Yael Bar Lavan

Yael Bar Lavan
Dead Sea-Arava Science Center (DSASC) Central Arava · Biotechnology

Ph.D

About

21
Publications
2,206
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
107
Citations
Citations since 2016
19 Research Items
95 Citations
20162017201820192020202120220510152025
20162017201820192020202120220510152025
20162017201820192020202120220510152025
20162017201820192020202120220510152025

Publications

Publications (21)
Article
Full-text available
Background: The evolutionary relationships between plants and their microbiomes are of high importance to the survival of plants in general and even more in extreme conditions. Changes in the plant's microbiome can affect plant development, growth, fitness, and health. Along the arid Arava, southern Israel, acacia trees ( Acacia raddiana and Acacia...
Preprint
Full-text available
Background: The evolutionary relationships between plants and their microbiome are of high importance to the survival of plants in extreme conditions. Changes in microbiome of plants can affect plant development, growth and health. Along the arid Arava, southern Israel, acacia trees ( Acacia raddiana and Acacia tortilis ) are considered keystone sp...
Preprint
Full-text available
Background: The evolutionary relationships and interactions between plants and their microbiomes are of high importance to the survival of plants in extreme conditions. Changes in the plant’s microbiome can affect plant development, growth and health. Along the arid Arava, southern Israel, acacia trees (Acacia raddiana and Acacia tortilis) are cons...
Preprint
Full-text available
Along the arid Arava, southern Israel, acacia trees ( Acacia raddiana and Acacia tortilis ) are considered keystone species. In this study, we investigated the ecological effects of plant species, microclimate (different areas within the tree canopies) and seasonality on the endophytic and epiphytic microbiome associated with these two tree species...
Article
Full-text available
Hematopoietic Stem Cells (HSCs) generate blood and immune cells through a hierarchical process of differentiation. Genes that regulate this process are of great interest for understanding normal and also malignant hematopoiesis. Surprisingly, however, very little is known about long-non-coding RNAs (lncRNA) in HSCs. Neat1 is a lncRNA that plays a m...
Article
Full-text available
Safeguarding the proteome is central to the health of the cell. In multi-cellular organisms, the composition of the proteome, and by extension, protein-folding requirements, varies between cells. In agreement, chaperone network composition differs between tissues. Here, we ask how chaperone expression is regulated in a cell type-specific manner and...
Data
Transcriptional analysis of muscle gene expression. Hierarchical clustering of the relative expression of 35 muscle-specific genes across 10 developmental stages (at 4-cells, E cell division, 4th-7th AB cell divisions, ventral enclosure (VE), comma stage (cs), first movement, and L1) [55]. MI marks the myogenesis-induced subset. (TIF)
Data
Modulating HSP90 levels results in embryo arrest. (A) Images of a population of wild type, unc-54(ts), HSP90M or HSP90M;unc-54(ts) embryos laid at 20°C. (B) Representative confocal images (>90%) of unc-54(ts), and HSP90M;unc-54(ts) embryos laid at 25°C and stained with anti-UNC-54 antibodies. The scale bar is 25 μm. (TIF)
Data
A mutation in the putative HLH-1-binding motif of daf-21(Hsp90) promoter affected its expression pattern in adult animals. Representative images of HLH-1(ec) animals expressing GFP under the regulation of the wild type or a mutant daf-21(Hsp90) promoter, without myogenic induction. Arrows indicate body-wall muscle cells. (TIF)
Data
Chaperone association with muscle and HLH-1 binding. (A) Flowchart outlining the filtering analyses of the chaperone list. (B) Summarized data from bioinformatics analyses. (XLSX)
Data
Heat shock-induced changes in chaperone expression. (A) Representative images (>90%) of the expression pattern of chaperones in wild type embryos untreated or subjected to heat shock after a 6 h recovery. Scale bar is 25 μm. (B-E) Relative chaperone mRNA levels in heat shock-treated wild type (gray) or HLH-1(ec) (red) embryos. Data are relative to...
Data
Reduced HLH-1 levels modulate the expression of some chaperones. (A) Representative images (>90%) of the expression pattern of the indicated chaperones in wild type embryos grown at 25°C. (B-C) Relative mRNA levels (25/15°C) of wild type (gray) or hlh-1(cc561) (green) embryos (normalize to T07A9.15). Data are presented as means ± SEM of 5 independe...
Data
Disruption of muscle proteostasis results in embryo arrest. (A) Embryonic arrest scored for Q35;hlh-1(cc561) or Q35 embryos treated with smg-2, smg-7 or empty vector control RNAi. Data are presented as means ± SEM of at least 3 independent experiments. (B) Representative confocal images of Q35;hlh-1(cc561) muscles. Scale bar is 10 μm. (C-D) Extract...
Data
Down-regulation of hsp-1(Hsc70), rme-8(Hsp40) and dnj-8(Hsp40) in DNJ-24M animals disrupts myosin organization. Representative confocal images of age-synchronized DNJ-24M animals treated with control, hsp-1(Hsc70), rme-8(Hsp40) or dnj-8(Hsp40) RNAi and stained with anti-MYO-3 antibodies. Scale bar is 25 μm. (TIF)
Data
List of strains used in this study. (PDF)
Data
List of quantitative PCR primers used in this study. (PDF)
Article
Quality control is an essential aspect of cellular function, with protein folding quality control being carried out by molecular chaperones, a diverse group of highly conserved proteins that specifically identify misfolded conformations. Molecular chaperones are thus required to support proteins affected by expressed polymorphisms, mutations, intri...
Article
Full-text available
Proteome stability is central to cellular function and the lifespan of an organism. This is apparent in muscle cells, where incorrect folding and assembly of the sarcomere contributes to disease and aging. Apart from the myosin-assembly factor UNC-45, the complete network of chaperones involved in assembly and maintenance of muscle tissue is curren...
Article
The long-term health of all metazoan cells is linked to protein quality control, which is achieved by proteostasis, a complex network of molecular interactions that determines the health of the proteome under physiological or stress conditions. Studying the regulation of cellular proteostasis in the context of the whole organism has unraveled multi...

Network

Cited By

Projects

Projects (2)
Project
looking into the interaction between the microbial communities and plants in extreme environment