Wim Teughels

Wim Teughels
KU Leuven | ku leuven · Department of Oral Health Sciences

DDS, Periodontology, PhD

About

236
Publications
79,972
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9,622
Citations
Additional affiliations
October 2010 - present
KU Leuven
Position
  • Professor (Associate)

Publications

Publications (236)
Article
Objective: The objective of this review was to assess the accuracy of available means of determining the BBT (buccal bone thickness) and/or BBL (buccal bone level). This was translated into the following research question: What is the accuracy of the available means of visualizing the BBP (buccal bone plate) to establish the BBT and/or the BBL, wh...
Poster
Dental biofilms are the main etiological factor for many oral diseases. They encompass commensal bacteria and pathobionts, which normally cohabitate the oral niches in symbiosis, causing no harm to the host. However, intra-oral environmental changes can induce dysbiosis, with an increase in pathobiont abundance in biofilms. Managing dysbiotic biofi...
Preprint
Antiseptics are widely used in oral healthcare to prevent or treat oral diseases, such as gingivitis and periodontitis. However, the incidence of bacteria being tolerant to standard antiseptics has sharply increased over the last few years. This stresses the urgency for surveillance against tolerant organisms, as well as the discovery of novel anti...
Article
Full-text available
The aim of this study was to evaluate the effect of local and systemic administration of antimicrobials to leukocyte- and platelet-rich fibrin (L-PRF). For part A, 16 tubes of venous blood were collected from each of eight systemically healthy subjects. Prior to blood centrifugation, 12 of the 16 tubes were injected with 0.125 ml, 0.25 ml or 0.50 m...
Article
Full-text available
Background Periodontitis is a chronic inflammatory gum disease associated with systemic diseases such as cardiovascular diseases. Aim To investigate the association of systemic blood biomarkers, C-reactive protein (CRP), levels of lipopolysaccharide (LPS), and IgG levels against periodontal pathogens Aggregatibacter actinomycetemcomitans (Aa) and...
Article
Full-text available
Peri-implantitis (PI) is a relatively frequent pathology that compromises the overall survival of the dental implant. Adjunctive approaches for the conventional mechanical debridement are being suggested to optimize the treatment of PI. The goal of the study was the assessment of the disinfection potential of the Q-Switch Nd: YAG laser on contamina...
Article
Full-text available
Peri‐implant diseases are one of the main causes of dental implant failure. New strategies for dental implants manufacturing have been developed to prevent the accumulation of bacteria and related inflammatory reactions. The main aim of this work was to develop laser‐treated titanium surfaces covered with silver that generate a electrical dipole to...
Article
Full-text available
Leucocyte- and platelet rich fibrin (L-PRF) is an autologous biomaterial used in regenerative procedures. It has an antimicrobial activity against P. gingivalis although the mechanism is not fully understood. It was hypothesized that L-PRF exudate releases hydrogen peroxide and antimicrobial peptides that inhibit P. gingivalis growth. Agar plate an...
Article
Full-text available
Background Choline-stabilized orthosilicic acid (CS-OSA) was previously found to stimulate bone collagen formation in osteopenia and to improve biomarkers of cartilage degradation in knee osteoarthritis. The aim of the present study was to investigate the effect of oral administration of CS-OSA on clinical symptoms of peri-implantitis and the assoc...
Article
Objective Chlorhexidine mouthrinses are marketed in different formulations. This study aimed at investigating qualitative and quantitative changes in in-vitro multispecies oral biofilms, induced by different chlorhexidine-containing mouthrinses. Background data Earlier studies comparing chlorhexidine mouthrinses are either clinical studies or in-v...
Article
Aim: The aim of this non-randomized, multicenter controlled clinical trial was to evaluate the impact of leukocyte and platelet rich fibrin (LPRF) on regenerative endodontic procedures (REP) of immature permanent teeth in terms of peri-apical bone healing (PBH) and further root development (RD). Methodology: Healthy patients between 6-25 years w...
Article
Full-text available
Previous research identified potential prebiotic substrates for oral health like the structural analogues N-acetyl-d-mannosamine (NADM) and N-acetyl-d-glucosamine (NADG). The main hypothesis of the current study was twofold. Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm com...
