Yahia Mabkhot

• Professor
• Saudi Arabia at King Khalid University

Expression of concern for ‘An efficient and green procedure for synthesis of rhodanine derivatives by aldol-thia-Michael protocol using aqueous diethylamine medium’ by Assem Barakat et al., RSC Adv., 2014, 4, 4909–4916, https://doi.org/10.1039/C3RA46551A.

In this study, the chemoselective synthesis of two new thiophene derivatives is presented. The structure of newly synthesized thiophenes derivatives; ethyl 4-acetyl-3-phenyl-5-(phenylamino)thiophene-2-carboxylate (5) and ethyl (E)-4-(3-(dimethylamino)acryloyl)-3-phenyl-5-(phenylamino)thiophene-2-carboxylate (8) were established using different FTIR...

The thiazole ring is found in many pharmaceutical and natural products. In this article, the convenient synthesis of two new hybrid molecules carrying the thiazole nucleus linked to pyrazole or pyridine rings is described. The structure of the synthesized hybrids is confirmed by spectroscopic and X-ray analysis. Using Hirshfeld analysis, the molecu...

Globally, novel coronavirus (nCoV19) outbreak is a great concern to humanity owing to the unavailability of effective medication or vaccine to date. Therefore, the development of drugs having anti-COVID-19 potential is a need of time. In this milieu, in-silico studies have proven to be rapid, inexpensive and effective as compared to other experimen...

In numerous studies related to tumor prognosis, programmed death-ligand 1 (PD-L1) has been identified as a biomarker. This work aimed to determine the prognostic importance of PD-L1 in breast cancer. We searched electronic databases such as PubMed, Google scholar, home pages of publishing groups, medical, clinical, and pharmaceutical sciences journ...

Green silver nanoparticles (AgNPs) and crude ethanolic, methanolic, aqueous, and acetonic extracts from leaves of Agave americana, Mentha spicata, and Mangifera indica were scrutinized for possible antineoplastic and cytotoxic efficacy. In this study, all the synthesized AgNPs were characterized using UV-Vis spectroscopy, X-ray diffraction, SEM (sc...

The current investigation is aimed at synthesizing nonhazardous, ecofriendly silver nanoparticles (AgNPs) from aqueous leaf extract of Acer pentapomicum and at evaluating its antibacterial, antifungal, and antioxidant activities. In the present study, AgNPs were synthesized at room temperature by mixing 7 mL of 1 mM AgNO3 with 1 mL of A. pentapomic...

Hyperlipidemia, the most common form of dyslipidemia, is the main source of cardiovascular disorders, characterized by elevated level of total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) with high-density lipoprotein cholesterol (HDL-C) in peripheral blood. It is caused by a defect in lipid metabolism in the...

Ferns are often used by indigenous people in Khyber Pakhtunkhwa, Pakistan. This study was designed to collect the ethnomedicinal and traditional knowledge of these locals about this group of vascular plants. Forty taxa belong to nineteen genera and ten families are used in the treatment of different diseases. The Pteridaceae was the most represe...

Herein we report the synthesis, DFT calculations, and molecular docking studies of a pyrazole derivative, (E)-N'-benzylidene-5-methyl-1H-pyrazole-3-carbohydrazide (E-BMPC) as α-glucosidase and α-amylase inhibitor. Molecular structure of E-BMPC has been confirmed by single crystal X-ray diffraction (XRD), FTIR, ¹H, and ¹³C NMR spectra. In addition,...

Studies of the ethyl acetate extract bark extract of Olea ferruginea led to the isolation of one new compound Ferruginan A (1) in addition to two known compounds, Ferruginan (2) and cycloolivil (3). Structures of the isolated compounds were confirmed by mass spectrometry (MS) and NMR spectral data. The ethyl acetate fraction and compounds (1–3) wer...

To prospect an isozyme-specific, effective inhibitor against the physiologically-crucial enzyme phosphodiesterase 1 (PDE1), phytochemicals from Pistacia integerrima galls were screened. The chloroform fraction of gall extract was subjected to column chromatographic which led to the isolation of compound 1, elucidated to be 5-hydroxy-7-methoxy-2-(4-...

