Xavier Berard

Xavier Berard
University of Bordeaux · Department of Life and Health Sciences

MD PhD

About

93
Publications
2,558
Reads
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660
Citations
Introduction
Skills and Expertise
Education
September 2008 - June 2012
University of Bordeaux
Field of study
  • Science, Vascular Biology
September 1994 - October 2005
University of Bordeaux
Field of study
  • Medecine

Publications

Publications (93)
Article
Introduction: Complete excision in patients with aortic vascular graft and endograft infections (VGEIs) is a significant undertaking and many patients never undergo definitive treatment. Knowing their fate is important to be able to assess the risks of graft excision vs alternative strategies. This study analyzed their life expectancy and sepsis-f...
Article
Objective Endovascular aortic repair (EVAR) surveillance relies on serial measurements of maximal diameter despite significant inter- and intra-observer variability. Volumetric measurements are more sensitive but general use is hampered by the time required for their implementation. An innovative fully automated software (PRAEVAorta® from Nurea), u...
Article
Background: Peripheral vascular graft infections are poorly-evaluated, despite high mortality and amputation rates. The vascular substitute of choice remains controversial when veins are unavailable. This study aims to evaluate the results of a biosynthetic collagen graft (Omniflow II®) in an infected field when autologous veins are unavailable....
Article
La prévalence des patients atteints d’artériopathie oblitérante des membres inférieurs (AOMI) est estimée entre 4,3 et 29 % selon les séries. Les patients les plus touchés sont essentiellement les populations âgées et de sexe masculin. Les autres facteurs de risques sont représentés par le tabagisme, l’hypercholestérolémie et le diabète. Près de 20...
Article
Full-text available
Background Many experimental models have been developed to decipher the mechanisms of vascular graft and endograft infections (VGEIs), and to elaborate strategies to prevent or treat their occurrence. We conducted a systematic literature research to identify the most accurate models for studying VGEIs, depending on the research question. Methods A...
Article
Objective The objective of this retrospective single centre study was to determine whether different enteric reconstruction methods and adjuncts confer a benefit after in situ reconstructions (ISRs) of graft aorto-enteric erosion (AEnE) and fistula (AEnF). Methods Primary endpoints were in hospital mortality and AEnE/F recurrence. Survival was est...
Article
Objective The purpose of this study was to evaluate survival and freedom from reinfection of patients with infected native aortic aneurysms (INAA) managed with in situ revascularization (ISR), either with open surgical repair (OSR) or endovascular aneurysm repair (EVAR), and identify outcome predictors. Methods Patients with INAA who underwent ISR...
Article
Full-text available
We report 5 cases of vascular Q fever complicated by polymicrobial superinfection in patients who had no risk factors for acute Q fever. Q fever was diagnosed by serologic and molecular assays for Coxiella burnetii. We confirmed additional infections using conventional graft cultures.
Article
Riassunto L’occlusione aortica acuta (OAA) è rara, ma resta un’urgenza grave in chirurgia vascolare. I segni clinici dipendono dal livello di occlusione e possono essere confusi con un accidente vascolare cerebrale o una patologia neurologica, generando un notevole ritardo diagnostico. Occorre concentrarsi sulla ricerca dell’eziologia, che influisc...
Article
Full-text available
Maïlys Ducours,1 Julie Leitao,1 Mathilde Puges,1 Sabine Pereyre,2,3 Frédéric Gabriel,4 Hervé Dutronc,1 Raphaelle Chevallier,1 Jean-Baptiste Pinaquy,5 Claire Carcaud,6 Xavier Berard,7 Charles Cazanave1,3 1CHU Bordeaux, Service des Maladies Infectieuses et Tropicales, Hôpital Pellegrin, Bordeaux, F-33000, France; 2CHU Bordeaux, Laboratoire de Bactéri...
Article
Objective Imaging softwares have become critical tools in the diagnosis and decision making for the treatment of abdominal aortic aneurysms (AAA). However, the inter-observer reproducibility of maximum cross-section diameter is poor. This study aimed to present and assess the quality of a new fully automated software (PRAEVAorta) that enables fast...
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Full-text available
Introduction Alarming outcomes have been reported following infected endovascular aortic aneurysm repair (EVAR) device explantation. Infected fenestrated-EVAR (FEVAR) exposes patients to even worse procedural risks. Report A 67 year old man with a prior history of FEVAR presented with impaired general condition, abdominal and back pain, and increa...
