Yali ChenMedik Pro Medical · Initiator/CEO
Yali Chen
Master of Business Administration
Medical | Stem Cells | Venture Capital | Finance | Adventurer | Love Reading | CEO（Find Partnership Opportunities）
About
44
Publications
7,808
Reads
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1,959
Citations
Introduction
I have rich investment background and management experience in the medical industry and stem cell industry. I welcome relevant people in this field to contact me for exchanges and discussions.
Possess the adventurous spirit of an entrepreneur and are keen to invest in various industries
This my Linkedin
https://www.linkedin.com/in/yali-chen-85850b294/
Additional affiliations
June 2017 - December 2023
Growth Medical Ltd.
Position
- CEO
Description
- Growth Medical Limited is a wholly-owned subsidiary of Elite Industrial Holdings Co. Limited. It is committed to high-end medical equipment business
August 2018 - present
February 2019 - present
Vertex Ventures
Position
- Financial Consultant
Description
- Conducted comprehensive financial analysis of potential investment opportunities across various sectors, evaluating financial statements, market trends, and risk factors. Collaborated with clients to develop tailored financial strategies that aligned with their long-term objectives. Provided insights into optimizing asset allocation, diversification, and risk management to enhance investment outcomes.
Education
January 2004 - August 2007
National Taiwan Normal University
Field of study
- Economics
Publications
Publications (44)
NADK is the sole cytosolic enzyme responsible for synthesizing NADP ⁺ from NAD ⁺ within cells. The homeostasis of NAD ⁺ /NADP ⁺ is controlled by NADK, usually dysregulated in various cancers, yet the precise underlying regulatory mechanisms remain largely unknown. In this study, we discover that PRMT6 methylates NADK at R39, R41, and R45, resulting...
Lung cancer is one of the most common malignancies and has the highest number of deaths among all cancers. Despite continuous advances in medical strategies, the overall survival of lung cancer patients is still low, probably due to disease progression or drug resistance. Ferroptosis is an iron-dependent form of regulated cell death triggered by th...
The mammalian cell cycle is divided into four sequential phases, namely G1 (Gap 1), S (synthesis), G2 (Gap 2), and M (mitosis). Wee1, whose turnover is tightly and finely regulated, is a well-known kinase serving as a gatekeeper for the G2/M transition. However, the mechanism underlying the turnover of Wee1 is not fully understood. Autophagy, a hig...
Brown adipose tissue (BAT) is an important regulator of energy homeostasis. Primary brown adipocyte culture provides a powerful and physiologically relevant tool for in vitro studies related to BAT. Here, we describe a detailed procedure for isolation and differentiation of adipocyte precursors from neonatal murine interscapular BAT (iBAT).
Background:
The AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, with deregulation leading to cancer and other diseases. However, how this pathway is dysregulated in cancer has not been well clarified.
Methods:
Using a tandem affinity purification/mass-spec technique and biochemical analyses, we identified tumor...
The AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, with deregulation leading to cancer and other diseases. When intracellular ATP levels decrease during energy stress, AMPK is phosphorylated and activated through AMP binding. However, how this pathway is dysregulated in cancer remains unclear. Here, we find that t...
O-linked β-N-acetyl glucosamine (O-GlcNAc) is attached to proteins under glucose-replete conditions; this posttranslational modification results in molecular and physiological changes that affect cell fate. Here we show that posttranslational modification of serine/arginine-rich protein kinase 2 (SRPK2) by O-GlcNAc regulates de novo lipogenesis by...
Type I interferon (IFN) plays an essential role in the host innate immune responses. Several ubiquitin-conjugating enzyme (E2) family members were reported to regulate type I IFN production and host antiviral immune responses. However, the molecular mechanisms are still not fully understood. Here, we report that UBE2S acts as a negative regulator i...
Hepatic lipid homeostasis is controlled by a coordinated regulation of various metabolic pathways involved in de novo synthesis, uptake, storage, and catabolism of lipids. Disruption of this balance could lead to hepatic steatosis. Peroxisomes play an essential role in lipid metabolism, yet their importance is often overlooked. In a recent study, w...
Autophagy is activated by prolonged fasting but cannot overcome the ensuing hepatic lipid overload, resulting in fatty liver. Here, we describe a peroxisome-lysosome metabolic link that restricts autophagic degradation of lipids. Acyl-CoA oxidase 1 (Acox1), the enzyme that catalyzes the first step in peroxisomal β-oxidation, is enriched in liver an...
Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations, but the underlying mechanism is not clear. Here, we report that the deub...
Despite gemcitabine being the leading chemotherapeutic drug for pancreatic cancer, many patients still relapse due to the drug resistance. We previously reported the molecular link between FKBP51 mediated AKT inhibition and gemcitabine response in pancreatic cancers. However, the upstream regulator of this pathway, especially the involvement of non...
NME1 (also known as NM23-H1) was the first identified tumor metastasis suppressor, which has been reported to link with genomic stability maintenance and cancer. However its underlying mechanisms are still not fully understood. Here we find that NME1 is required for non-homologous end joining (NHEJ) of DNA double-strand breaks (DSBs). Mechanistical...
Peroxisomes perform essential functions in lipid metabolism, including fatty acid oxidation and plasmalogen synthesis. Here, we describe a role for peroxisomal lipid metabolism in mitochondrial dynamics in brown and beige adipocytes. Adipose tissue peroxisomal biogenesis was induced in response to cold exposure through activation of the thermogenic...
