Wolfgang Johann Schnedl

Wolfgang Johann Schnedl
Medical University of Graz · Department of Medicine

Professor of Internal Medicine

About

171
Publications
32,182
Reads
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3,274
Citations
Citations since 2016
46 Research Items
1458 Citations
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2016201720182019202020212022050100150200250
Introduction
Non-specific abdominal complaints are a widespread and considerable problem worldwide. We analyze lactose intolerance (LI), fructose malabsorption (FM), histamine intolerance (HI), celiac disease (CD), and Helicobacter (H.) pylori infection in patients with unexplained gastrointestinal (GI) symptoms. Multiple combinations of LI, FM, HI, CD and H. pylori infection are present in our study cohort. Patients should get an individualized dietary advice and/or H. pylori eradication therapy.
Additional affiliations
January 2011 - present
Practice of General Internal Medicine
Position
  • Professor of Internal Medicine
January 2011 - present
Medical University of Graz, Graz, Austria
Position
  • Lecturer
Description
  • Lifestyle-Related Diseases (LIFEMED)
January 1993 - December 2006
Karl-Franzens-Universität Graz
Position
  • Specialist in Internal Medicine

Publications

Publications (171)
Article
Full-text available
Epiploic appendagitis is a rare cause of abdominal pain. Diagnosis of epiploic appendagitis, although infrequent, is easily made with CT or ultrasonography in experienced hands. As reported in the literature, most patients with primary epiploic appendagitis are treated conservatively without surgery, with or without anti-inflammatory drugs. A small...
Article
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The glucose analog streptozotocin (STZ) has long been used as a tool for creating experimental diabetes because of its relatively specific beta-cell cytotoxic effect, but the mechanism by which systemic injection of STZ causes beta-cell destruction is not well understood. In the current study, we have used insulinoma (RIN) and AtT-20ins cell lines...
Article
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Cases of deep venous thrombosis in the lower extremities triggered by abnormalities of the vena cava have been reported. To describe anomalies of the inferior vena cava in patients with deep venous thrombosis. Prospective, consecutive case series. University Hospital, Graz, Austria. 97 patients with deep venous thrombosis. Sonography, venography, o...
Article
Background The scale and the course of antibody production in patients with SARS-CoV-2 is highly variable. Factors involved in the immune regulation during the infection may play a major role in the antibody response. We investigated the relationship between the inflammatory markers of the kynurenine pathway and the concentration of antibodies agai...
Article
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Lactose intolerance (LIT) is one of the major causes of irritable bowel syndrome (IBS) spectrum complaints. Differences in inadequate lactose digestion are described as various LIT phenotypes with basically unknown pathophysiology. In LIT patients, we retrospectively assessed the effect of histamine intolerance (HIT) on expiratory hydrogen (H2 ) du...
Article
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Infection with Helicobacter pylori (H.pylori) may cause dyspepsia and/or unexplained functional nonspecific, gastrointestinal complaints of the irritable bowel syndrome (IBS) spectrum. Hitherto, in H. pylori infected patients with symptoms of the IBS spectrum the occurrence of additional food intolerance/malabsorption is not evaluated. We used a re...
Article
Background Immune dysregulation and inflammation in patients with SARS-CoV-2 is associated with a poor clinical outcome. We investigated the value of the inflammatory markers tryptophan and kynurenine in predicting the survival outcome of patients with SARS-CoV-2. Methods The study included 252 inpatients with a SARS-CoV-2 infection hospitalized b...
Article
In westernized countries, adverse reactions to ingested foods are reported to affect up to 20% of the population. Functional, nonspecific, non-allergic gastrointestinal complaints are mainly due to the intolerance/malabsorption of carbohydrates (lactose and fructose), proteins (gluten), and biogenic amines (histamine). Food intolerance/malabsorptio...
Article
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Understanding immune reactivity against SARS-CoV-2 is essential for coping with the COVID-19 pandemic. Herein, we discuss experiences and open questions about the complex immune responses to SARS-CoV-2. Some people react excellently without experiencing any clinical symptoms, they do not get sick, and they do not pass the virus on to anyone else ("...
