Xinlong Wang

Xinlong Wang
University of Texas at Arlington | UTA · Department of Bioengineering

About

58
Publications
7,159
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556
Citations
Citations since 2017
51 Research Items
546 Citations
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2017201820192020202120222023050100150
2017201820192020202120222023050100150

Publications

Publications (58)
Article
Full-text available
Enteral feeding is challenging in preterm infants because of gastrointestinal (GI) immaturity. Electrogastrography (EGG) is a non-invasive technology that measures gastric myoelectrical activity and can be utilized to measure changes that occur with maturation at different gestational ages (GA). Three gastric rhythms (GR) exist between 0.5–9 cycles...
Article
Full-text available
Objective: Transcranial photobiomodulation (tPBM) has shown promising benefits, including cognitive improvement, in healthy humans and in patients with Alzheimer's disease. In this study, we aimed to identify key cortical regions that present significant changes caused by tPBM in the electroencephalogram (EEG) oscillation powers and functional con...
Article
Full-text available
The resting-state infra-slow oscillation (ISO) of the cerebral cortex reflects the neurophysiological state of the human brain. ISO results from distinct vasomotion with endogenic (E), neurogenic (N), and myogenic (M) frequency bands. Quantification of prefrontal ISO in cortical haemodynamics and metabolism in the resting human brain may facilitate...
Article
Full-text available
Goal: It is challenging to clinically discern the severity of neonatal hypoxic ischemic encephalopathy (HIE) within hours after birth in time for therapeutic decision-making for hypothermia. The goal of this study was to determine the shortest duration of the EEG based PAC index to provide real-time guidance for clinical decision-making for neonat...
Article
Full-text available
This study presented a theoretical or analytical approach to quantify how the signal-to-noise ratio (SNR) of a near infrared spectroscopy (NIRS) device influences the accuracy on calculated changes of oxy-hemoglobin (Δ[HbO]), deoxy-hemoglobin (Δ[HHb]), and oxidized cytochrome c oxidase (Δ[oxCCO]). In theory, all NIRS experimental measurements inclu...
Article
Full-text available
Transcranial photobiomodulation (tPBM) has been considered a safe and effective brain stimulation modality being able to enhance cerebral oxygenation and neurocognitive function. To better understand the underlying neurophysiological effects of tPBM in the human brain, we utilized a 111-channel functional near infrared spectroscopy (fNIRS) system t...
Article
Full-text available
Transcranial Photobiomodulation (tPBM) has demonstrated its ability to alter electrophysiological activity in the human brain. However, it is unclear how tPBM modulates brain electroencephalogram (EEG) networks and is related to human cognition. In this study, we recorded 64-channel EEG from 44 healthy humans before, during, and after 8-min, right-...
Article
Full-text available
Our group previously examined 8 min photobiomodulation (PBM) by 1064 nm laser on the human forearm in vivo to determine its significant effects on vascular hemodynamics and cytochrome c oxidase redox activity. Since PBM uses a wide array of wavelengths, in this paper, we investigated (i) whether different wavelengths of lasers induced different PBM...
Article
Full-text available
Billions of neurons in the human brain form neural networks with oscillation rhythms. Infra-slow oscillation (ISO) presents three main physiological sources: endogenic, neurogenic, and myogenic vasomotions. Having an in vivo methodology for the absolute quantification of ISO from the human brain can facilitate the detection of brain abnormalities i...
Article
Background : Neonatal hypoxic ischemic encephalopathy (HIE) is difficult to classify within the narrow therapeutic window of hypothermia. Neurophysiological biomarkers are needed for timely differentiation of encephalopathy severity within the short therapeutic window for initiation of hypothermia therapy. Methods : A novel analysis of mean Phase...
Article
Full-text available
Background Hypoxic-ischemic encephalopathy (HIE) is a leading cause of morbidity and mortality in neonates, but quantitative methods to predict outcomes early in their course of illness remain elusive. Real-time physiologic biomarkers of neurologic injury are needed in order to predict which neonates will benefit from therapies. Neurovascular coupl...
Article
Full-text available
Our recent study demonstrated that prefrontal transcranial photobiomodulation (tPBM) with 1064-nm laser enables significant changes in EEG rhythms, but these changes might result from the laser-induced heat rather than tPBM. This study hypothesized that tPBM-induced and heat-induced alterations in EEG power topography were significantly distinct. W...
Article
Full-text available
There is a critical need for development of real time physiological biomarkers for birth asphyxia that constitutes a major global public health burden. Our recent study (Scientific Reports, V10:9183, 2020) established a novel non-invasive neurovascular coupling (NVC) assessment in newborns using dynamic wavelet transform coherence (WTC) analysis ir...
Preprint
Full-text available
Transcranial photobiomodulation (tPBM) of the prefrontal cortex can improve human cognition and increase electroencephalogram (EEG) alpha and beta powers, but it was unclear whether tPBM-induced heat would influence EEG oscillation powers. This study aimed to prove that tPBM-induced increases in anterior-posterior EEG powers at alpha and beta bands...
Article
Full-text available
