Wu Jacky

• Central China Normal University

Achieving outstanding narrow‐band emission and improving the triplet exciton utilization efficiency is crucial for high organic light‐emitting diodes (OLEDs) electroluminescence (EL) efficiency. Herein, novel 1,3‐asymmetrical substituted pyrene‐based blue “hot exciton” materials with aggregation‐induced emission (AIE) characteristics are synthesize...

In recent years, photoimmunotherapy has emerged as an innovative modality in antitumor therapy, garnering significant research interest due to its integration of the advantages of both phototherapy and immunotherapy. However, despite extensive efforts to advance photoimmunotherapy, the design strategies for photoimmunotherapy agents remain uncertai...

Organic materials featuring third harmonic generation (THG) hold great promise for deep‐tissue bioimaging due to their good biocompatibility and second near‐infrared excitation. However, minimizing photodamage from the incident light necessitates significant improvements in the third‐order nonlinear susceptibility. Herein, an organic luminogen call...

Ionic aggregates are among the most common forms of matter, yet the investigation of their molecular motion is often constrained by the instability of isolated anions and cations, as well as the lack of real-time monitoring techniques. This study presents a zwitterionic strategy that integrates both cations and anions into one fluorescent organic f...

Polyamides are a fascinating group of piezoelectric materials that are largely synthesized by the polycondesation of dicarboxylic acids with diamines or the ring‐opening polymerization of special lactams. However, developing a green polymerization approach for the facile synthesis of piezoelectric polyamides is highly desirable but also challenging...

The properties of perovskite precursors critically determine the ultimate performance of perovskite devices, yet simple and accessible real‐time precursor characterization methods remain scarce. Here, we systematically investigate the lead (Pb) coordination environment in perovskite precursors using fluorescence spectroscopy. By examining lead hali...

Marching toward next‐generation ultrahigh‐definition and high‐resolution displays, the development of high‐performance blue organic light‐emitting diodes (OLEDs) with narrow emission and high luminance is essential and requires conceptual advancements in both molecular and device design. Herein, a blue organic emitter is reported that exhibits hot‐...

Bottlebrush polymers, characterized by densely grafted side chains along a central backbone, have gained significant interest due to their unique properties in bulk and solution states. Despite extensive research, a comprehensive understanding of the internal crowdedness within single polymer chains in dilute solutions remains challenging, and dire...

Conventional combinational antibacterial therapy requires the complicated assembly of multiple components that might cause a premature leak of therapeutic agents. Thus the one‐pot assembly of highly integrated multifunctional antibacterial agents is highly desirable for treating multidrug‐resistant (MDR) bacteria. Herein, the vancomycin‐derived car...

Polyamides are a fascinating group of piezoelectric materials that are largely synthesized by the polycondesation of dicarboxylic acids with diamines or the ring‐opening polymerization of special lactams. However, developing a green polymerization approach for the facile synthesis of piezoelectric polyamides is highly desirable but also challenging...

The properties of perovskite precursors critically determine the ultimate performance of perovskite devices, yet simple and accessible real‐time precursor characterization methods remain scarce. Here, we systematically investigate the lead (Pb) coordination environment in perovskite precursors using fluorescence spectroscopy. By examining lead hali...

Bottlebrush polymers, characterized by densely grafted side chains along a central backbone, have gained significant interest due to their unique properties in bulk and solution states. However, a comprehensive understanding of the internal crowdedness within single polymer chains in dilute solutions remains challenging, and direct evidence to visu...

Photo‐immunotherapy is one of the most promising cancer treatment strategies. As immunotherapeutic agents, immune checkpoint blockade antibodies against programmed cell death protein 1 (PD‐1) or programmed cell death ligand 1 (PD‐L1) exhibit substantial potential, but have to face non‐specific distribution and the subsequent immune‐related adverse...

Organic dyes with photoluminescence in the second near‐infrared window (NIR‐II, 1000–1700 nm) are promising for bioimaging and optoelectronic devices. Photoluminescence quantum yield (PLQY) is a direct measure of their performance. Integrating sphere technology is effective in determining the absolute PLQY. However, the low PLQY values of most NIR‐...

