Woo Jae Kim

Woo Jae Kim
University of Ottawa · Department of Cellular and Molecular Medicine

PhD

About

21
Publications
1,720
Reads
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519
Citations
Additional affiliations
August 2008 - present
Howard Hughes Medical Institute
Position
  • PostDoc Position
Description
  • UCSF
March 2000 - February 2008
Pohang University of Science and Technology
Position
  • PhD Student

Publications

Publications (21)
Article
A primary function of males for many species involves mating with females for reproduction. Drosophila melanogaster males respond to the presence of other males by prolonging mating duration to increase the chance of passing on their genes. To understand the basis of such complex behaviors, we examine the genetic network and neural circuits that re...
Article
Full-text available
Rival exposure causes Drosophila melanogaster males to prolong mating. Longer mating duration (LMD) may enhance reproductive success, but its underlying mechanism is currently unknown. We found that LMD is context dependent and can be induced solely via visual stimuli. In addition, we found that LMD involves neural circuits that are important for v...
Article
Full-text available
The signaling lipid molecule 15-deoxy-delta 12,14-prostaglandin J2 (15d-PGJ2) has multiple cellular functions, including anti-inflammatory and antineoplastic activities. Here, we report that 15d-PGJ2 blocks translation through inactivation of translational initiation factor eIF4A. Binding of 15d-PGJ2 to eIF4A blocks the interaction between eIF4A an...
Article
Full-text available
The unfolded protein response (UPR) triggered by endoplasmic reticulum (ER) stress is a feature of many neurodegenerative diseases including Alzheimer’s disease, Huntington’s disease and Parkinson’s disease (PD). Although the vast majority of PD is sporadic, mutations in a number of genes including PARK7 which encodes the protein DJ-1 have been lin...
Article
Full-text available
15-deoxy-delta 12,14-prostaglandin J2 (15d-PGJ2) is anti-inflammatory/anti-neoplastic prostaglandin which functions through covalent binding to cysteine residues of various target proteins. We previously showed that 15d-PGJ2 mediated anti-inflammatory responses are dependent on the translational inhibition through its interaction with eIF4A. Bindin...
Preprint
Full-text available
15-deoxy-delta 12,14-prostaglandin J2 (15d-PGJ2) is anti-inflammatory/antineoplastic prostaglandin which functions through covalent binding to cysteine residues of various target proteins. We previously showed that 15d-PGJ2 mediated anti-inflammatory responses are dependent on the translational inhibition through its interaction with eIF4A. Binding...
Preprint
Full-text available
Males rely on a ‘time investment strategy’ to maximize reproductive success. Here we report a novel behavioral plasticity whereby male fruit flies exhibit a shortened mating duration when sexually satiated, which we named ‘Shorter-Mating-Duration (SMD)’. SMD requires the sexually dimorphic Gr5a-positive neurons for detecting female body pheromones....
Conference Paper
Full-text available
Environmental conditions, such as the socio-sexual context, can change rapidly. In these circumstances, the ability of animal of a genotype to express a different phenotype according to the environment can improve survival and reproductive success. A primary function of males for many species involves mating with females for reproduction. In this r...
Article
Full-text available
The repression of translation in environmentally stressed eukaryotic cells causes the sequestration of translation initiation factors and the 40S ribosomal subunit into discrete cytoplasmic foci called stress granules (SGs). Most components of the preinitiation complex, such as eIF3, eIF4A, eIF4E, eIF4G, and poly(A)-binding protein, congregate into...
Article
Full-text available
The cellular stress response (SR) is a phylogenetically conserved protection mechanism that involves inhibition of protein synthesis through recruitment of translation factors such as eIF4G into insoluble stress granules (SGs) and blockade of proinflammatory responses by interruption of the signaling pathway from tumor necrosis factor alpha (TNF-α)...
Article
Full-text available
The translation of polioviral mRNA occurs through an internal ribosomal entry site (IRES). Several RNA-binding proteins, such as polypyrimidine tract-binding protein (PTB) and poly(rC)-binding protein (PCBP), are required for the poliovirus IRES-dependent translation. Here we report that a poliovirus protein, 3Cpro (and/or 3CDpro), cleaves PTB isof...

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