Winfried Häuser

Winfried Häuser
Klinikum Saarbrücken · Internal Medicine 1

MD

About

650
Publications
287,768
Reads
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21,730
Citations
Introduction
Current research interests: Opioids; cannabis-based medicines; chronic pain; fibromyalgia; irritable bowel syndrome; psychological therapies (hypnosis; internet-based therapies) Methods: Health care services research; systematic reviews with meta-analyses; interdisciplinary and evidence-based guidelines Current projects: Health care services research; systematic reviews with meta-analyses; interdisciplinary and evidence-based guidelines for chronic non-cancer pain, IBS and fibromyalgia syndrome
Additional affiliations
September 2012 - present
Technische Universität München
Position
  • FIbromyalgia syndrome and posttraumatic stress disorder - a multicentre study
January 2011 - December 2012
Technische Universität München
January 2009 - December 2012
University of Duisburg-Essen
Education
October 1976 - October 1982
Universität des Saarlandes
Field of study
  • Medicine, Psychology

Publications

Publications (650)
Article
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Purpose of Review This review will address the many uncertainties surrounding the medical use of cannabidiol (CBD). We will begin with an overview of the legal and commercial environment, examine recent preclinical and clinical evidence on CBD, explore questions concerning CBD raised by healthcare professionals and patients, investigate dosing regi...
Article
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Background and objective: This systematic review evaluated the effectiveness, tolerability and safety of cannabis-based medicines (CbMs) for chronic non-cancer pain (CNCP) in long-term observational studies. Databases and data treatment: CENTRAL, EMBASE and MEDLINE were searched to December 2021. We included prospective observational studies wit...
Chapter
Musculoskeletal pain is the most prevalent pain type occurring in the general population and in the clinical setting. The two most common musculoskeletal pain conditions are: myofascial pain syndrome (MPS), a non‐specific local and regional chronic musculoskeletal pain condition; and fibromyalgia syndrome (FMS), characterized by chronic widespread...
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Background There are no outcome studies for coronavirus disease 2019 (COVID-19) survivors one year after hospital discharge in Germany. Methods This retrospective cohort study included all patients with polymerase chain reaction (PCR)-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hospitalized in the departments of internal...
Article
Background The guideline on fibromyalgia syndrome (FMS), AWMF number 041/004, was updated for the second time in 2017.Methods The guideline was developed by 13 scientific societies and two patient self-help organisations coordinated by the German Pain Society. Eight working groups with a total of 42 members were balanced with regard to sex, level o...
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Background: Subjective cognitive dysfunction (SCD) is common in fibromyalgia (FM), where it has been called 'fibrofog.' But its predictors and correlates are not well understood, including the extent to which SCD is present in fibromyalgia and non-fibromyalgia clinical populations. In addition, there are no studies available concerning SCD and fib...
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Neuropathic pain represents a broad category of pain syndromes that include a wide variety of peripheral and central disorders. The overall prevalence of neuropathic pain in the general population is reported to be between 7 and 10%. Management of neuropathic pain presents an unmet clinical need, with less than 50% of patients achieving substantial...
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Nociplastic pain is defined as pain due to sensitization of the nervous system, without a sufficient underlying anatomical abnormality to explain the severity of pain. Nociplastic pain may be manifest in various organ systems, is often perceived as being more widespread rather than localized and is commonly associated with central nervous system sy...
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This journal recently published a paper by Hjorthoj et al., entitled "Cannabis‐based medicines and medical cannabis for patients with neuropathic pain and other pain disorders: Nationwide register‐based pharmacoepidemiologic comparison with propensity score matched controls“ (Hjorthoj et al., in press). The urgent need to accrue evidence for effect...
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Zusammenfassung Hintergrund Es gibt keine Opioidkrise in Deutschland. Neue Studien mit Nichttumorpatienten mit chronischen Schmerzen (CNTS) in Deutschland zeigen jedoch eine unerwartet hohe Prävalenz von Opioidgebrauchsstörungen nach Diagnostic and Statistical Manual for Psychiatric Diseases 5 (DSM-5). Ziel der Arbeit Kritische Diskussion neuer S...
