Xavier Jean

Xavier Jean
Assistance Publique – Hôpitaux de Paris | AP-HP

MD, Ph.D

About

73
Publications
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1,288
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Publications

Publications (73)
Article
Full-text available
The study of human behaviors in cognitive sciences provides clues to understand and describe people’s personal and interpersonal functioning. In particular, the temporal analysis of behavioral dynamics can be a powerful tool to reveal events, correlations and causalities but also to discover abnormal behaviors. However, the annotation of these dyna...
Article
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Background: Compression garments (CGs) are an adjuvant treatment for generalized joint hypermobility (GJH), including the Ehlers–Danlos syndrome/hypermobility types. The effects of CGs are likely to be related to better proprioceptive control. We aimed to explore the use of CGs in individuals with autism and severe proprioceptive dysfunction (SPD),...
Article
Full-text available
Psychotic disorders in children are more heterogeneous than is captured by categorical diagnoses. In a new cohort of children and adolescents, we evaluated the relationships among age at onset (AAO), clinical symptoms and developmental impairments. Patients with schizophrenia and other "spectrum" psychotic diagnoses (N = 88; AAO 6-17, mean 12.6) we...
Article
Backgrounds Infant-directed speech (IDS) is part of an interactive loop that plays an important role in infants’ cognitive and social development. The use of IDS is universal and is composed of linguistic and emotional components. However, whether the emotional component has similar acoustics characteristics has not been studied automatically. Met...
Article
Objectives: Osteoporosis is a major risk factor for fracture and treatment is mainly preventive. Patients with severe psychiatric condition and treated with antipsychotics are at risk for vitamin D deficiency and iatrogenic hyperprolactinemia, two serious risk factors of osteoporosis. We aim to determine whether all antipsychotics are similar rega...
Article
Purpose of review: Over the past 10 years, the use of information and communication technologies (ICTs) has increased in regard to the treatment of individuals with autism spectrum disorders (ASDs). ICT support mechanisms (e.g. computers, laptops, robots) are particularly attractive and are adapted to children with ASD. In addition, ICT algorithms...
Article
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Background: Autism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental disorders which core symptoms are impairments in socio-communication and repetitive symptoms and stereotypies. Although not cardinal symptoms per se, motor impairments are fundamental aspects of ASD. These impairments are associated with postural and motor con...
Article
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Background: Impairments in imitation abilities have been commonly described in children with autism spectrum disorder (ASD). How motricity in interpersonal coordination impacts imitation, during long lasting semi-ecological conditions, has not been carefully investigated. Methods: Eighty-five children and adolescents (39 controls with typical devel...
Article
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Background: In motor imitation, taking a partner's perspective often involves a mental body transformation from an embodied, ego-centered viewpoint to a disembodied, hetero-centered viewpoint. Impairments of both own-body-transformation (OBT) and abnormalities in visual-spatial processing have been reported in patients with neurodevelopmental disor...
Article
Aim To explore the heterogeneity of Tourette syndrome as part of a neurodevelopmental spectrum. Method Using hierarchical ascendant clustering based on tic symptoms, developmental milestones, and neurodevelopmental comorbidities, we analyzed the heterogeneity of Tourette syndrome phenotypes in a sample of 174 children and adolescents with Tourette...
Article
Background Conventional gestures (CG) contribute to communication and are a precursor of verbal language. The aim of our study was: (a) to analyse the developmental course of CG comprehension in typical children; (b) from a clinical perspective, to document how children with autism spectrum disorders (ASD) and language disorder (LD) can understand...
Article
Myotonic dystrophy type 1 (DM1) is a multisystemic disorder with neuromuscular symptoms and brain dysfunctions. Depending on the phenotypic expression, the degree of cognitive impairment remains heterogeneous, ranging from moderate to severe intellectual disability in the congenital form, to executive, visuospatial and personality dysfunction in th...
Article
In this paper we explore the dynamics of Joint Attention (JA) in children with Autism Spectrum Disorder (ASD) during an interaction task with a small humanoid robot. While this robot elicits JA in children, a coupled perception system based on RGB-D sensors is able to capture their behaviours. The proposed system shows the feasibility and the pract...
Article
NR4A2, a member of the nuclear receptor superfamily, is involved in modulation of target gene transcription, regulating several developmental processes such as regulation of cellular homeostasis, neuronal development, inflammation and carcinogenesis. 2q24.1 deletions are extremely rare and only one patient with a de novo deletion encompassing only...
Article
Full-text available
Background The need for early treatment of autism spectrum disorders (ASD) necessitates early screening. Very few tools have been prospectively tested with infants of less than 12 months of age. The PREAUT grid is based on dyadic assessment through interaction and shared emotion and showed good metrics for predicting ASD in very-high-risk infants w...
Data
Table A. Clinical outcome of positive infants at one or more screening points. Table B. Clinical characteristics of ASD and ID cases detected (17 true positive cases) or missed at follow-up (1 false negative case). ASD: autism spectrum disorder; PDD-NS: pervasive developmental disorder; ID: intellectual disability; ADHD: attention deficit/hyperacti...
Data
Estimation of ASD diagnosis status for (1) infants positive at one screening but lost at FU; (2) infants negative at all screenings and estimated through the random sample. * Some individuals were positive at several tools. Number of Individuals are rounded to nearest integer. (DOCX)
