Xinxia Cai

Xinxia Cai
Chinese Academy of Sciences | CAS · Institute of Electronics

Prof./PhD

About

225
Publications
35,562
Reads
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1,905
Citations
Introduction
Current research interests include microelectrode array and scientific instrument for multichannel neural electrophysiological and chemical signals detection, paper-based microfluidic immunosensors, microsystems and nanotechnology.
Additional affiliations
March 2005 - present
Chinese Academy of Sciences
Position
  • Professor
Description
  • Bioelectronics
August 1991 - present
Chinese Academy of Sciences
Position
  • Professor
Description
  • Prof. Xinxia Cai a chief scientist of the national major scientific research project on nanoscience, a winner of national science fund for distinguished young scholars.
Education
October 1998 - November 2001
Department of Electronics & Electrical Engineering, Glasgow University
Field of study
  • Bioelectronics
September 1988 - July 1991
Institute of Semiconductors, Chinese Academy of Sciences
Field of study
  • Microelectronics
September 1984 - July 1988
Department of Electrical Engineering, Beijing Institute of Technology
Field of study
  • Microelectronics

Publications

Publications (225)
Article
Full-text available
Hemoglobin is a very important physiological index in human blood, especially for the evaluation of the physical performance of athletes. This paper reports an amperometric biosensor for the determination of blood hemoglobin, using potassium ferricyanide as a mediator, based on thin-film technology in a two-electrode system. The biosensor can be us...
Article
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The fabrication of microelectrodes integrated within ultra-low-volume microtiter chambers for the amperometric determination of metabolites continues to be of interest in the subject of single-cell and high-throughput screening. The microsystem described in this paper consists of a two-microelectrode sensor with a microfluidic dispensation technolo...
Article
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A biosensor for rapid detection of bacterial count based on adenosine 5'-triphosphate (ATP) bioluminescence has been developed. The biosensor is composed of a key sensitive element and a photomultiplier tube used as a detector element. The disposable sensitive element consists of a sampler, a cartridge where intracellular ATP is chemically extracte...
Article
Thesis (Ph. D.)--University of Glasgow, 2001.
Conference Paper
Full-text available
In this work the design, construction, control and applications of a computerized portable multichannel detection system suitable for electrochemical measurements was developed. The detection system is based on integrated eight homemade miniature potentiostat powered by two 9V batteries. The electrochemical control programme, developed in LabVIEW 6...
Article
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Place cells establish rapid mapping relationships between the external environment and themselves in a new context. However, the mapping relationships of environmental cues to place cells in short-term memory is still completely unknown. In this work, we designed a silicon-based motion microelectrode array (mMEA) and an implantation device to recor...
Article
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Grid cells with stable hexagonal firing patterns in the medial entorhinal cortex (MEC) carry the vital function of serving as a metric for the surrounding environment. Whether this mechanism processes only spatial information or involves nonspatial information remains elusive. Here, we fabricated an MEC-shaped microelectrode array (MEA) to detect t...
Article
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The neural mechanisms of torpor have essential reference significance for medical methods and long-term manned space. Changes in electrophysiology of suprachiasmatic nucleus (SCN) conduce to revealing the neural mechanisms from the torpor to arousal. Due to the lower physiology state during the torpor, it is a challenge to detect neural activities...
Article
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Both the cellular- and population-level properties of involved neurons are essential for unveiling the learning and memory functions of the brain. To give equal attention to these two aspects, neural sensors based on microelectrode arrays (MEAs) have been in the limelight due to their noninvasive detection and regulation capabilities. Here, we fabr...
Article
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Devices for continuous in-vivo testing (CIVT) can detect target substances in real time, thus providing a valuable window into a patient's condition, their response to therapeutics, metabolic activities, and neurotransmitter transmission in the brain. Therefore, CIVT devices have received increased attention because they are expected to greatly ass...
Article
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The medial amygdala (MA) plays an important role in the innate fear circuit. However, the electrophysiological mechanism of MA for processing innate fear needs to be further explored. In this study, we fabricated microelectrode arrays (MEAs) with detecting sites arranged to match the location and shape of MA in mice and detected the electrophysiolo...
Article
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Clinical transplantation of human embryonic stem cells derived dopaminergic neurons (hESC-DDNs) is expected to be a potential therapy for treating neurodegenerative diseases. However, the assessment of the physiological functions, including electrophysiology and dopamine (DA) vesicular exocytosis, of hESC-DDNs are not impeccable currently, which de...
Article
Gastrointestinal fistula, a complication of gastrointestinal cancer surgery, has a high mortality rate. Detection of both C-reactive protein (CRP) and prealbumin (PAB) is advantageous in the auxiliary diagnosis of postoperative complications. However, traditional detection methods are not capable of on-site rapid detection. In an attempt to overcom...
Article
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Defense is the basic survival mechanism of animals when facing dangers. Previous studies have shown that the midbrain periaqueduct gray (PAG) was essential for the production of defense responses. However, the correlation between the endogenous neuronal activities of the dorsal PAG (dPAG) and different defense behaviors was still unclear. In this a...