Article
Background and Aims Progressive legalization and increasing utilization of medical cannabis open up potential new applications, including for inflammatory bowel disease (IBD). This study aimed to collect current figures on the use of and experience with cannabis among IBD patients in Germany. Methods A 71-item questionnaire was mailed to a randomly...
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Background: There is considerable public interest in whether Europe is facing an opioid crisis comparable to the one in the U.S. and the contribution of opioid prescriptions for pain to a potential opioid crisis. Methods: A task force of the European Pain Federation (EFIC) conducted a survey with its national chapter representatives on trends of...
Article
Nociplastic pain is the semantic term suggested by the international community of pain researchers to describe a third category of pain that is mechanistically distinct from nociceptive pain, which is caused by ongoing inflammation and damage of tissues, and neuropathic pain, which is caused by nerve damage. The mechanisms that underlie this type o...
Article
Objectives: Medications have only small to moderate effects on symptoms in fibromyalgia (FM). Cannabinoids, including medical cannabis (MC) may have potential to fill this gap. Since recreational legalisation of cannabis in Canada, patients have easier access and may be self-medicating with cannabis. We have examined the prevalence and characteris...
Article
Objectives: The definition of the 2016 diagnostic criteria of fibromyalgia (FM) syndrome and of FM severities was based on studies with clinical samples. We tested if somatic symptom profiles consistent with the symptom pattern of the FM 2016 diagnostic criteria and of severities of FM can be found in the general population. Methods: Somatic sym...
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Aims The aim of this official guideline published and coordinated by the German Society of Gynaecology and Obstetrics (DGGG) in cooperation with the Austrian Society for Gynaecology and Obstetrics (OEGGG) and the Swiss Society for Gynaecology and Obstetrics (SGGG) was to provide consensus-based recommendations for the diagnosis and treatment of end...
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Background: Opioid use for chronic non-cancer pain (CNCP) is under debate. In the absence of pan-European guidance on this issue, a position paper was commissioned by the European Pain Federation (EFIC). Methods: The clinical practice recommendations were developed by eight scientific societies and one patient self-help organization under the co...
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Background: Opioid use for chronic non-cancer pain (CNCP) is complex. In the absence of pan-European guidance on this issue, a position paper was commissioned by the European Pain Federation (EFIC). Methods: The clinical practice recommendations were developed by eight scientific societies and one patient self-help organization under the coordin...
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Background Findings on the short‐ and long‐term effectiveness of intensive interdisciplinary pain treatment (IIPT) for children with severe chronic functional pain are promising. However, a definitive appraisal of long‐term effectiveness cannot be made due to a lack of comparison groups. The aim of the present study was to compare the health status...
Article
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Background The concept of chronic overlapping pain conditions (COPC) is relatively unknown in German pain medicine.AimsDefinition, prevalence, shared etiological and pathophysiological mechanisms of COPC. Summary of recommendations of the interdisciplinary S2k guidelines on diagnostics and treatment of endometriosis relevant for pain physicians.Met...
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Background: The many risks associated with opioid therapy for chronic noncancer pain (CNCP) have led to questions about use. This is particularly relevant for risk of increased mortality. However, underlying medical conditions of those using opioids may influence mortality findings due to confounding by indication. Similarly, non-opioid analgesics...
Article
Zusammenfassung In der neuen Klassifikation der Krankheiten (ICD-11) der Weltgesundheitsorganisation wurde das FMS – ohne Absprache mit rheumatologischen Fachgesellschaften – aus dem Kapitel „Erkrankungen des muskuloskelettalen System und des Bindegewebes“ entfernt und in ein neu geschaffenes Kapitel „Chronischer Schmerz“ aufgenommen. Pathologische...
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This cross-sectional study aimed to translate, culturally adapt, validate, and apply a Celiac Disease Quality of Life (CD-QoL) questionnaire to a representative sample of Argentina's celiac population. A previously developed and validated questionnaire (Celiac Disease Questionnaire: CDQ) was chosen as a tool for assessing the health-related quality...