Article
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Histamine intolerance (HIT) is assumed to be due to a deficiency of the gastrointestinal (GI) enzyme diamine oxidase (DAO) and, therefore, the food component histamine not being degraded and/or absorbed properly within the GI tract. Involvement of the GI mucosa in various disorders and diseases, several with unknown origin, and the effects of some...
Article
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Background: The branched-chain amino acids (BCAAs) valine, leucine and isoleucine are reported to influence erythropoiesis and the human iron status. Large study cohorts encompassing biomarkers of iron metabolism and BCAAs are still lacking. Methods: We investigated potential interactions between blood concentrations of all three BCAAs valine, l...
Article
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Single and/or combined food intolerance/malabsorption may cause nonspecific, functional gastrointestinal (GI) complaints. In lactose-intolerant patients we evaluated the influence of additional food intolerance/malabsorption with hydrogen (H 2) breath tests. In a retrospective analysis of charts from 279 lactose-intolerant patients, we found 128 pa...
Article
Monogenic mutations of the hepatocyte nuclear factor 1 homeobox A maturity onset diabetes of the young (HNF1A-MODY) is characterized by early onset, typically before the age of 25 years. Patients are often not clinically recognized; however, the identification of HNF1A-MODY patients is crucial because they require different antihyperglycemic medica...
Article
Background and pilot study: Celiac disease (CD) or gluten malabsorption is a well-defined autoimmune disorder characterized by mucosal gastrointestinal reaction to ingested gluten proteins. The necessary treatment for CD is a gluten-free diet. However, up to 30% of celiac patients experience persistent or recurring abdominal complaints despite foll...
Article
Objectives Recently, the fully automated flow cytometry-based UF-5000 (Sysmex Corboration, Kobe, Japan) urine sediment analyzer was developed providing bacteria (BACT) info flags for more accurate bacterial discrimination of urinary tract infections (UTIs). This study aimed to compare the reliability of the UF-5000 BACT-info flags with manual Gram...
Article
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Carnitine palmitoyltransferase II (CPT II) deficiency represents an inherited defect in mitochondrial long-chain fatty acid oxidation. Rhabdomyolysis with necrosis of muscle is caused by the destruction of skeletal muscle and leads to systemic, multiorgan complications due to the release of intracellular muscle components. Severe rhab-domyolysis ma...
Article
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Recently, the microbiome-derived trimethylamine-N-oxide (TMAO) was shown to be present in human cerebrospinal fluid (CSF). However, data on the potential of TMAO crossing the blood-CSF barrier are still lacking. This retrospective study aimed at investigating possible associations between the CSF/serum albumin (QALB) and TMAO (QTMAO) quotient and e...
Article
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The aim of the present study was to investigate possible associations between interleukin-6 (IL-6), interferon-gamma (INF-γ), tumor necrosis factor-alpha (TNF-α), lactoferrin and lipopolysaccharide binding protein (LBP) with TRP metabolism and signs of depression in a large cohort of outpatients referred for carbohydrate malab-sorption testing. Ser...
Article
Background Branched-chain amino acids (BCAAs) are reported to influence erythropoiesis and the human iron status. This study is aimed at investigating potential interactions between blood concentrations of all three BCAAs valine, leucine and isoleucine and indicators of human iron status. Methods Overall, 430 outpatients referred for a medical hea...
Article
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In recent years, concerns about transfusion-related risk factors, high blood acquisition costs, and blood shortages have gained substantial interest of hospitals in finding possible ways to decrease blood transfusions. Based on the knowledge of the side effects of allogenic blood transfusions, patient blood management (PBM) developed into an eviden...
Article
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Atherosclerosis (AS) leading to myocardial infarction and stroke remains worldwide the main cause for mortality. Vulnerable atherosclerotic plaques are responsible for these life-threatening clinical endpoints. Atherosclerosis is a chronic, complex, inflammatory disease with interactions between metabolic dysfunction, dyslipidemia, disturbed microb...
Article
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Sugars including lactose and fructose, or proteins (gluten), or biogenic amines (histamine), and combinations thereof may cause food intolerance/malabsorption. However, in usually asymptomatic patients with rare diseases, who present with functional, non-specific, non-allergic gastrointestinal (GI) complaints the etiologic factors of food intoleran...