The current study was intended to fabricate and evaluate ultrasonically assisted quercetin nanoemulsion (Que-NE) for improved bioavailability and therapeutic effectiveness against diabetes mellitus in rats. Ethyl oleate, Tween 20, and Labrasol were chosen as oil, surfactant, and cosurfactant, respectively. Box–Behnken design (BBD) was employed to s...

The removal of heavy metals is attracting considerable attention due to their undesirable effects on the environment. In this investigation, a new adsorbent based on silica functionalized with pyridin-2-ylmethanol (SiPy) was successfully synthesized to yield to a hybrid material. FTIR, SEM, TGA, and specific surface area analysis were used to chara...

Investigation on medicinal plants’ therapeutic potential has gained substantial importance in the discovery of novel effective and safe therapeutic agents. The present study is aimed at investigating the hepatoprotective potential of Seriphidium kurramense methanolic extract (SKM) against carbon tetrachloride- (CCl4-) induced hepatotoxicity in rats...

Arsenic (As) contamination in drinking groundwater is a common environmental problem in Pakistan. Therefore, sixty-one groundwater samples were collected from various groundwater sources in District Sanghar, Sindh province, Pakistan, to understand the geochemical behavior of elevated As in groundwater. Statistical summary showed the cations and ani...

Numerous medicinal plants have been utilized for the treatment of different types of diseases and disorders including gastrointestinal (GI) diseases. GI diseases are the most common complaints that normally affects the largest proportion of children and adolescents with overlapping clinical manifestation in diagnosis and medical needs. Drugs with a...

Numerous medicinal plants have been utilized for the treatment of different types of diseases and disorders including gastrointestinal (GI) diseases. GI diseases are the most common complaints that normally affects the largest proportion of children and adolescents with overlapping clinical manifestation in diagnosis and medical needs. Drugs with a...

Heterocyclic compounds possessing the thiophene nucleus have attracted tremendous interest in the field of medicinal chemistry due to their promising pharmacological properties. A series of new thiophene derivatives were designed synthesized using an appropriate synthetic route. The suggested structures of the synthesized thiophene derivatives were...

In this article, the synthesis of a new thiazole derivative using a novel and economic synthetic route is described. This compound has antitumor, antimicrobial, and larvicidal properties. It is worth noting that the synthesized thiazole has been patented [No. US 10,501,426 B1; date of patent: December 10, 2019].

The pharmacological activities of thiazole and pyrazole moieties as antimicrobial and anticancer agents have been thoroughly described in many literature reviews. In this study, a convenient synthesis of novel pyrazolo[5,1-b]thiazole-based heterocycles was carried out. The synthesized compounds were characterized by IR, ¹H and ¹³C NMR spectroscopy...

The causative agent of malaria, Plasmodium falciparum, has been developing resistance to several drugs worldwide since more than five decades. Initially, resistance was toward drugs such as chloroquine, pyrimethamine, sulfadoxine, mefloquine, and quinine. Research studies are now reporting the resistance of parasites to the most effective and novel...

A new crystal, i.e, (E)-5-methyl-N′-(pyridin-2-ylmethylene)-1H-pyrazole-3-carbohydrazide (E-MPPC) has been synthesized and characterized by using FT-IR, UV-Vis, ¹H-NMR, ¹³C-NMR, ESI-MS and single-crystal X-ray diffraction. In addition, a density functional theory study for the title compound was carried out. The theoretical geometry of the ground s...

Removal of heavy metals from drinking water sources and rivers is of strategic health importance and is essential for sustainable ecosystem development, in particular in polluted areas around the globe. In this work, new hybrid inorganic-organic material adsorbents made of ortho- (Si-o-OR) or para-Schiff base silica (Si-p-OR) were synthesized and c...

Pistacia integerrima grows in some areas of Pakistan and some other south Asian countries such as Afghanistan, India, Nepal, and Myanmar. It is an important medicinal plant which has been traditionally used for the treatment of asthma, cough, and dysentery. In the present study, we intend to re-isolate bioactive compounds (I–III) from P. integerrim...

In this work, a novel crystal i.e (E)-N'-(4-chlorobenzylidene)-5-phenyl-1H-pyrazole-3-carbohydrazide has been synthesized and characterized using various spectroscopic techniques. The (E)-configuration of the azomethine (N=CH) was confirmed by single crystal X-ray analysis. The molecule crystallizes in the monoclinic space group, P21/c, a = 15.629(...

