Wioletta Nowak

Wrocław University of Science and Technology | WUT

A procedure to detect irregular signal responses to pupil light reflex (PLR) was developed to detect Alzheimer’s Disease (AD) using a functional data analysis (FDA) technique and classification with an Elastic Net. In considering the differences in features of PLRs between AD and normal control (NC) participants, signals of summations and different...

A procedure for detecting cognitive impairment in senior citizens is examined using pupil light reflex (PLR) to chromatic light pulses and a portable measuring system. PLRs of both eyes were measured using blue and red light pulses aimed at either of the two eyes. The symptoms of cognitive function impairment were evaluated using a conventional dem...

INTRODUCTION: Various studies conducted to predict Alzheimer’s disease (AD) indicate that some pupillight reflex (PLR) features may contain symptoms of the disease. An effective procedure that can predict thedisease using PLRs is needed. OBJECTIVES: Two analytic approaches were examined in order to estimate the possibility of identifying Alzheimer’...

INTRODUCTION: Some Alzheimer’s Disease (AD) patients respond to chromatic light stimulus, which mayinfluence intrinsically photosensitive retinal ganglion cells (ipRGCs), due to factors common to both AD andAge-Related Macular Disease (AMD).OBJECTIVES: In this study, short light pulses of three colours were introduced to a novel diagnostic procesur...

The waveforms of the pupillary light reflex (PLR) can be analyzed in a diagnostic test that allows for differentiation between disorders affecting photoreceptors and disorders affecting retinal ganglion cells, using various signal processing techniques. This procedure has been used on both healthy subjects and patients with age-related macular dege...

Background An objective and noninvasive examination of pupil size variability can be used to assess the activity of the autonomous nervous system. We designed a system that enables binocular, fast, and accurate recordings of different types of pupil variabilities, which are synchronous with other biosignals. This type of measurement system is neede...

This paper presents a measurement system for binocular pupil size variability study. The measurements can be taken at a rate up to 256 Hz with a linear accuracy better than 0.02 mm during both the pupil light reflex induced by computer-controlled light stimuli and the spontaneous pupil fluctuation. The unique system design and method of detecting a...

The wavelet transform technique was used to analyze the spontaneous fluctuations in pupil size behavior measured by dynamic pupillometry. The fluctuations show a wide frequency scale and their periods varied in time. Within the frequency range studied, 0-~2 Hz, the characteristic oscillations were revealed, arising from both local and central regul...

The pupillary light reflex is a useful diagnostic tool used to assess the function of the eye and the visual system. The increased interest in testing the pupillary light reflex is the discovery that the intrinsically photosensitive retinal ganglion cells are involved in the reflex physiology. The aim of this study was to evaluate the usefulness of...

This paper examines the possibility of detecting 2 conditions which cause vision to deteriorate: Aged-Related Macular Degeneration (AMD), and the effects of aging on eyes using the features of PLR waveforms. These features were extracted using Fourier descriptors of PLR waveform shapes, weighted amplitudes of the waveforms, and a balanced combinati...

The waveform of the Pupil Light Response (PLR) to chromatic stimuli is a key point in non-invasive assessment of the activity of the melanopsin-associated photo receptive system, which is considered as the basis for preparing new diagnostic procedures in ophthalmology. The article shows a procedure for a quantitative description of the PLR waveform...

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The effectiveness and simplicity of measuring EEGs and pupillometry make them very useful tools for personalized health management. Each of these signals has been tested many times, but an interesting issue seems to be to determine the relationship between them by testing them together. In this study, simultaneously recorded changes of the pupillom...

The purpose of this study was to assess the characteristics of frequency domain analysis of the sustained phase of pupil light reflex (PLR) to short and long wavelength light. In the work to be presented, spectra of the sustained phase of the PLR to short- and long- wavelength light in low and high photopic conditions were tested. The findings show...

The aim of this work has been to develop a new method of variability description for the spontaneous pupillary fluctuation (SPF) signal, based on the time-frequency analysis. In the work we have studied the variability of the SPF signal spectrum. Based on the KPSS (Kwiatkowski, Philips, Schmidt, Shin) test, it has been shown that the SPF signal is...

Analysis of human eye pupil reactivity is a very valuable diagnostic method used mainly for evaluation of the condition of the autonomic nervous system and the visual system. The paper presents an experimental pupillometer built in the Institute of Physics of the Wroclaw University of Technology. The apparatus makes it possible to record and analyz...

The human pupillomotor response to light (the pupil light reflex -- PLR) is an example of nonlinear biological systems. The time characteristic of the PLR response is determined by the successive activation of the parasympathetic and sympathetic innervation of the iris muscles. The shape of characteristics is typically evaluated from the changes in...

The paper presents the measurement system for quantitative investigation into the consensual reaction of pupil to light. This reaction is called the pupil light reflex (PLR). The system enables the recording and analysis of the time characteristics of pupil radius variation during PLR. In the measurement the stimulating light is projected on the le...

This paper reports the method of recording the Pupil Light Reflex with using a CCD linear sensor as a detector. The system allows to obtain a linear resolution 0,005 mm and a temporary resolution 11 ins. The principle of measuring method and example results of PLR study are presented.

A new photoreception process based on intrinsically photosensitive retinal ganglion cells (ipRGC) contributes to the Pupillary Light Reflex (PLR). This reflex is controlled by two antagonistic iris muscles, the sphincter (the parasympathetic component) and the dilator (the sympathetic component). ipRGC activity and PLR, when tested using long pulse...