Woojae Myung

Woojae Myung
Seoul National University Bundang Hospital | snuh · Department of Neuropsychiatry

M.D. Ph.D. M.S. in statistics

About

137
Publications
13,679
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,650
Citations
Citations since 2016
91 Research Items
1550 Citations
20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
Introduction
My primary interest is to investigate the etiology of neuropsychiatric diseases using data-driven methods of genetic data, observational data, public data, or social media data.
Additional affiliations
March 2018 - present
Seoul National University Bundang Hospital, Seoul National University
Position
  • Professor (Assistant)
March 2017 - February 2018
CHA Bundang Medical Center, CHA University
Position
  • Professor (Assistant)
May 2015 - February 2017
Samsung Medical Center
Position
  • Fellow
Education
March 2015 - August 2017
Sungkyunkwan University
Field of study
  • Neuropsychiatry
March 2012 - August 2014
Korea National Open University
Field of study
  • Statistics & Bioinformatics
March 2001 - February 2007
Sungkyunkwan University
Field of study
  • Medicine

Publications

Publications (137)
Article
Objective: Mood disorder and borderline personality pathology (BPP) are frequently comorbid and relate to childhood trauma. We investigated the relationship between childhood trauma and BPP features in mood disorder patients versus controls. Methods: A total of 488 mood disorder patients, particularly major depressive disorder (MDD), bipolar I d...
Article
Background Childhood trauma has lasting negative impacts on individuals' psychological functioning. However, there is limited empirical evidence on the association between childhood trauma and resilience and none examining such relationship among diverse clinical populations. This study aimed to investigate the relationship in patients with major d...
Preprint
BACKGROUND Maternal-fetal attachment (MFA) has been reported to be associated with postpartum mother-to-infant relationship. Seeing the fetus through ultrasound might influence MFA and the effect could be increased by more realistic images, for example, generated by virtual reality (VR). OBJECTIVE The aim was to determine the effect of prenatal co...
Article
Full-text available
Objective: The Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A) has been validated in more than 30 languages and is noted for its broad application in research and clinical settings. This study presents the first attempt to examine the reliability and validity of the TEMPS-A in Korea. Methods: A total of...
Article
Full-text available
Background Although transcranial direct current stimulation (tDCS) is known to be a promising therapeutic modality for unipolar depression, the efficacy and safety of tDCS for bipolar depressive episodes (BD) are still unknown and clinical trials of home-based tDCS treatment are scarce. As a result, we set out to investigate the efficacy and safety...
Preprint
Creativity is heritable and exhibits familial aggregation with psychiatric disorders, but its genomic basis and genetic relationship with psychiatric disorders remain largely unknown. Here, we conducted a genome-wide association study (GWAS) using an expanded, machine learning-based definition of creativity in individuals of European ancestry from...
Article
Full-text available
Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci...
Article
Full-text available
Background The psychiatric treatment gap is substantial in Korea, implying barriers in seeking help. Objectives This study aims to explore barriers of seeing psychiatrists, expressed on the internet by age groups. Methods A corpus of data was garnered extensively from internet communities, blogs and social network services from 1 January 2016 to...
Article
Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As existing genome-wide association studies (GWAS) have been conducted predominantly in individuals of European descent, the limited transferability of PRS reduces their clinical value in non-European populations, and may exacerbate healthcare disparities. Recent e...
Article
Full-text available
It is widely known that exposure to residential greenness is beneficial for health. However, few studies have analyzed the association between greenery and Parkinson’s disease (PD). We selected 313,355 participants who matched the inclusion criteria from the National Health Insurance Service-National Sample Cohort, followed up from 2007 to 2015. Re...
Article
Full-text available
Psychosis can include schizophrenia, mood disorders with psychotic features, delusional disorder, active delirium, and neurodegenerative disorders accompanied by various psychotic symptoms. Late-onset psychosis requires careful intervention due to the greater associated risks of secondary psychosis; higher morbidity and mortality rates than early-o...
Article
There has been increasing interest in the neurological impact of particulate matter (PM). However, its association with the incidence of Parkinson's disease (PD) remains unclear. We selected 313,355 participants satisfying inclusion criteria from the National Health Insurance Service-National Sample Cohort based on the nationwide population of Sout...
