Xuchen Shan

Xuchen Shan
Beihang University (BUAA) | BUAA ·  Department of Physics

Doctor of Philosophy

About

28
Publications
5,373
Reads
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373
Citations
Citations since 2017
28 Research Items
372 Citations
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2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
Introduction
Currently, I am interested in nano force detecting based on optical tweezers with machine learning.

Publications

Publications (28)
Article
Full-text available
Optical tweezers are widely used in materials assembly¹, characterization², biomechanical force sensing3,4 and the in vivo manipulation of cells⁵ and organs⁶. The trapping force has primarily been generated through the refractive index mismatch between a trapped object and its surrounding medium. This poses a fundamental challenge for the optical t...
Article
Full-text available
Point spread function (PSF) engineering by an emitter's response can code higher‐spatial‐frequency information of an image for microscopy to achieve super‐resolution. However, complexed excitation optics or repetitive scans are needed, which explains the issues of low speed, poor stability, and operational complexity associated with the current las...
Article
Full-text available
Multiphoton fluorescence microscopy (MPM), using near infrared excitation light, provides increased penetration depth, decreased detection background, and reduced phototoxicity. Using stimulated emission depletion (STED) approach, MPM can bypass the diffraction limitation, but it requires both spatial alignment and temporal synchronization of high...
Article
Full-text available
Interferometric Scattering Microscopy Rayleigh scattering of the nanoparticles can be engineered by doping lanthanide ions, which is based on the enhanced polarizability of the nanoparticles when the excitation wavelength matches the ion resonance frequency of the lanthanide ions. More details can be found in article number 2203354 by Baolei Liu, C...
Preprint
Full-text available
Ultraviolet (UV) imaging enables a diverse array of applications, such as material composition analysis, biological fluorescence imaging, and detecting defects in semiconductor manufacturing. However, scientific-grade UV cameras with high quantum efficiency are expensive and include a complex thermoelectric cooling system. Here, we demonstrate a UV...
Article
Full-text available
Manufacturing sharp features is one of the most desired requirements for lithography. Here, we demonstrate a dual-path self-aligned polarization interference lithography (Dp-SAP IL) for fabricating periodic nanostructures, featuring high-steepness and high-uniformization. Meanwhile, it can manufacture quasicrystals with adjustable rotation symmetry...
Article
Full-text available
In this paper, we present a dual-mode adaptive singular value decomposition ghost imaging (A-SVD GI), which can be easily switched between the modes of imaging and edge detection. It can adaptively localize the foreground pixels via a threshold selection method. Then only the foreground region is illuminated by the singular value decomposition (S...
Preprint
In this paper, we present a dual-mode adaptive singular value decomposition ghost imaging (A-SVD GI), which can be easily switched between the modes of imaging and edge detection. It can adaptively localize the foreground pixels via a threshold selection method. Then only the foreground region is illuminated by the singular value decomposition (SVD...
Preprint
Full-text available
In this paper, we present a dual-mode adaptive singular value decomposition ghost imaging (A-SVD GI), which can be easily switched between the modes of imaging and edge detection. It can adaptively localize the foreground pixels via a threshold selection method. Then only the foreground region is illuminated by the singular value decomposition (SVD...
Conference Paper
Nanoscale weak force sensing in aqueous solution is of great interest to researchers from broad areas, including physics and biology. Here we developed a video tracking-based optical tweezers calibration method that enables the detection of the trap stiffness for low refractive index nanoparticles. We found that under resonance conditions, doping l...
Preprint
Full-text available
Precise force measurement is critical to probing biological events and physics processes, spanning from molecular motor’s motion to the Casimir effect ¹ and the detection of gravitational wave ² . Yet, despite extensive technology developments, the 3D nanoscale measurement of weak forces in aqueous solutions poses a significant challenge. Technique...
Article
Full-text available
Single-beam super-resolution microscopy, also known as superlinear microscopy, exploits the nonlinear response of fluorescent probes in confocal microscopy. The technique requires no complex purpose-built system, light field modulation, or beam shaping. Here, we present a strategy to enhance this technique's spatial resolution by modulating excitat...
Article
Full-text available
Light scattering from nanoparticles is significant in nanoscale imaging, photon confinement. and biosensing. However, engineering the scattering spectrum, traditionally by modifying the geometric feature of particles, requires synthesis and fabrication with nanometre accuracy. Here it is reported that doping lanthanide ions can engineer the scatter...
Preprint
Full-text available
Single-beam super-resolution microscopy, also known as superlinear microscopy, exploits the nonlinear response of fluorescent probes in confocal microscopy. The technique requires no complex purpose-built system, light field modulation, or beam shaping. Here, we present a strategy to enhance spatial resolution of superlinear microscopy by modulatin...
Article
Full-text available
The diverse photoresponses from different energy levels in lanthanide‐doped nanoparticles enables simultaneous generation of multiple point‐spread functions with one doughnut‐shaped excitation beam. In article number 2008847, Fan Wang, Dayong Jin, and co‐workers explore a new imaging modality to extend the capabilities of the engineered point‐sprea...
Preprint
Full-text available
Point spread function (PSF) engineering by emitter's response can code higher spatial frequency information of an image for microscopy to achieve super-resolution. However, complexed excitation optics or repetitive scans are needed, which explains the issues of low speed, poor stability and operational complexity associated with the current laser s...
Conference Paper
Full-text available
To simplify the reconstruction algorithms in ghost imaging, we present a feedback-based approach to reduce reconstruction times. We introduce a genetic algorithm to optimize the illumination patterns in real-time to match with the object's shape.
Article
Full-text available
Correction for ‘Video-rate upconversion display from optimized lanthanide ion doped upconversion nanoparticles’ by Laixu Gao et al. , Nanoscale , 2020, DOI: 10.1039/d0nr03076g.
Article
Full-text available
We developed a video-rate upconverting display system with much enhanced brightness. The integral emission intensity of the single Volumetric displays that create bright image points within a transparent bulk is one of the most attracting technologies in everyday life. Lanthanide ions doped upconversion nanoparticles (UCNPs) is an promising lumines...
Article
Full-text available
Video-rate super-resolution imaging through biological tissue can visualize and track biomolecule interplays and transportations inside cellular organisms. Structured illumination microscopy allows for wide-field super resolution observation of biological samples but is limited by the strong extinction of light by biological tissues, which restrict...
Preprint
Full-text available
Video-rate super-resolution imaging through biological tissue can visualize and track biomolecule interplays and transportations inside cellular organisms. Structured illumination microscopy allows for wide-field super resolution observation of biological samples but is limited by the strong absorption and scattering of light by biological tissues,...
Article
Full-text available
In article number 1905572, Fan Wang and co‐workers develop near‐infrared Bessel‐beam emission saturation nanoscopy to simultaneously tackle the problems in light absorption and scattering for biological tissues, enabling the tracking of single nanoparticles inside a multicellular tumor spheroid in the depth over 55 µm with an imaging resolution of...
Article
Full-text available
Cancer spheroids have structural, functional, and physiological similarities to the tumor, and have become a low‐cost in vitro model to study the physiological responses of single cells and therapeutic efficacy of drugs. However, the tiny spheroid, made of a cluster of high‐density cells, is highly scattering and absorptive, which prevents light mi...
Conference Paper
Bright and photo-stable luminescent nanoparticles held great potential for bioimaging, long-term molecular tracking. Rare-earth-doped upconversion nanoparticles (UCNPs) have been recently discovered with unique properties for Stimulated Emission Depletion (STED) super-resolution microscopy imaging. However, this system strictly requires optical ali...

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