Photodynamic immunotherapy presents a non‐invasive strategy characterized by spatiotemporal control and minimal side effects to induce immunogenic cell death (ICD). This approach significantly enhances the release of tumor‐associated antigens and damage‐associated molecular patterns, thereby improving cancer immunotherapy outcomes. However, hypoxia...

Control of the dissymmetry of circularly polarized luminescence (CPL) is intriguing and has great potential for applications in the field of optics. The traditional control strategy involves using the opposite enantiomers to achieve reversal of CPL signs. However, regulating CPL reversal by controlling only the transition dipole moments without cha...

Efficient photosensitizers are crucial for the success of photodynamic therapy (PDT). Herein, we reported two [3+2+1] coordinated organometallic Iridium (III) complexes (labeled as Ir‐C1 and Ir‐C4). Ir‐C1/C4 can generate both type I and type II reactive oxygen species (ROS). In vitro experiments, Ir‐C1/C4 show low biotoxicity and high phototoxicity...

Photosensitizers (PSs) featuring type I reactive oxygen species (ROS) generation and aggregation‐induced emission (AIE) activity offer a promising solution to achieve non‐invasive and precise theranostics. However, the reported AIE luminogens (AIEgens) with both AIE characteristic and strong type‐I ROS generation are still scarce and the structure‐...

Fe–N–C materials are emerging catalysts for replacing precious platinum in the oxygen reduction reaction (ORR) for renewable energy conversion. However, their potential is hindered by sluggish ORR kinetics, leading to a high overpotential and impeding efficient energy conversion. Using iron phthalocyanine (FePc) as a model catalyst, we elucidate ho...

Aggregation-induced emission (AIE) luminogens, exemplified by tetraphenylethylene (TPE), exhibit enhanced fluorescence in aggregated states and have promising applications in display, photodetectors, fluorescent probes, bioimaging, and biomedicine. This study investigates the influence of varying degrees of deuteration on the photophysical properti...

The design and fabrication of organic X-ray imaging scintillators with large Stokes shift, narrow-band, fast, and efficient radioluminescence becomes an attractive research direction in many fields, such as medical diagnostics, scientific instruments and high-energy physics. However, the trade-off between these diverse scintillation properties is a...

The discovery of tertiary lymphoid structures (TLS) within tumor tissues provides a promising avenue to promote the efficacy of cancer immunotherapy. Yet, the lack of effective strategies to induce TLS formation poses a substantial obstacle. Thus, the exploration of potential inducers for TLS formation is of great interest but remains challenging....

Donor‐acceptor (D‐A) compounds are particularly important in optoelectronic and biological applications. However, they are normally synthesized in the presence of transition metal catalysts. Herein, we report a metal‐free method by a complex‐mediated nucleophilic aromatic substitution of aryl nitriles with amines. The method can lead to rich D‐A ty...

Photodynamic therapy (PDT) is a promising cancer treatment that uses photosensitizers (PSs) to generate cytotoxic reactive oxygen species (ROS) under light, but improving its efficacy is crucial for clinical applications. To address this, we propose a smart nanoplatform (P@BAO-DOX) for synergistic chemo-photodynamic therapy, featuring efficient PDT...

Limited by the energy gap law, purely organic materials with efficient near‐infrared room temperature phosphorescence are rare and difficult to achieve. Additionally, the exciton transition process among different emitting species in host–guest phosphorescent materials remains elusive, presenting a significant academic challenge. Herein, using a mo...

Vacuoles are unique organelles of fungi. The development of probes targeting the vacuoles membrane will enable visualization of physiological processes and precise diagnosis and therapy. Herein, a zwitterionic molecule, MXF-R, comprising of an aggregation-induced emission (AIE) photosensitizing unit and an antibiotic moxifloxacin, was found capable...

