Xerxes Seposo

Xerxes Seposo
Nagasaki University · School of Tropical Medicine and Global Health

MENRM, MPH, PhD

About

116
Publications
25,345
Reads
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1,961
Citations
Education
October 2017 - April 2021
University of the Philippines Open University
Field of study
  • Public Policy and Public Administration
April 2014 - March 2017
University of Tsukuba
Field of study
  • Human Care Science
April 2014 - March 2016
University of Tsukuba
Field of study
  • Health Economics

Publications

Publications (116)
Article
Full-text available
Background Identifying how greenspace impacts the temperature-mortality relationship in urban environments is crucial, especially given climate change and rapid urbanization. However, the effect modification of greenspace on heat-related mortality has been typically focused on a localized area or single country. This study examined the heat-mortali...
Article
Background: The most common preventative measure against mumps is vaccination with mumps vaccine. Over 122 countries have implemented mumps vaccine routine immunization programs, mostly via Measles-Mumps-Rubella (MMR) vaccine. In Japan, the unexpectedly high incidence of aseptic meningitis caused by mumps vaccine led to the discontinuation of the...
Article
Full-text available
Background Increased mortality risk is associated with short-term temperature variability. However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperatu...
Article
Full-text available
Epidemiological analyses of health risks associated with non-optimal temperature are traditionally based on ground observations from weather stations that offer limited spatial and temporal coverage. Climate reanalysis represents an alternative option that provide complete spatio-temporal exposure coverage, and yet are to be systematically explored...
Article
Full-text available
Arsenic (As) is a highly toxic, carcinogenic trace metal that can potentially contaminate groundwater sources in volcanic regions. This study provides the first comparative documentation of As concentrations in groundwater in a volcano-sedimentary region in the Philippines. Matched, repeated As measurements and physico-chemical analyses were perfor...
Article
Full-text available
Studies have investigated the effects of heat and temperature variability (TV) on mortality. However, few assessed whether TV modifies the heat-mortality association. Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries. TV was calculated as the standard deviation of the average of the sam...
Article
Background Upper Northern Thailand (UNT) has been episodically affected by air pollution from vegetation burning, which causes adverse respiratory health effects. However, no study has evaluated the effect of regulatory actions to prohibit vegetation burning on respiratory morbidity. We examined the effect of a burning ban enforced in May 2016 on h...
Article
Full-text available
Background: Enteric infections cause significant deaths, and global projection studies suggest that mortality from enteric infections will increase in the future with warmer climate. However, a major limitation of these projection studies is the use of risk estimates derived from nonmortality data to project excess enteric infection mortality asso...
Article
Full-text available
Background In summer 2020 under the COVID-19 pandemic, the Ministry of Health, Labour and Welfare has made public warnings that specific preventive measures such as maskwearing, stay-at-home orders, may increase heatstroke risk. In our previous work, we found a lower risk of heatstroke-related ambulance dispatches (HSAD) during the COVID-19 period,...
Article
Air pollution has been associated with childhood neurodevelopment. However, the role of indoor air pollution, especially volatile organic compounds (VOCs), on childhood neurodevelopment has been poorly explored to date. We investigated the association between indoor air pollutants and childhood neurodevelopment in 5,017 randomly selected children f...
Preprint
Full-text available
Background: Identifying how greenspace impacts the temperature-mortality relationship in urban environments is crucial, especially given climate change and rapid urbanization. To date, studies on this topic have indicated conflicting findings and typically focus on a localized area or single country. We evaluated the effect modification of greenspa...
Article
Full-text available
Adolescence is a key developmental period in one’s life course; health-related behaviors of adolescents can be linked to lifelong consequences, which affect their future health. Previous studies highlight the role of family and its significant association with adolescents’ health. In East Asia and the Pacific, the Philippines is the only country th...
