Xiaochun Cheng

Xiaochun Cheng
Middlesex University, UK · Department of Computer Science

About

287
Publications
14,690
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6,043
Citations
Citations since 2016
40 Research Items
1724 Citations
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250

Publications

Publications (287)
Article
Background: Antibody-mediated rejection has long been known to be one of the major organ failure mechanisms in xenotransplantation. In addition to the porcine α1,3-galactose (α1,3Gal) epitope, N-Glycolylneuraminic acid (Neu5Gc), a sialic acid, has been identified as an important porcine antigen against which most humans have pre-formed antibodies....
Article
We report on a method to achieve multiple microscopic particles trapping and transverse manipulation using a size-tunable Bessel beam generated by cross-phase modulation (XPM) based on the thermal nonlinear optical effect. The results demonstrates that multiple polystyrene particles can be stably trapped simultaneously, and the number of the trappe...
Conference Paper
Due to market volatility, forecasting stock market trend is one of the most complicated tasks. There is a heated debate about the effectiveness of predicting market movement based on public sentiments expressed in written news, whether through social media, web pages, or financial news. However, past researches ignore a crucial source of knowledge,...
Article
We report a method for optical trapping and three-dimensional manipulation of light-absorbing particles in air based on a hollow beam. The particles can be stably trapped for hours in the focused hollow beam with either horizontal or vertical trapping configuration. Particle revolution in the lateral plane ( x-y plane) is achieved by employing a we...
Article
Purpose Antibody-mediated xenograft rejection is inhibited by knock-out (KO) of porcine carbohydrates (CHO), including Galα1,3Gal. The β4Gal epitope was discovered using serum from xenograft-sensitized baboons. However, it remains controversial if humans and baboons have detectable titers of preformed anti-β4Gal antibody (as humans do for Neu5Gc),...
Article
We report the investigation on the nonlinear optical properties of two typical two-dimensional metal-organic frameworks (2D MOFs) - 2D Cu-MOF and Zn-MOF (copper/zinc 1,4-benzene dicarboxylate, CuBDC and ZnBDC) using spatial self-phase modulation (SSPM) and spatial cross-phase modulation (SXPM) methods. It is found that 2D Cu-MOF exhibits a large no...
Article
Full-text available
Elemental identification of individual microsized aerosol particles is an important topic in air pollution studies. However, simultaneous and quantitative analysis of multiple constituents in a single aerosol particle with the noncontact in situ manner is still a challenging task. In this work, we explore the laser trapping-LIBS-machine learning to...
Chapter
Full-text available
Market prediction offers great profit avenues and is a fundamental stimulus for most researchers in this area. To predict the market, most researchers use either technical or fundamental analysis. Technical analysis focuses on analyzing the direction of prices to predict future prices, while fundamental analysis depends on analyzing unstructured te...
Article
We report on the investigation on the transverse effect of superradiation (SR) in Rb atomic medium by analyzing and comparing the diffraction patterns in the far-field under the circumstances that Gaussian and Bessel beam are taken as the excitation respectively. It is found that Gaussian SR shows a ring-pattern and its beam profile is closely depe...
Article
The traditional multiwave mixing setups are always complicated because multiple laser beams are involved, and they are required to be aligned into certain spatial configurations to get the phase-matching condition satisfied. Here, we report on a multiwave mixing method using a single vector optical field. The spatially separated phase-matching beam...
Article
We demonstrate dark-hollow beam (DHB) generation based on cross-phase modulation (XPM) in the hot Rb cell. It is found that a Gaussian beam (probe beam) can be converted into a DHB when the Rb cell is illuminated by a relatively intense counter-propagating Gaussian beam (pump beam). The size of the DHB can be adjusted by the pump power and sample t...
Article
We report on the study of the thermally-induced nonlinear optical (NLO) properties of the commonly used organic solvents at the near-infrared range using spatial cross-phase modulation (SXPM). The results indicate that those solvents (alcohols, formic acid and acetic acid) with functional groups -OH and -COOH have obvious NLO effect at near-infrare...