The current investigation aims to synthesize gold nanoparticles (AuNPs) from aqueous extract of Tamarindus indica and to evaluate the antibacterial effects of crude extract as well as synthesized AuNPs. Several methods have been reported to synthesize AuNPs; however, most of them were not ecofriendly. In the present study, the green synthesis of Au...

A series of thiophene bearing pyrazolo[3,4-d]pyridazine and pyridine moieties were synthesized and characterized by IR, NMR, mass spectroscopic analytical techniques. In vitro antimicrobial activity of the synthesized compounds was screened against selected gram positive and gram negative bacteria, including Streptococcus pyogenes, Bacillus subtili...

One of the major challenges in the community and healthcare was an impedance of pathogenic bacteria to antibiotics. This work developed 2-aminothiophene derivatives as novel antimicrobial agents. Various 2-aminothiophene derivatives (3a-f, 5a-c, 6a, b, 7, 8a, b and 9) with cyclic and heterocyclic moieties at 5-position were synthesized, and charact...

Trachyspermum ammi seeds were selected for photochemical study. The crude T. ammi methanol and aqueous extracts showed the presence of alkaloids, saponins, steroid sterpenoids, caumarines, betacynins, flavonoids and soluble starch. The synthesis of gold nanoparticles (AuNPs) using T. ammi extract was characterized using UV-visible, and FT-IR spectr...

This study deals with facile and rapid synthesis of silver nanoparticles (AgNPs) and Gold nanoparticles (AuNPs) using Mentha longifolia leaves extracts (MLE). The synthesized AgNPs and AuNPs were characterized by UV-visible spectroscopy (UV-Vis), Fourier transformed infra-red spectroscopy (FT-IR), atomic force microscopy (AFM) and transmission elec...

This paper describes the anti-nociceptive activity of isolated di-naphthodiospyrols from Diospyros lotus L., Ebenaceae. The roots of D. lotus were collected from the surroundings of Razagram, Pakistan. Six dimeric di-naphthodiospyrols were isolated by column chromatography and identified as follows: 5,4-dihydroxy-1-methoxy-6,6-dimethyl-7,3-binaphth...

Background: Studies on the interaction between bioactive molecules and HIV-1 virus have been the focus of recent research in the scope of medicinal chemistry and pharmacology. Objective: Investigating the structural parameters and physico-chemical properties of elucidating and identifying the antiviral pharmacophore sites. Method: A mixed computati...

The reaction of ethyl 3-oxobutanoate, carbon disulfide, and chloroacetone in the presence of K2CO3 afforded a novel bis(2-thienyl)disulfide derivative (4). The structure of the synthesized compound was confirmed by spectral and X-ray analyses. Hirshfeld quantitative analysis of molecular packing showed that the H���H (40.8–42.1%), O���H (19.7–23.9%...

Coronavirus disease 2019 (COVID-19) which originated in an outbreak in 2019 in Wuhan, Hubei province, China is caused by the SARS-CoV-2 virus. The virus belongs to the beta-coronavirus class, like the Middle East Respiratory Syndrome coronavirus and Severe Acute Respiratory Syndrome coronavirus. Interestingly, the virus binds with angiotensin-conve...

The present study was carried out to determine the effect of plant extract of Syzygium cumini and their silver nanoparticles (AgNPs) against the poultry pathogens. The plant extract was prepared in methanol, ethanol, ethyl acetate, chloroform, and n-hexane. The results of phytochemical screening showed that the leaf extract of S. cumini have medici...

The aim of present finding was to explore the extracts of Skimmia laureola barks and leaves for various pharmacological activities. The extract showed strong susceptibility against Micrococcus leutus, Escherichia coli, Pasteurella multocida, Bacillus subtilis and Streptococcus viridans with MIC in range of 0.65-125 mg/ml, 0.67-5 mg/ml, 0.65-125 mg/...