The Hippo pathway is crucial in organ size control and tissue homeostasis, with deregulation leading to cancer. An extracellular nutrition signal, such as glucose, regulates the Hippo pathway activation. However, the mechanisms are still not clear. Here, we found that the Hippo pathway is directly regulated by the hexosamine biosynthesis pathway (H...
To prevent genomic instability, cells respond to DNA lesions by blocking cell cycle progression and initiating DNA repair. Homologous recombination repair of DNA breaks requires CtIP-dependent resection of the DNA ends, which is thought to play a key role in activation of CHK1 kinase to induce the cell cycle checkpoint. But the mechanism is still n...
BRCA1 is an important mediator of the DNA damage response, which promotes homologous recombination (HR) and antagonizes 53BP1-dependent non-homologous end joining in S/G2 phase. But how this is achieved remains unclear. Here, we report that the E3 ubiquitin ligase UHRF1 (Ubiquitin-like, with PHD and RING finger domains 1) directly participates in t...
Supplementary Figures 1-7
Analysis summary of microarray data
DNA end resection is a highly regulated and critical step in DNA double-stranded break (DSB) repair. In higher eukaryotes, DSB resection is initiated by the collaborative action of CtIP and the MRE11-RAD50-NBS1 (MRN) complex. Here, we find that the deubiquitylating enzyme USP4 directly participates in DSB resection and homologous recombination (HR)...
O-GlcNAcylation is an important post-translational modification and has been implicated in many fundamental cellular processes. Recent studies showed that O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) mediated O-GlcNAcylation of histone H2B Ser 112 (H2B S112 GlcNAcylation) plays an important role in gene transcription. However, the role o...
Histone H2B O-GlcNAcylation is an important post-translational modification of chromatin during gene transcription. However,
how this epigenetic modification is regulated remains unclear. Here we found that the energy-sensing adenosine-monophosphate-activated
protein kinase (AMPK) could suppress histone H2B O-GlcNAcylation. AMPK directly phosphoryl...
The pattern recognition receptor, RAGE, has been shown to be involved in adaptive immune responses but its role on the components of these responses is not well understood. We have studied the effects of a small molecule inhibitor of RAGE and the deletion of the receptor (RAGE-/- mice) on T cell responses involved in autoimmunity and allograft reje...
Receptor for advanced glycation end products (RAGE) is an activation receptor triggered by inflammatory S100/calgranulins and high mobility group box-1 ligands. We have investigated the importance of RAGE on Ag priming of T cells in murine models in vivo. RAGE is inducibly up-regulated during T cell activation. Transfer of RAGE-deficient OT II T ce...
The multiligand receptor for advanced glycation end products (RAGE) of the Ig superfamily transduces the biological impact of discrete families of ligands, including advanced glycation end products, certain members of the S100/calgranulin family, high mobility group box-1, Mac-1 (alpha(M)beta(2), CD11b/CD18), and amyloid-beta peptide and beta-sheet...
Safe induction of autoantigen-specific long-term tolerance is the "holy grail" for the treatment of autoimmune diseases. In animal models of type 1 diabetes, oral or i.n. immunization with islet antigens induces Tregs that are capable of bystander suppression. However, such interventions are only effective early in the prediabetic phase. Here, we d...
Many studies have suggested that the expression of RAGE (receptor for advanced glycation end products) is upregulated in human tissues susceptible to the long-term complications of diabetes. From the kidneys to the macrovessels of the aorta, RAGE expression is upregulated in a diverse array of cell types, from glomerular epithelial cells (podocytes...
Ligation of the receptor for advanced glycation end products (RAGE) occurs during inflammation. Engagement of RAGE results in enhanced expression of addressins and it is therefore, not surprising that previous studies have shown a role of RAGE/ligand interactions in immune responses including cell/cell contact but the role of RAGE in spontaneous au...
Questions
Questions (4)
Will a 5% ten year in 2024 and a impending maturity wall of required U.S.Treasury refinancings lead interest on the debt overtake Defense, Social security，and Medicare as the single largest line item in the Federal budget？How can a government so indebted pay a mkt rate？
The most common MSCs are: bone marrow MSCs, adipose MSCs, placental MSCs, amniotic membrane MSCs, umbilical cord MSCs, and so on. Clinical studies have shown that these stem cells have therapeutic potential and promote the regeneration and repair of aging tissues.
Life is a journey of continuous learning. Like an experienced doctor who can see the cause of a disease at a glance, Dalio has found the same core logic that has been interpreted over and over again in these many seemingly independent and unrelated events. By analyzing multiple cases at each economic stage and searching for commonalities, we can better envision and test their causal relationships, think about where crises come from and how to avoid risks. So that when the next crisis arises, we can better cope with it.
History is always strikingly similar, and the optimism in the US about beating inflation always comes a little too early. Thinking about this while reading the book, as someone who is preparing to immigrate to the United States, I am a bit worried about whether the future of the United States is optimistic?（Inflation Similar To The 1970s）
#money #inflation #America #USA #Economy #wealth
I am planning to expand my business and hope to learn some industry information from you in your area. Or share some resources and explore potential cooperation opportunities.
#Medicine #Biotechnology #Doctor#Research