Polymers containing lactam structures play a crucial role in both natural biological systems and human life, and their synthesis, functions and applications are of utmost importance for biomimetics and the creation of new materials. In this study, we developed an efficient heterogeneous Pauson–Khand polymerization (h‐PKP) method for the controlled...

Clusteroluminescence (CL) materials without largely conjugated structures have gained significant attention due to their unique photophysical properties and potential in bioimaging. However, low luminescence efficiency and short emission wavelength limit their development. This work designs three luminogens with CL properties (CLgens) by introducin...

Clusteroluminescence (CL) materials without largely conjugated structures have gained significant attention due to their unique photophysical properties and potential in bioimaging. However, low luminescence efficiency and short emission wavelength limit their development. This work designs three luminogens with CL properties (CLgens) by introducin...

Host‐guest systems have emerged as an efficient strategy for promoting organic room temperature phosphorescence (RTP). Despite the advantages of doping guest molecules into a host matrix, the complexity of these systems and the lack of techniques to visualize host‐guest interactions at the molecular scale pose significant challenges in understandin...

Coinage bonds, a type of noncovalent interaction, occur between group 11 elements (Au, Ag, and Cu) with electron donor groups. Despite theoretical validation, empirical evidence remains limited. In this study, an aggregation‐induced emission (AIE)‐active Au(I) complex, ITCPAu, which exhibits Au···I coinage bonds, was revealed based on the single‐cr...

Electrochemical CO2 reduction reaction (CO2RR) offers a promising approach to close the carbon cycle and reduce reliance on fossil fuels. However, traditional decoupled CO2RR processes involve energy‐intensive CO2 capture, conversion, and product separation, which increases operational costs. Here, we report the development of a bismuth‐poly(ionic...

Circularly polarized luminescence (CPL) materials with delayed fluorescence have attracted much attention due to their ability to efficiently trap triplet state excitons, thereby improving the photoluminescence quantum yields of CPL materials. However, much effort has been normally focused on the utilization of T1 excitons but seldom on the utiliza...

Limited by the energy gap law, purely organic materials with efficient near‐infrared room temperature phosphorescence are rare and difficult to achieve. Additionally, the exciton transition process among different emitting species in host‐guest phosphorescent materials remains elusive, presenting a significant academic challenge. Herein, using a mo...

Despite the extensive reporting of versatile aggregation‐induced emission luminogens (AIEgens), boosting their molar extinction coefficient (MEC, ε ≈ 10³–10⁴ M⁻¹cm⁻¹) remains a formidable challenge, which poses a significant obstacle to achieving the ceiling of their output performance. In this work, an “aggrandizing absorption reservoir” approach...

Bacteria share a longstanding and complex relationship with humans, playing a role in protecting gut health and sustaining the ecosystem to cause infectious diseases and antibiotic resistance. Luminogenic materials that share aggregation‐induced emission (AIE) characteristics have emerged as a versatile toolbox for bacterial studies through fluores...

Polymers containing lactam structures play a crucial role in both natural biological systems and human life, and their synthesis, functions and applications are of utmost importance for biomimetics and the creation of new materials. In this study, we developed an efficient heterogeneous Pauson‐Khand polymerization (h‐PKP) method for the controlled...

The therapeutic efficacy of photosensitizers in photodynamic therapy (PDT) largely depends on the reactive oxygen species production, types, and tissue penetration depth. Particularly in malignant tumors, hypoxia is widely recognized as a major obstacle for PDT. Herein, a two‐photon‐excitable heavy‐atom free photosensitizer PNF is designed. PNF can...

A stimuli‐responsive multiple chirality switching material, which can regulate opposed chiral absorption characteristics, has great application value in the fields of optical modulation, information storage and encryption, etc. However, due to the rareness of effective functional systems and the complexity of material structures, developing this ty...

The emergence of aggregation-induced emission (AIE) phenomenon two decades ago marked a significant advancement in chemical science. It has fostered the development of versatile AIE luminogens (AIEgens) applicable in bioimaging, optoelectronics, and biochemical sensing. However, the application potential of synthetic AIEgens is limited owing to the...

