Winfred Mugge

Winfred Mugge
Delft University of Technology | TU · Department of Biomechanical Engineering

PhD

About

47
Publications
8,418
Reads
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482
Citations
Citations since 2016
27 Research Items
284 Citations
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201620172018201920202021202201020304050

Publications

Publications (47)
Conference Paper
Full-text available
Tele-impedance increases interaction performance between a robotic tool and unstructured/unpredictable environments during teleoperation. However, the existing tele-impedance interfaces have several ongoing issues, such as long calibration times and various obstructions for the human operator. In addition, they are all designed to be controlled by...
Article
Tremor is thought to be an effect of oscillatory activity within the sensorimotor network. To date, the underlying pathological brain networks are not fully understood. Disentangling tremor activity from voluntary motor output and sensorimotor feedback systems is challenging. To better understand the intrinsic sensorimotor fingerprint underlying tr...
Chapter
Careful control of joint impedance, or dynamic joint stiffness, is crucial for successful performance of movement. Time-varying system identification (TV-SysID) enables quantification of joint impedance during movement. Several TV-SysID methods exist, but have never been systematically compared. Here, we simulate time-varying joint behavior and pro...
Conference Paper
Motion capture systems are extensively used to track human movement to study healthy and pathological movements, allowing for objective diagnosis and effective therapy of conditions that affect our motor system. Current motion capture systems typically require marker placements which is cumbersome and can lead to contrived movements.Here, we descri...
Article
Accurate and swift tuning of joint impedance is crucial to perform movement and interaction with our environment. Time-varying system identification enables quantification of joint impedance during movement. Many methods have been developed over the years, each with their own mathematical approach and underlying assumptions. Yet, for the identifica...
Article
Objective A major role of the motor cortex in tremor generation in essential tremor (ET) is assumed, yet the directionality of corticomuscular coupling is unknown. Our aim is to clarify the role of the motor cortex. To this end we also study ‘familial cortical myoclonic tremor with epilepsy’ (FCMTE) and slow repetitive voluntary movements with a kn...
Article
Full-text available
Skeletal muscles generate force, enabling movement through a series of fast electromechanical activations coordinated by the central nervous system. Understanding the underlying mechanism of such fast muscle dynamics is essential in neuromuscular diagnostics, rehabilitation medicine and sports biomechanics. The unique combination of electromyograph...
Article
Study design This study is a cross-sectional case-control study. Introduction Sensorimotor control can be disturbed in musculoskeletal disorders due to multiple causes including pain and trauma. There is scarce comprehension about which component of the sensorimotor system would benefit the most from treatment in distal radius fracture (DRF). Pur...
Article
Full-text available
Background: Parkinson's disease (PD) and essential tremor (ET) are neurodegenerative diseases characterized by movement deficits. Especially in PD, maintaining cyclic movement can be significantly disturbed due to pathological changes in the basal ganglia and the cerebellum. Providing external cues improves timing of these movements in PD and also...
Article
Full-text available
There is no objective gold standard to detect tremors. This concerns not only the choice of the algorithm and sensors, but methods are often designed to detect tremors in one specific group of patients during the performance of a specific task. Therefore, the aim of this study is twofold. First, an objective quantitative method to detect tremor win...
Conference Paper
Current methods to track the progression and evaluate treatment of muscular dystrophies are scarce. The electromechanical delay (EMD), defined as the time lag from muscle electrical activity to motion onset, has been proposed as a biomarker, but provides only limited insight in the pathophysiology of muscle function. This work proposes and evaluate...
Conference Paper
Effective treatment of movement disorders requires thorough understanding of human limb control. Joint dynamics can be assessed using robotic manipulators and system identification. Due to tendon compliance, joint angle and muscle length are not proportional. This study uses plane-wave ultrasound imaging to investigate the dynamic relation between...
Article
Full-text available
Background The basal ganglia and cerebellum are brain structures involved in movement initiation, execution and termination. They are thought to be involved in the tremor generation and movement deficits in Parkinson’s disease (PD) and essential tremor (ET). Especially in PD, maintaining cyclic movement, such as walking or tapping can be significan...
Chapter
