Xueping Yao

Porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2) lineage 8 was first detected in mainland China in 2006 and has since rapidly spread to become the primary epidemic strain in the country. In this study, samples such as lung tissue, hilar lymph nodes, abortion fetuses, and blood were collected from large-scale pig farms across 11...

The objective of this study was to investigate the mechanism of prenatal stress on the cognitive function of offspring, and clarify the change of histone deacetylase 2 (HDAC2) expression in hippocampal neurons of offspring. 16 pregnant SD rats were randomly divided into control group and stress group, with eight rats in each group. The stress group...

Glaesserella parasuis is a gram-negative bacterium that causes fibrotic polyserositis and arthritis in pig, significantly affecting the pig industry. The pan-genome of G. parasuis is open. As the number of genes increases, the core and accessory genomes may show more pronounced differences. The genes associated with virulence and biofilm formation...

NADC34-like porcine reproductive and respiratory syndrome virus first appeared in 2017 in a herd of pigs in Liaoning Province, China. The virus was subsequently found in other provinces. Given the potential for this virus to cause an epidemic, rapid, sensitive, and specific detection of NADC34-like PRRSV is required. The virus’ ORF5 gene was artifi...

Neurotropic viruses severely damage the central nervous system (CNS) and human health. Common neurotropic viruses include rabies virus (RABV), Zika virus, and poliovirus. When treating neurotropic virus infection, obstruction of the blood–brain barrier (BBB) reduces the efficiency of drug delivery to the CNS. An efficient intracerebral delivery sys...

This study investigated the effects of nine colour environments on visual tracking accuracy and visual strain during normal sitting (SP), -12° head-down bed (HD) and 9.6° head-up tilt bed (HU). In a standard posture change laboratory study, fifty-four participants performed visual tracking tasks in nine colour environments while in the three postur...

Dairy cows with ketosis have high circulating beta-hydroxybutyric acid (BHBA) concentrations alongside which inflammation is concomitantly developed. Tryptophan (Trp) is an essential amino acid that participates in the regulation of the inflammatory response. However, the association between Trp metabolism and inflammation in dairy cows with ketosi...

The effect of oat β-glucan on intestinal function and growth performance of weaned rabbits were explored by multi-omics integrative analyses in the present study. New Zealand White rabbits fed oat β-glucan [200 mg/kg body weight (BW)] for 4 weeks, and serum markers, colon histological alterations, colonic microbiome, colonic metabolome, and serum m...

Understanding the colour preference in microgravity environments will enable better design of future spacecraft and extra-terrestrial environments. In this study, a space station’s crew cabin was simulated and evaluated in 33 different colours by 55 participants using a standard body position change methodology in controlled conditions. Three bo...

Background Glässer's disease, caused by Haemophilus parasuis (HPS), is responsible for economic losses in the pig industry worldwide. However, the existing commercial vaccines offer poor protection and there are significant barriers to the development of effective vaccines. Methods In the current study, we aimed to identify potential vaccine candi...

Lagovirus europaeus GI.1 belongs to Lagovirus in the Caliciviridae family. GI.1 causes an acute, septic, and highly lethal disease in rabbits. Lagovirus europaeus GI.2, a new variant of GI.1, has caused explosive mortality in rabbits of all ages in Sichuan Province, China. To explore the differences in pathogenicity of rabbits infected with GI.1/GI...

Background Staphylococcus arlettae is a rarely reported coagulase-negative staphylococcus (CoNS) isolated from infected humans and livestock. Observing phage-bacteria interaction could improve the understanding of bacterial pathogenetic mechanisms, providing foundational evidence for phage therapy or phage detection. Herein, we aimed to characteris...

Purpose/Objective(s) The adapt to shape (ATS) workflow of 1.5 T MR-Linac 1.5 allows plan adaptation according to the new patient anatomy with a plan optimization on daily magnetic resonance imaging (MRI)-based synthetic computed tomography (syCT). This study evaluates the effectiveness of introducing into the clinical workflow a per/patient assessm...

Among the fitness and body shaping exercises of Chinese women, swimming has become an increasingly popular sporting activity. Swimsuits are fundamental to participation in this sport and paramount to achieving the wearers' aim of participation. A survey of 3348 Chinese women showed that body fit is central to the purchase of a swimsuit, whether one...

This study implemented a short-term virtual reality examination of the impacts of environmental colour and posture changes (to simulate microgravity and lunar gravity) on cognitive task performance and emotions. In a standard posture change laboratory study, sixty participants performed a simple cognitive task battery (finding A's test and number c...

Left displaced abomasum (LDA) in postpartum dairy cows contributes to significant economic losses. Dairy cows with LDA undergo excessive lipid mobilization and insulin resistance. Although gut dysbiosis is implicated, little is known about the role of the gut microbiota in the abnormal metabolic processes of LDA. To investigate the functional links...