Article
Purpose: To characterize the short-term results of a newly available self-expanding covered stent (Covera; CR Bard Peripheral Vascular Inc., Murray Hill, New Jersey) for the reconstruction of target vessels in complex aneurysms. Materials and methods: From August 2017 to November 2018, this self-expanding covered stent was used in 17 patients (m...
Article
Full-text available
Bartonella alsatica is a wild rabbit pathogen causing bacteremia rarely reported in humans, with only three cases published so far, including one lymphadenitis and two endocarditis cases. Here, we report the case of a 66-year-old man who suffered from acute renal failure due to a membranoproliferative glomerulonephritis. Fluorodeoxyglucose (FDG) po...
Presentation
-Introduction: aortic (endo)graft infection is a rare (up to 5%) but devastating complication. In-situ repair provides better outcome but the choice of the substitute is crucial: autogenous veins revascularization represent, when possible, the best option. Cryopreserved arterial allografts and antimicrobial prosthesis are a valid alternative. -Purp...
Article
Objective: An endovascular-first approach is usually recommended in femoropopliteal occlusive disease. However, despite high technical success, plain old balloon angioplasty (POBA) is burdened with high restenosis rates. To reduce this phenomenon, local delivery of drugs has been proposed by way of drug-coated balloons (DCBs). Our goal was to revi...
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Full-text available
Objectives Prosthetic vascular graft infections (PVGIs) are associated with high mortality rates. To improve treatment outcome, an early and definite diagnosis is critical, and current diagnostic criteria are often insufficient. The accuracy of 2-deoxy-2-[fluorine-18]-fluoro-d-glucose positron emission tomography integrated with computed tomography...
Article
Purpose: To report the midterm experience with chimney-endovascular aneurysm repair (Ch-EVAR) with the use of open self-expending stents for branch vessel preservation. Materials and methods: From July 2010 to May 2017, 67 patients underwent open Ch-EVAR because their proximal landing zones were adjacent to, or covered, the renal or mesenteric a...
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Full-text available
Objectives The aim was to compare the antimicrobial efficacy of four different grafts: a standard graft (Intergard, IG), an IG graft soaked in rifampicin (IGrif), a silver impregnated graft (Intergard Silver, IGS), and a silver + triclosan impregnated graft (Intergard Synergy, IGSy). Methods This was a seven day in vitro study. The IG, IGrif, IGS,...
Article
Background The treatment of choice in end-stage renal disease is transplantation. Hemodynamic disturbances can evoke graft loss, while early ultrasound identification of vascular problems improves outcome. The aim of this study was to identify differences in postoperative complications with and without systematic intraoperative Doppler ultrasound u...
Article
Background: There has been increasing evidence to support the endovascular-first approach in the treatment of below-the-knee (BTK) lesions. Plain old balloon angioplasty (POBA), with bailout bare-metal stent scaffolding in case of flow limiting dissection or recoil, have been considered the standard treatment of choice but industries are continuall...
Article
Full-text available
Objectives: Vascular graft infections (VGIs) are severe and require prolonged adequate antimicrobial therapy. However, up to 45% of conventional cultures are negative. Sonication and genus specific PCRs for microbiological diagnosis of VGI was evaluated. Methods: Samples were prospectively obtained from explanted vascular grafts in Bordeaux Univ...
Article
We report herein the successful laparoscopic resection of an asymptomatic 3-cm middle colic artery aneurysm in a young woman. Endovascular treatment represents nowadays the first-line option facing visceral artery aneurysm but, in this case, embolization was excluded because of hostile anatomy. Advantages of laparoscopic approach were the safe rese...
Article
Background: Acetylsalicylic acid (ASA) is recommended before, during and after carotid endarterectomy (CEA). Efficacy of ASA is influenced by numerous biological and genotypic factors. Objectives: To determine the biological efficacy of ASA by using the Multiplate® method and to explore the biological parameters and genomic factors influencing t...
Article
L’ischémie critique chronique (ICC) représente le stade ultime de l’artériopathie oblitérante des membres inférieurs (AOMI), associé à un risque élevé d’événements cardiovasculaires. Pour assurer le sauvetage de membre et la cicatrisation des troubles trophiques, la restauration d’un flux sanguin direct dans le pied est nécessaire. Le pontage dista...
