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Publications (12)
The objective of this investigation was to find out whether L-carnitine-loaded nanoparticle (LCn) could reduce the reproductive toxicity of cypermethrin (CYP), the widely used insecticide in veterinary medicine in male rats. Twenty male Wistar rats that weighed between 210 and 240 g were split into four groups and treated daily for 2 months. The co...
Craniosynostosis, the premature ossification of cranial sutures, is a developmental disorder of the skull vault, occurring in approximately 1 in 2250 births. The causes are heterogeneous, with a monogenic basis identified in ~25% of patients. Using whole-genome sequencing, we identified a novel, de novo variant in BCL11B, c.7C>A, encoding an R3S su...
B-cell lymphoma/leukemia 11B (Bcl11b) is a transcription factor critical for thymocyte development. We have previously characterized the kinetic post-translational modifications (PTMs) of Bcl11b in double-positive (DP) thymocytes during stimulation of the T cell receptor-activated MAP kinase pathway. However, the PTMs of Bcl11b in thymocytes from o...
The anesthetic and some cardiopulmonary effects of Fentanyl-Ketamine (FK) and Xylazine-Ketamine (XK) combinations were studied and compared in rabbits. A sixteen rabbits were randomly assigned to (2) different group FK and XK groups. The rabbits in FK group (n=8) were injected 0.02 mg/ kg B. W of fentanyl and 40 mg/ kg B. W of ketamine. The XK grou...
Goal: The present study was undertaken to assess the neurotoxic effect of metronidazole in rabbits .Eighteen rabbits were randomly divided into three equal groups ,first group was injected with metronidazole at the therapeutic dose 02 mg/kg.B.W. , second group was injected with metronidazole at double therapeutic dose where as the last group serve...
This study was assigned to evaluate the sedative effect of intranasal administration of xylazine or diazepam (with or without Chitosan) in budgerigar. A pilot study conducted to determine the effective dose of each drug that cause adequate sedation in these birds and on which the experiment 2 was built. It involved slowly administration of various...
The present study was undertaken to assess the neurotoxic effect of metronidazole in rabbits .Eighteen rabbits were randomly divided into three equal groups ,first group was injected with metronidazole at the therapeutic dose 20 mg/kg.B.W. , second group was injected with metronidazole at double therapeutic dose where as the last group serve as a c...
The present study was designed to investigate the antinociceptive activity of the watery suspension of powdered Nigella sativa seeds in mice. The antinociceptive effect of the watery suspension of Nigella sativa seeds compared with that of Naproxen was evaluated by formalin test in which the stimulus is standardized and measures potency and duratio...
The anaesthetic and some cardiopulmonary effects of Fentanyl-Ketamine (FK) and Xylazine-Ketamine (XK) combinations were studied and compared in rabbits. A sixteen rabbits were randamoly assigned to (2) different group FK and XK groups. The rabbits in FK group (n=8) were injected 0.02 mg/ kg B. W of fentanyl and 40 mg/ kg B. W of ketamine. The XK gr...
The methanolic extract of Ceratonia siliqua fruit was evaluated for its
antidiarrhoeal potential activity in mice and rats. The methanolic extract of the fruit of
this plant, at graded dose (250 and 500 mg/kg BW, p.o) was investigated by using three
experimentally- induced diarrhea models, in order to understand the mechanism of its
antidiarrhoe...
The present study was designed to investigate the antinociceptive activity of the watery suspension of powdered Nigella sativa seeds in mice. The antinociceptive effect of the watery suspension of Nigella sativa seeds compared with that of Naproxen was evaluated by formalin test in which the stimulus is standardized and measures potency and duratio...
Questions
Questions (4)
Any ideas about the differences between DN and DP thymocytes in terms of α chain?
Any ideas about the differences between Pre-TCR and TCR signaling pathways in thymocytes in terms of downstream signaling pathways?
(I am not asking about the cellular level of β-catenin) Thanks