Background Recent studies have characterized that microRNA (miRNA) is a suitable candidate for the study of bleomycin/LPS-induced pulmonary fibrosis, but the knowledge on miRNA in bacteria-induced pulmonary fibrosis (BIPF) is limited. Forest musk deer ( Moschus berezovskii , FMD) is an important endangered species that has been seriously affected b...

Rabbit hemorrhagic disease virus (RHDV) belongs to Lagovirus in the Caliciviridae family. RHDV is an acute, septic, and highly lethal disease in rabbits. RHDV2, a new variant of RHDV, caused explosive mortality in rabbits of all ages in Sichuan Province, China. To explore the differences in pathogenicity of rabbits infected with RHDV2/RHDV, we inve...

Introduction In May 2020, an outbreak of rabbit haemorrhagic disease 2 (RHD2) caused by the rabbit haemorrhagic disease virus 2 (RHDV2, GI.2) occurred in Sichuan, China. The acute onset and short disease course resulted in rabbit mortality as high as 42.86%. Currently, basic research on the aetiology and genetic characteristics of GI.2 is lacking i...

The hygiene area is one of the most important facilities in a space station. If its environmental lighting is appropriately designed, it can significantly reduce the psychological pressure on astronauts. This study investigates the effect of correlated colour temperature (CCT) on heart rate, galvanic skin response, emotion and satisfaction in the h...

The present study aims to evaluate the alterations in gut microbiome and plasma metabolites of dairy calves with β-glucan (BG) supplementation. Fourteen healthy newborn dairy calves with similar body weight were randomly divided into control (n = 7) and BG (n = 7) groups. All the calves were fed on the basal diet, while calves in the BG group were...

In complex human-machine systems such as spacecraft, poor astronaut performance leads to dangerous accidents, and assessing the functional state of astronauts during a mission has positive impacts on risk reduction and efficiency. This paper aimed to assess the functional state of astronauts in performing target tracking tasks of different difficul...

The effect of the Astragalus membranaceus root (AMR) on the serum metabolic profiles of preweaning calf were investigated in this study. Sixteen preweaning Holstein calves were randomly allocated into two groups with eight calves per group, and offered a control basal diet (CON group) or supplemented with 20 g superfine powder of AMR (AMR group) fo...

The integration of solar photovoltaic (PV) power generation technology into electric vehicle (EV) charging systems is of great significance, and it is very important to analyze the influencing factors of vehicle operating parameters on the generation power of vehicle PV system. In this paper, a model is developed to predict the power generated by v...

Bovine mastitis is a common disease occurring in dairy farms and can be caused by more than 150 species of pathogenic bacteria. One of the most common causative organisms is Streptococcus agalactiae , which is also potentially harmful to humans and aquatic animals. At present, research on S . agalactiae in China is mostly concentrated in the northe...

Foodborne pathogens have become the subject of intense interest because of their high incidence and mortality worldwide. In the past few decades, people have developed many methods to solve this challenge. At present, methods such as traditional microbial culture methods, nucleic acid or protein-based pathogen detection methods, and whole-genome an...

Prepartum exercise (PA) has been proposed as a strategy for the peripartum management of dairy cows; however, the mechanism by which PA affects metabolism has not been elucidated. Here, we investigated the metabolic changes in transition dairy cows with PA. Holstein transition multiparous dairy cows were assigned to an exercise (n = 12) or a contro...

(1) Background: In recent years, the porcine reproductive and respiratory syndrome virus (PRRSV) has become a virulent pathogen that has caused devastating diseases and economic losses worldwide in the swine industry. IRPS has attracted extensive attention in the field of virology. However, it is not clear that IRPS has an antiviral effect on PRRSV...

During space missions, astronauts live in a confined technological environment, completely isolated and deprived of the variety and variation found in the environment on Earth. This circumstance has a strong impact on the psycho-physiological states of the crew. Particularly in light of the plans for long-duration missions, new research needs to be...

With the improper use of antibiotics, an increasing number of multidrug-resistant bacteria have been reported worldwide, posing challenges for disease treatment. Klebsiella pneumoniae is an important zoonotic pathogen that colonises the respiratory tract. Endolysin therapy has emerged with the development of phages. In this study, a lytic phage vB_...

Dissimilar welding of TiAl-based alloy and Ni-based superalloy with different single alloying element (Ti, Nb, V, Cu) was performed by laser. Detailed effects of alloying element on microstructural characterization and mechanical properties of the joints were investigated. The results showed that laser welding of TiAl/Ni-based superalloy was not ac...