Preprint
Full-text available
Modulation of the commensal oral microbiota is a promising preventive or therapeutic strategy for oral health and can for instance be achieved by increasing the abundance and/or activity of certain species. This study evaluated whether 10 selected substrates could modulate in vitro multi-species oral biofilms towards a more health-associated state....
Article
Full-text available
Background: Modulation of the commensal oral microbiota constitutes a promising preventive/therapeutic approach in oral healthcare. The use of prebiotics for maintaining/restoring the health-associated homeostasis of the oral microbiota has become an important research topic. Aims: This study hypothesised that in vitro 14-species oral biofilms can...
Article
Full-text available
Background The association of scaling and root planing (SRP) with systemic metronidazole (MTZ) plus amoxicillin (AMX) has shown to be an effective treatment protocol, particularly for periodontitis stages III and IV, generalized. More recently, probiotics have also been suggested as a promising adjunctive treatment for periodontal diseases due to t...
Article
Full-text available
Objective This integrative review aimed to report the toxic effect of submicron and nano-scale commercially pure titanium (cp Ti) debris on cells of peri-implant tissues. Materials and methods A systematic search was carried out on the PubMed electronic platform using the following key terms: Ti “OR” titanium “AND” dental implants “AND” nanopartic...
Article
Full-text available
Recently, new centrifugation protocols for the preparation of platelet-rich fibrin (PRF) have been introduced in an attempt to further improve the beneficial impact of these 2nd generation platelet concentrate membranes. This in-vitro study aimed to compare the biological and physical characteristics of three types of PRF membranes using two differ...
Article
Background: A large number of clinicians reuse healing abutments to decrease treatment costs although it can promote infection due to the presence of remnant biofilm biomass. Objective: The purpose of this study was to evaluate the sterilization effectiveness against biofilms on retrieved healing abutments used in implant dentistry. Methods: One hu...
Article
Full-text available
This work highlights the issue of interference by growth media when measuring bacterial H2O2 production. H2O2 was shown to be stable in phosphate buffered saline (PBS) but not in growth media. The protocol used for evaluating the intrinsic capacity of oral streptococci to produce H2O2 was shown to be reliable.
Article
The development of viability qPCR (v-qPCR) has allowed for a more accurate assessment of the viability of a microbial sample by limiting the amplification of DNA from dead cells. Although valuable, v-qPCR is not infallible. One of the most limiting factors for accurate live/dead distinction is the length of the qPCR amplicon used. However, no conse...
Article
Full-text available
Oral diseases (e.g., dental caries, periodontitis) are developed when the healthy oral microbiome is imbalanced allowing the increase of pathobiont strains. Common practice to prevent or treat such diseases is the use of antiseptics, like chlorhexidine. However, the impact of these antiseptics on the composition and metabolic activity of the oral m...
Article
Focused question: Is there a role for alternative therapies in controlling intra-oral halitosis? Treatments other than tongue cleaning and anti-halitosis products containing zinc, chlorhexidine and cetylpyridinium chloride were considered as alternative therapies. Materials and methods: Four databases were searched (PubMed, EMBASE, Web of Scienc...
Article
Full-text available
There is increasing public interest in natural or herbal‐based healthcare products. This trend is not only visible in supermarkets and dental practices, but also in the scientific world. An improving number of clinical trials are being conducted to validate the claims made about these products in regards to periodontal health. Among single componen...
Article
Full-text available
This study aimed to assess the dosage and types of antibiotics prescribed in oral implant surgery, compare them among the different subpopulations (country and prescription regimens) and against the evidence-based recommended dosage: a 2-gram single preoperative dose of amoxicillin. A meta-analysis of cross-sectional surveys was conducted, which re...
Article
Full-text available
Objectives Already decades ago, the diagnosis of halitosis was facilitated with the arrival of chair-side instruments to score the breath odor. These devices are used for a more objective assessment of halitosis compared with organoleptic scoring, but these too have their disadvantages. To overcome some of the drawbacks of the original model of the...
Article
Purpose: The aim of this study was to evaluate the influence of different density and amplitude of electric current on the percentage of bone-implant contact (BIC) using the finite element method. Materials and Methods: Numerical models were performed on commercially pure titanium grade IV implants connected to a 1.5 V battery with an electrical r...
