Wonder Abotsi

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Verified

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• Doctor of Philosophy
• Lecturer at Kwame Nkrumah University of Science and Technology

Purpose Major depressive disorder is one of the most common and burdensome psychiatric disorders worldwide. This study evaluated the anxiolytic- and antidepressant-like activity of three semi-synthetic derivatives of xylopic acid (XA) to identify the most promising derivative based on mechanism(s) of action, in vivo pharmacokinetics and in vitro cy...

Introduction Depression affects an estimated 350 million people worldwide and is implicated in up to 60% of suicides. Only about 60–70% of patients respond to antidepressant therapy. One of the factors causing patients to not attain therapeutic goals is herb-drug interactions. Objective To investigate any potential herb-drug interaction that might...

Background Xylopic acid (XA), a kaurene diterpene from the dried fruits of Xylopia aethiopica, has anxiolytic- and antidepressant-like activity in mice and zebrafish. We aimed to assess the potential synergistic antidepressant-like effects of XA when combined with selected antidepressants in the mouse forced-swim test. Materials and methods The an...

Leea guineensis G. Don (Family: Leeaceae) is an evergreen shrub or small tree used in Ghanaian traditional medicine to treat various ailments including epileptic fits and pain. However, little scientific evidence exists to support its use. The present study examined the anti-nociceptive, anti-anxiety and anticonvulsant effects of the aqueous leaf e...

Ethnopharmacological relevance: The root extract of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) is traditionally used in the management of pain and fever. However, little scientific data exists in literature to support its use. Aim of study: The present study evaluated the anti-nociceptive and antipyretic properties of the hydroeth...

Eight monoterpene indole alkaloids (1-8), including one new picraline-type alkaloid, 2-hydroxyakuammiline (4) and seven known compounds: akuammigine (1), akuammine (2), akuammidine (3), akuammiline (5a), akuammiline N-oxide (5b), akuammiline (6), rhazimol (7), and alstonine (8) were isolated from the seeds of Picralima nitida. Structure elucidation...

Background: In Ghana, decoctions of various parts of Psydrax subcordata, Bridson (Rubiaceae) are employed in the management of inflammatory conditions. However, not much scientific data is available to back such folkloric use of the plant. This study, therefore, seeks to investigate the chronic anti-inflammatory activity of hydroethanolic root ext...

Psydrax subcordata (DC.) Bridson (Rubiaceae) is traditionally used to treat pain and inflammatory conditions in Ghana. There is, however, little scientific evidence to support its use in Ghanaian Traditional Medicine. This study, therefore, evaluated the antinociceptive and anti-inflammatory effects of hydroethanolic root extract of Psydrax subcord...

Xylopic acid (XA) is a kaurene diterpene which naturally exists in African plants such as Xylopia aethiopica. It has been established to exhibit acute and chronic anti-inflammatory activities from our earlier studies. This current work sets out to shed light on the potential molecular target(s) of xylopic acid. Selection of investigated targets (NF...

Background Ceiba pentandra (L.) Gaertn. (Malvaceae) is a plant documented folklorically to be used in the management of epilepsy but with no scientific evidence to support its efficacy. Aim The aim of this study was to evaluate the anticonvulsant properties of a hydroethanolic leaf extract of Ceiba pentandra (CPLE). Methods Mouse models of acute...

Introduction Pain is a major symptom of many clinical disorders and its relief has long been a concern for individuals across the globe. There is therefore an unmet need to search for new efficacious agents for the effective management of pain. The stem bark of the savanna tree Burkea africana (Hook) (Family: Leguminosae) is used in the Ghanaian tr...

Background Albizia zygia (DC.) J.F. Macbr. (Leguminosae) has been used to treat mental disorders in traditional African medicine. Nonetheless, there is limited scientific evidence to justify its present use. The aim of this study was to evaluate the antidepressant activity of the hydroethanolic extract of A. zygia roots (AZE) in murine models. Met...