Article
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Background: The microbiome-derived trimethylamine-N-oxide (TMAO) and the intestinal permeability marker zonulin are considered to be linked with depression. Moreover, carbohydrate malabsorption (CMA) was shown to be associated with signs of depression. This study is aimed at investigating possible sex-specific associations between TMAO and zonulin...
Article
Background Recently, several manufacturers have launched automated urinalysis platforms. This study aimed to compare the diagnostic performance of the UF-5000 (Sysmex Corporation, Kobe, Japan) and the cobas ® u 701 (Roche Diagnostics, Rotkreuz, Switzerland) urine sediment analyzers with manual phase-contrast microscopy as the reference method. Met...
Article
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Current literature proposes associations between tryptophan metabolism and anaemia. However, study cohorts are rather small and final conclusions are still lacking. Here, we evaluated potential associations of tryptophan, kynurenine, and kynurenic acid with indicators of iron metabolism (i.e., mean corpuscular volume, mean corpuscular haemoglobin,...
Article
Full-text available
Primary epiploic appendagitis (PEA) is an uncommon and self-limiting cause of acute or subacute abdominal complaints. The diagnosis of PEA, with its characteristic appearance, is made with computed tomography (CT). This report describes a patient seven months after a CT-confirmed diagnosis of PEA. Because of persistent and recurring, functional, no...
Article
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Healthy human blood contains only a trace amount of methemoglobin (Hb M), less than 1%. In Hb M iron is present in the oxidized ferric state (Fe³⁺) not in the reduced ferrous form (Fe²⁺) and this reduces the ability of hemoglobin to bind oxygen. The described rare hemoglobin variant Hb M‑Hyde Park (also known as Hb M-Akita) results from the substit...
Article
Background Helicobacter pylori has been associated with iron deficiency (ID). This study is aimed at investigating ID with conventional (ferritin, transferrin saturation [TSAT]) and new biomarkers (soluble transferrin receptor [sTfR], sTfR/log ferritin, reticulocyte hemoglobin content [CHr], hepcidin-25) in patients sub-grouped by the presence or a...
Article
Full-text available
Histamine intolerance (HIT) is thought to becaused by a disproportionate amount of histamine in thebody. The enzyme diamine oxidase (DAO) is consideredfor the gastrointestinal degradation of histamine. For thisopen-label interventional pilot study, we identified 28patients with HIT. For 4 weeks, they were instructed totake DAO capsules before meals...
Article
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We read with interest the manuscript by Onderwater et al. that reported on alcoholic beverages as a trigger factor for migraines [1]. Although, epidemiological studies have found a correlation between alcohol intake and headaches, a specific pathophysiologic mechanism of this headache remains unidentified [2]. Particularly red wine was documented a...
Article
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Background/aims: Food intolerance/malabsorption, particularly histamine intolerance (HIT), may cause nonspecific functional gastrointestinal and extraintestinal symptoms. We evaluated gastrointestinal and extraintestinal symptoms in patients with HIT. Methods: In an analysis of outpatients' charts we identified 133 patients, who presented with r...
Article
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Diagnosis of histamine intolerance (HIT) has been based on low serum diamine oxidase (DAO) values, functional gastrointestinal disorders and improvement of symptoms with a histamine-reduced diet (HRD). In a retrospective analysis of outpatients’ charts we identified 101 patients with HIT. After a median of 13 months, a questionnaire was distributed...
Article
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Background Current literature proposes associations between homocysteine (HCY), folic acid (FA), vitamin B12 metabolism and depression. However, the exact underlying biological mechanisms remain unclear. This study aimed at evaluating a possible link between primary adult-type lactose malabsorption (PALM), HCY, FA and vitamin B12 metabolism and dep...
Data
The data set of the study is provided. (XLSX)
Article
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Background So far, studies on possible association of plasma lipid levels and depressive disorder are contradictory. This prospective work aimed at assessing a plasma lipid profile in individuals with major depression and healthy controls. Methods In total, 94 patients with major depression and 152 healthy controls were included in this prospect...