Article
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Background During the COVID-19 pandemic, several illnesses were reduced. In Japan, heat-related illnesses were reduced by 22% compared to pre-pandemic period. However, it is uncertain as to what has led to this reduction. Here, we model the association of maximum temperature and heat-related illnesses in the 47 Japanese prefectures. We specifically...
Article
Full-text available
Background Ambient temperature may contribute to seasonality of mortality; in particular, a warming climate is likely to influence the seasonality of mortality. However, few studies have investigated seasonality of mortality under a warming climate. Methods Daily mean temperature, daily counts for all-cause, circulatory, and respiratory mortality,...
Article
Full-text available
What this study adds The minimum mortality temperature (MMT) is an important indicator of the relationship between temperature and mortality. It indicates the adaptability to climate, but little is known about its geographical changes in the global distribution. This article investigates the geographic differences of the MMT on a global scale and s...
Article
Background Kidney dysfunction is considered a cardiovascular risk factor. However, few longitudinal studies have examined the effects of air pollution on kidney function. We evaluated associations between long-term air pollution exposure and estimated glomerular filtration rate (eGFR) using data from a cohort of the Electricity Generating Authority...
Article
Full-text available
Background Although seasonal variations in mortality have been recognized for millennia, the role of temperature remains unclear. We aimed to assess seasonal variation in mortality and to examine the contribution of temperature. Methods We compiled daily data on all-cause, cardiovascular and respiratory mortality, temperature and indicators on loc...
Article
Full-text available
Background: Minimum mortality temperature (MMT) is an important indicator to assess the temperature-mortality association, indicating long-term adaptation to local climate. Limited evidence about the geographical variability of the MMT is available at a global scale. Methods: We collected data from 658 communities in 43 countries under different...
Article
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The nonpharmaceutical interventions (NPIs) on COVID-19 can impact current and future dynamics of respiratory syncytial virus infections (RSV). In Tokyo, RSV activity declined by 97.9% (95%CI: 94.8% - 99.2%) during NPIs. A longer period of NPIs could expand susceptible populations, enhancing the potential for larger RSV outbreaks after NPIs ends.
Article
It has been reported that long-term exposure to air pollution is linked to metabolic syndrome (MetS), which is an important risk factor for cardiovascular diseases. However, no study has investigated the epidemiological association between long-term air pollution exposure and MetS in Southeast Asia. We examined the association between long-term exp...
Article
Full-text available
The high level of ambient particulate matter in many developing countries constitutes a major health burden, but evidence on its impact on children’s health is still limited in these regions. We conducted a time-stratified case-crossover analysis to quantify the short-term association between fine particulate matter (PM2.5) and hospital admissions...
Article
Full-text available
Background Exposure to cold or hot temperatures is associated with premature deaths. We aimed to evaluate the global, regional, and national mortality burden associated with non-optimal ambient temperatures. Methods In this modelling study, we collected time-series data on mortality and ambient temperatures from 750 locations in 43 countries and f...
Article
Full-text available
Background Mortality due to enteric infections is projected to increase because of global warming; however, the different temperature sensitivities of major enteric pathogens have not yet been considered in projections on a global scale. We aimed to project global temperature-attributable enteric infection mortality under various future scenarios o...
Article
Full-text available
Objectives To investigate the extent to which temperature and influenza explained seasonality of mortality in Japan and to examine the association of the seasonality with prefecture-specific characteristics. Design We conducted time-series analysis to estimate the seasonal amplitude before and after adjusting for temperature and/or influenza-like...
Article
Background Studies on the association between smoke haze (hereafter ‘haze’) and adverse health effects have increased in recent years due to extreme weather conditions and the increased occurrence of vegetation fires. The possible adverse health effects on under-five children (U5Y) is especially worrying due to their vulnerable condition. Despite c...
Article
Background Ankle-brachial index (ABI) and cardio-ankle vascular index (CAVI) are surrogate measures of atherosclerosis based on the functional performance of vessels, and are highly related to cardiovascular events. However, only a few longitudinal studies have been conducted on their associations with long-term air pollution exposure. Objective T...