Context. The stem bark of the savanna tree Burkea africana (Hook) (family: Leguminosae) is used in the Ghanaian traditional medicine for the management of various pain-related diseases. Objective: This study seeks to investigate the possible antiallodynic and antihyperalgesic effects of the hydroethanolic stem bark extract of B. africana in a vin...

Background The root extract of Albizia zygia (DC.) J.F. Macbr. (Leguminosae) is used to manage mental disorders in African traditional medicine. However, its value, particularly, against negative and cognitive symptoms of schizophrenia have not been evaluated. Aim The aim of this study was to evaluate the antipsychotic properties of the hydroeth...

Ethnopharmacological relevance: Psydrax subcordata (DC.) Bridson is a tropical medicinal plant used traditionally for the management of epilepsy. However, there is little scientific evidence to support its use. Aim of study: The current study investigated the anticonvulsant properties of the hydroethanolic leaf extract of Psydrax subcordata (PSE...

Background Despite substantial advances in pain research and treatment, millions of people continue to suffer from pain and this has been attributed mainly to the unavailability of effective and safer analgesics. The use of plants as medicines is still widespread and plants constitute a large source of novel phytocompounds that might become leads f...

Various parts of Albizia zygia (DC.) Macbr. (Family: Leguminosae-Mimosoideae) are used traditionally in the management of arthritis and pain. The present study evaluated the anti-inflammatory and in vivo antioxidant effects of the hydroethanolic root extract of Albizia zygia in animal models. Oedema was induced by the injection of carrageenan (2% s...

Background Geraniin, a dehydroellagitannin, is a major component of the aqueous extract of the aerial parts of Methods The nature of the interactions of morphine and diclofenac with geraniin was evaluated by undertaking the isobolographic analysis. Mice were treated with geraniin (3–30 mg/kg), morphine (1–10 mg/kg), and diclofenac (10–100 mg/kg) t...

Context: Various parts of Ziziphus abyssinica Hochst ex. A. Rich (Rhamnaceae) have been used in Ghanaian and African traditional medicine as an analgesic. However, there are little scientific data to support the anti-nociceptive effects of the hydro-ethanolic leaf extract of Ziziphus abyssinica (EthE) as well as the possible mechanisms involved in...

Context: The leaves of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) are used in Ghanaian traditional medicine for the treatment of pain, inflammatory disorders and fever (including malaria). Objectives: The present study evaluated the anti-inflammatory, antipyretic and analgesic effects of the hydroethanol leaf extract of Albizia zygia...

Context: Fruits of Xylopia aethiopica (Dunal) A. Rich. (Annonaceae) are used traditionally to manage arthritis, headache and other pain disorders. Objective: The analgesic properties of the X. aethiopica ethanol fruit extract (XAE) and xylopic acid (XA) were evaluated in musculoskeletal pain models. Materials and methods: Acute muscle pain was indu...

Allodynia and hyperalgesia comprise the main and frequent symptoms suffered by patients with neuropathic pain, which responds poorly to therapy. An earlier study reported that stem bark extracts of Maerua angolensis exhibited dose-dependent anti-nociceptive effect against the neurogenic and inflammatory phases of the formalin test. The current stud...

Ethnopharmacological relevance: Phyllanthus muellerianus (Kuntze) Exell. which belongs to the Family Euphorbiaceae is a shrub widely distributed in West Africa. It is used traditionally to manage wounds and wound infections, menstrual disorders, fevers, pain and inflammation. Hence to confirm its ethnobotanical uses in managing inflammation, we in...

Background: A common practice of managing pain globally is the combination of analgesics and this is aimed at facilitating patient compliance, simplifying prescription, and improving efficacy without increasing adverse effects. Fruit extracts of Xylopia aethiopica are used traditionally in the management of pain disorders and xylopic acid (XA) pre...