Article
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Introduction Food intolerance/malabsorption is caused by food ingredients, carbohydrates (mainly lactose and fructose), proteins (gluten), and biogenic amines (histamine) which cause nonspecific gastrointestinal and extra-intestinal symptoms. Here we focus on possible etiologic factors of intolerance/malabsorption especially in people with non-celi...
Article
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Das Syndrom polyzystischer Ovarien (PCOS) gilt als die häufigste endokrine Erkrankung bei Frauen mit Kinderwunsch und ist ein klinisches Syndrom mit unterschiedlichen phänotypischen Ausprägungen. Bei PCOS gibt es kein einzelnes diagnostisches Kriterium für die klinische Diagnostik, sondern meist besteht eine Kombination mehrerer klinischer Symptome...
Article
Das Syndrom polyzystischer Ovarien (PCOS) gilt als die häufigste endokrine Erkrankung bei Frauen mit Kinderwunsch und ist ein klinisches Syndrom mit unterschiedlichen phänotypischen Ausprägungen. Bei PCOS gibt es kein einzelnes diagnostisches Kriterium für die klinische Diagnostik, sondern meist besteht eine Kombination mehrerer klinischer Symptome...
Article
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Background: β-thalassemia minor is characterized by reduced β-haemoglobin chain synthesis and sometimes mild anaemia, although carriers of β-thalassemia minorare usually clinically asymptomatic.Nonspecific abdominal complaints may be caused by gastrointestinal carbohydrate malabsorption (lactose and fructose) and/or malabsorption of biogenic amines...
Article
This prospective cross-sectional study aimed to investigate the potential association between primary-adult lactose malabsorption, fructose malabsorption, tryptophan (TRP) metabolism and the presence of depressive signs. Overall 251 patients, who were referred for lactase gene C/T−13910 polymorphism genotyping and fructose hydrogen/methane breath t...
Article
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Benign pancreatic hyperenzymemia (Gullo syndrome) is characterized by a more than threefold increase of the pancreatic enzymes lipase and amylase in the absence of a pancreatic disease over a period of more than 1 year, with elevations and significant undulations of pancreatic enzyme serum concentrations occurring on a day-today basis for 5 consecu...
Article
Full-text available
Primary Epiploic Appendagitis (PEA) is a rare cause of acute or subacute abdominal complaints and non-migratory pain. Usually the diagnosis of PEA is made when Computed Tomography (CT) reveals characteristic figures. Nonspecific abdominal complaints including diffuse abdominal pain may be caused by carbohydrate and/or protein malabsorption. We repo...
Article
Full-text available
The aim of this retrospective study was to analyze the concomitant prevalence rates for lactose malabsorption (LM), fructose malabsorption (FM), and histamine intolerance (HI) in patients with so far unexplained gastrointestinal (GI) symptoms. A total of 439 outpatients, who presented unclear abdominal discomfort, underwent lactose (50 g) and fruct...
Article
Objectives: Recently, an intermediate lactose intolerance (LI) phenotype based on the lactase gene (LCT) C/T-13910 polymorphism was proposed. However, a multifactorial genesis of LI phenotypic variation including endogenous and exogenous factors cannot be ruled out. Therefore, this study was conducted to investigate a possible association between...
Article
Cardiovascular risk is increased in obese subjects. Nevertheless, some overweight and obese remain cardio metabolically healthy, and normal-weight persons develop cardiovascular disease (CVD). Herein, we investigate the potential of branched chain amino acids (BCAAs) to identify an increased CVD risk in a cross-sectional study of 666 adults and juv...
Article
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Patients with anomalies of the inferior vena cava (IVC) are rare, are usually asymptomatic and this developmental anomaly is detected during radiologic evaluation of deep vein thrombosis or incidentally during abdominal radiologic evaluation. We report on time resolved three-dimensional magnetic resonance angiography (4D MRA) in a patient with cong...
Article
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In the context of enteral feeding in children the influence on growth and the question of fat resorption is of great interest. We, therefore, measured the thickness of subcutaneous body fat in a sample of long-term enterally fed toddlers and healthy controls. In 33 long-term enterally fed toddlers (10 girls, 23 boys) and 275 healthy controls (128 g...