Article
Although dust storms have been associated with adverse health outcomes, studies on the burden of dust storms on deaths are limited. As global warming has induced significant climate changes in recent decades, which have accelerated desertification worldwide, it is necessary to evaluate the burden of dust storm-induced premature mortality using a cr...
Preprint
Full-text available
Objectives: We applied Mendelian randomization (MR) to investigate the causal associations of body mass index (BMI) and waist circumference (WC) with 19 gastrointestinal (GI) disorders. Design: MR study. Setting: The UK Biobank, Genetic Investigation of Anthropometric Traits (GIANT) Consortium, FinnGen consortium, and genome-wide association studie...
Article
There is a growing concern that air pollution exacerbates mental disorders. However, studies assessing the relationship between short-term exposure to ambient air pollution and acute exacerbation of psychotic symptoms in psychiatric disorders are limited. This study aims to examine the association between short-term air pollution exposure and acute...
Article
Occupational attainment, which represents middle-age cognitive activities, is a known proxy marker of cognitive reserve for Alzheimer's disease. Previous genome-wide association studies have identified numerous genetic variants and revealed the genetic architecture of educational attainment, another marker of cognitive reserve. However, the genetic...
Article
Full-text available
Background and objectives: Mood instability (MI) is a stable trait associated with psychiatric disorders, yet there is a lack of tools to measure MI. The purpose of this study was to develop and validate the Mood Instability Questionnaire-Trait (MIQ-T) to evaluate MI in mood disorder patients. Material and methods: Items were taken from various est...
Article
Full-text available
Background and objectives: Parkinson’s disease (PD) and schizophrenia often share symptomatology. Psychotic symptoms are prevalent in patients with PD, and similar motor symptoms with extrapyramidal signs are frequently observed in antipsychotic-naïve patients with schizophrenia as well as premorbid families. However, few studies have examined the...
Article
Objective To prevent copycat suicides following media reporting of celebrity suicides, the South Korean government enacted a ‘suicide prevention law’ in 2012 and revised the media guidelines for suicide reporting in 2013. This study examined how these two regulatory measures affected suicide trends among the general population in South Korea. Meth...
Preprint
Full-text available
The International Classification of Diseases (ICD) codes represent the global standard for reporting disease conditions. The current ICD codes are hierarchically structured and only connote partial relationships among diseases. Therefore, it is important to represent the ICD codes as mathematical vectors to indicate the complex relationships across...
Article
Full-text available
Background Dementia is a progressive neurocognitive disease with a substantial social burden. No apparent breakthroughs in treatment options have emerged so far; thus, disease prevention is essential for at-risk populations. Depression and cerebrovascular disease (CVD) are independent risk factors for dementia, but no studies have examined their in...
Article
Full-text available
Achieving remission following initial antidepressant therapy in patients with major depressive disorder (MDD) is an important clinical result. Making predictions based on genetic markers holds promise for improving the remission rate. However, genetic variants found in previous genetic studies do not provide robust evidence to aid pharmacogenetic d...
Article
Background: Whether the epidemiological association of amyloid-β (Aβ) and tau pathology in late-onset Alzheimer's disease (LOAD) is causal remains unclear. Objective: We aimed to investigate the shared genetic background between the cerebrospinal fluid (CSF) biomarkers for Aβ and tau pathology and the risk of LOAD. Methods: We conducted a two-...
Article
Background: While atypical antipsychotic medications are widely used for treating depressive disorders, their long-term effects on the risk of subsequent dementia have not been studied adequately. Objective: To investigate whether the risk of dementia differs according to the use of atypical antipsychotic drugs, and compare the effects of antips...
Article
Full-text available
Aims It has been well known that air pollution and sleep deprivation individually have impacts on human health; however, the association between the two has not been well researched. The aim of this study was to investigate this relationship at a community level. Methods We collected sleep outcomes from the Korean Community Health Survey between y...
Article
Although injury is a leading cause of death worldwide, the association between ambient temperature and injury has received little research attention compared to the association of temperature with mortality and morbidity from non-external causes. With current climate change and increases in weather extremes, assessing the association between temper...
Preprint
Occupational attainment is a known proxy marker of cognitive reserve for neurodegenerative diseases. However, its genetic architecture remains unclear. Here, we report a genome-wide association study of occupational attainment, involving 310,527 European individuals from the UK Biobank. We identified 32 significant loci; 12 were novel variants, una...