Data
Estimation of ND (ASD or ID) diagnosis status for (1) infants positive at one screening but lost at FU; (2) infants negative at all screenings and estimated through the random sample. * Some individuals were positive at several tools. Number of Individuals are rounded to nearest integer. (DOCX)
Article
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Gilles de la Tourette syndrome (TS) is a complex developmental neuropsychiatric condition in which motor manifestations are often accompanied by comorbid conditions that impact the patient’s quality of life. In the DSM-5, TS belongs to the “neurodevelopmental disorders” group, together with other neurodevelopmental conditions, frequently co-occurri...
Article
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Borderline personality disorder (BPD) is a severe and frequent disorder characterized by a pervasive pattern of instability affecting impulse control, emotional regulation, cognitive processing, self-image and interpersonal relationships. Patients’ personal histories are often marked by stressful or traumatic experiences, either unique or repeated....
Conference Paper
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Interactive Machine Learning considers that arobot is learning with and/or from a human. In this paper,we investigate the impact of human social traits on the robotlearning. We explore social traits such as age (children vs.adult) and pathology (typical developing children vs. childrenwith autistic spectrum disorders). In particular, we considerlea...
Article
Though whole exome sequencing is the gold standard for the diagnosis of neurodevelopmental disorders, it remains expensive for some genetic centers. Commercialized panels comprising all OMIM-referenced genes called "medical exome" constitute an alternative strategy to whole exome sequencing, but its efficiency is poorly known. In this study, we rep...
Article
Objectives Pediatric catatonia is a rare and life-threatening syndrome. Around 20% of juvenile catatonia is associated with organic condition (Consoli et al., 2012). Autoimmune conditions represent a diagnostic and therapeutic challenge since specific antibodies can be missed. To facilitate decision making, we recently formulated a causality assess...
Article
Imitation plays a critical role in the development of intersubjectivity and serves as a prerequisite for understanding the emotions and intentions of others. In our review, we consider spontaneous motor imitation between children and their peers as a developmental process involving repetition and perspective-taking as well as flexibility and recipr...
Article
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We report the case of a young boy with nonverbal autism and intellectual disability, with a rare de novo 1q21.3 microdeletion. The patient had early and extreme self-injurious behaviours that led to blindness, complicated by severe developmental regression. A significant reduction in the self-injurious behaviours and the recovery of developmental d...
Article
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Children with developmental dyspraxia (DD) express impairments in the acquisition of various motor skills and in the development of their social cognition abilities. Although the neural bases of this condition are not fully understood, they are thought to involve frontal cortical areas, subcortical structures, and the cerebellum. Although cerebella...
Article
Le nombre d’études sur l’utilisation des technologies de l’information, de la communication et de la robotique au service des enfants autistes a progressé rapidement au cours des 15 dernières années. Nous détaillons les espoirs, mais aussi les écueils et les verrous technologiques des deux domaines les plus dynamiques, à savoir : (1) la réalisation...
Article
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Background To meet the required hours of intensive intervention for treating children with autism spectrum disorder (ASD), we developed an automated serious gaming platform (11 games) to deliver intervention at home (GOLIAH) by mapping the imitation and joint attention (JA) subset of age-adapted stimuli from the Early Start Denver Model (ESDM) inte...
Article
In the field of biology, the study of bonding has been renewed by the discovery of non-genetic transmission of behavioral traits through early mother-infant interaction and the role of oxytocin. Despite maintenance of oxytocin regulation during evolution, social signals that mediate early interaction have evolved dramatically to reach a high level...
Article
Full-text available
Meeting the required intensive intervention hour for treating children with autism is challenging in terms of trained manpower needed and costs. Advances in Information Communication Technology and computer gaming may help in this respect by creating a nomadically deployable closed loop intervention system involving the child and active participati...
Data
This file contains the description of the other nine games of the gaming platform which have not been described in the paper.
Data
This file contains the data used for the analysis of the games Bake a recipe and Free Drawing presented in the Results and Discussion section.
Article
Full-text available
Objective: Wolfram syndrome (WS, MIM 222300) is a rare autosomal, recessive neurodegenerative disorder associated with mutations in WFS1, a gene that has been associated with bipolar disorder (BD). WS, characterized by the association of juvenile-onset diabetes mellitus (DM) and bilateral progressive optic atrophy (BPOA), encompasses several other...
Article
Full-text available
Although deficits in emotion recognition have been widely reported in autism spectrum disorder (ASD), experiments have been restricted to either facial or vocal expressions. Here, we explored multimodal emotion processing in children with ASD (N = 19) and with typical development (TD, N = 19), considering uni (faces and voices) and multimodal (face...
Article
Résumé Les troubles praxiques constituent un motif fréquent de consultation en psychiatrie de l’enfant et de l’adolescent. Nous proposons une synthèse de l’état actuel des connaissances utile au clinicien confronté à ces troubles. Les dyspraxies de développement correspondent au regard du DSM-5 aux troubles développementaux de la coordination (TDC)...
Article
