Xavier Lozoya

Xavier Lozoya
Phytomedicamenta S.A. de C.V. · Scientific Research Center

Professor

About

76
Publications
6,249
Reads
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1,045
Citations
Citations since 2016
2 Research Items
281 Citations
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050

Publications

Publications (76)
Book
Full-text available
This book is about the Equibiotics, a class of natural matrices intendeed to mantain the equilibrium of normal microbiote and overcome the problems associated with bacterial resistance to antibiotics.
Patent
The use of a synergic combination of plant extracts with equibiotic properties allow the recomposition and balance of local microbiota including antiinflammatory and immunodefensive effects as complementary treatment of gastrointestinal infections.
Article
Full-text available
It is described the synergistic properties of a mixture of Psidium guajava L., extract standardized in its content of flavone glycosides and Coptis chinensis Franch, extract standardized in its content of benzophenantridinic alkaloids, for developing a phytodrug for the treatment and prevention of chronic gastritis induced by Helicobacter pylori. T...
Article
It is shown that heteronuclear correlated spectra in which delay times are optimized for geminal and vicinal 13C–1H couplings rather than direct, 13C–1H couplings can be used to assign quaternary carbons in the 13C spectrum of kauradien-9(11),16-oic acid. These spectra in combination with normal heteronuclear correlated spectra plus homonuclear cor...
Article
Full-text available
We used a random amplified polymorphic DNA (RAPD) amplification method to identify molecular markers associated with high quercetin accumulation in the leaves of Psidium guajava L. trees, selected from four different Mexican agronomic regions. We identified six polymorphic RAPD fragments of 620, 590, 370, 690, 480 and 460 bp among individuals of P....
Article
The bark of the Mimosa tenuiflora (Willd.) Poiret (Leguminoseae) tree, known as tepescohuite in Mexico, is commonly used in this country and in Central America to elaborate different products for the treatment of skin burns and lesions. The cicatrizing properties of extracts obtained from this bark have been scientifically studied, attributing the...
Chapter
SummaryA renewed interest in the systematic study of indigenous medicines and associated medicinal plants arose in the 1970s. In Mexico the government established a national pharmaceutical industry to make use of the valuable colonial heritage of traditional practices combined with European medical concepts and resources. In 1975 the Mexican Instit...
Article
To assess the efficacy of two different doses of a Psidii guajavae folium extract in the management of primary dysmenorrhea. A double-blinded randomized clinical trial was conducted in 197 women with primary dysmenorrhea. Four intervention groups were defined: two extract doses (3 and 6 mg/day); ibuprofen (1200 mg/day); placebo (3mg/day). Participa...
Article
Full-text available
The cortex of Mimosa tenuiflora is a popular remedy utilized in Mexico for the treatment of skin lesions. Modern studies support the existence in this cortex of compounds with cicatrizing properties. In the present study the therapeutic effectiveness of an extract elaborated with this bark in the treatment of venous leg ulceration disease was explo...
Article
In recent years, medicinal plants have been used in the phytodrug industry directly from the plant drug or their active compounds. At this time, general manufacturing procedures are recognized both from national authorities like the National Health Secretaria and international organisms like the World Health Organization. Techniques for quality con...
Article
Full-text available
An effi cient whole plant regeneration method from callus cultures of Piper au-ritum was achieved through organogenesis derived from leaf tissue. Proliferating callus and shoot cultures derived from leaf tissue explants placed on Murashige and Skoog (MS) medium supplemented with 2.0 mg·L –1 2, 4-dichlorophenoxyacetic acid (2,4-D) plus 1.5 mg·L –1 k...
Article
From the moment the territory known today as Latin America became part of the "Western world" some fi ve hundred years ago, two different viewpoints of the same process have existed-two ways of analyzing the history of a region that for fi ve centuries has tried to fi nd the syncretism necessary to eradicate the great social and economic difference...
Article
Plants from the Gnaphalium genus have been used in the Mexican traditional medicine for digestive and respiratory complaints. In the present study, the effect of methanolic extract from Gnaphalium conoideum HBK on the responses to contractile agonists was assessed in guinea pig tracheas, and the possible role of L-type Ca2+ channels was explored in...
Article
We evaluated the immune response of healthy control and stressed Wistar rats submitted to hypothalamic-pituitary-adrenal (HPA) axis activation. Rats were treated with Ginkgo biloba extract (EGb 761) orally (100 mg/kg per day for 7 days). EGb 761 stimulated the digestion index of peritoneal and alveolar macrophages (PM and AM) of stressed rats. Like...
Article
The leaves of Psidii guajavae L. (Myrtaceae) (Guava) are popularly used in tropical countries to prepare a remedy for the treatment of patients suffering of liquid stools; this traditional use is now scientifically supported by the existence in the leaf of a group of quercetin-derived flavonoids with intestinal anti-motility, spasmolytic and anti-i...
Article