Article
Background Elevated pulmonary vascular resistance (PVR), platelet adhesion, coagulation activation, and inflammation are prominent features of xenolung rejection. Here, we evaluate the role of thromboxane and histamine on PVR, and their contribution to other lung xenograft injury mechanisms. Methods GalTKO.hCD46 single pig lungs were perfused ex v...
Article
In this work, we studied the thermally-induced optical nonlinearity of alcohols by analyzing the far-filed diffraction rings patterns, which are generated when the alcohols are illuminated by a laser beam resonant to their overtones. We deduced the nonlinear refractive index coefficient n2 generated by thermal nonlinear optical effect to be -(20.53...
Article
We report micron-sized particle trapping and manipulation using a hollow beam of tunable size, which was generated by cross-phase modulation via the thermal nonlinear optical effect in an ethanol medium. The results demonstrated that the particle can be trapped stably in air for hours and manipulated in millimeter range with micrometer-level accura...
Article
We report on the enhancement of phase conjugation degenerate four-wave mixing (DFWM) in hot atomic Rb vapor by using a Bessel beam as the probe beam. The Bessel beam was generated using cross-phase modulation based on the thermal nonlinear optical effect. Our results demonstrated that the DFWM signal generated by the Bessel beam is about twice as l...
Article
Background: Human neutrophils are sequestered by pig lung xenografts within minutes during ex vivo perfusion. This phenomenon is not prevented by pig genetic modifications that remove xeno-antigens or added human regulatory molecules intended to down-regulate activation of complement and coagulation pathways. This study investigated whether recipi...
Article
Full-text available
Background. Inducible costimulator (ICOS) is rapidly upregulated with T-cell stimulation and may represent an escape pathway for T-cell costimulation in the setting of CD40/CD154 costimulation blockade. Induction treatment exhibited no efficacy in a primate renal allograft model, but rodent transplant models suggest that the addition of delayed ICO...
Article
Background: Alongside the need to develop more effective and less toxic immunosuppression, the shortage of human organs available for organ transplantation is one of the major hurdles facing the field. Research into xenotransplantation, as an alternative source of organs, has unveiled formidable challenges. Porcine lungs perfused with human blood...
Article
Background: Selective CD28 inhibition is actively pursued as an alternative to B7 blockade using CTLA4-Ig based on the hypothesis that the checkpoint immune regulators CTLA-4 and PD-L1 will induce tolerogenic immune signals. We previously showed that blocking CD28 using a monovalent nonactivating reagent (single chain anti-CD28 Fv fragment linked...
Article
We propose a new method to generate Bessel-like beam using cross-phase modulation. The hot rubidium atomic sample is shown to have the ability to vary a Gaussian beam (probe beam) into a Bessel-like beam when the sample is illuminated with a counter-propagating Gaussian beam (pump beam) tuned close to the atomic resonances. It is demonstrated that...
Article
Full-text available
Background: Wild-type pigs express several carbohydrate moieties on their cell surfaces that differ from those expressed by humans. This difference in profile leads to pig tissue cell recognition of human blood cells causing sequestration, in addition to antibody-mediated xenograft injury. One such carbohydrate is N-glycolylneuraminic acid (Neu5Gc...
Article
Background: Gamma-glutamyl carboxylase (GGCX) was apparently decreased in cartilage tissue from OA patients. However, whether GGCX overexpression has functions in regulating chondrocytes from osteoarthritis (OA) model is still unknown. Objective: This study aimed to explore the effects of GGCX gene overexpression on cell differentiation of chondroc...
Article
Background: Specific blockade of T cell costimulation pathway is a promising immunomodulatory approach being developed to replace our current clinical immunosuppression therapies. The goal of this study is to compare results associated with 3 monoclonal antibodies directed against the CD40/CD154 T cell costimulation pathway. Methods: Cynomolgus...
Article
Background: Lung xenografts remain susceptible to loss of vascular barrier function within hours in spite of significant incremental advances based on genetic engineering to remove the Gal 1,3-αGal antigen (GalTKO) and express human membrane cofactor protein (hCD46). Natural killer cells rapidly disappear from the blood during perfusion of GalTKO....