Preprint
Full-text available
Background: The association of scaling and root planing (SRP) with systemic metronidazole (MTZ) plus amoxicillin (AMX) has shown to be an effective treatment protocol, particularly for Periodontitis Stages III and IV, generalized. More recently, probiotics have also been suggested as a promising adjunctive treatment for periodontal diseases due to...
Article
Background: Periodontitis is a chronic inflammatory disease characterized by gram-negative bacteria responsible of the degradation of tissues surrounding tooth. Moreover, periopathogens can invade the bloodstream, made dissemination and promote cardiovascular disease, such as the link between Porphyromonas gingivalis and atherosclerosis. The aim o...
Article
Aim: The aim of this retrospective radiographic study in Flemish children was to examine the bone level and bone loss around deciduous molars and factors influencing this. Materials and methods: 2896 digital intra-oral radiographs of children younger than 18 years old were screened for eligibility. The distance from the cementoenamel junction to...
Article
Full-text available
Objectives The objectives of this cross-sectional survey were to determine the prevalence of secondary caries (SC) in general population, to identify patient- and material-related factors which may affect the prevalence, and to describe some clinical characteristics of SC lesions. Materials and methods A total of 4036 restorations in 450 patients,...
Article
Aim: To answer the following PICOS questions: in patients with periodontitis, which is the efficacy of adjunctive systemic antimicrobials, in comparison with subgingival debridement plus a placebo, in terms of probing pocket depth (PPD) reduction, in randomized clinical trials with at least 6 months of follow-up. Material and methods: A systemat...
Article
Aim: To answer the following PICOS question: in adult patients with periodontitis, which is the efficacy of adjunctive locally delivered antimicrobials, in comparison with subgingival debridement alone or plus a placebo, in terms of probing pocket depth (PPD) reduction, in randomized clinical trials with at least 6 months of follow-up. Material a...
Article
Objectives: Examine the clinical and microbiological benefits of a dual-strain Lactobacillus reuteri probiotic on the non-surgical therapy of initial peri-implantitis. Materials and methods: This randomized, double-blind study targeted patients with initial peri-implantitis, i.e. peri-implantitis with a maximum mean probing pocket depth of 6mm a...
Article
Full-text available
Peri‐implantitis can be explained using a multicausality model. Many factors are involved in the etiology of peri‐implantitis, but patient compliance also plays a key role. Oral hygiene, attending recall visits, smoking behavior, and therapy comprehension are relevant factors that contribute to peri‐implant health. The clinician should create the m...
Article
Full-text available
Peri-implantitis (PI) is an inflammatory disease of peri-implant tissues, it represents the most frequent complication of dental implants. Evidence revealed that microorganisms play the chief role in causing PI. The purpose of our study is to evaluate the cleaning of contaminated dental implant surfaces by means of the Q-switch Nd:YAG (Neodymium-do...
Article
Aim: The aim of the study was to evaluate whether the use of a xenograft is not inferior to the use of xenograft and autogenous bone chips in treating dehiscences at implant placement. Materials & methods: After implant placement, leaving a dehiscence, control sites were treated using a composite graft (autogenous bone chips and xenograft) and a...
Article
Full-text available
Aim: Examine the adjunctive effect of a Lactobacillus reuteri probiotic (ATCC PTA 5289 & DSM 17938) on the re-instrumentation of residual pockets. Materials and methods: This randomized, double-blind, placebo controlled study included 39 previously non-surgically treated periodontitis patients. A re-instrumentation was carried out and probiotic...
Article
The main aim of this study was to perform a scoping review on the titanium electric stimuli approach to inhibit biofilm accumulation. An electronic search was conducted using key terms related to the incorporation of metal particles on the titanium surface for antibacterial purposes. The search identified 163 studies, of which 37 were considered re...
Article
Objective: The ESCAPE multicentre survey was designed to (1) compare the agreement of three relevant aesthetic scoring systems among different centres, and (2) evaluate the reproducibility of each question of the questionnaires. Materials and methods: EFP centres (n=14) were involved in an e-survey. Forty-two participants (28 teachers, 14 postgr...
Article
The aim of this study was to investigate the cytotoxic activity and inhibitory effect of terpinen-4-ol (T4ol) and carvacrol against single- and multi-species biofilms. The toxicity of each compound was tested on oral keratinocytes and evaluated by XTT assay. Inhibition and eradication of single-species biofilms were analyzed by crystal violet assay...
