Xiang Yi- Shanghai Jiao Tong University
Xiang Yi
- Shanghai Jiao Tong University
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9
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Publications (9)
It is unclear whether siRNA-based agents can be a safe and effective therapy for diseases. In this study, we demonstrate that microphthalmia-associated transcription factor-siRNA (MITF-siR)-silenced MITF gene expression effectively induced a significant reduction in tyrosinase (TYR), tyrosinase-related protein 1, and melanocortin 1 receptor (MC1R)...
Alignment of Alu elements longer than 200 nt.
Sixty predicted miRNAs downstream of Alu elements.
Alignment of Alu elements shorter than 200 nt.
The relationships between predicted miRNA and its mature sequences identified by Solexa sequencing.
The known miRNAs and predicted miRNAs identified by Solexa sequencing site downstream of MIRs.
Despite many studies on the biogenesis, molecular structure and biological functions of microRNAs, little is known about the transcriptional regulatory mechanisms controlling the spatiotemporal expression pattern of human miRNA gene loci. Several lines of experimental results have indicated that both polymerase II (Pol-II) and polymerase III (Pol-I...
Until now it is still not clear how many types and amounts of small RNAs (sRNAs) exist in humans. Here we report the identification of 1258 distinct sRNAs derived from intronic regions of protein-coding genes in human with a new approach. These endogenous short hairpin RNAs (shRNAs) appear to be similar to exogenous shRNAs in structure, have a broa...
