a long time because of the microgravity condition, which leads to anxiety, affects their learning and memory abilities, and seriously impairs the health of astronauts. Aromatherapy can improve the physical and mental health of astronauts in a way that moisturizes them softly and silently. However, the strong vol...

Most brain diseases such as tumors and neurodegenerative diseases are devastating for patients with high morbidity and mortality. Gene therapy is a promising strategy for the treatment of brain diseases. The widespread use of brain gene therapy requires the development of safe and effective non-viral vectors as its efficiency is seriously limited d...

The most critical problem in the treatment of neurodegenerative diseases is brain neuronal protection, which can be overcome by clearing pathological substances and regulating the immune environment. In the above treatment strategies, the traditional poor drug delivery problem is inevitable. Here, we show an engineering core-shell hybrid system nam...

Leukemia is a liquid tumor caused by a hematopoietic stem cell malignant clone, which seriously affects the normal function of the hematopoietic system. Conventional drugs have poor therapeutic effects due to their poor specificity and stability. With the development of nanotechnology, nonviral nanoparticles bring hope for the efficient treatment o...

Diabetes mellitus has been described as a chronic endocrine and metabolic disease, which is characterized by hyperglycemia and the coexistence of multiple complications. At present, the drugs widely applied in clinical treatment of diabetes mellitus mainly include insulin, insulin analogs, non-insulin oral hypoglycemic drugs and genetic drugs. Neve...