Article
Only a few studies have investigated the association between long-term exposure to air pollution and alterations of serum lipids and blood sugar level in developing countries. The present longitudinal study examined associations between long-term air pollution exposure and serum lipids [total cholesterol (TC), triglycerides (TG), high-density lipop...
Article
Cases of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), have been increasing since the virus emerged in Wuhan, China, in December 2019. As of 13 March 2021, confirmed COVID-19 cases have exceeded 119 million infected individuals across 188 countries, with m...
Article
Full-text available
Exposure to outdoor air pollution has been consistently associated with asthma. In this study, we reviewed the epidemiological studies published within the last 5 years on the association between outdoor air pollution and exacerbation and onset of asthma. A large number of studies have been published within the last 5 years. Short-term exposure to...
Article
Full-text available
The novel coronavirus, which was first reported in Wuhan, China in December 2019, has been spreading globally at an unprecedented rate, leading to the virus being declared a global pandemic by the WHO on 12 March 2020. The clinical disease, COVID-19, associated with the pandemic is caused by the pathogen severe acute respiratory syndrome coronaviru...
Article
Full-text available
This study evaluated the larval settlement inducing effect of sugars and a conspecific cue from adult shell extract of Crassostrea gigas. To understand how the presence of different chemical cues regulate settlement behavior, oyster larvae were exposed to 12 types of sugars, shell extract-coated and non-coated surfaces, and under varied sugar expos...
Article
Background Epidemiological studies based on mortality and crime data have indicated that short-term exposure to higher temperature increases the risk of suicide and violent crimes. However, there are few studies on non-fatal intentional injury, especially on non-fatal self-harm which is much more common than suicide. Objectives We aimed to clarify...
Article
In 2020, Coronavirus disease 2019 (COVID-19) pandemic has brought a huge impact in daily life and has prompted people to take preventive measures. In the summertime, however, the Japanese government has cautioned that some COVID-19 pandemic conditions may affect the risk to heatstroke. This study investigated how the COVID-19 pandemic setting affec...
Article
Full-text available
Background Air pollution and poor ambient air quality are significantly related to multiple health risks. One associated disease is chronic obstructive pulmonary disease (COPD), a preventable disease with several contributing factors and one of the leading causes of morbidity/mortality locally and globally. A potentially high-risk population are tr...
Article
We describe three waves of COVID-19 infections in Manila. First, imported cases among Chinese nationals; second, infections amongst Filipinos residing in less densely populated areas; and third, infections amongst Filipinos residing in high-density areas. We highlight this using admissions data from the National Infectious Diseases hospital in Mani...
Article
Background: Pregnant women and infants are known as high risk groups for influenza. WHO recommend pregnant women be vaccinated with inactivated influenza vaccine. In Japan, some municipalities started to give subsidy to encourage pregnant women to receive a shot on their own accord, which has made the introduction of seasonal antepartum maternal v...
Article
Full-text available
Background Several studies have shown the health effects of air pollutants, especially in China, North American and Western European countries. But longitudinal cohort studies focused on health effects of long-term air pollution exposure are still limited in Southeast Asian countries where sources of air pollution, weather conditions, and demograph...
Article
Full-text available
The first wave of COVID-19 epidemic began in late January in Malaysia and ended with a very small size. The second wave of infections broke out in late February and grew rapidly in the first 3 weeks. Authorities in the country responded quickly with a series of control strategies collectively known as the Movement Control Order (MCO) with different...
Article
Full-text available
Abstract This study presents the results of the ERTDF S-12 project for searching an optimum reduction scenario of the short-lived climate pollutants (SLCPs) to simultaneously mitigate the global warming and environmental problems. The study utilized REAS emission inventory, Asia-Pacific Integrated Model-Enduse (AIM/Enduse), MIROC6 climate model, NI...
Article
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Background: Coronavirus disease 2019 (COVID-19) has spread to almost every region and country in the world, leading to widespread travel restrictions and national lockdowns. Currently, there are limited epidemiological and clinical data on COVID-19 patients from low and middle-income countries. We conducted a retrospective single-center study of t...