Article
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Unspecific abdominal complaints including bloating and irregular bowel movements may be caused by carbohydrate malabsorption syndromes, e.g., lactose and fructose malabsorption. These symptoms were investigated with hydrogen (H2) breath tests and correlated to carbohydrate malabsorption. During performing these H2-breath tests the patient presented...
Article
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N ach der Aufnahme von Nahrung mit Histamin können bei Störung des His-taminstoffwechsels individuell viel-fältige, unterschiedlichste Symptome wie zum Beispiel migränoide Cephalea, Diarrhoe, Dysmenorrhoe, Hypotension, Arrhythmien, Urtikaria, Juckreiz, Flushsymptomatik, Asth-maanfälle, kollaptische Zustandsbilder und andere Beschwerden auftreten. D...
Article
Obesity is associated with non-alcoholic fatty liver disease (NAFLD), and the patatin-like phospholipase 3 (PNPLA3) rs738409 (Ile148Met, C>G) gene polymorphism is one of the most important genetic determinants of NAFLD. Carriers have been reported to better respond to lifestyle modification. To investigate the effect of rs738409 on overweight/obese...
Article
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Contradictory results exist of vitamin D in cardiovascular disease (CVD) of obesity and metabolic syndrome (MetS). To clarify this, we investigated 527 participants of the STYJOBS/EDECTA cohort (NCT00482924)‎ aged between 10 and 65 years. Anthropometry, carotid intima media thickness (IMT), and laboratory analysis including 25OH-Vitamin D3 (vitD),...
Article
Aim: Evaluation of anthropometry and subcutaneous body fat on long--term enterally--fed children during tube weaning. Prospective cohort study: Pre--post--test design. Methods: The LIPOMETER, an optical device, was used to measure the thickness of subcutaneous adipose tissue (SAT) layers (in mm). The specification of 15 evenly--distributed body...
Article
Full-text available
Primary epiploic appendagitis (PEA) is a rare cause of abdominal acute or subacute complaints. Diagnosis of PEA is made when computed tomography (CT) reveals a characteristic lesion. We report on contrast-enhanced CT images of a patient with PEA and regression of inflammation and the reduction in size of the inflamed appendage over the time period...
Article
Objective: Obesity-related immune mediated systemic inflammation was associated with the development of the metabolic syndrome by induction of the tryptophan (TRP)-kynurenine (KYN) pathway. The study aimed to assess whether this holds true across the lifespan from juvenility to adulthood. Design and methods: Five hundred twenty-seven participant...
Article
Levels of 25-hydroxy vitamin D [25(OH)D] are reported to be decreased in cardiovascular disease (CVD) and in other chronic immunopathologies. Vitamin D (vitD) has been shown to be significantly linked to mortality, and is thought to be a predictor of survival. Therefore, supplementation with vitD has been suggested as an option to improve clinical...
Article
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We aimed to describe the relationship between BMI and the subcutaneous adipose tissue topography within young athletes and non-athletic controls, to comparatively evaluate the diagnostic powers of subcutaneous adipose tissue thicknesses at different body sites, furthermore to explore appropriate cut-offs to discriminate between athletes and control...
Data
Specified body sites employed for LIPOMETER measurements of SAT thickness [21] . (TIF)
Data
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Although the body mass index (BMI, kg/m 2) is widely used as a surrogate measure of adiposity, it is a measure of ex-cess weight, rather than excess body fat, relative to height. The BMI classification system is derived from cut points ob-tained from the general population. The influence of large muscle mass on BMI in athletes and young adults may...
Article
Full-text available
Although the body mass index (BMI, kg/m2) is widely used as a surrogate measure of adiposity, it is a measure of excess weight, rather than excess body fat, relative to height. The BMI classification system is derived from cut points obtained from the general population. The influence of large muscle mass on BMI in athletes and young adults may mis...
Article
Full-text available
Hashimoto's encephalopathy (HE) is a rare immune-mediated encephalopathy associated with autoimmune Hashimoto's thyroiditis. We report on a patient with HE and significant clinical improvement correlating with an increase in cerebral blood flow demonstrated by hexamethylpropyleneamine oxime (HMPAO) single-photon emission computed tomography (SPECT)...