Recognition of emotional expressions plays an essential role in children's healthy development. Anomalies in these skills may result in empathy deficits, social interaction difficulties and premorbid emotional problems in children and adolescents with schizophrenia. Twenty-six subjects with early onset schizophrenia spectrum (EOSS) disorders and tw...
Article
Developmental coordination disorders, which consist of developmental dyspraxia, are a frequent reason for consultations in child psychiatry, given their impact on learning. These motor impairments, associated with visuo-spatial difficulties, can also penalize the child in his imitative exchanges and have an impact on social integration. The diversi...
Article
Autism is a large group of disorders. From the first description in 1943 until know, attempts to propose nosological boundaries, through successive redefinitions of diagnostic criteria, have not succeeded in constraining the extensiveness nor in explaining the heterogeneity of autism. The failure of the categorical approach is revealed by several i...
Article
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There is a growing interest in the role of biological and behavioral rhythms in typical and atypical development. Recent studies in cognitive and developmental psychology have highlighted the importance of rhythmicity and synchrony of motor, emotional, and interpersonal rhythms in early development of social communication. The synchronization of rh...
Article
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During adolescence, some individuals with autism spectrum disorder (ASD) engage in severe challenging behaviors, such as aggression, self-injury, disruption, agitation and tantrums. We aimed to assess risk factors associated with very acute behavioral crises in adolescents with ASD admitted to a dedicated neurobehavioral unit. We included retrospec...
Article
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Several studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and clinical genetics, the genetic risk factors remain difficult to identify, with the exception of a few chromosomal disorders and several single gene disorders associated with a...
Article
Full-text available
We aimed to compare, during a joint attention (JA) elicitation task, how children with autism spectrum disorder (ASD) and children with typical development (TD) behave and explore their 4 dimensional (meaning spatial 3D + time) when interacting with a human or with a robotic agent. We built a system that employed a Nao robot and a perception system...
Article
La douleur est avant tout une expérience. Cette expérience peut être fortement altérée chez les patients présentant des troubles psychiatriques. La douleur s’exprime, également, et l’expression comportementale peut être modifiée, voire rendue difficilement compréhensible, dans le cas de pathologies psychiatriques sévères. Nous proposons une revue c...
Article
To cooperate with a partner, it is essential to communicate by sharing information through all available avenues, including hand gestures, gazes, head gestures and naturally, speech. In this paper, we compare the communicative and coordination skills of children with typical development to those of children with Autism Spectrum Disorders (ASDs) in...
Article
Full-text available
The main mechanisms of children's imitative exchanges with peers are highlighted here through a developmental approach taking into account the importance of rhythmicity and synchrony. We focused on spontaneous motor imitation to describe a playful dynamic that is paradoxical: in the experience of play in which roles are not clearly distributed, mut...
Article
Using an integrative approach, we address the mechanisms inherent to a child's imitative play with peers. From a psychoanalytic perspective, in a study of the fraternal bond, we see that these exchanges in which the discovery linked to the other and itself originate from the experience of a game, in the name of intimate connection, in the heart of...
Article
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Plusieurs études ont rapporté l’existence de troubles du sommeil et d’altération des rythmes circadiens dans l’autisme suggérant des perturbations de la physiologie de la mélatonine, neurohormone de la glande pinéale sécrétée pendant la nuit. De plus, les résultats d’une étude que nous avons réalisée sur 49 enfants présentant un diagnostic d’autism...
Article
The Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) category is a psychopathological entity few have described and is poorly, and mainly negatively, defined by autism exclusion. In order to limit PDD-NOS heterogeneity, alternative clinical constructs have been developed. This study explored the reliability and the diagnostic effi...
Article
Full-text available
This study presents a preliminary investigation into the automatic assessment of language-impaired children's (LIC) prosodic skills in one grammatical aspect: sentence modalities. Three types of language impairments were studied: autism disorder (AD), pervasive developmental disorder-not otherwise specified (PDD-NOS), and specific language impairme...
Article
Nous proposons d’aborder la clinique de l’anorexie mentale a l’adolescence du point de vue du fraternel, a partir de trois situations cliniques. Chez ces patientes anorexiques, leur lien fraternel (ou sororal) presente une histoire et une configuration particuliere. Le declenchement des troubles correspond a une forme d’experience interpersonnelle...
Article
Since their first description, neuromuscular disorders are considered as pathologies of the peripheral nervous system; nevertheless recent studies suggest the involvement of the central nervous system as well, manifesting in cognitive and psychiatric impairments. The aim of this literature review is to examine the phenotype of children neuromuscula...
Article
Praxic disorders are a relatively frequent reason for consultations in child psychiatry on account notably of their impact on development of basic skills. In order to evaluate and understand such disorders, an approach which is both developmental and integrative, which takes into account the cognitive, linguistic and affective dimensions inherent i...
Article
Full-text available
Children language disorders are a frequent reason of consultation. Language is not only a means of expression, knowledge and communication but it also contributes to psychic development. Its exploration is an integral part of children psychiatrical examination. Language disorders appear in very different situations and the polymorphism of the cases...