Article
Several studies have noted that the existence of comorbidities lead to an increase in the risk of premature mortality and morbidity. Most of the studies examining the effects of air pollution on comorbidity visits were from Northern American countries, with scarce literature from Asia. This study contributes to existing, yet limited understanding o...
Article
Full-text available
More than half of the world’s population currently live in urban areas and are particularly at risk from the combined effects of the urban heat island phenomenon and heat increases due to climate change. Here, by using remotely sensed surface temperature data and social-ecological indicators, focusing on the hot dry season, and applying the risk fr...
Article
Full-text available
A reduction in heart rate variability (HRV) is reportedly associated with an increased risk of cardiovascular mortality and morbidity. In previous studies, an inverse association was noted between HRV and particulate air pollution, but the sample populations were small and most consisted only of elderly individuals. We examined the association betw...
Article
Numerous epidemiological studies have demonstrated that short-term exposure to ambient PM2.5 increases mortality and morbidity. Investigating the association using hourly ambient PM2.5 exposure may provide important insights, as current evidence is limited mostly to daily lag term. This study aimed to investigate the hourly association between ambi...
Article
Exposure to fine particulate matter (PM2.5) is a potential aggravating factor for respiratory and allergic diseases. However, which PM2.5 sources are associated with such diseases remains unclear. This study aimed to investigate the association of PM2.5 sources with allergic and respiratory symptoms in schoolchildren. PM2.5 samples were collected i...
Article
Background: Previous literature suggests that higher ambient temperature may play a role in increasing the risk of suicide. However, no multi-country study has explored the shape of the association and the role of moderate and extreme heat across different locations. Objectives: We examined the short-term temperature-suicide relationship using d...
Article
Full-text available
Background: Previous literature suggests that higher ambient temperature may play a role in increasing the risk of suicide. However, no multi-country study has explored the shape of the association and the role of moderate and extreme heat across different locations. Objectives: We examined the short-term temperature-suicide relationship using d...
Article
Full-text available
The Philippine health system has undergone various changes which addressed the needs of the time. These changes were reflected in the benchmarks and indicators of performance of the whole health system. To understand how these changes affected the health system (HS), this study determined the changes in the Philippine health system in relation to d...
Article
Full-text available
Background: Globally, local and frontline HIV service delivery units have been deployed to halt the HIV epidemic. However, with the limited resources, there is a need to understand how these units can deliver their optimum outputs/outcomes efficiently given the inputs. This study aims to determine the efficiency of the social hygiene clinics (SHC)...
Article
Background The approval of the extended use of 1-dose varicella vaccine (VVL) in adults aged 50 and older against herpes zoster (HZ) in 2016 and the 2-dose recombinant zoster vaccine (RZV) in 2018 raised the need to evaluate the value for money between these two vaccines. Methods We conducted a cost-effectiveness analysis with Markov modelling to...
Data
It has been reported that a reduction of heart rate variability (HRV) is related to increased risk of cardiovascular mortality and morbidity. The previous studies suggest an inverse association between HRV and air pollution. However, they were performed in relatively small study population and only a few analysed the effect modification by sex and...
Poster
Background/Aim It has been reported that a reduction of heart rate variability (HRV) is related to increased risk of cardiovascular mortality and morbidity. The previous studies suggest an inverse association between HRV and air pollution. However, they were performed in relatively small study population and only a few analysed the effect modifica...
Article
Full-text available
Background: The health burden associated with temperature is expected to increase due to a warming climate. Populations living in cities are likely to be particularly at risk, but the role of urban characteristics in modifying the direct effects of temperature on health is still unclear. In this contribution, we used a multi-country dataset to stud...
Article
Full-text available
Background: Previous research has highlighted the importance of major atmospheric aerosols such as sulfate, through its precursor sulfur dioxide (SO2), black carbon (BC), and or