Xi Zhang

Xi Zhang
Chinese PLA General Hospital (301 Hospital) · Department of Geriatric Neurology

MD, PhD

About

53
Publications
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2,049
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Publications

Publications (53)
Article
Full-text available
Macroscale functional gradient techniques provide a continuous coordinate system that extends from unimodal regions to transmodal higher‐order networks. However, the alterations of these functional gradients in AD and their correlations with cognitive terms and gene expression profiles remain to be established. In the present study, we directly stu...
Article
The intricate spatial configurations of brain networks offer essential insights into understanding the specific patterns of brain abnormalities and the underlying biological mechanisms associated with Alzheimer’s disease (AD), normal aging, and other neurodegenerative disorders. This study investigated alterations in the topographical structure of...
Article
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BACKGROUND Alzheimer's disease (AD) is a neurodegenerative condition characterized by cognitive decline. To date, the specific dysfunction in the brain's hierarchical structure in AD remains unclear. METHODS We introduced the structural decoupling index (SDI), based on a multi‐site data set comprising functional and diffusion‐weighted magnetic res...
Article
Full-text available
The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer’s disease (AD). We conducted data-driven meta-analyses to combine 3,118 structural magnetic resonance images from three datasets to obtain robust atrophy patterns. Then we introduced a set of radiogenomic analyses to investigat...
Article
Full-text available
Background Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that poses a worldwide public health challenge. A neuroimaging biomarker would significantly improve early diagnosis and intervention, ultimately enhancing the quality of life for affected individuals and reducing the burden on healthcare systems. Methods Cross-sectional...
Article
Alzheimer's disease (AD) is associated with the impairment of white matter (WM) tracts. The current study aimed to verify the utility of WM as the neuroimaging marker of AD with multisite diffusion tensor imaging datasets [321 patients with AD, 265 patients with mild cognitive impairment (MCI), 279 normal controls (NC)], a unified pipeline, and ind...
Article
Full-text available
Alzheimer's disease (AD) is a common neurodegeneration disease associated with substantial disruptions in the brain network. However, most studies investigated static resting-state functional connections, while the alteration of dynamic functional connectivity in AD remains largely unknown. This study used group independent component analysis and t...
Article
Full-text available
Background: Alzheimer's disease (AD) is a neurodegenerative disease associated with widespread disruptions in intrinsic local specialization and global integration in the functional system of the brain. These changes in integration may further disrupt the global signal (GS) distribution, which might represent the local relative contribution to glo...
Article
Full-text available
Numerous studies have shown abnormal brain functional connectivity in individuals with Alzheimer’s disease (AD) or amnestic mild cognitive impairment (aMCI). However, most studies examined traditional resting state functional connections, ignoring the instantaneous connection mode of the whole brain. In this case-control study, we used a new method...
Article
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by progressive dementia, and amnestic mild cognitive impairment (aMCI) has been defined as a transitional stage between normal aging and the development of AD. Accumulating evidence has shown that altered functional connectivity (FC) and structural connectivity (SC) in th...
Article
Background Alzheimer's disease (AD) is a neurodegenerative disorder with significant heterogeneity. Different AD phenotypes may be associated with specific changed brain networks. Uncovering disease heterogeneity by using functional network could provide insights into precise diagnoses. Methods We investigated the subtypes of AD using non-negative...
Article
Full-text available
Background : Hippocampal atrophy is a characteristic of Alzheimer’s disease (AD). However, alterations in structural connectivity (number of connecting fibers) between the hippocampus and whole brain regions due to hippocampal atrophy remain largely unknown in AD and its prodromal stage, amnestic mild cognitive impairment (aMCI). Methods : We colle...
Article
Full-text available
Background Diffusion tensor imaging (DTI) has been widely used to identify structural integrity and to delineate white matter (WM) degeneration in Alzheimer's disease (AD). However, the validity and replicability of the ability to discriminate AD and normal controls (NCs) of WM measures are limited due to the use of small cohorts and diverse image...
Article
Full-text available
Precision medicine for Alzheimer's disease (AD) necessitates the development of personalized, reproducible, and neuroscientifically interpretable biomarkers, yet despite remarkable advances, few such biomarkers are available. Also, a comprehensive evaluation of the neurobiological basis and generalizability of the end‐to‐end machine learning system...
Article
Full-text available
Alzheimer's disease (AD) is associated with disruptions in brain activity and networks. However, there is substantial inconsistency among studies that have investigated functional brain alterations in AD; such contradictions have hindered efforts to elucidate the core disease mechanisms. In this study, we aim to comprehensively characterize AD‐asso...
Article