Article
Introduction Le pronostic des infections de prothèses vasculaires (IPV) est grevé d’un taux de mortalité élevé. Un diagnostic fiable et précoce, souvent difficile en particulier dans les IPV latentes est un pré-requis indispensable à l’amélioration de la prise en charge thérapeutique de ces infections. Notre étude a comparé, chez des patients suspe...
Article
Introduction Les infections de prothèses vasculaires (IPV) sont associées à des taux de mortalité élevés. Le diagnostic est souvent difficile, surtout dans les infections latentes. Pour améliorer le résultat du traitement médical et chirurgical, un diagnostic précoce et précis est primordial et les critères de diagnostic réels sont souvent insuffis...
Article
Les infections de protheses vasculaires (IPV) sont associees a des taux de mortalite eleves et de diagnostic difficile. Differentes etudes evaluant les performances de la TEP au 18-FDG (TEP) ont ete publiees utilisant cependant souvent des criteres d’interpretation differents. De plus, ces echelles visuelles d’interpretation semblent presenter des...
Article
Objective: Increasing experience with fenestrated endovascular aortic repair (FEVAR) of complex aortic aneurysms has shown excellent short- to long-term results, even in high-risk patients. However, anatomical constrains, high price, and lengthy manufacturing time restrict their use to elective patients in specialized centers. Off-the-shelf availab...
Article
Objective: The primary objective of this retrospective study was to analyze the early impact of chimney (CG) versus fenestrated grafts (FG) on renal parenchymal vascularization and function. Methods: All consecutive patients with juxta-renal abdominal aortic aneurysm (JR-AAA) treated by endovascular repair from December 2013 to July 2014 at the...
Article
Objective: To evaluate the impact of different types of hypertension on the development of intimal hyperplasia (IH). Method: Genetic, surgical, and pharmacological models of hypertension were used to compare IH formation in a murine model of carotid artery ligation (CAL). CAL was performed in normotensive WT male mice and in three mouse models o...
Article
Objectives The aim was to compare the antimicrobial efficacy of the silver impregnated collagen coated polyester vascular graft (IGS) with an identical graft combining silver and triclosan (IGSy). Methods This was an in vitro study. A non-antimicrobial collagen polyester vascular graft served as control (IG). The IG, IGS, and IGSy grafts were cont...
Article
Diagnosis of prosthetic vascular graft infection (PVGI) is a clinical challenge requiring accurate diagnostic methods for their optimal management. A 65-year-old patient with suspected PVGI was explored by 18F-FDG PET-CT (PET) for pre-treatment staging. Standard imaging was unrevealing but PET images showed multiple foci with increased uptake sugge...
Article
The primary end points of this study were safety and efficacy of early cannulation of the Flixene graft (Maquet-Atrium Medical, Hudson, NH). Secondary end points were complications and patency. This is a prospective single-center nonrandomized study. Study data included patient characteristics; history of vascular access; operative technique; inter...
Article
Compare outcomes of early (<15 days) versus delayed carotid endarterectomy in symptomatic patients. All CEA procedures performed for symptomatic carotid stenosis between January 2006 and May 2010 were retrospectively reviewed. Postoperative mortality (within 30 days), stroke, and Myocardial Infarction (MI) rates were analysed in the early and delay...
Article
Diagnosis of prosthetic vascular graft infection (PVGI) is a clinical challenge requiring accurate diagnostic methods for their optimal management. A 65-year-old patient with suspected PVGI was explored by fluorodeoxyglucose positron emission tomography combined with computed tomography ((18)F-FDG PET-CT) for pretreatment staging. Standard imaging...
Article
Peripheral arterial disease (PAD) usually presents with claudication or critical limb ischemia (CLI), burdened by high morbi-mortality. One-third of CLI patients have isolated infra-popliteal disease and need below the knee (BTK) interventions. 42% are diabetic and 50% will benefit from a revascularization procedure during their lives with major am...
Article
Peripheral arterial disease has become more and more present in daily practice, mostly due to the increase of cardiovascular risk factors, especially in below the knee (BTK) area in diabetic patients. Critical limb ischemia (CLI) is the most usual clinical presentation with a major amputation rate of 30%, mortality rate of 25%, and chronic pain of...
Article
Diagnosis of prosthetic vascular graft infections (PVGI) is a clinical challenge and surgical therapy is associated with comorbidity. Therefore accurate diagnostic methods are required for their optimal management.ReportA 61-year-old-patient presented with erisypelas of the right lower limb 7 months after receiving a hybrid femoro-popliteal bypass...