In this present work, the newly synthesized compound E)-N'-(5-bromo-2-hydroxybenzylidene)isonicotinohydrazide (2) has been synthesized and characterized by IR, ¹H &¹³C NMR, ESI-MS and single crystal X-ray diffraction analysis using experimental and theoretical methods. The molecular geometry, vibrational frequencies, frontier molecular orbital (HOM...

Objectives The recent viral pandemic poses a unique challenge for healthcare providers. Despite the remarkable progress, the number of novel antiviral agents in the pipeline is woefully inadequate against the evolving virulence and drug resistance of current viruses. This highlights the urgent need for new and improved vaccines, diagnostics and the...

Background One of the best methods to treat Alzheimer disease (AD) is through the effective use of cholinesterase inhibitors as vital drugs due to the identification of acetylcholine deficit in the AD patients. Objective The present study aims the investigation of spiro heterocyclic compounds as potential AD agents supported by their metal chelati...

A need exists to develop safe and efficacious medications to treat major diseases such as cancer and infectious diseases. In response to this need, we synthesized a novel enaminone, which structurally belongs to the trithiocarbonate class engrafted by an enaminone group. The anticancer and antimicrobial activities were evaluated by utilizing three...

Diospyros lotus, also known as date-plum, belongs to the Ebenaceae family and is mostly recognized as a rootstock for D. kaki. Similar classes of naphthoquinones in D. lotus are investigated against cancer and inflammation and have antimicrobial, sedative, and analgesic properties. Six chemical constituents (1-6) were isolated from Diospyros lotus...

Thiophene is a core structure in many marketed drugs, such as Duloxetine, Tiotropium, Raloxifene, Dorzolamide, Tioconazole, Citizolam, Sertaconazole Nitrate and Benocyclidine. Thiophene derivatives are reported to have several types of pharmacological and biological activities. The synthesis of new thiophene derivatives is important to pharmaceutic...

5‐(2‐Bromoacetyl)‐2,3,4‐trisubstituted‐thiophene was used as a synthetic intermediate to prepare a series of thiophene derivatives and thiophene incorporating oxazole, imidazole, thiazole, pyrrole, and pyridine rings via substitution and cyclo‐condensation reactions. The data were extracted from the spectra of the resulting products confirmed their...

Seriphidium kurramense (S. kurramense) are highly recommended by local homeopathic for curing diseases like a cough, cold and headache etc. Phytochemical tests of plant extracts were performed to identify secondary metabolites for curing human diseases. Our results exhibited the presence of glycosides, saponins, flavonoids, phalobatanins, reducing...

Salvia leriifolia Benth., Lamiaceae, an endemic medicinal plant of the northern region of Iran, has been documented as sedative. It has been used in traditional medicine for its muscle relaxation effect. The need for sedation and muscle relaxation are common problems which are usually treated with different synthetic drugs, which are associated wit...

This paper describes the anti-nociceptive activity of isolated di-naphthodiospyrols from Diospyros lotus L., Ebenaceae. The roots of D. lotus were collected from the surroundings of Razagram, Pakistan. Six dimeric di-naphthodiospyrols were isolated by column chromatography and identified as follows: 5,4-dihydroxy-1-methoxy-6,6-dimethyl-7,3-binaphth...

The [AgL2]ClO4 complex, where L is ketene S,S-dithioacetal type ligand, is synthesized and characterized using elemental analysis, different spectroscopic techniques (FTIR and NMR) and single crystal X-ray diffraction (SC-XRD). The Ag-atom is coordinated by two oxygen and two sulfur atoms of both bidentate ligands resulting in a distorted square pl...

The aim of current study was to investigate Ziziphus nummularia root for phytochemical composition as well as antimicrobial and antioxidant potential. The preliminary phytochemical screening of Z. nummularia root extract revealed the presence of different types of secondary metabolites including glycosides, tannins, phenols, saponins, alkaloids, re...

Discovery of new anti-tuberculosis drugs with novel mode of action is urgently needed. The tryptophan synthase is a genetically validated enzyme that catalyzes last step of tryptophan biosynthetic pathway required for growth and survival of Mycobacterium tuberculosis. Here, a ligand-based pharmacophore model was built using molecular operating envi...