Article
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Research on the intracerebral mechanism of insomnia induced by serotonin (5-HT) deficiency is indispensable. In order to explore the effect of 5-HT deficiency-induced insomnia on brain regions related to memory in rats, we designed and fabricated a microelectrode array that simultaneously detects the electrical activity of the dorsal raphe nucleus...
Article
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There are approximately 50 million people with epilepsy worldwide, even about 25% of whom cannot be effectively controlled by drugs or surgical treatment. A wireless closed-loop system for epilepsy detection and suppression is proposed in this study. The system is composed of an implantable optrode, wireless recording, wireless energy supply, and a...
Article
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Acupoint specificity for diseases has consistently been the focus of acupuncture research owing to its excellent prospects for clinical diagnosis and treatment. However, the specificity of cardiovascular and sleep functions in terms of electrical signals at acupoints remains unclear. In this study, five volunteers were recruited and their electroph...
Article
Epilepsy detection and focus location are urgent issues that need to be solved in epilepsy research. A cortex conformable and fine spatial accuracy electrocorticogram (ECoG) sensor array, especially for real-time detection of multicortical functional regions and delineating epileptic focus remains a challenge. Here, we fabricated a polydimethylsilo...
Article
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Microelectrode arrays (MEAs) are crucial tools for evaluating the modulating effects during in vivo neuromodualtion and it is crucial to develop novel strategies that allow for high spatiotemporal resolution, sustainable potential and dynamic monitoring during neurological disease therapy. Herein, we used a hydrogelator to assemble with ruthenium-b...
Article
Total sleep deprivation (TSD) produces impairments in cognitive on individuals. The measurement of rat hippocampal CA1 neural activity after TSD is of importance to understand the harmful effect induced by TSD on the cellular level. In this work, the deficit of spatial learning and memory maintenance caused by TSD was demonstrated in the Morris Wat...
Article
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Temporal lobe epilepsy (TLE) is a form of refractory focal epilepsy, which includes a latent period and a chronic period. Microelectrode arrays capable of multi-region detection of neural activities are important for accurately identifying the epileptic focus and pathogenesis mechanism in the latent period of TLE. Here, we fabricated multi-shank ME...
Article
In this study, a biosensor assembly based on microelectrode arrays (MEAs) modified with PtNPt/MWCNT-PEDOT:PSS nanocomposites is presented to synchronously detect the dopamine (DA) and electrophysiological activities in rat brains. Different morphological and electrochemical characterizations were conducted to show the excellent mechanical and elect...
Article
As programmed death-ligand 1 (PD-L1) is considered a referenced therapeutic biomarker, a rapid and low-cost method to detect PD-L1 in body fluids is necessary. In this work, a paper-based microfluidic aptasensor for label-free electrochemical detection of PD-L1 in liquids was fabricated. The aptasensor integrates a reaction cell and a three-electro...
Article
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Detecting vascular endothelial growth factor C (VEGF-C), a kind of tumor biomarker, is of significant clinical importance in evaluating the prognosis of patients with cancer. However, laboratory analyses are usually not suitable for point-of-care testing because they are expensive and time consuming. In response to these challenges, we fabricated a...
Article
This paper presents a microfluidic system with multiple constriction channels in parallel capable of characterizing cortical tension of single cells in a continuous manner. Single cells are forced to travel through constriction channels (cross-sectional area smaller than single cells) in a quasi-static manner with front/rear membrane curves of defo...
Article
Isoflurane is a reversible anesthetic which is widely used in the surgery and animal experiments. It was still not clear whether isoflurane would affect the pattern of epileptiform signals even without seizure. In this work, an implantable and nanocomposites coated microelectrode array (MEA) was fabricated to study the neural spike firing and local...
Article
The acute hippocampal slice is useful for understanding how epilepsy spatially initiates, propagates, and terminates in the hippocampus, which is vital to study the epileptic mechanism in it. However, it is challenging to detect the electrical signals of the main cell layer (the granular cell layer in the dentate gyrus (DG) and the pyramidal cell l...
Article
For in-situ disease markers detection, point-of-care (POC) diagnosis has great advantages in speed and cost compared with traditional techniques. The rapid diagnosis, prognosis, and surveillance of diseases can significantly reduce disease-related mortality and trauma. Therefore, increasing attention has been paid to the POC diagnosis devices due t...
Article
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(1) Background: Deep brain stimulation (DBS) is considered as an efficient treatment method for alleviating motor symptoms in Parkinson’s disease (PD), while different stimulation frequency effects on the specific neuron patterns at the cellular level remain unknown. (2) Methods: In this work, nanocomposites-modified implantable microelectrode arra...
Article
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Temporal lobe epilepsy (TLE) is a focal, recurrent, and refractory neurological disorder. Therefore, precisely targeted treatments for TLE are greatly needed. We designed anti-CB1 liposomes that can bind to CB1 receptors in the hippocampus to deliver photocaged compounds (ruthenium bipyridine triphenylphosphine γ-aminobutyric acid, RuBi-GABA) in th...
Article
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The detection of neuroelectrophysiology while performing optogenetic modulation can provide more reliable and useful information for neural research. In this study, an optical fiber and a microelectrode array were integrated through hot-melt adhesive bonding, which combined optogenetics and electrophysiological detection technology to achieve neuro...