Background: Alzheimer's disease (AD) is the most common cause of dementia in older individuals, and amnestic mild cognitive impairment (aMCI) is currently considered the prodromal stage of AD. The hippocampus and fornix interact functionally and structurally, with the fornix being the major efferent white matter tract from the hippocampus. Object...
Article
Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by progressive dementia. Diffusion tensor imaging (DTI) has been widely used to show structural integrity and delineate white matter (WM) degeneration in AD. The automated fiber quantification (AFQ) method is a fully automated approach that can rapidly and reliably identi...
Article
Full-text available
Hippocampal morphological change is one of the main hallmarks of Alzheimer's disease (AD). However, whether hippocampal radiomic features are robust as predictors of progression from mild cognitive impairment (MCI) to AD dementia and whether these features provide any neurobiological foundation remains unclear. The primary aim of this study was to...
Preprint
Full-text available
Background: Hippocampal morphological change is one of the main hallmarks of Alzheimer's disease (AD). The primary aim of this study is to explore whether radiomics feature is a robust biomarker for AD and further explore the biological basis of those features.Methods: Hippocampal radiomic features were extracted for classification and prediction u...
Preprint
Full-text available
Background: Hippocampal morphological change is one of the main hallmarks of Alzheimer's disease (AD). The primary aim of this study is to explore whether radiomics feature is a robust biomarker for AD and further explore the biological basis of those features. Methods: Hippocampal radiomic features were extracted for classification and prediction...
Conference Paper
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive dementia. Diffusion tensor imaging (DTI) has been used widely to delineate the white matter integrity/degeneration in AD. Automated fiber quantification (AFQ) method is a fully automated method, which can identify the major white matter fiber tracts and then evalua...
Article
Full-text available
Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of loca...
Article
Hippocampal morphological change is one of the main hallmarks of Alzheimer's disease (AD). However, whether hippocampal radiomic features are robust as predictors of progression from mild cognitive impairment (MCI) to AD dementia and whether these features provide any neurobiological foundation remains unclear. The primary aim of this study was to...
Article
Full-text available
Alzheimer’s disease (AD) is characterized by progressive dementia, especially in episodic memory, and amnestic mild cognitive impairment (aMCI) is associated with a high risk of developing AD. Hippocampal atrophy/shape changes are believed to be the most robust magnetic resonance imaging (MRI) markers for AD and aMCI. Radiomics, a method of texture...
Article
Alzheimer’s disease (AD) is a worldwide progressive neurodegenerative disorder in the elderly. Previous research has indicated that Alzheimer’s disease impairs white matter (WM) tracts. Anatomical and neuroimaging studies have indicated that WM tracts are associated with cognitive function. Whether the abnormal WM integrity in AD is associated with...
Article
Full-text available
Acute sleep restriction heavily influences cognitive function, affecting executive processes such as attention, response inhibition, and memory. Previous neuroimaging studies have suggested a link between hippocampal activity and short-term memory function. However, the specific contribution of the hippocampus to the decline of short-term memory fo...
Article
Full-text available
Alzheimer's disease (AD) patients and those with high-risk mild cognitive impairment are increasingly considered to have dysfunction syndromes. Large-scale network studies based on neuroimaging techniques may provide additional insight into AD pathophysiology. The aim of the present study is to evaluate the impaired network functional connectivity...
Article
Full-text available
The purpose of our study was to investigate whether the whole-brain functional connectivity pattern exhibits disease severity-related alterations in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Resting-state functional magnetic resonance imaging data were acquired in 27 MCI subjects, 35 AD patients, and 27 age- and ge...
Data
Table S1: Demographic, clinical and neuropsychological data in normal control (NC), mild cognitive impairment (MCI) and Alzheimer's disease (AD) subjects. Table S2: Cortical and subcortical regions defined in Automated Anatomical Labeling template image in standard stereotaxic space. Table S3: The impaired connectivity AD, also the correlation betw...
Article
Structural magnetic resonance imaging (sMRI) is an established technique for measuring brain atrophy, and dynamic positron emission tomography with (11)C-Pittsburgh compound B ((11)C-PIB PET) has the potential to provide both perfusion and amyloid deposition information. It remains unclear, however, how to better combine perfusion, amyloid depositi...
Article
Full-text available
Rapid eye movement (REM) sleep behavior disorder (RBD) is commonly associated with neurodegenerative disorders characterized by α-synuclein deposition, including Parkinson's disease, multiple system atrophy, and Lewy body dementia. However, this tendency in tauopathy-mediated diseases is rare and only sporadically reported. We systematically illust...
Article
Full-text available
Mild cognitive impairment (MCI) is considered to be the prodromal stage of Alzheimer's disease (AD). The amygdala, which is considered to be a hub, has been shown to have widespread brain connections with many cortical regions. Longitudinal alterations in the functional connectivity of the amygdala remain unclear in MCI. We hypothesized that the im...