Background: Pyridines have been reported to possess various pharmacological activities. Results: Sodium 3-oxo-3-(2-oxo-2H-chromen-3-yl)prop-1-en-1-olate (2) and sodium 3-oxo-3-(3-oxo-3H-benzo[f]chromen-2-yl)prop-1-en-1-olate (7) were prepared and reacted with 2-cyano-N'-(1-aryl(heteryl)ethylidene)acetohydrazides 3a-d to produce 2-oxo-1,2-dihydro...

Background Studies on the interaction between bioactive molecules and HIV-1 virus has been the focus of recent research in the scope of medicinal chemistry and pharmacology. Objective Investigating the structural parameters and physic-chemical properties of elucidating and identifying of the antiviral pharmacophore sites. Method A mixed computati...

SYNTHESIS OF THIAZOLE DERIVATIVE AS ANTICANCER AND ANTIANTIBIOTICS RESISTANT BACTERIA AGENT

Polydimethylsiloxane belongs to a polymeric organosilicon compounds that is widely used as silicon-based organic polymer. Polydimethylsiloxane is a basically optically clear, inert, nontoxic and inflammable material which is widely used in medical devices, as an elastomer, antifoaming agent, heat-resistant lubricants, fire retardants, in cosmetics...

A comprehensive theoretical model was designed for two new flavanols that have been reported from Glycosmis pentaphylla, differing in the placement of α‐pyrone ring. The density functional theory (DFT) approach was utilized for computing different properties of these compounds to validate the experimental findings and stereochemical assignments. El...

Picea smithiana is an important tree, belonging to the family Pinaceae, having many medicinal uses. The local people use it for a variety of diseases including eye, kidney and skin. The plant was investigated scientifically for phytochemical constituents and cytotoxicity effect on human tumor cell line; MCF-7, K-562, HT-29, H-460, M-14 and HUTU-80....

Twelve new Schiff base derivatives have been prepared by the condensation reaction of different amino substituted compounds (aniline, pyridin-2-amine, o-toluidine, 2-nitrobenzenamine, 4-aminophenol, and 3-aminopropanol) and substituted aldehydes such as nicotinaldehyde, o,m,p-nitrobenzaldehyde, and picolinaldehyde in ethanol using acetic acid as a...

Phenacylbromide derivatives constitute a multilateral group of precursors for the synthesis of numerous heterocycles of organic compounds. Briefly, 5‐(2‐bromo‐acetyl)‐substituted‐thiophene derivative has been used as a synthon for synthesis of new thiophene‐containing compounds through the reaction with nucleophilic nitrogen compounds and thioamide...

The Zika virus (ZIKV) has gained attention for the last few years due to the congenital microcephaly and Guillain-Barre Syndrome that resulted in humans. The non-structural protein-3 (NS3) helicase of ZIKV play an important role in viral RNA replication. In this article, we performed hundred nanosecond molecular dynamics simulation and molecular do...

Background: Since deficit of acetylcholine has been evidenced in the Alzheimer's disease (AD) patients, cholinesterase inhibitors are currently the most specified drug category for the remediation of AD. Method: In the present study, 16 compounds (1-16) with dicarbonyl skeletons have been synthesized and tested for their inhibitory potential in vit...

A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing ¹H-NMR, ¹³C-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The results revealed that the thiazolines 5b and 2c exhibited...

Background: Since deficit of acetylcholine has been evidenced in the patients of Alzheimer's disease (AD), cholinesterase inhibitors are currently the most prescribed drug class for the treatment of AD. Results: In the present study, 16 compounds (1-16) with dicarbonyl skeletons have been synthesized and tested for their inhibitory potential in...

Background: 4-Thiazolidinone ring is reported to have almost all types of biological activities. Also, it present in many marketed drugs. Results: Ethyl acetoacetate reacted with phenyl isothiocyanate and ethyl chloroacetate in presence of K2CO3 and DMF to afford the thiazolidinone derivative 5. Thiazolidinone 5 reacted with dimethylformamide-di...

The molecular structure of the 2-(4-oxo-3-phenylthiazolidin-2-ylidene) malononitrile (3) is calculated using DFT B3LYP/6-311G(d, p) method. The calculated geometric parameters are in good agreement with the experimental data. The NBO calculations were performed to predict the natural atomic charges at the different atomic sites and study the differ...