Chapter
CED sind keine psychosomatischen Erkrankungen (psychische Faktoren sind Mitursache der Erkrankung) im engeren Sinne. Der Krankheitsverlauf und die Therapie können zu psychischen und sozialen Belastungen der Patienten führen (somatopsychische Erkrankung). Seelische Faktoren (Stress, Depression) können einen ungünstigen Einfluss auf den Krankheitsver...
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The opioid epidemic in North America challenges national guidelines worldwide to define the importance of opioids for the management of chronic noncancer pain (CNCP). Methods: The second update of the German guidelines on long-term opioid therapy for CNCP was developed by 26 scientific associations and 2 patient self-help organizations. A systema...
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Background: Hitherto only studies with selected populations have found an increased all-cause mortality of some selected opioids compared to selected non-opioids for chronic non-cancer pain (CNCP). We have examined the all-cause mortality for CNCP associated with all established opioids compared to non-opioid analgesic therapy (anticonvulsants, an...
Article
Zusammenfassung Die COVID-19-Pandemie ist ein weltweiter Ausbruch von neu aufgetretenen Infektionen mit dem SARS-CoV-2-Virus, von denen weltweit derzeit mehr als 10.670.000 Menschen erkrankt sind bzw. waren. In Deutschland leiden ca. 450.000 Patienten an einer chronisch entzündlichen Darmerkrankung; diese Patienten benötigen in der Regel eine konti...
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Background The second scheduled update of the German S3 guidelines on long-term opioid therapy for chronic noncancer pain (CNCP), the LONTS (AWMF registration number 145/003), was started in December 2018.Methods The guidelines were developed by 28 scientific societies and 2 patient self-help organizations under the coordination of the German Pain...
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Background The update of the German S3 guidelines on long-term opioid therapy of chronic noncancer pain (CNCP), the LONTS (AWMF registration number 145/003), was scheduled for February 2020 due to the expiry of the validity period.Methods The guidelines were updated by 28 scientific societies and 2 patient self-help organizations under the coordina...
Article
Objective To study the prevalence of fibromyalgia in the general population according to the 2016 modification of the American College of Rheumatology (ACR) criteria (FM 2016) and the ACTTION‐APS Pain Taxonomy criteria (AAPT), and to compare diagnostic and clinical variables between the criteria sets. Methods We studied 2,531 randomly selected sub...
Article
Objective To study the prevalence and clinical characteristics of Somatic Symptom Disorder (SSD), Bodily Distress Syndrome (BDS) and fibromyalgia syndrome (FMS) and their overlap in the general German population. Methods A cross-sectional nationally representative population survey was performed. 2531 participants (mean age 48.8 ± 17.85 years, 53....
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Objective Recreational legalization of cannabis may influence the medical use by patients. When only medical access was legally available in Canada, 4.3% of rheumatology patients reported use. With the current recreational legalization, we have reexamined the prevalence and characteristics of medical cannabis use in this same rheumatology setting....
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Objective: To compare the concordance of the three diagnostic criteria, respectively the 2011 ACR criteria (ACR 2011 Cr), the ACR 2016 criteria (ACR 2016 Cr) and the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION)-APS Pain Taxonomy criteria (AAPT Cr), and to explore the performance...
Article
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Cannabidiol (CBD), a major metabolite of Cannabis sativa, is popularized as a medicinal product, with potential for analgesic, anti‐inflammatory and antioxidant effects. CBD may hold promise as a treatment in rheumatic diseases, but evidence to date remains preclinical. Preclinical effects on pain and inflammation is encouraging, but clinical study...
Article
Objective The Bodily Distress Syndrome 25 (BDS 25) checklist is a self-report instrument that can be used for case finding of a BDS in both clinical practice and research. We assessed the reliability and the internal and external validity of the German version of the BDS 25 in a sample of the general German population. Methods The psychometric pro...
Article
Purpose: Studies of the relation of fibromyalgia (FM) and widespread pain (WSP) to mortality have differed as to the presence or absence of an association and the extent of cause-specific mortality. However, no studies have investigated which definitions of FM and WSP associate with mortality, nor of FM mortality in other diseases. We investigated...