Article
In this work, we characterized the performance of optical limiting by self-phase modulation (SPM) in hot atomic vapor cell. The results indicated that the performance of the optical limiter is closely related to the position of the sample cell, which is determined by the Rayleigh lenght of beam. The lowest limiting threshold and clamp output were o...
Article
Full-text available
Background: Here, we ask whether platelet GPIb and GPIIb/IIIa receptors modulate platelet sequestration and activation during GalTKO.hCD46 pig lung xenograft perfusion. Methods: GalTKO.hCD46 transgenic pig lungs were perfused with heparinized fresh human blood. Results from perfusions in which αGPIb Fab (6B4, 10 mg/l blood, n = 6), αGPIIb/IIIa F...
Article
Full-text available
Objective: Our correlation study investigated the relationships of the expression of hepcidin and ferroportin (fpn) in tissues and serum from breast cancer (bca) patients and the relationships of hepcidin and fpn with anemia. Methods: We used elisa and immunohistochemistry to detect the expression of hepcidin and fpn in tissue and serum from 62...
Article
Phase-conjugate degenerate four-wave mixing (PCDFWM), as a sub-Doppler spectroscopy technique, can be employed to selectively analyze Li isotopes. It is necessary to explore the optimal incident powers in order to measure the Li isotope ratio accurately. In this case, the power condition of PCDFWM signal is first investigated using samples with var...
Article
Opal films made of 205, 230, 270, 290 nm monodisperse polystyrene (PS) microsphere were prepared with vertical self-assembly method. The opal films show different colours in natural light and the light of halogen tungsten lamp. The PS microsphere in opal films arranged as well-ordered hexagonal close-packed structure on top view, and face-centred c...
Article
A 1–3 type multi-element piezoelectric composite was fabricated using silicon as decoupling material to ensure the independence of transmitted acoustic beam and strengthen the signal power. The consistency and acoustic coupling of all elements in the composite were investigated. The results showed that the piezoelectric, dielectric and ferroelectri...
Article
The THINS project of the 7th Framework EU Program on nuclear fission safety is devoted to the investigation of crosscutting thermal hydraulic issues for innovative nuclear systems. A significant effort in the project has been dedicated to the qualification and validation of system codes currently employed in thermal hydraulic transient analysis for...
Article
To obtain a Doppler-free resolution, we employ phase-conjugate degenerate four-wave mixing (PCDFWM) to isotope selectively analyze 6Li and 7Li in a graphite furnace atomizer. After the investigation of concentration and power dependences of PCDFWM, the optimal sample concentration and power conjugation are determined. Under the optimized conditions...
Article
Cardiovascular disease (CVD) is characterized by extensive remodeling of the extracellular matrix (ECM) architecture of the cardiovascular system. Among the many extracellular proteolytic enzymes present in cardiovascular cells and inflammatory cells and involved in ECM remodeling, members of the matrix metalloproteinase family and serine protease...
Article
Full-text available
Dental caries is closely associated with the microbial disequilibrium between acidogenic/aciduric pathogens and alkali-generating commensal residents within the dental plaque. Fluoride is a widely used anticaries agent, which promotes tooth hard-tissue remineralization and suppresses bacterial activities. Recent clinical trials have shown that oral...
Article
Thermal-hydraulics is recognized as a key scientific subject in the development of innovative reactor systems. In Europe, a consortium is established consisting of 24 institutions of universities, research centers and nuclear industries with the main objectives to identify and to perform research activities on important crosscutting thermal-hydraul...
Article
The crossovers in conventional saturated absorption spectroscopy (SAS) are always harmful and undesired, especially for those pairs of transitions with very small frequency differences. To reduce the number and intensity of the crossovers, two copropagating beams from one laser were employed to detect SAS of rubidium (Rb) D2 line at 780 nm. It is f...