The aerial parts of Hilleria latifolia are used in Ghanaian traditional medicine for the treatment of pain and inflammatory disorders. In the current study, the anti-nociceptive and anti-inflammatory effects of the hydro-ethanol (HAE), ethyl acetate (EAE) and petroleum ether (PEE) extracts of the aerial parts of the plant were investigated in anima...

Vincristine-induced neuropathy is a major dose-limiting side effect of cancer chemotherapy and thus effective therapeutic strategy is required. The present study utilized a rodent model of neuropathy to determine whether an ethanolic leaf extract of Palisota hirsuta (PHE), a plant widely used in West African traditional medicine for pain management...

Fruit extracts of Xylopia aethiopica are used traditionally in the management of pain disorders including headache and neuralgia. An animal model of vincristine-induced sensory neuropathy was developed after repeated intraperitoneal injection in rats and used in the present work to study the effects of the ethanolic extract of X. aethiopica (XAE) a...

Acute and sub-chronic toxicity studies of the aqueous extract of the root bark of C. sieberiana (Caesalpiniaceae), a plant used locally in Ghana for the treatment of pain, was carried out in rodents. In the acute study, a single oral dose (5000 mg/kg) of the aqueous extract of C. sieberiana (NPK) was administered to six rats and six mice, and obser...

Background: Leaf extracts of Ficus exasperata has been used traditionally in Ghana for the management of sprains, sore eyes, rheumatism and arthritis. Objective: This study evaluates the scientific basis for the use of Ficus exasperata leaves in the management of acute and chronic musculoskeletal pain Methods: The carrageenan-kaolin-induced hyperal...

Phyllanthus muelllerianus (Kuntze) Exell. (Family Euphorbiaceae) is a tropical plant used for the management of menstrual disorders, fever and pains [1]. In this study, acute and chronic anti-inflammatory activity of aqueous leaf extract (ALE) of P. muellerianus and its isolate, geraniin, were investigated. Anti-inflammatory activity of ALE (30, 10...

Background: The anti-inflammatory and anti-nociceptive effect of the ethyl acetate fraction of the root bark of Cassia sieberiana D.C. (Caesalpiniaceae), a plant used locally in Ghana for treating pain associated with ulcer and menstruation, was evaluated in various rodent models. Method: The anti-inflammatory property was assessed using carrageena...

Background: The present study examined the possible mechanism(s) of analgesic action of the ethanol extract of the fruits of Xylopia aethiopica (XAE) and its kaurene diterpene constituent, xylopic acid (XA). Methods: Naloxone (2 mg kg-1 i.p.), L-NAME (10 kg-1 i.p.), ondansetron (0.5 mg kg-1 i.p.), theophylline (5 mg kg-1 i.p.), glibenclamide (8 mg...

The study evaluated the antioxidant potential and phytochemical constituents in the stem bark extracts of Trichilia monadelpha (Thonn) JJ De Wilde (Family: Meliaceae). Petroleum ether (PEE), ethyl acetate (EthE) and ethanol extracts (EAE) of the stem bark of T. monadelpha were screened for the presence of phytochemicals. The in vitro antioxidant po...

Various parts of Newbouldialaevis (Bignoniaceae) including the leaves have been used to relieve stomach pains, pelvic pain, haemorrhoids, and rheumatic swellings in Ghanaian and West African folk medicine with little or no scientific evidence. This study was therefore aimed at evaluating the scientific basis for the traditional use of Newbouldialae...

Various parts of Trichilia monadelpha (Thonn) JJ De Wilde (Fam. Meliaceae) are used in Ghanaian traditional medicine for the treatment of painful and inflammatory conditions. The present study examined the analgesic properties of the petroleum ether (PEE), ethyl acetate (EAE), and the hydro-ethanolic (HAE) extract of the stem bark of the plant in m...

Fruit extracts of Xylopia aethiopica are used traditionally in the management of pain disorders including rheumatism, headache, colic pain, and neuralgia. Little pharmacological data exists in scientific literature of the effect of the fruit extract and its major diterpene, xylopic acid, on pain. The present study evaluated the analgesic properties...