Article
The mainstay of contemporary therapies for extensive occlusive arterial disease is venous bypass graft. However, its durability is threatened by intimal hyperplasia (IH) that eventually leads to vessel occlusion and graft failure. Mechanical forces, particularly low shear stress and high wall tension, are thought to initiate and to sustain these ce...
Article
Owing to the lower risk of stroke in patients receiving an adapted medical treatment, the indications of carotid surgery have been recently reviewed. It is recommended to consider surgery for symptomatic carotid stenosis ≥ 50 % and ≥ 70 % asymptomatic stenosis. To reduce the risk of recurrence, symptomatic patients should be scheduled for surgery w...
Article
In arterial replacement there is a clear clinical need for a functional substitute possessing appropriate haemocompatible properties to be implanted as small diameter artery. Endothelial cell seeding constitutes an appreciated method to improve blood compatibility on the condition that cells firmly adhere to the support. Along this way, an innovati...
Article
New data suggest that arteriovenous fistulas compared with prosthetic grafts may not be a superior predialysis approach to vascular access for haemodialysis in patients aged ≥80 years. However, the use of catheters as the first vascular access was associated with significantly increased mortality in these patients and should be avoided.
Article
Background: Human saphenous vein grafts are one of the salvage bypass conduits when endovascular procedures are not feasible or fail. Understanding the remodeling process that venous grafts undergo during exposure to arterial conditions is crucial to improve their patency, which is often compromised by intimal hyperplasia. The precise role of hemo...
Article
Objectives A straightforward original Chimney Graft (CG) protocol has been developed at our institution in selected cases of juxta-renal aortic aneurysm (JRAA). To present our clinical experience of consecutive series with use of uncovered self-expanding stent (SES) as “Open Chimney” (OCh) in the endovascular repair (EVAR) of JRAA. Methods A stand...
Article
The purpose of this study was to assess short- and mid-term results of in-situ revascularisation (ISR) using silver-coated Dacron prostheses and bowel repair for management of secondary aorto-enteric fistulae (SAEF). Single-centre retrospective chart review. This study includes all the patients treated by ISR using silver-coated Dacron for SAEF bet...
Article
A mycotic pseudoaneurysm of the popliteal artery is usually a consequence of septic embolization and often a result of bacterial endocarditis. Conventional treatment is surgical and avoids the placement of foreign material in infected sites. Here we report our treatment of a 59-year-old man who presented with a rupture of a mycotic pseudoaneurysm o...
Article
The study aims to assess the feasibility and midterm outcome of trans-peritoneal laparoscopy for coeliac artery compression syndrome (CACS). Retrospective chart review involving four European vascular surgery departments and two surgical teams. charts for patients who underwent laparoscopy for symptomatic CACS between December 2003 and November 200...
Article
To analyse perioperative and midterm outcomes of carotid artery stenting (CAS) for symptomatic >50% and asymptomatic >70% restenosis after open carotid surgery (OCS). A multicentric retrospective study. Outcome measures 30-day death, neurologic and anatomic (thrombosis, restenosis) events. Univariant and multivariant logistic regression analyses we...
Article
Nous décrivons deux cas d’anévrysmes vrais de l’artère pédieuse chez des hommes référés pour masse pulsatile de la partie dorsale du pied. Les deux anévrysmes ont été réséqués avec interposition d’un segment court de veine saphène. L’analyse histologique a montré un anévrysme vrai lié à l’athérosclérose. À notre connaissance, seulement 12 cas de vé...
Article
We describe two cases of true dorsalis pedis artery aneurysms in men referred for pulsatile mass of the dorsal part of the foot. Both aneurysms were resected and grafted with interposition of a short segment of saphenous vein. Histological analysis showed true aneurysm associated with atherosclerosis. To our knowledge, only 12 cases of true dorsali...
Article
Vessel wall trauma induces vascular remodeling processes including the development of intimal hyperplasia (IH). To assess the development of IH in human veins, we have used an ex vivo vein support system (EVVSS) allowing the perfusion of freshly isolated segments of saphenous veins in the presence of a pulsatile flow which reproduced arterial condi...
Article
Extracranial carotid aneurysm is a rare vascular manifestation of Behçet disease. To our knowledge, only 32 cases have been reported. This article presents a complex case of a 28-year-old man who was first treated by vein graft reconstruction. At 12 months of follow-up, a nonanastomotic false aneurysm of the vein graft occurred and was treated by i...