Xin-Fang Leong

Xin-Fang Leong
Universiti Kebangsaan Malaysia | ukm

BSc Biomedical Sciences (Hons), PhD (Pharmacology)

About

18
Publications
16,987
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842
Citations
Additional affiliations
June 2012 - present
Universiti Kebangsaan Malaysia
Position
  • Lecturer
July 2008 - December 2012
Universiti Kebangsaan Malaysia
Education
June 2010
University Medical Centre of Groningen (UMCG)
Field of study
  • International Student Congress of Medical Sciences (ISCOMS) Research Fellowship
June 2008
Universiti Kebangsaan Malaysia
Field of study
  • Pharmacology
June 2004 - May 2007

Publications

Publications (18)
Article
Reusing cooking oil in food preparation, especially during deep-frying, is a common practice to save costs. Repeated heating of the oil accelerates oxidative degradation of lipids, forming hazardous reactive oxygen species and depleting the natural antioxidant contents of the cooking oil. Long-term ingestion of foods prepared using reheated oil cou...
Article
Full-text available
Hypertension and atherosclerosis are among the most common causes of mortality in both developed and developing countries. Experimental animal models of hypertension and atherosclerosis have become a valuable tool for providing information on etiology, pathophysiology, and complications of the disease and on the efficacy and mechanism of action of...
Article
Cardiovascular disease (CVD) is one of the leading major causes of morbidity and mortality worldwide. It may result from the interactions between multiple genetic and environmental factors including sedentary lifestyle and dietary habits. The quality of dietary oils and fats has been widely recognised to be inextricably linking to the pathogenesis...
Article
Full-text available
This review is to examine the current literatures on the relationship between periodontitis and hypertension as well as to explore the possible biological pathways underlying the linkage between these health conditions. Hypertension is one of the major risk factors for cardiovascular diseases. Oxidative stress and endothelial dysfunction are among...
Article
Full-text available
This study aimed to investigate the antibacterial activity of three endodontic sealers, AH Plus, iRoot SP, and EndoSeal MTA, against four planktonic bacteria species. The antibacterial activity of the three endodontic sealers was assessed using a modified direct contact test. Bacteria suspension of Actinomycoses viscosus, Enterococcus faecalis, Sta...
Article
Full-text available
Atherosclerosis poses serious health problems and increases the risk of various cardiovascular diseases, including myocardial infarction, heart failure, ischemic stroke, and peripheral arterial disease. Atherosclerosis patients require long-term medications to prevent complications, some of which are costly and may result in unwanted adverse reacti...
Article
Full-text available
Cardiovascular diseases such as hypertension and atherosclerosis are the common causes of mortality in developed and developing countries. Repeated heating of the dietary oil is a common practice to reduce cost during food preparation. When the cooking oil is heated at high temperatures, production of free radicals augments the oxidative degradatio...
Article
Background Periodontitis is a noncommunicable inflammatory disease of the soft tissue and bone surrounding the teeth in the jaw, which affects susceptible individuals with poor oral hygiene. A growing interest has been seen in the use of dietary supplements and natural products for the treatment and prevention of periodontitis. Vitamin E consists o...
Article
Full-text available
Cardiovascular diseases (CVDs) such as angina, hypertension, myocardial ischemia, and heart failure are the leading causes of morbidity and mortality worldwide. One of the major transcription factors widely associated with CVDs is nuclear factor-kappa B (NFκB). NFκB activation initiates the canonical and non-conical pathways that promotes activatio...
Article
Full-text available
Untreated hypertension is a major cause for a variety of cardiovascular diseases, including coronary artery disease, heart failure, peripheral vascular disease, and stroke. Oxidative stress has been implicated in the development of hypertension. Elevation of blood pressure is attributed to an impairment between the balance of antioxidants and pro-o...
Article
Full-text available
Hypertension increases the risk for a variety of cardiovascular diseases, including stroke, coronary artery disease, heart failure, and peripheral vascular disease. The increase in oxidative stress has been associated with the pathogenesis of hypertension. Increase of blood pressure is due to an imbalance between antioxidants defence mechanisms and...
Article
Full-text available
The goal of this study was to determine the possible mechanism that is involved in the blood pressure-raising effect of heated vegetable oils. Adult male Sprague-Dawley rats were divided into 11 groups; the control group was fed with rat chow, and the other groups were fed with chow that was mixed with 15% weight/weight palm or soy oils, which were...
Article
Full-text available
Poor control of blood pressure leads to hypertension which is a major risk factor for development of cardiovascular disease. The present study aimed to explore possible mechanisms of elevation in blood pressure following consumption of heated vegetable oil. Forty-two male Sprague-Dawley rats were equally divided into six groups: Group I (control)--...
Article
Full-text available
Oxidization of dietary cooking oil increases the risk of cardiovascular diseases such as hypertension by increasing the formation oxidative oxygen radicals. The aim of study was to investigate the effects of repeatedly heated palm oil on blood pressure, plasma nitrites, and vascular reactivity. Nitrites were measured, as an indirect marker for nitr...
Article
Palm oil used worldwide contains considerable amounts of antioxidants, namely, vitamin E and carotenes. The purpose of the study was to observe the effect of heated palm oil on blood pressure and observe the cardiac histological changes in rats. Forty male Sprague Dawley rats were divided equally into four groups and given treatment as follows: (i)...

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