Xianglu Han

Xianglu Han
The ILSI Research Foundation

PhD

About

21
Publications
9,212
Reads
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1,466
Citations
Citations since 2017
0 Research Items
679 Citations
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2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100

Publications

Publications (21)
Article
Food contact materials can release low levels of multiple chemicals (migrants) into food and beverages, to which individuals can be exposed through food consumption. This paper investigates the potential for non-carcinogenic effects from exposure to multiple migrants using the Cefic Mixtures Ad hoc Team (MIAT) decision tree. The purpose of the asse...
Article
Full-text available
Background A decision tree has been developed for evaluating risks posed by combined exposures to multiple chemicals. The decision tree divides combined exposures of humans and ecological receptors into groups where one or more components are a concern by themselves, where risks from the combined exposures are of low concern, and where there is a c...
Article
Full-text available
Maximum cumulative ratio (MCR) is a person's cumulative exposure to multiple chemicals divided by the maximum chemical-specific exposure where exposure is expressed on a toxicologically equivalent basis. It is a tool for assessing the need for performing cumulative exposure assessments. In this paper, MCR values were calculated for the three groups...
Article
There is an urgent need for in vitro screening assays to evaluate nanoparticle (NP) toxicity. However, the relevance of in vitro assays is still disputable. We administered doses of TiO(2) NPs of different sizes to alveolar epithelial cells in vitro and the same NPs by intratracheal instillation in rats in vivo to examine the correlation between in...
Article
Full-text available
Background The Cefic Mixtures Industry Ad-hoc Team (MIAT) has investigated how risks from combined exposures can be effectively identified and managed using concepts proposed in recent regulatory guidance, new advances in risk assessment, and lessons learned from a Cefic-sponsored case study of mixture exposures. Results A series of tools were cre...
Article
Full-text available
The maximum cumulative ratio (MCR) developed in previous work is a tool to evaluate the need to perform cumulative risk assessments. MCR is the ratio of the cumulative exposures to multiple chemicals to the maximum exposure from one of the chemicals when exposures are described using a common metric. This tool is used to evaluate mixtures of chemic...
Article
Full-text available
Due to the vast number of possible combinations of chemicals to which individuals are exposed and the resource-intensive nature of cumulative risk assessments, there is a need to determine when cumulative assessments are most required. This paper proposes the use of the maximum cumulative ratio (MCR) as a tool for this evaluation. MCR is the ratio...
Article
Engineered nanoparticles (NP) are being developed and incorporated in a number of commercial products, raising the potential of human exposure during manufacture, use, and disposal. Although data concerning the potential toxicity of some NP have been reported, validated simple assays are lacking for predicting their in vivo toxicity. The aim of thi...
Article
Full-text available
Exposure assessment studies in the developing world are important. Although recent years have seen an increasing number of traffic-related pollution exposure studies, exposure assessment data on this topic are still limited. Differences among measuring methods and a lack of strict quality control in carrying out exposure assessment make it difficul...
Article
A traffic-related exposure study was conducted among 58 workers (drivers, vendors, traffic police, and gas station attendants) and 10 office workers as controls in Trujillo, Peru, in July 2002. PM2.5 was collected, carbon monoxide (CO) was measured, volatile organic compounds (VOCs) were sampled and analyzed. Newspaper vendors had the highest full-...
Article
A traffic-related exposure study was conducted among 58 workers (drivers, vendors, traffic police, and gas station attendants) and 10 office workers as controls in Trujillo, Peru, in July 2002. PM2.5 was collected, carbon monoxide (CO) was measured, volatile organic compounds (VOCs) were sampled and analyzed. Newspaper vendors had the highest full-...

Questions

Questions (2)
Question
Usually we use LD50 to get an idea about how acutely toxic a chemical is, but what if I want to know whether somebody can still perform their duty as usual (whatever their job is) with nearly zero impact right after they get exposed to a chemical by accident and the exposure amount is known?
In principle, no treatment is needed if there is no symptom or functional change (though there may be a temporary change in some blood chemistry parameters or liver weight change). However, for a risk assessment, I am not sure if I can just rely on clinical symptoms and functional changes as indicators when assessing safety like this. As you know, NOAEL would usually consider the adversity of changes in biochemistry and blood chemistry. Thanks~
Question
Hi everyone,
I am a toxicologist, and do not know much about water solubility of a lot of chemicals. People working with polymers often talk about water-soluble and water-insoluble polymers. Is there a widely accepted definition about each? What is the water solubility cutoff to distinguish these two categories? If it is vague, may be two cutoffs, between which is a gray area?
Thanks,
Xianglu

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Projects (4)