Article
Purpose: The leukocyte- and platelet-rich fibrin block (L-PRF block) is a composite graft that combines a xenograft that is acting as a scaffold with L-PRF membranes that serve as a bioactive nodule with osteoinductive capacity. This study evaluated the properties of the L-PRF block and its components in terms of release of growth factors, cellula...
Article
Full-text available
There is evidence that pathogenic bacteria can adapt to antiseptics upon repeated exposure. More alarming is the concomitant increase in antibiotic resistance that has been described for some pathogens. Unfortunately, effects of adaptation and cross-adaptation are hardly known for oral pathogens, which are very frequently exposed to antiseptics. Th...
Article
Full-text available
Various studies have described the biological properties of the Leucocyte- and Platelet Rich Fibrin (L-PRF) such as the antimicrobial effect against wound bacteria, but less is known about the effect against periodontal pathogens. The aim of this study was to evaluate the antibacterial properties of the L-PRF membrane and L-PRF exudate against the...
Article
Purpose: Sinus floor elevation (SFE) and simultaneous implant placement is predictable and reproducible. However, the graft material for the antral cavity remains a topic of debate. Considering the high osteogenic potential of the sinus membrane, most graft materials are generally accepted. This study aimed to assess the outcome of simultaneous SF...
Article
Statement of problem: Implant-based prosthetic solutions can be time consuming. If implants can be placed successfully with a guide, surgery time can be reduced. Purpose: The purpose of this randomized controlled clinical trial was to assess implant outcomes, both clinical and radiological, comparing guided with nonguided implant placement after...
Article
Oral biofilms form on all hard and soft surfaces of the oral cavity. When the microbial balance in this biofilm is disturbed, pathogens can take the overhand, and this can lead to periodontitis (i.e. a chronic and inflammatory disease of the gum and tooth supporting tissues). In this work, a dual species community model containing one commensal bac...
Article
There is some evidence that periodontitis increases the risk of atherothrombosis. Abdominal aortic aneurysm (AAA) is a cardiovascular disease with specific risk factors and physiopathological mechanisms that can lead to rupture in the absence of treatment. The aim of the present systematic review was to explore the influence of periodontitis on the...
Article
The aim of this study was to evaluate surface changes on dental implant systems and ions release after immersion in fluoride and hydrogen peroxide. Ten implant‐abutment assemblies were embedded in acrylic resin and cross‐sectioned along the implant vertical axis. Samples were wet ground and polished. Delimited areas of groups of samples were immers...
Article
Aim: To examine an organoleptic scoring method (OLS) whereby the sample is collected by negative pressure in a syringe and is subsequently smelled and rated away from the patient. Materials and methods: Data of 476 patients visiting a specialized halitosis clinic in Leuven (Belgium) after the introduction of this new method were reviewed retrosp...
Article
The aim of this study was to conduct a literature review on the potential benefits of custom‐made root‐analogue zirconia implants. A PubMed and ScienceDirect bibliographical search was carried out from 1969 up to 2017. The increased interest in zirconia‐based dental structures linked to aesthetic and biological outcomes have been reported in litera...
Article
Recent research clearly indicates that wound heal- ing in both soft and hard tissue can be significantly enhanced by L-PRF (leukocyte- and platelet-rich fibrin). This second generation of platelet concentrates may even have the potential to replace substitutes like growth factors and biomaterials in many situations. A further benefit is its easy an...
Article
Background This study aims to evaluate the use of the leukocyte‐ and platelet‐rich fibrin (L‐PRF) membranes in increasing the width of the keratinized mucosa (KM) around implants. Material and methods Eight patients in need for bilateral widening of the KM around implants in the lower jaw were recruited for a spit‐mouth randomized controlled trial...
Article
Full-text available
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium...
Technical Report
Favourable wound healing has always been a major quest in dental surgery. It is a concern in healthy as well as compromised patients. In an effort to improve and accelerate healing of both hard- and soft-tissues, sub- stitutes including growth factors and biomaterials have been traditionally employed. Membranes were also intro- duced to separate ti...
Article
Aim To compare the clinical and microbiological performance of minimally and moderately rough implants in patients with a history of severe periodontitis. Material and methods Forty‐eight minimally (Tur) and moderately (TiU) rough implants were placed in eighteen patients according to a split‐mouth protocol. Marginal bone loss, probing pocket dept...