Article
Full-text available
Background Panic disorder is a common anxiety disorder affecting up to 5% of the population. Although its pathogenesis is unclear, evidence about its association with ambient temperature is limited. We aimed to investigate the association between short‐term exposure to increased ambient temperature and exacerbation of panic attacks requiring emerge...
Article
Full-text available
Background: The clinical guidelines related to the primary prevention of Alzheimer's disease (AD) have focused on the management of vascular risk factors. However, the link between vascular risk factors and AD in older adults remains unclear. This study aimed to determine the association between vascular risk factors and subsequent AD in 178,586 o...
Article
Background: Population-based studies on the mortality burden of nontuberculous mycobacteria (NTM) infection are lacking. We compared the long-term mortality of NTM-infected patients with tuberculosis (TB)-patients and the general-population, and investigated mortality-associated factors. Methods: We analyzed nationwide-data from the Korean Natio...
Article
Full-text available
Increased serum uric acid (SUA) levels cause gout and are associated with multiple diseases, including chronic kidney disease. Previous genome-wide association studies (GWAS) have identified more than 180 loci that contribute to SUA levels. Here, we investigated genetic determinants of SUA level in the Korean population. We conducted a GWAS for SUA...
Preprint
Full-text available
Background: Dementia is a progressive neurocognitive disease with a substantial social burden. No apparent breakthroughs in treatment options have evolved so far, suggesting that disease prevention for at-risk populations is essential. Depression and cerebrovascular disease (CVD) are known independent risk factors for dementia, but no studies have...
Preprint
Full-text available
Background: Dementia is a progressive neurocognitive disease with a substantial social burden. No apparent breakthroughs in treatment options have emerged so far; thus, disease prevention is essential for at-risk populations. Depression and cerebrovascular disease (CVD) are independent risk factors for dementia, but no studies have examined their i...
Preprint
Full-text available
Background: Dementia is a progressive neurocognitive disease with a substantial social burden. No apparent breakthroughs in treatment options have emerged so far; thus, disease prevention is essential for at-risk populations. Depression and cerebrovascular disease (CVD) are independent risk factors for dementia, but no studies have examined their i...
Article
Full-text available
Background: Subjective cognitive decline (SCD) is a potential risk factor for dementia. We aimed to investigate the association between SCD and subsequent dementia in a nationwide population-based cohort in South Korea. Methods: This cohort included 579,710 66-year-old adults who were followed for a total of 3,870,293 person-years (average 6.68...
Preprint
Background: The clinical guidelines related to the primary prevention of Alzheimer’s disease (AD) have focused on the management of vascular risk factors. However, the link between vascular risk factors and AD in older adults remains unclear. This study aimed to determine the association between vascular risk factors and subsequent AD in 178,586 ol...
Preprint
Full-text available
Background: The clinical guidelines related to the primary prevention of Alzheimer’s disease (AD) have focused on the management of vascular risk factors. However, the link between vascular risk factors and AD in older adults remains unclear. This study aimed to determine the association between vascular risk factors and subsequent AD in 178,586 ol...
Preprint
Full-text available
Background: Whether the epidemiological association of amyloid beta (Aβ) and tau pathology with Alzheimer’s disease (AD) is causal remains unclear. Recent failures to demonstrate the efficacy of several Aβ-modifying drugs may indicate a possibility that the observed association is not causal, which led to efforts to develop tau-directed treatments...
Article
Full-text available
Purpose: Thepurposeofthisstudywastoinvestigatewhethertheriskofschizophrenia iscausallyassociatedwiththeriskofbreastcancer. Methods: Bidirectionaltwo-sampleMendelianrandomization(TSMR)wasperformed usinggenome-wideassociationstudysummarydatafromatotalof311,266individu-als.Thecausalrelationshipwasestimatedusinganinverse-varianceweightedmethod (IVW).Fo...
Article
Although multiple sclerosis (MS) has been the leading cause of neurologically-induced disability in young adults, risk factors for the relapse and acute aggravation of MS remain unclear. A few studies have suggested a possible role of temperature changes on the relapse and acute aggravation of MS. We investigated the association between short-term...
