Xu Wu

• University of Shanghai for Science and Technology

Terahertz metasurface biosensors based on the quasi‐bound state in the continuum (QBIC) offer label‐free, rapid, and ultrasensitive biomedical detection. Recent advances in deep learning facilitate efficient, fast, and customized design of such metasurfaces. However, prior approaches primarily establish one‐to‐one mappings between structure and opt...

Vitamin C (VC) and Vitamin B9 (VB9) are essential micronutrients integral to numerous biological functions and critical for maintaining human health. The rapid detection of these vitamins is important for verifying nutritional supplements and aiding in clinical diagnoses. This study combined terahertz time-domain spectroscopy (THz-TDS) with metasur...

Rivaroxaban, a direct oral anticoagulant, is widely used in the management and prevention of thrombotic conditions. Dose adjustments are necessary to optimize efficacy based on individual physiological differences. However, current analytical methods are impractical for clinical use due to complex sample preparation and lengthy detection times. Thi...

In this paper, we proposed a polarization-independent terahertz surface plasmon resonance (SPR) biosensor based on an angular cyclic element structure. The biosensor has the advantages of high sensitivity detection and high stability against the polarization change of incident terahertz light. Based on the principle that the spatial longitudinal el...

Spintronic heterostructures consisting of ferromagnetic (FM) and nonmagnetic (NM) have become increasingly important devices for terahertz (THz) pulse generation, named as spintronic THz emitter (STE). The recycling of the laser pump energy is known to have a key impact on further improvement of the THz emission. Here, an efficient and practical ap...

Industrial solid waste refers to the solid waste that is produced in industrial production activities. Without correct treatment and let-off, industrial solid waste may cause environmental pollution due to a variety of pollutants and toxic substances that are contained in it. Conventional detection methods for identifying harmful substances are hig...

Terahertz technology has broad application prospects in biomedical detection. However, the mixed characteristics of actual samples make the terahertz spectrum complex and difficult to distinguish, and there is no practical terahertz detection method for clinical medicine. Here, we propose a three-step one-way terahertz model, presenting a detailed...

Chiral drugs are drugs with chiral or asymmetric centres in their molecular structure. Different enantiomers of the same chiral drug have noticeably different pharmacological activities and pharmacokinetic properties. However, its distinction has been perplexing scholars for many years in the qualitative and quantitative detection of antagonistic d...

Terahertz technology has broad application prospects in biomedical detection. However, the mixed characteristics of actual samples make the terahertz spectrum complex and difficult to distinguish, and there is no practical terahertz detection method for medical clinics. Here, we propose a three-step one-way terahertz model, presenting a detailed fl...

Panax quinquefolium is a perennial herbaceous plant that contains many beneficial ginsenosides with diverse pharmacological effects. 24(R)-pseudoginsenoside F 11 is specific to P . quinquefolium , a useful biomarker for distinguishing this species from other related plants. However, because of its nonconjugated property and the complexity of existi...

Caffeine is an alkaloid and may be the most commonly ingested pharmacologically active substance in the world, but continuous abuse may lead to “caffeine poisoning”. In this study, we propose a method for the qualitative and quantitative analysis of caffeine in various medicines using terahertz spectroscopy combined with chemometrics. By comparing...

Terahertz time-domain spectroscopy (THz-TDS) systems are widely used to obtain fingerprint spectra of many different biomedical substances, and thus the identification of different biological materials, medicines, or dangerous chemicals can be realized. However, the spectral data for the same substance obtained from different THz-TDS systems may ha...

Terahertz (THz) waves are electromagnetic waves with frequency in the range from 0.1 to 10 THz. THz waves have great potential in the biomedical field, especially in cancer diagnosis, because they exhibit low ionization energy and can be used to discern most biomolecules based on their spectral fingerprints. In this paper, we review the recent prog...

Terahertz wave has a good ability to identify biomolecules due to its fingerprint spectrum characteristics. However, the minimum detectable limit of terahertz technology by conventional tablet pressing method is in the order of milligram, which cannot meet the application requirements of low concentration detection in biomedical field—near or below...

Homocysteine (C4H9NO2S) is a variant of the amino acid cysteine, a harmful substance to the human body, which is closely related to cardiovascular disease, senile dementia, fractures, et al. At present, conventional methods for detecting homocysteine in biological samples include high performance liquid chromatography (HPLC), fluorescence polarizat...

Rivaroxaban, as a direct oral anticoagulant, has been widely used in the treatment and prevention of thrombosis disease (TD). However, even if taking the same dose of rivaroxaban, different pathophysiological characteristics of TD patients determine the difference of plasma concentrations between individuals, leading to the difficulties of dosage s...

Methyglyoxal (MGO) is an important pathological factor for diabetic cardiovascular complications. Conventional methods for MGO detection in biological samples, such as high performance liquid chromatography (HPLC)-UV spectrometry, LC-fluorescence spectrometry, and HPLC-mass spectrometry, are time-consuming, high-cost, and complicated. Here, we pres...

Terahertz precision spectrum has many important applications in biomedical detection. Here, we present our recent results about biomarkers exist in liquid form (such as urine) and solid form (such as tissue), and we also proposed quantitative identification algorithms, which have great meaning for the nondestructive accuracy biomedical detection. C...

Homocysteine is an amino acid related to metabolism in human vivo, which is closely related to cardiovascular disease, senile dementia, bone fracture, et al. Currently, the usual medical test methods for homocysteine include high performance liquid chromatography (HPLC), fluorescence polarization immunoassay (FPIA) and enzyme-linked immunosorbent a...

The mechanism of β-sheet crystallization in silk fibroin remains unclear, due to the incomplete information of protein assembly and structural state. The emerging terahertz (THz) spectroscopy (<10 THz) has been taken as an important tool to detect new aspects of biomolecular structure and is used for the first time to analyze the methanol–water (Me...

Results: show that from silk gland to cocoon, fibroin experiences a significant transformation in crystal structure from a typical silk I, to a silk I-rich mixed structure, and finally to a typical silk II state, accompanied with a change in secondary structure from α-helix and random coil structures to preferential orientation β-sheets. Compared...

Electrospinning is a simple but efficient procedure enabling the parallel fabrication of a multitude of inorganic fibers. But the precise control of the fiber’s morphology, which seriously affects the electrical, optical and other important properties of such electrospun materials, is still less developed. The creation of nanoscale indium tin oxide...

The purpose of this paper is to prepare an integrating light propagative, transparent and conductive optical fiber. This optical fiber is made by the coating of a thin layer of indium tin oxide (ITO) nanofibers. ITO nanofibers are fabricated via centrifugal spinning process and wrap around the quartz optical fiber. Field emission scanning electron...

This paper studies the effect of Sn doping on the morphological, structural, and electrical properties of the Sn-doping In2O3 nanofiber networks. In2O3-based nanofibers with various relative concentration of Sn precursor (0–20 mol%) were fabricated through the electrospinning method. Scanning electron microscopy observations show that, depending on...

Transparent conductive indium tin oxide (ITO) film was prepared on optical fiber through a multi-step sol–gel process. The influence of annealing temperature on the adhesion of ITO coated optical fibers was studied. Different surface treatments were applied to improve the adhesion between ITO film and quartz optical fiber. Field emission scanning e...