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Purpose Interest in cannabinoids as a therapy in rheumatic diseases has grown exponentially. With legalization of medical and recreational cannabis in many jurisdictions worldwide, patients have easier access and opportunity to explore medicinal use. We report on the evidence for effect of cannabinoids in rheumatic diseases and critically address t...
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Background and objective: This updated systematic review evaluated the efficacy, tolerability and safety of opioids compared to placebo in non-malignant chronic low back pain. Databases and data treatment: Clinicaltrials.gov, CENTRAL, MEDLINE and PsycINFO were searched from October 2013 to May 2019. Randomized controlled trials comparing opioids...
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Background and objective: This updated systematic review evaluated the efficacy and safety of opioids compared to placebo for chronic osteoarthritis pain. Databases and data treatment: Clinicaltrials.gov, CENTRAL, MEDLINE and PsycINFO were searched from October 2013 to July 2019. Randomized controlled trials comparing opioids with placebo and at...
Article
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Background and objective: This updated systematic review evaluated the efficacy, tolerability and safety of opioids compared to placebo in chronic non-cancer neuropathic pain. Databases and data treatment: Clinicaltrials.gov, CENTRAL, PubMed, and PsychInfo were searched from October 2013 to June 2019. Randomized controlled trials comparing opioi...
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Background and objective: This updated systematic review evaluated the efficacy, acceptability and safety of long-term opioid therapy (LTOT) for chronic non-cancer pain (CNCP). Databases and data treatment: Clinicaltrials.gov, CENTRAL and MEDLINE were searched to June 2019. We included open-label extension trials with a study duration ≥ 26 weeks...
Article
Background and aims Persons with chronic widespread pain (CWP) have poor medical outcomes and increased mortality. But there are no universally accepted criteria for CWP or of methods to assess it. The most common criteria come from the 1990 American College of Rheumatology (ACR) fibromyalgia (FM) criteria, but that method (WP1990) can identify CWP...
Article
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Medical cannabis is being increasingly used in the treatment of rheumatic diseases because, despite the paucity of evidence regarding its safety and efficacy, a growing number of countries are legalising its use for medical purposes in response to social pressure. Cannabinoids may be useful in the management of rheumatic disorders for two broad rea...
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Since March 2017, the prescription of medical cannabis at the expense of the statutory health insurance is possible after approval by the respective medical services. Chronic pain is the most common indication, as health claims data and the accompanying survey show. From the point of view of the law, a prescription is indicated in cases of serious...
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Erratum zu: Schmerz 2019 10.1007/s00482-019-0383-1 Wir danken einem aufmerksamen Leser, der uns auf zwei Fehler in unserem Beitrag hingewiesen hat. Die Ethikkommission, welche die Studie genehmigt hat, war nicht die Ethikkommission der Universitätskliniken des Saarlandes, sondern die …
Article
Seit der Verabschiedung des Gesetzes vom 06.03.2017 können alle deutschen Ärzte Cannabisblüten sowie cannabisbasierte Rezeptur- und Fertigarzneimittel verschreiben. Spezifische Indikationen für die Verschreibung werden im Gesetz nicht genannt. Die gesetzlichen Krankenkassen übernehmen die Kosten nach Prüfung des Antrags auf Kostenübernahme durch de...
Article
Background: Insufficient data are available on the administrative incidence and prevalence of irritable bowel syndrome (IBS) in Germany, as well as on its comorbidities, diagnostic evaluation, treatment, and costs. Methods: We analyzed routine data from a statutory health insurance carrier with approximately eight million insurees. IBS was ident...
Chapter
Patienten mit chronischen Schmerzen in mehreren Körperregionen sind eine klinische Realität. Die Klassifikation des Beschwerdekomplexes (Rheumatische Erkrankung? Psychische Störung? Chronische Schmerzkrankheit?) ist umstritten.
Chapter
Grundlagenwissenschaftler definieren viszerale Schmerzen als Schmerzen, die von viszeral innervierten Organen des Thorax, Abdomens und Beckens ausgehen. Kliniker sprechen von Brust- (thorakalen), Bauch- (abdominellen) und Unterbauch- sowie Beckenboden- (pelvinen) Schmerzen.