This paper focuses on the pathophysiology of fixed dystonia (i.e., sustained muscle contractions resulting in abnormal postures) in Complex Regional Pain Syndrome from an engineering point of view. Although the mechanisms are still elusive, the evidence implicating involvement of aberrant muscle force feedback is compelling. A neuromuscular model w...
Chapter
The central nervous system controls body functions and initiates actions through an integrated system of multiple feedback loops. System identification can be a valuable tool to assess the system dynamics. The challenge is to assess the functioning of an intact feedback system in vivo, where cause and effect are intermingled. In this paper we show...
Article
During movements, humans continuously regulate their joint impedance to minimize control effort and optimize performance. Joint impedance describes the relationship between a joint's position and torque acting around the joint. Joint impedance varies with joint angle and muscle activation and differs from trial-to-trial due to inherent variability...
Conference Paper
During movement, our central nervous system (CNS) takes into account the dynamics of our environment to optimally adapt our joint dynamics. In this study we explored the adaptation of shoulder joint dynamics when a participant interacted with a time-varying virtual environment created by a haptic manipulator. Participants performed a position task,...
Conference Paper
The stiffness of an Ankle-Foot-Orthosis (AFO) that aims to assist walking affects the gait biomechanics of patients with impaired gait. In patients with equinus (spastic paresis of the lower leg), impaired gait is a consequence of an increased passive ankle joint stiffness (originated from calf muscles) in combination with reduced active muscle str...
Article
When using an automated system, user trust in the automation is an important factor influencing performance. Prior studies have analyzed trust during supervisory control of automation, and how trust influences reliance: the behavioral correlate of trust. Here, we investigated how reliance on haptic assistance affects performance during shared contr...
Article
The purpose of this study is to develop and validate a human-like steering model that can capture, not only the mean, but also the intradriver variability (IDV) of steering behavior, in both routine and emergency scenarios. The IDV model proposed in this study is based on the assumption that steering behavior, in both scenarios, is governed by the...
Article
Full-text available
In haptic shared control systems (HSC), a fixed strength of guidance force equates to a fixed level of control authority, which can be insufficient for complex tasks. An adaptable control authority based on operator input can allow the HSC system to better assist the operator under varied conditions. In this paper, we experimentally investigate (n...
Article
Full-text available
To effectively interpret and interact with the world, humans weight redundant estimates from different sensory cues to form one coherent, integrated estimate. Recent advancements in physical assistance systems, where guiding forces are computed by an intelligent agent, enable the presentation of augmented cues. It is unknown, however, if cue weight...
Article
Full-text available
When subjects reach for a visual target with their unseen hand, they make systematic errors (visuo-haptic matching errors). Visuo-haptic matching errors are idiosyncratic and consistent over time. Therefore, it might be useful to compensate for these subject-specific matching errors in the design of haptic guidance to make the guidance perceptually...
Article
Full-text available
Humans make both random and systematic errors when reproducing learned movements. Intuitive haptic guidance that assists one to make the movements reduces such errors. Our study examined whether any additional haptic information about the location of the target reduces errors in a position reproduction task, or whether the haptic guidance needs to...
Article
Dedicated pairs of isometric wrist flexion tasks, with and without visual feedback of the exerted torque, were designed to target activation of the CBL and BG in healthy subjects during functional magnetic resonance imaging (fMRI). Selective activation of the cerebellum (CBL) and basal ganglia (BG), often implicated in movement disorders such as tr...
Article
When reproducing a previously perceived force or position humans make systematic errors. This study determined the effect of force level on force and position reproduction, when both target and reproduction force are self-generated with the same hand. Subjects performed force reproduction tasks at different force levels, against a fixed handle, and...
Article
Full-text available
In a previous study, we found the perception of force magnitude to be anisotropic in the horizontal plane. In the current study, we investigated this anisotropy in three dimensional space. In addition, we tested our previous hypothesis that the perceptual anisotropy was directly related to anisotropies in arm dynamics. In experiment 1, static force...
Article
Full-text available
In an admittance-controlled haptic device, input forces are used to calculate the movement of the device. Although developers try to minimize delays, there will always be delays between the applied force and the corresponding movement in such systems, which might affect what the user of the device perceives. In this experiment we tested whether the...