Small organic photothermal agents (PTAs) with absorption bands located in the second near‐infrared (NIR‐II, 1000–1700 nm) window are highly desirable for effectively combating deep‐seated tumors. However, the rarely reported NIR‐II absorbing PTAs still suffer from a low molar extinction coefficient (MEC, ϵ), inadequate chemostability and photostabi...

Seeking new methods to realize multiple fluorescence changes in a single luminogenic system is of great im-portance for both chemistry and bionics research. However, due to the lack of proper strategies and functional motifs, novel chameleon luminogens with multiple switching and controllable models is still scarce. Herein, we reported a chromone-b...

The development of luminescent materials via mechanochemistry embodies a compelling yet intricate frontier within materials science. Herein, we delineate a methodology for the synthesis of brightly luminescent polymers, achieved by the mechanochemical coupling of aggregation-induced emission (AIE) prefluorophores with generic polymers. An array of...

A stimuli‐responsive multiple chirality switching material, which can regulate opposed chiral absorption characteristics, has great application value in the fields of optical modulation, information storage and encryption, etc. However, due to the rareness of effective functional systems and the complexity of material structures, developing this ty...

Fluorescent imaging and biosensing in the near‐infrared‐II (NIR‐II) window holds great promise for non‐invasive, radiation‐free, and rapid‐response clinical diagnosis. However, it's still challenging to develop bright NIR‐II fluorophores. In this study, we report a new strategy to enhance the brightness of NIR‐II aggregation‐induced emission (AIE)...

Small organic photothermal reagents (PTAs) with absorption bands located in the second near‐infrared (NIR‐II, 1000‐1700 nm) window are highly desirable for effectively combating deep‐seated tumors. However, the rarely reported NIR‐II absorbing PTAs still suffer from a low molar extinction coefficient (MEC, ε), inadequate chemostability and photosta...

Polymeric materials with antibacterial properties hold great promise for combating multidrug‐resistant bacteria, which pose a significant threat to public health. However, the synthesis of most antibacterial polymers typically involves complicated and time‐consuming procedures. In this study, we demonstrate a simple and efficient strategy for synth...

Aggregation is a conventional method to enhance the quantum yields (QYs) of pure organic luminophores due to the restriction of intramolecular motions (RIM). However, how to realize RIM in metal–organic frameworks (MOFs) is still unclear and challenging. In this work, the ligand meta‐anchoring strategy is first proposed and proved to be an effectiv...

Lung cancer, a highly prevalent and lethal form of cancer, is often associated with oxidative stress. Photodynamic therapy (PDT) has emerged as a promising alternative therapeutic tool in cancer treatments, but its efficacy is closely correlated to the photosensitizers generating reactive oxygen species (ROS) and the antioxidant capacity of tumor c...

The diminishing effectiveness of existing aminoglycoside antibiotics (AGs) compels scientists to seek new approaches to enhance the sensitivity of current AGs. Despite ongoing efforts, currently available approaches remain restricted. Herein, a novel strategy involving the rational construction of an aggregation‐induced‐emission luminogen (AIEgen)...

Recent advances in the design of AIE platinum complexes: structural regulation strategies, mechanisms, and applications.

Fluorescent imaging and biosensing in the near‐infrared‐II (NIR‐II) window holds great promise for non‐invasive, radiation‐free, and rapid‐response clinical diagnosis. However, it’s still challenging to develop bright NIR‐II fluorophores. In this study, we report a new strategy to enhance the brightness of NIR‐II aggregation‐induced emission (AIE)...

Visible light‐based human–machine interactive media is capable of transmitting electrical readouts to machines and providing intuitive feedback to users simultaneously. Currently, many inorganic mechanoluminescent (ML) materials‐based interactive media, typically ZnS‐loaded phosphors (ZLPs), have been successfully demonstrated. However, organic ML...

Photosensitizers (PSs) with aggregation‐induced emission (AIE) characteristics are competitive candidates for bioimaging and therapeutic applications. However, their short emission wavelength and nonspecific organelle targeting hinder their therapeutic effectiveness. Herein, a donor–acceptor modulation approach is reported to construct a series of...