The growing utilization of complementary and alternative medicine (CAM) therapies represents one of the characteristic phenomena facing scientific medicine. Studies of the patient’s opinions and attitudes toward CAM therapies are scarce. Among doctors, it is widely considered that the use of CAM therapies is only linked to a particular social or cu...
Article
We evaluated the effects of Ginkgo biloba extract (EGb 761) on the cellular immune response of rats with immunosuppression induced by activation of the hypothalamic-pituitary-adrenal (HPA) axis. Groups of five rats were subjected to chronic stress by the application of daily electric shocks (ES) over 7 days. This stress produced a significant decre...
Article
Ancestral medicinal use of guava (Psidium guajava L. Fam. Myrtaceae) is today supported by numerous biomedical studies concerning the properties of leaf extracts. However, insufficient clinical studies are reported on the use of this plant resource in the treatment of gastrointestinal ailments. The present work reports a randomized, double-blinded,...
Article
Full-text available
The phagocytic activity and delayed-type Hypersensitivity (DTH) response to dinitrofluorobenzene (DNFB) of healthy BALB/c mice treated orally (100 mg/kg/day for 7 days) using two Ginkgo biloba extracts were studied. The phytopharmaceuticals Gb 30 (Alban Muller International, France) and EGb 761 (Schwabe, Germany) administered orally stimulated the...
Article
The immunomodulatory effect of hydrosoluble extracts of four Chilean Cyttaria species (Discomycetes, Fungi) was assessed in mice with L5178Y lymphoma. Oral administration of 100 mg extract per day for 7 days enhanced the percentual phagocytosis and phagocytosis index in animals receiving Cyttaria berteroi, Cyttaria darwinii, Cyttaria espinosae and...
Article
The present paper reports a model of stress induction, based on electrical stimulation of the brain in normal Wistar rats. Stress-related stimulation of the hypothalamic-pituitary-adrenal axis produced a rise in circulating corticosterone levels that correlated significantly with the impairment of some immunological parameters, such as delayed hype...
Article
In Mexico, scorpion poisoning is a health problem because the poison has beta toxins that affect sodium channel activation. Lidocaine decreases ion permeability across the sodium channel acting in the opposite manner. The aim of this work is to determine whether lidocaine antagonized the toxic effect of the crude poison of Centruroides limpidus lim...
Article
Full-text available
The apoptotic index (AI) of peripheral blood lymphocytes (PBL) and plasma corticosterone (CS) levels were determined in Wistar rats treated with phenytoin (PHT) at therapeutic and toxic doses (100 or 200 mg/kg/day, respectively, over a period of 7 days) and stressed by bifrontal electric shock (60 Hz/40 mA/0.2 seg). The values of CS and AI were fou...
Article
Among the numerous in vitro methods for studying the antimicrobial activity of plant drugs, bioautography has found widespread applications, especially for the detection of new compounds in complex plant extracts. This paper describes the results obtained during the application of the bioautographic method to detect antimicrobial compounds in a chl...
Article
An experimental in vitro model was developed for the study of plant extracts reported by traditional medicines in the treatment of diarrhea. The guinea-pig isolated ileum is perfused with the plant extract using an intraluminal approach. The peristaltic reflex is induced by electrical stimulation while the plant extract is perfused. The spasmolytic...
Chapter
The interest in a systematic study of indigenous medicines first appeared in Mexico in the seventies of this century. It was, as in other countries, influenced by the vindicative movement of the World Health Organization (WHO). Owning a vigorous heritage of prehispanic indian culture, Mexico appears as a nation with strong manifestations of traditi...
Article
Montanoa tomentosa (zoapatle) is a Mexican plant popularly used for antifertility purposes and with promising characteristics for the development of a new oral contraceptive agent with uteroevacuant properties. In a previous pharmacological report we established the ambivalent myometrial response to zoapatle leaves aqueous extract (ZACE) depending...
Book
Full-text available
Libro para proporcionar al medico familiar informacion basica sobre la Medicina Tradicional
Article
The imidazolic derivatives present in the seeds and leaves of Casimiroa edulis (Rutaceae), a antihypertensive popular remedy, were successfully separated and estimated by high-performance liquid chromatography. Dimethylhistamine, methylhistamine and casimiroedine were separated by paired ion chromatography while histamine was derivatized and determ...
Article
Full-text available
A collection of Montanoa (Cerv) specimens was conducted throughout Mexico. Twenty-one specimens were classified, some of them grown in the greenhouse and transplanted in an agricultural experimental field station in the Valley of Mexico. In vitro uterotonic potency was assayed and the results expressed as equivalents of oxytocine, by using estrogen...
Article
Full-text available
Differences in uterotonic activity were observed between zoapatle Montanoa (Cerv.), plants growing in their natural habitat and plants growing in an experimental agricultural plot. Details of an in vitro analogic model for assaying uterotonic potency in guinea pig strips is described. Important species differences on the uterine response to zoapatl...
Article
Full-text available
The zoapatle aqueous crude extract has been used in Mexico for the last 5 centuries for the induction of labor, treatment of post-partum bleeding problems, and as a menses inducer. Today, it is sold in street markets, and its long documented history of use by humans could be taken as indirect evidence of a lack of toxicity. Rigorous pharmacological...