Article
Laparoscopic and robotic partial nephrectomy have become the preferred option for surgical management of incidentally discovered small renal tumors. Currently there is no consensus on which aspects of the procedure should be performed laparoscopically versus robotically. We believe that combining a laparoscopic exposure and hilar dissection followe...
Article
Evaluation of lungs from GalTKO.hCD46 pigs, genetically modified to lack the galactose-α(1,3)-galactose epitope (GalTKO) and to express human CD46, a complement regulatory protein, has not previously been described. Physiologic, hematologic and biochemical parameters during perfusion with heparinized fresh human blood were measured for 33 GalTKO.hC...
Article
Full-text available
Hepatitis B virus (HBV) antiviral therapy is plagued by limited efficacy and resistance to most nucleos(t)ide analog drugs. We have proposed that the complex RNA binding mechanism of the HBV reverse transcriptase (P) may be a novel target for antivirals. We previously found that RNA binds to the duck HBV (DHBV) P through interactions with the T3 an...
Conference Paper
One of the attacks observed against HTTP protocol is HTTP-GET attack using sequences of requests to limit accessibility of webservers. This attack has been researched in this report, and a novel detection technique has been developed to tackle it. In general, the technique uses entropy-based clustering and application of likelihood analysis to dist...
Conference Paper
One of the attacks observed against HTTP protocol is HTTP-GET attack using sequences of requests to limit accessibility of web servers. This attack has been researched in this report, and a novel detection technique has been developed to tackle it. In general, the technique uses entropy-based clustering and application of Bayes factors to distingui...
Conference Paper
In this paper, we present a formal model and analysis for the security extensions of the Domain Name System (DNSsec) in the interactive theorem prover Isabelle/HOL. Based on the inductive approach of security protocol analysis by Paulson in Isabelle/HOL, we show how the protocol can be modelled and important properties are proved. We prove that ori...
Article
PurposeTo describe the characteristic ophthalmic phenotypes of a large Chinese family with familial amyloid polyneuropathy due to a missense mutation in transthyretin (TTR) (c.307 C>G).Methods Twenty-seven individuals (12 affected, 15 unaffected) from a five-generation Chinese family underwent general medical examination and comprehensive ophthalmi...
Article
A kind of embedded acoustic emission (AE) sensor for the concrete health monitoring was fabricated by using the 1-3 polymer/cement-based piezoelectric composite. The frequency bandwidth, sensitivity, threshold value, and response of the sensor were investigated. The results show that the embedded acoustic emission sensor has broad frequency bandwid...
Conference Paper
This paper addresses how to leverage the spatial multiplexing function of MIMO links to improve wireless network throughput. Wireless interference modeling of a half-duplex MIMO node is presented, based on which, routing, spatial multiplexing and scheduling are jointly considered in one optimization model. A linear program-based algorithm is propos...
Article
The development of GalTKO pigs with additional expression of hCD46 has contributed to significantly improved outcome of lungs in an ex vivo xenogenic perfusion setting. However, “survival” of those lungs varies from a very early failure to an elective termination after 4h of perfusion. Here we evaluate factors that correlate with early GalTKO.hCD46...
Article
Full-text available
Analyses of xenogenic GalTKO.hCD46 organ perfusions have revealed that activation of complement cascade and platelets play a substantial role in rejection of the perfused organ. With the aim of better controlling these mechanisms, human endothelial protein C receptor (hEPCR), a receptor facilitating protein C activation by the thrombin-thrombomodul...
Conference Paper
Full-text available
Liquid metal cooled reactors are envisaged to play an important role in the future of nuclear energy production because of their possibility to use natural resources efficiently and to reduce the volume and lifetime of nuclear waste. Typically, sodium and lead(-alloys) are envisaged as coolants for such reactors. Obviously, in the development of th...
Article
Full-text available
We developed a system with high levels of dissolved CO2 for water disinfection. Bacteriophages MS2, Qbeta and phiX174 were selected as the inactivation targets. A relatively mild inactivation effect was observed on MS2 and Qbeta at different initial concentrations of dissolved CO2 at 0.3 MPa in 20-30 min. When the pressure was increased to 0.6 MPa,...