Wim van den Brink

Academisch Medisch Centrum Universiteit van Amsterdam | AMC · Department of Psychiatry

The purposes of this study were to (1) characterize the social disability associated with the common psychiatric illnesses of primary care patients in terms of role dysfunction (self-care, family role, social role, occupational role) and (2) establish whether severity of psychiatric illness and disability level show synchrony of change. A two-stage...

This report examines the prevalence of personality disorders among hospitalized alcoholics and polydrug addicts and the extent and nature of the overlap between different axis II disorders. Subjects were 178 alcoholics admitted to a diagnostic unit of an addiction treatment institute and 86 polydrug addicts admitted to the therapeutic community of...

Synopsis The question of the relationship between anxiety and depression remains to be solved. The fact that clinical pictures show substantial overlap makes it difficult, using conventional instruments, to distinguish between the co-occurrence of anxiety and depression and overlap in definitions and measurement of the two syndromes. This calls for...

This study compares the screening capacity of an age-adjusted child-oriented questionnaire, the Young Adult Self Report (YASR) with two adult-oriented questionnaires, the General Health Questionnaire-28 (GHQ-28) and Symptom Checklist-90 (SCL-90) in a sample of young adults (18-25 years). The YASR performed just as well as the SCL-90 and both perfor...

This article addresses the issues of recognition of psychiatric disorders by general physicians (GPs) and the effects of recognition on management and course. Among 1994 patients who were screened with the General Health Questionnaire and who were rated by their GP, 1450 (72.7%) had not been identified by the GP as having a psychiatric disorder in...

This study examines the scientific basis for mental health intervention programs in primary care. The validity of five underlying assumptions is evaluated, using the results of a naturalistic study covering a representative sample of 25 Dutch family practices and data from the literature. Our findings corroborate the validity of the assumptions. Fi...

Synopsis This article addresses the issues of recognition and labelling of psychological disorders (PDs) by general practitioners (GPs), and he association of recognition with management and outcome. Nearly 2000 attenders of 25 GPs were screened with the GHQ and a stratified sample of 296 patients was examined twice, using the Present State Examina...

We have investigated the effects of sulfated chitin derivatives and heparin on the invasion of B16-BL6 melanoma cells through reconstituted basement membrane Matrigel which contains laminin, type IV collagen, heparan sulfate proteoglycan, and entactin. 6-O-sulfated chitin (S-chitin) and 6-O-sulfated and carboxymethyl chitin (SCM-chitin) significant...

Synposis Substantial cross-sectional correlations have been reported between the GHQ and PSE (and CIS) total scores. Although necessary, this is not a sufficient condition for assuming good validity of the GHQ as a severity measure in longitudinal and health care evaluation studies. For this purpose the GHQ should also accurately reflect changes in...

The available evidence suggests that the GHQ is a valid case-finding and screening instrument and a reasonable measure of severity of functional non-psychotic psychopathology. However, recently Henderson et al. (1981) have demonstrated a substantial retest effect for the GHQ, which may affect its usefulness in longitudinal population and outcome st...

The sensitivity of the GHQ and a revised scoring procedure (CGHQ) for chronic psychiatric complaints was investigated on 175 out-patients. The mean level of severity of symptoms of the groups with and without chronic complaints was not significantly different. However, patients with chronic complaints showed a significantly lower mean GHQ score tha...

Two diagnostic systems are compared in a psychiatric outpatient population of 175 patients. The Present State Examination (PSE)-Catego system identified 121 patients (69%) as "cases," whereas DSM-III identified 152 patients (87%) as cases. The two systems converged in 115 patients, yielding a kappa coefficient of only .32. Approximately one third o...

• Two diagnostic systems are compared in a psychiatric outpatient population of 175 patients. The Present State Examination (PSE)—Catego system identified 121 patients (69%) as "cases," whereas DSM-III identified 152 patients (87%) as cases. The two systems converged in 115 patients, yielding a K coefficient of only.32. Approximately one third of t...

In the past research has been done on cooperative systems resulting in, among others, the CALM architecture which is used in NextGenITS. The project focuses on the scalability issues of routing protocols and energy optimizations for cooperative vehicular ad hoc network (VANET) systems. The resulting solutions will be simulated using TraNS and Nscli...

High doses of pharmaceutical graded heroin in combination with methadone are prescribed nowadays in a Dutch trial with methadone treatment refractory heroin addicts. Heroin is prescribed either through intravenous injection or inhalation. One of the major risks of using opioids is ventilatory depression. In this study, the effect of heroin on oxyge...

ñ Introduction. The objective of the study was to investigate the knowledge, opinions and attitudes of Hungarian psychiatrists about drug addicts and their treatment. Methods. A total of 118 psychiatrists (40% male, average age 44.4 years) were administered an anonymous questionnaire in 2001. Results. Two thirds of the surveyed professionals (68%)...

Objective: To examine the diagnostic accuracy of the four-item self-report and parent- report versions of the CAGE-AID as a screen for substance-use disorders (SUD) among adolescents in mental health care. Method: Patients were 190 Dutch treatment-seeking adolescents (12-18 years old, mean age 15.5 years, 53% boys) and their parents who completed t...

To explore the relationship between major depression and quality of life and resource use among primary care patients, a multi-centre, cross-cultural study was started in 1998. In this study - the Longitudinal Investigation of Depression Outcomes (LIDO) - respondents from sites in Israel, Spain, Russian Federation, Brazil, Australia and United Stat...

This systematic review summarises evidence of the effectiveness of naltrexone (NTX) and the added value of psychosocial treatment in the maintenance treatment of opioid and alcohol dependence. Studies were selected through a literature search conducted in March 2004. Seven opioid and seventeen alcohol studies were identified. When possible, meta-(r...

Background: There is increasing interest in naltrexone, an opiate antagonist, in the treatment of opiate addicts. The effects of naltrexone are often compromised by a lack of compliance and drop-out. The effects of this compound are probably more favorable when combined with a psychosocial intervention such as the Community Reinforcement Approach (...