Yahya Madkhali

Yahya Madkhali
University of Hull · Department of Biological Sciences

PhD

About

12
Publications
1,328
Reads
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45
Citations
Citations since 2017
12 Research Items
45 Citations
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201720182019202020212022202302468101214
201720182019202020212022202302468101214
201720182019202020212022202302468101214

Publications

Publications (12)
Article
Full-text available
Introduction In Saudi Arabia, the epidemiology of rheumatoid arthritis (RA) is not well studied and is marked by inconsistencies in clinical diagnosis. Therefore, in this study, we explored the prevalence, clinical characteristics, and diagnostic validity of a prediction score based upon disease markers in orthropedic clinics’ patients in the Madin...
Article
Full-text available
Introduction: The ongoing coronavirus disease 2019 (COVID-19), which emerged in December 2019, is a serious health concern throughout the world. Despite massive COVID-19 vaccination on a global scale, there is a rising need to develop more effective vaccines and drugs to curb the spread of coronavirus. Methodology: In this study, we screened the...
Article
Full-text available
Neurodegenerative disorders involve various pathophysiological pathways, and findinga solution for these issues is still an uphill task for the scientific community. In the present study, acombination of molecular docking and dynamics approaches was applied to target different pathwaysleading to neurodegenerative disorders such as Alzheimer’s disea...
Article
Full-text available
A library of 1,4-dihydropyridine-based 1,2,3-triazol derivatives has been designed, synthesized , and evaluated their cytotoxic potential on colorectal adenocarcinoma (Caco-2) cell lines. All compounds were characterized and identified based on their 1 H and 13 C NMR (Nuclear Magnetic Resonance) spectroscopic data. Furthermore, molecular docking of...
Article
Full-text available
Background and Objective: Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the major global public health concerns. Considering the limitations of the current anti-TB chemotherapy and due to the emergence of drug-resistant M. tuberculosis strains, there is an urgent need to discover and/or develop new drugs against TB. Plants and...
Article
Full-text available
Acetylcholinesterase (AChE) inhibition is a key element in enhancing cholinergic transmission and subsequently relieving major symptoms of several neurological and neuromuscular disorders. Here, the inhibitory potential of geraniol and its mechanism of inhibition against AChE were elucidated in vitro and validated via an in silico study. Our in vit...
Article
Full-text available
Procoagulant activity of tissue factor (TF) in response to injury or inflammation is accompanied with cellular signals which determine the fate of cells. However, to prevent excessive signalling, TF is rapidly dissipated through release into microvesicles, and/or endocytosis. To elucidate the mechanism by which TF signalling may become moderated on...
Article
Full-text available
Accumulation of tissue factor (TF) within cells leads to cellular apoptosis mediated through p38 and p53 pathways. In this study, the involvement of Src1 in the induction of TF-mediated cell apoptosis, and the mechanisms of Src1 activation were investigated. Human coronary artery endothelial cell (HCAEC) were transfected with plasmids to express th...
Article
The activation of protease-activated receptor (PAR)-2 by factor Xa (fXa) promotes the release of tissue factor-positive microvesicles (TF+MV), and contributes to proliferation in cancer cells. This study examined the ability of direct oral anticoagulants (DOACs), apixaban and rivaroxaban, to inhibit the release of TF+MV from two cell lines (MDA-MB-...
Article
Full-text available
Tissue factor (TF)-positive microvesicles from various sources can promote cellular proliferation or alternatively induce apoptosis, but the determining factors are unknown. In this study the hypothesis that the ratio of fVIIa:TF within microvesicles determines this outcome was examined. Microvesicles were isolated from HepG2, BxPC-3, 786-O, MDA-MB...

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Question (1)
Question
Why Clotting Time becomes faster as the number of passage increased? 

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