Article
Complex Regional Pain Syndrome (CRPS) is a multifactorial disorder associated with an aberrant host response to tissue injury. About 25% of CRPS-patients suffer poorly understood involuntary sustained muscle contractions associated with dysfunctional reflexes that result in abnormal postures (fixed dystonia). A recent modeling study simulated fixed...
Conference Paper
Full-text available
Haptic guidance systems can support the operator in task execution using additional forces on the input device. Scaling of the guidance forces determines the control authority of the support system. As task complexity may vary, one level of the guidance scaling may be insufficient, and adaptation of the control authority may be helpful. The availab...
Conference Paper
For optimal haptic tele-manipulation system design, it is important to understand the accuracy and limitations of human force perception. Previous research demonstrated that humans generate higher forces when asked to reproduce an externally applied force; these studies proposed that the nervous system attenuates feedback from self-generated forces...
Article
Full-text available
Complex regional pain syndrome (CRPS) is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25% of cases develop fixed dystonia. The origin of this movement disorder is poorly understood, although recent insights suggest involvement of disturbed force feedback. Assessment of sensorimotor integrat...
Article
Motor control tasks like stance or object handling require sensory feedback from proprioception, vision and touch. The distinction between tactile and proprioceptive sensors is not frequently made in dynamic motor control tasks, and if so, mostly based on signal latency. We previously found that force control tasks entail more compliant behavior th...
Article
Humans control their movements using adaptive proprioceptive feedback from muscle afferents. The interaction between proprioceptive reflexes and biomechanical properties of the limb is essential in understanding the etiology of movement disorders. A non-linear neuromuscular model of the wrist incorporating muscle dynamics and neural control was dev...
Article
To evaluate if hyperreflexia (exaggerated reflexes) due to disinhibition is associated with dystonia in Complex Regional Pain Syndrome (CRPS). Stretch reflexes at the wrist were assessed in healthy controls (n=10) and CRPS-patients with dystonia (n=10). Subjects exerted a wrist flexion torque of 5% of maximum voluntary contraction torque (T(MVC)) t...
Article
Full-text available
Complex regional pain syndrome (CRPS) may occur after trauma, usually to one limb, and is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25% of cases develop fixed dystonia. Involvement of dysfunctional GABAergic interneurons has been suggested, however the mechanisms that underpin fixed dyst...
Article
Full-text available
This study aims to quantify the separate contributions of muscle force feedback, muscle spindle activity and co-contraction to the performance of voluntary tasks ("reduce the influence of perturbations on maintained force or position"). Most human motion control studies either isolate only one contributor, or assume that relevant reflexive feedback...
Article
In daily life humans integrate force and position feedback from mechanoreceptors, proprioception, and vision. With handling relatively soft, elastic objects, force and position are related and can be integrated to improve the accuracy of an estimate of either one. Sensory weighting between different sensory systems (e.g., vision and proprioception)...
Article
The dynamic behavior of a neuromusculoskeletal system results from the complex mechanical interaction between muscle visco-elasticity resulting from (co-)contraction and afferent feedback from muscle spindles and Golgi tendon organs. As a result of the multiple interactions the individual effect of each of the structures to the overall dynamics is...
Conference Paper
Many human motion control studies use system identification methods to estimate the human admittance (the frequency response function from force to position). Admittance was found to be affected by task instruction, environmental properties and perturbation properties. From literature it is known the frequency content (bandwidth) of the perturbatio...
Article
Laparoscopic graspers used for manipulating delicate tissue generally possess jaws with fenestrations (windows). The fenestrations should enhance the grip on the tissue; however, fenestrations reduce the contact area between jaws and tissue, leading to higher local pressures and possibly tissue damage. Experiments were performed to determine the ef...
Article
Complex Regional Pain Syndrome (CRPS) is a disabling syndrome associated with sensory (e.g., burning pain, allodynia, hyperalgesia), autonomic (e.g., edema, skin color and temperature changes), and motor impairments (e.g., tremor, myoclonus, dystonia). Approximately 25% of the patients with CRPS develop fixed dystonia which is characterized by abno...

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Projects (5)
Project
IMDI NeuroControl is Centre of Research Excellence focusing on development of innovative tools for treatment and prevention of disabilities caused by neurological diseases.