Article
Microgravity can cause body fluids to accumulate in the brain, resulting in brain damage. There are few studies that focus on the detection of electrophysiological signals in simulated microgravity rats, and the precise mechanisms are unknown. In this study, a new device was established to investigate the influence of microgravity on hippocampal ne...
Article
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Epilepsy is a common neurological disorder. There is still a lack of methods to accurately detect cortical activity and locate lesions. In this work, a flexible electrocorticography (ECoG) electrode array based on polydimethylsiloxane (PDMS)-parylene was fabricated to detect epileptiform activity under glutamate (Glu) and gamma-aminobutyric acid (G...
Conference Paper
Depression is a harmful disease with high incidence. However, no effective method based on physiological information detection has been published to diagnose depression. Electroencephalography (EEG) has been used as a tool to detect physiological information of depressed patients and the symmetry of EEG receives much attention. This research focuse...
Conference Paper
Full-text available
Parkinson's disease (PD) is characterized by excessively synchronized neural activity. In this paper, we recorded electrophysiological signals in Cortex of normal and PD mode monkey using homemade implantable microelectrode arrays (MEA), and analyzed the characteristics of action potentials (APs) and local field potentials (LFPs). Results showed th...
Article
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Effective and precise neural modulation with real-time detection in the brain is of great importance and represents a significant challenge. Nanoliposome-encapsulated light-sensitive compounds have excellent characteristics such as high temporal and spatial resolution, delayed drug clearance, and restricted drug biodistribution for neural modulatio...
Article
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In this work, an electrochemical paper-based aptasensor was fabricated for label-free and ultrasensitive detection of epidermal growth factor receptor (EGFR) by employing anti-EGFR aptamers as the bio-recognition element. The device used the concept of paper-folding, or origami, to serve as a valve between sample introduction and detection, so redu...
Article
Objective: Epilepsy affects 50 million people worldwide and its pathogenesis is still unknown. In particular, the movement-related neural activities involving glutamate (Glu) and electrophysiological signals at cellular level remains unclear. Methods: In this work, a cellular-scale implantable microelectrode array (MEA) was fabricated to detect...
Article
The electromagnetic stirring (EMS) effects on peritectic solidification kinetics of undercooled liquid Fe-Ti alloys have been investigated by electrostatic levitation(ESL) and electromagnetic levitation (EML) methods assisted with in-situ diagnostic techniques. The high-sensitivity pyrometer and high-speed camera were employed to monitor the comple...
Article
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In this study, a 60-channel microelectrode array (MEA) was fabricated and used to monitor the neural spikes and local field potentials (LFPs) of neurons differentiated from rat neural stem cells in vitro. The neurons were grown on the MEA surface to detect neural signals. Glutamate (Glu) was used to modulate neural activity during experiments. To e...
Article
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Microgravity is the key environment of weightlessness experienced by all astronauts during spaceflights that cause severe physiological alterations in the human body. The effect of microgravity on the nervous system has not been elucidated. In this study, hindlimb unloading rats were used as the simulated microgravity model, and self-designed novel...
Article
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Precise functional localization plays an important role in deep brain stimulation for treatment of Parkinson’s disease (PD) to target the lesion of stimulation and observe spike morphology of the neural circuit for evaluating effect of stimulation. This research described a functional localization method in the brain of a cynomolgus monkey based on...
Article
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Sleep deprivation (SD) is the partial or complete loss of sleep and has long been used as a tool in sleep research to interfere with normal sleep cycles in rodents and humans. The progressively-accumulating sleep pressure induced by sleep deprivation can lead to a variety of physiological changes and even death. Compared to traditional detection me...
Article
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Apomorphine (APO) is often used to treat Parkinson’s Disease (PD) while the mechanism in PD treatment remains unclear. In this study, a four-shank microelectrode array (MEA) was fabricated to monitor cortex (two shorter shanks) and Caudate Putamen (CPu) (two longer shanks) signals simultaneously. Dopamine (DA) concentration and neural spike firing...
Article
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Little is known about the efficacy of Deep Brain Stimulation (DBS) as an effective treatment for Parkinson’s Disease (PD) because of the lack of multichannel neural electrical and chemical detection techniques at the cellular level. In this study, a 7 mm-long and 250 μm-wide microelectrode array (MEA) was fabricated to provide real-time monitoring...
Article
Full-text available
A CMOS low-power 8-channel electro-encephalograph front-end circuit is presented. The single-stage instrumental amplifier in each channel employs current-reuse and chopper-stabilization technology to improve power and noise performance. An output-current-tuning ripple reduction loop (RRL) is designed to reduce the intrinsic offset of the instrument...
Article
Electroencephalography (EEG) is an important method for investigating and analyzing neuro electrophysiological properties because of its superior temporal resolution. Conventional wet electrodes are widely used in recording EEG signals, which are, however, limited by long-time skin preparation and the usage of a wet gel. To supplement the shortcomi...