As part of transcranial photobiomodulation, transcranial infrared laser stimulation (TILS) refers to the non-invasive delivery of 1064 nm wavelength infrared laser light to the brain to modulate energy metabolism and hemodynamics. The primary mechanism rests on the photo-oxidation of cytochrome-c-oxidase, the key mitochondrial enzyme that catalyzes...
Article
Full-text available
While many publications have reported brain hemodynamic responses to decision-making under various conditions of risk, no inventory management scenarios, such as the newsvendor problem (NP), have been investigated in conjunction with neuroimaging. In this study, we hypothesized (I) that NP stimulates the dorsolateral prefrontal cortex (DLPFC) and t...
Conference Paper
We conducted wavelet coherence analysis to quantify/image the cerebral neurovascular coupling at infra-slow frequencies during four different awake-to-sleep vigilance states using whole-head, simultaneous EEG and functional Near Infrared Spectroscopy measurements from 15 healthy human brains.
Conference Paper
This study presented a theoretical analysis to quantify how random measurement errors affect the calculation accuracy of chromophore concentration changes using an error propagation matrix estimated from the least-squares fitting model.
Conference Paper
This study proposes methods to quantify, address, and, if applicable, calibrate errors propagated from spectral noise and drift to calculated chromophore concentrations. Phantom and human measurements were done to illustrate and evaluate these generalized methods.
Conference Paper
Right frontal delivery of transcranial photobiomodulation with 1064-nm laser enabled to increase the alpha oscillation power of nine resting-state brain networks as quantified by group singular value decomposition based on EEG signals from 37 healthy subjects.
Conference Paper
1064-nm Transcranial Photobiomodulation (tPBM) on the right prefrontal cortex can increase the local hemodynamic oxygenation in the right prefrontal cortex and the dorsolateral prefrontal cortex. Also, tPBM can time-dependently improve the global brain connectivity.
Conference Paper
This study conducted a Granger-causality analysis using eCONNECTOME on tPBM-evoked EEG data taken from 19 human subjects. Results revealed significant alteration in information flow in the cortical source space by sham-controlled tPBM with 1064-nm laser.
Conference Paper
We investigated the effect of transcranial photobiomodulation induced by light emitting diodes by recording 64-chennel electroencephalogram in vivo. Compared to sham, subjects with tPBM showed an increase in vigilance and enhanced EEG alpha power.
Conference Paper
Dependance of variance in calculated changes of hemoglobin concentrations was investigated using theoretical error propagation. Larger signal-to-noise ratios lead to smaller variance while selection of two wavelengths affects the variance as well.
Article
Full-text available
Transcranial photobiomodulation (tPBM) with near-infrared light on the human head has been shown to enhance human cognition. In this study, tPBM-induced effects on resting state brain networks were investigated using 111-channel functional near-infrared spectroscopy over the whole head. Measurements were collected with and without 8-minute tPBM in...
Conference Paper
Full-text available
To understand how correlated the human brain is across multiple subjects or multiple trials when people make risky decisions, economical decision-making based on the Newsvendor Problems (NP) were investigated with 64-channel electro-encephalography (EEG) taken from 23 human subjects. Specifically, in this work, we analyzed the EEG signals recorded...
Article
Full-text available
Background and objectives: In our previous proof-of-principle study, transcranial photobiomodulation (tPBM) with 1,064-nm laser was reported to significantly increase concentration changes of oxygenated hemoglobin (∆[HbO]) and oxidized-state cytochrome c oxidase (∆[oxi-CCO]) in the human brain. This paper further investigated (i) its validity in t...
Article
Full-text available
Twenty-three young adults (4 Females, 25.13 ± 3.72 years) performed an intermittent maximal handgrip force task using their dominant hand for 20 min (3.5 s squeeze/6.5 s release, 120 blocks) with concurrent cortical activity imaging by functional Near-Infrared Spectroscopy (fNRIS; OMM-3000, Shimadzu Corp., 111 channels). Subjects were grouped as ph...
Preprint
Full-text available
Neuroeconomics with neuroimaging is a novel approach involving economics and neuroscience. The newsvendor problem (NP) is a prevalent economics concept that may be used to map brain activations during NP-evoked risky decision making. In this study, we hypothesized that key brain regions responsible for NP are dorsolateral prefrontal cortex (DLPFC)...
Conference Paper
We conducted broadband near-infrared spectroscopy to measure the effects of transcranial photobiomodulation (tPBM). Compared to sham, tPBM enhanced power of slow-oscillation for hemoglobin and oxidized cytochrome-c-oxidase. Frontal bilateral coherence of these two chromophores were desynchronized.
Conference Paper
Functional near-infrared spectroscopy measured the alterations in functional connectivity from non-invasive transcranial photobiomodulation with a 1064-nm continuous-wave laser on eighteen adults. These results indicate improved functional connectivity after laser stimulus exposure.
Conference Paper
The effects of tPBM on the brain are still unknown. This study has conducted a Granger based information flow analysis on tPBM data to uncover changes in information flow which were seen in delta/beta bands.
Conference Paper
Due to the small amount of experimental data present on 1064-nm fluence, this study used a tissue phantom to measure fluence at varying depths. Analytical solutions and experimental data were found to be highly consistent