Introduction Porcine circovirus 4 (PCV4) was first discovered in 2019 in a herd of pigs with porcine respiratory disease, dermatitis and nephropathy syndrome in Hunan Province, China. It has subsequently been detected in other provinces and in South Korea. In consideration of the potential of the virus to cause an epidemic, rapid, sensitive, and sp...

Background Upadacitinib (UPA), an oral selective and reversible JAK inhibitor, demonstrated significantly greater efficacy compared to placebo (PBO) as treatment for moderate to severe ulcerative colitis (UC), in phase 3 induction (U-ACHIEVE and U-ACCOMPLISH) and maintenance (U-ACHIEVE Maintenance) studies. We evaluated UPA efficacy on histologic o...

Background Upadacitinib (UPA), a selective and reversible Janus kinase inhibitor, has been shown to be safe and effective when administered at a dose of 45 mg once daily (QD) as 8-week induction therapy in moderate-to-severe Ulcerative Colitis (UC). This analysis evaluated outcomes following extended induction (45 mg QD for 16 weeks) followed by ma...

Background Upadacitinib (UPA), an oral, reversible JAK inhibitor engineered for increased selectivity for JAK1 over JAK2, JAK3, or tyrosine kinase 2 (TYK2), demonstrated significantly greater efficacy compared with placebo (PBO) for induction of remission in patients with moderately to severely active ulcerative colitis (UC) in two phase 3 trials,...

Background Health-related quality of life (HRQOL) is reduced in patients (pts) with ulcerative colitis (UC). We report on the HRQOL benefits of maintenance treatment with upadacitinib (UPA), a selective and reversible Janus kinase inhibitor, in pts with moderately to severely active UC in the Phase, 3 multicentre, randomised, double-blind U-ACHIEVE...

Background Abdominal pain (AP), bowel urgency (BU), and fatigue are debilitating symptoms that reduce quality of life in patients with active ulcerative colitis (UC). Results from two Phase 3 induction trials (U-ACHIEVE induction [NCT02819635] and U-ACCOMPLISH [NCT03653026]) showed significant improvements in AP, BU, and fatigue following induction...

Background Upadacitinib (UPA) is an oral, once-daily (QD), selective Janus kinase inhibitor that has demonstrated efficacy in the induction and maintenance treatment of Ulcerative Colitis (UC). This analysis aimed to assess the impact of baseline UC characteristics on clinical outcomes following UPA therapy. Methods Patients (pts) with moderately...

Background EIMs are common in patients with UC and are associated with impaired quality of life. This analysis evaluated the impact of treatment with the selective Janus kinase 1 inhibitor UPA on EIMs in patients with moderate-to-severe UC. Methods Data were included from two induction studies (U-ACHIEVE Induction [NCT02819635] and U-ACCOMPLISH [N...

It is widely believed that liver transplantation is the only way to cure hepatic cirrhosis. However, due to limited funds and liver donors, liver transplantation is seldom performed in Asia, especially in China. For patients who have experienced oesophageal and gastric varices bleeding and waiting for a liver transplant, transjugular intrahepatic p...

Histology and embryology is a science that studies the micro structure and function of the body and embryogenesis, and has insight into the microcosmic world of human body. It is delicate and ingeniousness, which greatly satisfy our thirst for knowledge and visual appreciation. This paper expounds the beauty of Science in histology and Embryology f...

Many experiments have proved that vision and hearing effect each other in many ways, and this phenomenon is of great significance to design (Zhang，2019)(Anderson，2014). Among the design of car cockpit, color is one of the most important elements of cockpit visual design, and different color directly affect people's experience in the cockpit (Satake...

Neurotropic viruses have neural-invasive and neurovirulent properties to damage the central nervous system (CNS), leading to humans’ fatal symptoms. Neurotropic viruses comprise a lot of viruses, such as Zika virus (ZIKV), herpes simplex virus (HSV), rabies virus (RABV), and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Effecti...

Purpose/Objective(s) To compare the dosimetry differences between coplanar and non-coplanar modes and analyze the feasibility of single non-coplanar mode in the stereotactic radiosurgery of brain metastases. Materials/Methods Retrospective analysis were made on the 14 patients with brain metastases and all the plans take the VMAT and FFF technolog...

Aim To describe short and longer-term mortality following major lower extremity amputation (LEA) by diabetes status over two time periods Method A retrospective cohort study of patients who underwent major LEA between 2004 and 2013 was conducted based on linkage of national population-based hospital records and a register of people with diagnosed...

The screening of reference genes for real-time quantitative PCR (qPCR) in forest musk deer (FMD) tissue is of great significance to the basic research on FMD. However, there are few reports on the stability analysis of FMD reference genes so far. In this study, We used qPCR to detect the expression levels of 11 reference gene candidates (18S rRNA,...