Various parts of the perennial herb Hilleria latifolia (Lam.) H. Walt. (Family: Phytolaccaceae) are used in Ghanaian traditional medicine for the treatment of several inflammatory-related disorders. The present study examined the anti-inflammatory effect of an ethanolic extract of the aerial parts of Hilleria latifolia (HLE) in acute and chronic in...

Various parts of the perennial herb Hilleria latifolia (Lam.) H. Walt. (Family: Phytolaccaceae) are used in Ghanaian traditional medicine for the treatment of several inflammatory-related disorders. The present study examined the anti-inflammatory effect of an ethanolic extract of the aerial parts of Hilleria latifolia (HLE) in acute and chronic in...

Hilleria latifolia (Lam.) H. Walt. (Phytolaccaceae) is a perennial herb used in Ghanaian traditional medicine for the treatment of various painful conditions. Little scientific evidence exists in literature on the effect of this plant on pain. The present study examined the antinociceptive effect of the ethanolic extract of the aerial parts of H. l...

Ficus exasperata Vahl (Moraceae) is a terrestrial afro-tropical tree used as an antiepileptic remedy in African traditional medicine. This study investigated the anticonvulsant effect of a hydroalcoholic leaf extract of F. exasperata against seizures induced by pentylenetetrazole, picrotoxin or maximal electroshock in mice. The extract (30-300 mg k...

Background Hilleria latifolia is a perennial herb commonly used in Ghanaian traditional medicine. However, little scientific evidence exists in literature on the safety of this plant. Objectives and Methods The present study evaluated the potential toxicity of the ethanolic extract of the aerial parts of Hilleria latifolia (HLE) in acute and sub-ac...

Background: Leaves of Palisota hirsuta K. Schum. (Commelinaceae) have been used to relieve inflammation and rheumatism in Ghanaian and West African traditional medicine. Nevertheless, scientific information regarding this species is scarce.

Background: Anxiety and depression remain the most common psychiatric disorders affecting man. To date, the effi cacy of the drugs for these conditions is very limited and requires the search for newer, better-tolerated, and more effi cacious treatments. The present study evaluated the anxiolytic-and antidepressant-like effects of the ethanolic ext...

The present study reports the effects of a hydro-ethanolic extract of the whole plant of Synedrella nodiflora (L) Gaertn, a plant traditionally used in Ghana for the treatment of epilepsy, in the elevated plus-maze (EPM), light/dark test (LD), the VersaMax animal activity monitor system (VAMS) and the pentobarbitone-induced sleep test. In the EPM p...

Background: Ficus exasperata Vahl (fam. Moraceae) is a terrestrial afro-tropical plant used in African traditional medicine for the treatment of inflammation, pain and central nervous system disorders. To date, there is little pharmacological data on the effect of this plant of anxiety. Objectives: The present study evaluated the effect of a hydroa...

Leaf extracts of Ficus exasperata P. Beauv. (Moraceae) are commonly used in Ghanaian traditional medicine for the treatment of several pathological states including inflammatory disorders. The present study was undertaken to evaluate the antiarthritic effect of an ethanolic extract of F. exasperata (FEE) in the Freund's adjuvant-induced arthritis m...

The hydro alcoholic leaf extract of Ficus exasperata (Vahl) (family Moraceae) (FEE) was evaluated for its antinociceptive, anti-inflammatory and anti-pyretic properties in animal models. The leaf extract (10-300 mg kg-1) showed a dose-dependent anti-inflammatory activity in carrageenan-induced foot oedema in chicks, with an IC50 of 46.05±12.3 mg kg...

Root extracts of Carissa edulis (Forsk.) Vahl (Apocynaceae) are used for the treatment several pathological states including inflammatory disorders. The present study was undertaken to evaluate the effect of an alcoholic extract of C. edulis (CEE) on carrageenan-induced foot oedema in chicks. Also since free radicals and reactive oxygen species are...