Conference Paper
An economic decision-making protocol was employed to investigate human brain responses in the frontal areas with multi-channel fNIRS from 27 human subjects. The results showed significant activations in dorsolateral prefrontal and orbitofrontal cortex.
Conference Paper
To understand the mechanism of action of transcranial photobiomodulation, we measured and compared alpha rhythms evoked by transcranial laser and thermal stimulations. The two types of stimulations resulted in distinct difference in alpha topographs.
Article
Full-text available
The temporal evolution of cortical activation and connectivity patterns during a fatiguing handgrip task were studied by functional near-infrared spectroscopy (fNIRS). Twenty-three young adults (18 to 35 years old) were recruited to use a handheld force sensor to perform intermittent handgrip contractions with their dominant hand at their personal...
Article
Noninvasive transcranial photobiomodulation (tPBM) with a 1064-nm laser has been reported to improve human performance on cognitive tasks as well as locally upregulate cerebral oxygen metabolism and hemodynamics. However, it is unknown whether 1064-nm tPBM also modulates electrophysiology, and specifically neural oscillations, in the human brain. T...
Preprint
Full-text available
Non-invasive transcranial photobiomodulation with a 1064-nm laser (tPBML1064) has been reported to improve human performance on cognitive tasks as well as locally upregulate cerebral oxygen metabolism and hemodynamics. However, it is unknown whether tPBML1064 also modulates electrophysiology, and specifically neural oscillations, in the human brain...
Conference Paper
We measured laser- and heat-induced cerebral responses of the human forehead during placebo-controlled photobiomodulation by 1064-nm laser. Significant enhancement in cerebral cytochrome-c-oxidase and hemodynamics was observed, revealing physiological mechanisms of transcranial photobiomodulation.
Conference Paper
We conducted placebo-controlled 1064 nm Transcranial Laser Stimulation (TLS) on 20 human foreheads. Significant alterations of EEG power and information flow were observed, indicating important neurophysiological benefits of photoneuromodulation by 1064 nm laser.
Article
Transcranial infrared laser stimulation (TILS) has shown effectiveness in improving human cognition and was investigated using broadband near-infrared spectroscopy (bb-NIRS) in our previous study, but the effect of laser heating on the actual bb-NIRS measurements was not investigated. To address this potential confounding factor, 11 human participa...
Article
Full-text available
Transcranial Infrared Brain Stimulation (TIBS) with a 1064-nm laser applied to the right forehead has been shown to improve human cognitive function. To explore the neurophysiological effect of this photobiomodulation, we measured the 64-channel electroencephalogram (EEG) before, during and after the laser stimulation. After data collection from 20...
Article
Transcranial infrared laser stimulation (TILS) is a noninvasive form of brain photobiomulation. Cytochrome-c-oxidase (CCO), the terminal enzyme in the mitochondrial electron transport chain, is hypothesized to be the primary intracellular photoacceptor. We hypothesized that TILS up-regulates cerebral CCO and causes hemodynamic changes. We delivered...
Article
Full-text available
Photobiomodulation, also known as low-level laser/light therapy (LLLT), refers to the use of red-to-near-infrared light to stimulate cellular functions for physiological or clinical benefits. The mechanism of LLLT is assumed to rely on photon absorption by cytochrome c oxidase (CCO), the terminal enzyme in the mitochondrial respiratory chain that c...
Article
Objective: To assess the efficacy of Light reflectance spectroscopy (LRS) to detect positive surgical margins (PSM) on ex vivo radical prostatectomy specimens. Materials and methods: A prospective evaluation of ex vivo prostate specimens using LRS was performed at a single institution from June 2013 to September 2014. LRS measurements were perfo...
Conference Paper
We assessed the effects of low-level laser therapy (LLLT) on human tissues in vivo with broadband near-infrared spectroscopy (NIRS). LLLT increased concentrations of oxygenated hemoglobin and cytochrome c oxidase as compared with placebo.
Article
Objectives: Intraoperative frozen section analysis is not routinely performed to determine positive surgical margins (PSM) at radical prostatectomy (RP) due to time requirement and unproven clinical utility. Light reflectance spectroscopy (LRS) measures light intensity reflected or backscattered from tissues and can be used to differentiate malign...
Article
Full-text available
Previous work has validated that the accuracy of absorption coefficient can be improved using frequency-domain (FD) DOT measurements with multiple modulation frequencies. In this paper, we investigate the use of multi-frequency FD-DOT to improve the recovery accuracy of scattering coefficient, which is of great interest to cancer study. A new metho...
Conference Paper
We employed light reflectance spectroscopy to quantify light scattering of prostate cancer on the gland capsules from ex-vivo human prostates. Results confirmed that light scattering is distinct between cancerous and benign prostate tissue.

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We have Zoom conference meetings where researchers have a forum to present their research in PERSON to their peers and we have a lively discourse after and during!! Its more like a one hour presentation so we get into details and we can ask questions. We also have a place to postulate new theories and express our opinions. This field needs standards and they should be set by the scientific experts.