Article
Full-text available
Kauradienoic acid was obtained from the hexanic extract of M. tomentosa (Cerv) leaves by chromatographic separation. This substance influenced the in vitro contractility of the rat, dog and guinea pig uterine strips. It also induced strong contractions of the guinea pig uterus in vivo when administered intravenously, without changes on arterial blo...
Article
Full-text available
The effects produced by perezone, which was isolated from Perezia cuernavacana Rob. et Greenm., and hydroxyperezone monoangelate, from Perezia hebeclada (D.C.) A.Gray, on intestinal motility in vivo and in vitro in animal experiments are reported. It is suggested that hydroxyperezone monoangelate is a laxative principle present in certain species o...
Article
This article reviews the state of research for a number of plants traditionally related to treatment of cardiovascular diseases. It stresses the importance of both anthropological surveys and historical studies for the proper understanding of this ancient and still very popular medicine.
Article
Preliminary screening studies of the aqueous extracts of flowers and leaves of Magnolia grandiflora L. were carried out on different animal models in an attempt to confirm their effects on the cardiovascular system, in view of the wide use of this plant in traditional Mexican medicine.
Article
Water extract from seeds of Annona cherimola was tested in vitro on uterus strips of nongravid guinea-pigs. The extract resulted in possessing utero-constrictive properties due to the presence of a gluco-steroidal substance isolated from it.
Article
Crossed-perfusions of homologous loci of the mesencephalic reticular formation were carried out on pairs of “encéphale isolé” cats in order to detect the possible secretion of a chemical substance mediating electrocortical synchronization and desynchronization. Special care was taken in quantitatively determining (i) the precise site and diffusion...
Article
The hypotensive activity of the alcoholic and aqueous extracts of C. edulis has been previously reported. The present paper describes the pharmacological studies of a substance isolated from the alcoholic extract. Preliminary chemical and pharmacological data allowed a histamine-like compound to be proposed as the hypotensive principle. Studies wer...
Article
The hypnotic properties of leaves and seed of Casimiroa edulis (zapote blanco) a tropical fruit, are well known. In the present investigation, pharmacological studies on aqueous and alcoholic extracts were carried out in dogs, cats, rabbits and guinea pigs, using different experimental models. The action of the extracts upon blood pressure, cardiac...
Article
Correlation of hormonal changes and EEG activity requires objective measurements to define the behavior of the different frequency bands during sleep. With this purpose, EEG activity of six healthy male volunteers (19-22 years) was recorded throughout all night during spontaneous sleep. The C4-left mastoid EEG combination was channeled to a frequen...
Article
The histopathological characteristics of epileptogenic lesions produced by single microinjections of alumina cream (AC) were studied serially in the brains of 18 cats sacrificed during the latent, convulsive and remission stages of the spontaneous course. In addition, the thickness and cellularity of the cerebral cortex were measured quantitatively...
Article
The histopathological characteristics of epileptogenic lesions produced by single microinjections of alumina cream (AC) were serially studied in brains of 18 cats sacrificed during the latent, convulsive and remission stages of the spontaneous course. In addition, the thickness and cellularity of the cerebral cortex were measured quantitatively at...
Article
Acetylcholine (ACh), injected in the lateral ventricles of the brain, is known to produce dramatic and long lasting effects. It is not known, however, how long ACh remains within the ventricular system and whether the observed effects depend solely upon its presence in the ventricular fluid or are due to its perfusion through the periventricular ti...
Article
The cerebral cortex of the cat was systematically stimulated with electric shocks, and the recording of the evoked potentials in the hypothalamus was performed with macro- and microelectrodes stereotaxically guided. Stimulation of definite cortical loci evoked potentials in several hypothalamic nuclei studied. Three focuses were found, coincident w...
Article
The manner in which the electroencephalogram is conventionally used suffers from a number of drawbacks of which the most important is the difficulty in quantitatively evaluating electrocortical activity. When this same procedure is used to determine cerebral death, it is crucial to find a method which enables one to establish the state of conscious...
Article
in recent years, medicinal plants have been used in the phytodrug industry directly from the plant drug or their active compounds. At this time, general manufacturing procedures are recognized both from national authorities like the Na- tional Health Secretaria and international organisms like the World Health Organization. Techniques for quality c...
Article
Uno de los aspectos más apasionantes del estudio de los pueblos que habitaron en el territorio mesoamericano, antes de su descubrimiento y colonización por el europeo, es el uso que aquéllos hicieron de la abundante flora local. De entre los cientos de plantas con propie­ dades biodinámicas que nos legaron las culturas del. pasado, las lla­ madas p...

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