• In recent years, natural Pinellia ternata populations of have gradually been exhausted, while the cultivated yield has been limited due to lack of research and uncertain climate condition. Therefore, it is necessary to explore methods of improving yield and quality in P. ternata using brassinolide (BR) treatments and choice of a suitable seed bul...

Forest musk deer ( Moschus berezovskii ) is an endangered, protected species in China. Intestinal coccidiosis is a significant problem for captive forest musk deer. However, there are few reports on the prevalence and molecular characteristics of Eimeria sp. in forest musk deer. We sought to investigate the prevalence of Eimeria sp. in forest musk...

Klebsiella pneumoniae is an important pathogen that can infect both humans and cattle. The widespread K. pneumoniae and its high drug resistance make it difficult to treat Klebsiella infections/diseases. In this study, a lytic K. pneumoniae bacteriophage vB_Kpn_B01 was isolated from a dairy farm trough in Sichuan Province, and its biological proper...

Endometritis is caused by endometrial cell injury and chronic inflammation of uteri infected by pathogens, leading to reproductive failure in dairy cows. Changes of the endometrial immune response regulates the development of endometritis. In a recent discovery, exosomes acted as a functional regulator secreted by a variety of cells, however, its r...

In order to obtain the high-precision star centroid position under complex working conditions, a centroid location method based on position matrix under extremum value analysis is proposed. Firstly, a coarse extraction algorithm of star point dispersion region is proposed under extreme value analysis, and the star point local region is restricted a...

(1) Background: Short-read sequencing allows for the rapid and accurate analysis of the whole bacterial genome but does not usually enable complete genome assembly. Long-read sequencing greatly assists with the resolution of complex bacterial genomes, particularly when combined with short-read Illumina data. However, it is not clear how different a...

Taraxasterol (TAR) is a kind of active compound extracted from dandelion and its molecular structure resembles steroid hormones. Recently, TAR has been reported to show an anti-tumor activity. However, the specific role of TAR in papillary thyroid cancer (PTC) has not been clarified. In this study, we investigated the effect of TAR on PTC cell migr...

For large-scale manned spacecraft bound for the Moon and Mars, lighting should be explored that can reduce safety risks while increasing visual capability. The use of appropriate lighting in large-scale manned spacecraft can provide astronauts with a comfortable and safe living and working environment while reducing the energy consumption of the li...

Giant rock avalanche is uncommon globally, but quite devastative, so its recognition is important both for deepening our understanding of regional tectonic background, and for disaster reduction and engineering safety. Based on remote sensing, UAV surveying and filed reconnaissance, a newly recognized Basu giant rock avalanche is reported, with its...

We report the results of a muon spin relaxation study of slow magnetic fluctuations in the pseudogap phase of underdoped single-crystalline YBa2Cu3Oy, y=6.77 and 6.83. The dependence of the dynamic muon spin relaxation rate on applied magnetic field yields the rms magnitude Blocrms and correlation time τc of fluctuating local fields at muon sites....

Tracking changes in the number and function of T cells is of great value to clinical diagnosis and evaluation of the efficacy of allergen immunotherapy. This review summarizes research progress in detection methods for allergen-specific T cells and their application, such as carboxyfluorescein succinimidyl ester dilution assay, enzyme-linked immuno...

In May 2020, the first outbreak of rabbit viral hemorrhagic disease (RHD) caused by rabbit hemorrhagic disease virus type 2 (GI.2) occurred in Sichuan, China. The acute onset and short disease course resulted in rabbit mortalities as high as 42.86%. Currently, basic research on the etiology and genetic characteristics of GI.2 is lacking in China. P...

Haemophilus parasuis (H. parasuis) is a conditional pathogen with the ability to form biofilms which can lead to ineffective drug treatment and severe chronic infections resulting in significant economic losses to the pig industry. Currently, knowledge of biofilm formation by H. parasuis is not well developed. The objective of this study was to inv...

In order to solve the problems of low efficiency, high redundancy, interaction conflict and high resource consumption of multi-agent system in dealing with complex tasks, this paper proposes an optimization algorithm of multi-agent system based on complex tasks. It is improved based on the differential evolution algorithm and the local optimization...

Aims Mortality rates from chronic kidney disease (CKD) have increased in the last decade. In this pre-specified analysis of the DAPA-CKD trial, we determined the effects of dapagliflozin on cardiovascular and non-cardiovascular causes of death. Methods and results DAPA-CKD was an international, randomized, placebo-controlled trial with a median...

Bibersteinia trehalosi is a zoonosis bacterial species, There are few reports of the disease in our country, and there is no fast, sensitive and efficient detection method have been developded. Therefore, the Quantitative Real-time PCR (q-PCR) for detecting Bibersteinia trehalosi has been established, and the specific primers desigened based on the...