Article
Full-text available
Specific patterns of brain atrophy may be helpful in the diagnosis of Alzheimer's disease (AD). In the present study, we set out to evaluate the utility of grey-matter volume in the classification of AD and amnestic mild cognitive impairment (aMCI) compared to normal control (NC) individuals. Voxel-based morphometric analyses were performed on stru...
Article
Full-text available
The marginal division (MrD) is a neostriatum subregion that links the limbic system and basal nucleus of Meynert; it is an important subcortical center that is involved in learning and memory. Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the elderly. AD clinically manifests as gradually progressi...
Article
Full-text available
Objectives: The current study evaluated whether the functional connectivity pattern of the thalamo-cortical network in patients with Alzheimer' s disease (AD) and mild cognitive impairment (MCI) would show disease severityrelated alterations. Methods: Resting-state functional magnetic resonance imaging (MRI) data were obtained from 35 patients w...
Article
Full-text available
The ability to resolve conflicts is indispensable to the function of daily life and decreases with cognitive decline. We hypothesized that subjects with different levels of cognitive impairment exhibit different conflict resolution performances and may be susceptible to interference effects at different stages. Sixteen normal controls (NC), 15 mild...
Article
Alzheimer's disease (AD), the most common cause of dementia, is thought to be a progressive neurodegenerative disease that is clinically characterised by a decline of memory and other cognitive functions. Mild cognitive impairment (MCI) is considered to be the prodromal stage of AD. However, the relationship between AD and MCI and the development p...
Article
Alzheimer's disease (AD), the most prevalent cause of dementia in the elderly, is characterized by progressive cognitive and intellectual deficits. Most patients with mild cognitive impairment (MCI) are thought to be in a very early stage of AD. Resting-state functional magnetic resonance imaging reflects spontaneous brain activities and/or the end...
Article
This study focused on frontal dysfunction during a brief visual delayed matching-to-sample (DMS) task in patients with severe obstructive sleep apnea syndrome (OSAS). We also aimed to assess whether mismatch- or match-task would be more sensitive in the evaluation of OSAS frontal impairment and to determine the factors responsible for the associati...
Article
To investigate the prevalence of cognitive and motor disorders as well as emotional and sleep abnormality in the veterans from military communities in Beijing. The participants underwent a comprehensive in-person evaluation including detailed neuropsychological testing, Hospital Anxiety and Depression Scale and special questionnaires for movement a...
Article
To measure the microstructural differences in the brains of participants with amnestic mild cognitive impairment (aMCI) and compare with a control group using a magnetic resonance diffusion tensor imaging (DTI) technique with fully automated image analysis tools. A standardized clinical and neuropsychological evaluation was conducted on each subjec...
Article
Our previous ERP studies have consistently demonstrated that a negativity N270 elicited by incongruent information in visual S1-S2 matching task represents a type of conflict process, which is distinct from that represented by the classic conflict task or other negative components in delayed matching-to-sample stimulus presentation patterns, since...
Article
Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently seen in patients with neurodegenerative diseases. It can also be seen in brainstem lesions involving the pons. However, RBD in patients with a pure pontine infarction has been rarely reported. A 68-year-old man had a two-month history of violent behavior during sleep. His nocturna...
Article
Twelve subjects were asked to perform visual stimulus presentation tasks. Two figures were presented either simultaneously or sequentially. They were either in congruity (same shapes) or in conflict (different shapes) with each other. Conflicting stimulus pairs presented sequentially evoked a negative event-related component with a fronto-central a...
Article
To clarify the brain mechanism for multifeature stimulus comparison, subjects matched the features of two serial visual stimuli in pairs. Stimulus pairs were of four categories: C-S-, color same, shape same (match); C-S+, color same, shape different (shape mismatch); C+S-, color different, shape same (color mismatch); C+S+, color different, shape d...
Article
N270, an endogenous ERP component of conflict effect, was evoked in previous studies with S1-S2 paradigm. The present experiment is designed to confirm the speculation that this conflict-related negativity could also be elicited by stimulus probes having conflict with a memorized item in a visual post-retrieval comparison task. A Sternberg probe-ma...
Article
Event-related potentials (ERPs) were recorded in subjects while they were performing a matching task. The focus of the present study was on the contributions made by ERP recording to revealing the time-course of multi-conflict information processing in the brain during visual attention. Participants were instructed to discriminate whether the attri...
Article
Event-related potentials (ERPs) were recorded to visual stimuli in a task that required matching the shape and serial position of the probes against previously memorized items. The effects of hypoxia on ERP were investigated in 24 patients with obstructive sleep apnea syndrome (OSAS) and a matched control group. N2b-late positive-going (LPC) compon...

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