Steviosides, rebaudiosides and their analogues constitute a major class of naturally occurring biologically active diterpene compounds. The wide spectrum of pharmacological activity of this group of compounds has developed an interest among medicinal chemists to synthesize, purify, and analyze more selective and potent isosteviol derivatives. It ha...

This commentary highlights the recent work published in journal Nature on the structural based discovery of novel analgesic compounds for opioid receptors with minimal effects. Manglik et al. selectively targeted the Gi based μOR pathway instead of the β-arrestin pathway of the opioids. The computational screening of millions of compounds showed a...

The aim of the current work was to explore the muscle relaxant effect of pistagremic acid (PA) isolated from Pistacia integerrima in various animal paradigms. In a rotarod test, PA caused a significant (p<0.05) muscle relaxant potential in a dose-dependent manner. When studied in the inclined plane test, pretreatment with PA (5 and 10 mg/kg) caused...

The present subject matter is directed to an enaminone grafted trithiocarbonate compound having the structure :and the anticancer and antimicrobial activities exhibited by the compound

Background: Honokiol ((3',5-di-(2-propenyl)-1,1'-biphenyl-2,2'-diol), a lignan, is a promising antitumor compound, having exerted activity against a number of human cancer cell lines. Honokiol has inhibitory role on the proliferation, invasion and survival of cancer cells in in vitro as well as in vivo studies. It interferes with signaling pathway...

Substituted[4,5]thieno[2,3- d ]thiazolo[3,2- a ]pyrimidin-5-one ( 3a–b ) and pyrimidin-5(6 H )-imine ( 3c–e ) were synthesized via reaction of the starting compounds, ethyl 2-amino-substituted[ b ]thiophene-3-carboxylate ( 2a–c ) and 2-amino-substituted [ b ]thiophene-3-carbonitrile ( 2d–f ), respectively, with 2-bromothiazole. Synthesis of (bromo-...

Medicinal and food plants as well as their bioactive fractions have been used by diverse human cultures since ancient times. These plants provide multiple health benefits because of the presence of a plethora of phytochemicals including phenylpropanoids, isoprenoids, alkaloids, sulphated compounds, peptides and polysaccharides that are responsible...

Synthesis and Antimicrobial Use of a Trithiocarbonate Derivative

The reaction of 1,5,5′-trimethyl-1H,1′H-3,3′-bipyrazole (Hbpz) with copper and manganese salts (Cu(BF4)2·6H2O, MnCl2·4H2O and Mn(NCS)2) leads to the formation of three mononuclear coordination complexes [Cu(Hbpz)3](BF4)2 (1), [Mn(Hbpz)2Cl2]·CH3CN (2) and [Mn(Hbpz)2(NCS)2]·Et2O (3). These compounds have been characterized using single crystal X-ray...

Two new coordination polymers, namely, ZnL2(BF4)2 (1) and CuL2(NO3)2 (2) were constructed from a new flexible acyclic cryptate-bis(1H-1,2,4-triazole) ligand. Both coordination polymers were characterized by FT-IR, UV-vis, and thermal analysis and the crystal structures were confirmed by single crystal XRD analysis. According to single crystal X-ray...

A series of new substituted pyrazoles embedded with a variety of function groups has been synthesized from 4-[4-(1,2-dihydro-2,3-dimethyl-1-phenyl-5-oxo-3H-pyrazol-4-yl)]-2-cyano-4-oxo-butanenitrile (4). The synthesized compounds were fully characterized and their structures were elucidated based on elemental analysis, spectral data, and alternativ...

Background: The synthesis of new thiazole derivatives is very important because of their diverse biological activities. Also , many drugs containing thiazole ring in their skeletons are available in the market such as Abafungin, Acotiamide, Alagebrium, Amiphenazole, Brecanavir, Carumonam, Cefepime, and Cefmatilen. Results: Ethyl cyanoacetate rea...

Background Pyrazole is an important class of heterocyclic compound, has been shown to exhibit diverse biological and pharmacological activities such as anti-inflammatory, anti-cancer, antioxidant, etc. Methods In this study, a series of novel 3,5-dimethyl-1H-pyrazole derivatives containing hydrazine 4a-l have been synthesized via the reaction of t...