Article
Full-text available
Background: Asian dust storms (ADSs) have been associated with adverse health outcomes, including respiratory and cardiovascular diseases. Considering the increasing global desertification driven by climate change, it is necessary to assess dust storm-related adverse health effects for establishing appropriate public health interventions. Recent s...
Preprint
Full-text available
Background: Subjective cognitive decline (SCD) is a potential risk factor for dementia. We aimed to investigate the association between SCD and subsequent dementia in a nationwide population-based cohort in South Korea. Methods: This cohort included 579,710 66-year-old adults who completed a questionnaire about SCD and were followed-up for a total...
Preprint
Full-text available
Background Subjective cognitive decline (SCD) is a potential risk factor for dementia. We aimed to investigate the association between SCD and subsequent dementia in a nationwide population-based cohort in South Korea. Methods This cohort included 579,710 66-year-old adults who were followed for a total of 3,870,293 person-years (average 6.68±1.33...
Article
Full-text available
Objective: Alcohol use disorder (AUD) is one of the most frequent comorbid conditions in mood disorders. We aimed to examine the relationships between clinical phenotypes of acutely depressed subjects and co-occurring AUD. Methods: Clinical assessment including diagnosis of mood disorder and co-occurring AUD, the severity of depressive or manic...
Article
Full-text available
Differentiating between inherited renal hypouricemia and transient hypouricemic status is challenging. Here, we aimed to describe the genetic background of hypouricemia patients using whole-exome sequencing (WES) and assess the feasibility for genetic diagnosis using two founder variants in primary screening. We selected all cases (N = 31) with ext...
Article
Objectives To investigate the association between zolpidem prescription and suicide attempts in people with depression Method A nationwide, population-based electronic medical records database from the Health Insurance Review & Assessment service of South was used to investigate the incidence rate ratios (IRRs) of suicide attempts and probable sui...
Data
Increasing temporal trend of diurnal temperature range as well as ambient temperature during 1970-2015, Seoul, South Korea.
Article
Full-text available
Whether the epidemiological association of amyloid beta (Aβ) and tau pathology with Alzheimer's disease (AD) is causal remains unclear. The recent failures to demonstrate the efficacy of several amyloid beta-modifying drugs may indicate the possibility that the observed association is not causal. These failures also led to efforts to develop tau-di...
Article
Full-text available
Neuroimaging research increasingly suggests there are biological features related to suicidal risk, including brain morphometric features, leading to an elaborate suicide risk assessment. However, few studies have focused on the severity of suicidal ideation and its association with subcortical anatomy in patients with major depressive disorder (MD...
Article
Full-text available
Objective: Suicide is the leading cause of death in 10-39-year-olds in South Korea, and the second highest rate among the OECD countries. However, few studies have investigated the particularity of completed suicide in South Korea. Methods: Study subjects consisted of 2,838 suicide cases and 56,758 age and sex matched living controls from a nati...
Article
Epidemiologic studies regarding the relationship between short-term exposure to particulate matter with a median aerodynamic diameter < 2.5 µm (PM2.5) and mental disease are limited. This study examined the effects of short-term exposure to PM2.5 on emergency admissions to the hospital for mental disease in Seoul, Korea. Data regarding 80,634 emerg...
Article
Background: Psychological distress symptoms are associated with an increased risk of psychiatric disorders and medical illness. Although psychological distress is influenced by environmental factors, such as socioeconomic status, lifetime events, or interpersonal relationships, substantial interindividual variation also exists. However, heritabili...
Article
Full-text available
The prevalence and incidence of nontuberculous mycobac-terial (NTM) infections increased in South Korea from 2007 to 2016. Annual prevalence of NTM infection increased to 39.6 cases/100,000 population in 2016 and annual incidence to 19.0 cases/100,000 population. Overall prevalence for the study period was higher in the elderly, in females , and in...
Article
There is a growing concern that air pollution, especially those particles <2.5 μm (PM2.5), could increase the risk of cognitive impairment and mental disorders. However, the relationship between ambient PM2.5 and neuropsychiatric symptoms in people with cognitive impairment is still undetermined. This longitudinal study included 645 pairs of cognit...
Article
Background: Amyotrophic lateral sclerosis (ALS) is a progressive and devastating neurodegenerative disease, eventually leading to respiratory failure. Although the only currently available therapeutic interventions merely slow the disease progression, few studies have examined risk factors associated with ALS exacerbation and progression. Objecti...