Polymeric materials with antibacterial properties hold great promise for combating multidrug‐resistant bacteria, which pose a significant threat to public health. However, the synthesis of most antibacterial polymers typically involves complicated and time‐consuming procedures. In this study, we demonstrate a simple and efficient strategy for synth...

Aggregation is a conventional method to enhance the quantum yields (QYs) of pure organic luminophores due to the restriction of intramolecular motions (RIM). However, how to realize RIM in metal‐organic frameworks (MOFs) is still unclear and challenging. In this work, the ligand meta‐anchoring strategy is first proposed and proved to be an effectiv...

Ultrahigh dose-rate (FLASH) radiotherapy is an emerging technology with excellent therapeutic effects and low biological toxicity. However, tumor recurrence largely impede the effectiveness of FLASH therapy. Overcoming tumor recurrence is crucial for practical FLASH applications. Here, we prepared an agarose-based thermosensitive hydrogel containin...

A derivative of tetraphenylpyrazine shows strong, narrow and stable deep-blue emission in the aggregate state. It can be further fabricated into aggregation-induced emission microfiber to remotely light-up the colorful emission by waveguiding excitation, which is favor in the exploration of substance in the microscopic world.

Schiff bases are a crucial component in various functional materials but often exhibit non‐emissive behavior which significantly limits their potential applications as luminescent materials. However, traditional approaches to convert them into aggregate emitters often require intricate molecular design, tedious synthesis, and significant time and r...

Schiff bases are a crucial component in various functional materials but often exhibit non‐emissive behavior which significantly limits their potential applications as luminescent materials. However, traditional approaches to convert them into aggregate emitters often require intricate molecular design, tedious synthesis, and significant time and r...

Currently used drugs for glioblastoma (GBM) treatments are ineffective, primarily due to the significant challenges posed by strong drug resistance, poor blood-brain barrier (BBB) permeability, and the lack of tumor specificity. Here, we report two cationic fluorescent anticancer agents (TriPEX-ClO4 and TriPEX-PF6) capable of BBB penetration for ef...

Achieving efficient near‐infrared room‐temperature phosphorescence of purely organic phosphors remains scarce and challenging due to strong nonradiative decay. Additionally, the investigation of triplet excimer phosphorescence is rarely reported, despite the fact that excimer, a special emitter commonly formed in crystals with strong π–π interactio...

Stimuli‐responsive molecules with dynamic covalent bonds show physicochemical changes in response to external stimuli but also exhibit active molecular motions and poor luminescent properties. Hence, the manipulation and balance of dynamic and static behaviors are crucial for the development of multifunctional materials. In this work, a series of h...

Based on an excellent deep-blue aggregation-induced emission (AIE) dye of TPP-4OMe, the AIE microfibers can be readily fabricated which show an active waveguide with a very low optical loss coefficient as well as a rare full-visible broadband passive waveguide. Moreover, the deep-blue AIE microfibers can act as a wave-guiding excitation source to r...

We report the engineering of aggregation‐induced emission luminogens (AIEgen) based covalent organic frameworks (COFs), TDTA‐COF, BTDTA‐COF, and BTDBETA‐COF, as hyperthermia agents for inhibiting the occurrence of malignant ventricular arrhythmias (VAs). These AIE COFs exhibit dual functionality, as they not only directly modulate the function and...

Organic photosensitizers (PSs) with aggregation‐induced emission (AIE) characteristics have shown several advantages in photodynamic therapy (PDT). However, how to design PSs with the required optical and biological properties is a formidable challenge. In this work, a series of AIE active pyridine‐ and pyridinium‐functionalized carbazole with diff...

The development of high‐performance organic blue light‐emitting emitters is in urgent to act as an excitation source to contribute the white light generation. On the other hand, the investigation on optical waveguides have been received increasing attentions because they can manipulate the light propagation accurately in the microscale to boost the...