Wilson Ehidiamen Sadoh

Wilson Ehidiamen Sadoh
University of Benin · Department of Child Health

MB.BS, MPH, FWACP, FACC

About

102
Publications
34,058
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,280
Citations
Citations since 2016
36 Research Items
938 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Additional affiliations
September 2005 - present
University of Benin Teaching Hospital
Position
  • Head, Pediatric Cardiology Unit
April 2004 - December 2015
University of Benin
Position
  • Head, Paediatric Cardiology Unit

Publications

Publications (102)
Article
Background: Circulatory failure (shock) is a life-threatening emergency referring to a state of poor tissue perfusion and resultant anaerobic respiration at a cellular level. It is a common pathway for several severe pediatric morbidities. Aim: We evaluated the clinical predictors of shock and coexisting morbidities in acutely-ill children. Pat...
Article
Background: Congenital heart diseases (CHD) are the most important congenital anomaly. The burden and types are important for health planning and preparation for surgery. This study was conducted to determine the prevalence, anatomic types and defect sizes of the CHDs seen in a tertiary hospital. Methods: A retrospective review of echocardiograp...
Article
Full-text available
Introduction: circulatory failure is a major childhood emergency. Several disease-related and patient-related factors can predispose children to shock. Early detection of such factors will improve its prevention, management and outcome. This study aimed to evaluate the incidence, socio-demographic characteristics and pre-hospital care of children...
Article
Introduction: Glutathione is a powerful naturally occurring anti-oxidant in the human body and is important in immunological response to infection. Glutathione depletion may play a pivotal role in the pathogenesis and progression of HIV disease. This study was done to compare plasma glutathione levels between HIV infected and uninfected children,...
Article
Full-text available
Background: Congenital heart disease (CHD) is an important cause of childhood morbidity. The birth prevalence and distribution of CHD among neonates in a tertiary hospital in Nigeria was determined. Methods: This descriptive, cross-sectional study involved consecutive neonates in the neonatal and postnatal wards of the hospital. Bedside echocardiog...
Article
Background The European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration (FHSC) global registry provides a platform for the global surveillance of familial hypercholesterolaemia through harmonisation and pooling of multinational data. In this study, we aimed to characterise the adult population with heterozygous familial...
Article
Full-text available
Background: Congenital heart disease (CHD) is an important cause of childhood morbidity. The birth prevalence and distribution of CHD among neonates in a tertiary hospital in Nigeria was determined. Methods: This descriptive, cross-sectional study involved consecutive neonates in the neonatal and postnatal wards of the hospital. Bedside echocard...
Article
Background: Human immunodeficiency virus (HIV) infection is a global pandemic affecting mostly sub-Saharan Africa. It is a multisystem disease. Cardiovascular involvement detected by electrocardiogram (ECG) has been described mostly in adult populations with few studies on children. In this study, the ECG findings of HIV-infected as against HIV-un...
Article
Full-text available
Background: Childhood hypertension is a public health concern because of associated cardio-metabolic morbidities in adulthood. Overweight and obesity are main drivers and predictors of childhood hypertension. There is paucity of studies on waist circumference (WC) and waist-hip ratio (WHR) – measures of central obesity - as predictors of hypertensi...
Article
Background CHDs can be complicated by renal injury which worsens morbidity and mortality. Urinary neutrophil gelatinase-associated lipocalin, a sensitive and specific biomarker of renal tubular injury, has not been studied in children with uncorrected CHDs. This study evaluated renal injury in children with uncorrected CHDs using this biomarker. M...
Article
Full-text available
Keywords: Adolescence, non-high-density lipoprotein cholesterol, obesity, overweight, Nigeria. Correspondence: e-mail< alpndiony@yahoo.com>. Background/Aim: Non-high-density lipoprotein cholesterol (non-HDL-C) concentration include both cholesterol-rich and triglycerides-rich atherogenic apolipoprotein B-containing lipoproteins. The present study d...
Article
Background: Rheumatic Heart Disease (RHD) is a major form of acquired heart disease amongst children in developing countries, where it continues to be a cause of childhood morbidity and mortality. Objective: To describe the prevalence and spectrum of valvular affectation in children with RHD from the echocardiography laboratory. Methods: The record...
Article
Full-text available
Background: Pneumonia in children is a leading cause of morbidity and mortality in developing countries. It is often complicated by Congestive Cardiac Failure (CCF), with some of the symptoms similar to those of pneumonia. Brain Natriuretic Peptide (BNP) assay can differentiate cardiac from respiratory-related causes of respiratory distress. Object...
Article
Background and aims: Management of familial hypercholesterolaemia (FH) may vary across different settings due to factors related to population characteristics, practice, resources and/or policies. We conducted a survey among the worldwide network of EAS FHSC Lead Investigators to provide an overview of FH status in different countries. Methods:...
Article
Full-text available
Background: Supraventricular tachycardia (SVT) is the commonest arrhythmias in children. Prompt and appropriate treatment with adenosine and other medicines can be lifesaving. Objectives: To determine the prevalence, management and outcome of children with SVT in an emergency room in a tertiary centre in Nigeria. Method: This prospective, cross sec...
Article
Full-text available
Background: Down syndrome (DS) is a common chromosomal disorder associated with congenital heart disease (CHD) which could lead to severe morbidity or mortality. Objective: To determine the frequency and spectrum of clinical features, CHD and other comorbidities in children with DS in a tertiary care centre in Nigeria. Method: Consecutive children...
Article
Objective: The aim of this study was to evaluate the predictors of mortality in childhood heart failure (HF) in 2 tertiary hospitals. Methods: A 51-month retrospective review of case notes of children with HF admitted into children's emergency rooms of 2 tertiary centers in Southern Nigeria was done. Bio-data and certain sociodemographic variabl...
Article
Full-text available
Situs inversus totalis (SIT) is a rare anomaly in which there is a reversal of abdominal and thoracic organs. The condition may come to light when affected patients who uncommonly have congenital heart disease (CHD), manifest with one. A case of a 10 year old boy with SIT and tetralogy of Fallot (TOF) that was complicated with cerebral abscess is p...
Article
Full-text available
Background: Congenital heart defects (CHDs) are common birth defects with significant impact on morbidity and mortality. We aimed to compare regional patterns of CHDs in Nigeria using a registry-based approach. Methods: Children with echocardiography-confirmed CHDs at 17 medical centers across the country were enrolled in a pilot National Pediat...
Article
Full-text available
Background: The plasma levels of amino terminal pro-B type natriuretic peptide (NT-proBNP) have been found to be useful in evaluating children with heart failure in developed countries where the cause is mainly structural heart lesions. There is paucity of similar studies from developing countries where the causes are mostly of infectious origin....
Article
Background: Overweight and obesity in children, and adolescents is on the rise globally. Affected children are prone to cardio-metabolic problems later in life, especially hypertension. The prevalence of obesity/overweight may differ depending on school type. Private schools are attended mostly by children of the affluent, while public schools are...
Article
Introduction: Adverse events following immunization (AEFI) may follow the use of any vaccine. There is thus a need for documentation of the types and prevalence of AEFIs for each vaccine and early identification of new events or those occurring at rates higher than expected. When one vaccine replaces another, it is important to document the safety...
Article
Full-text available
Background The level of BNP is usually used as a guide to heart failure. However, there is need for the level of this peptide to be known in non-cardiac conditions that may cause inflammation and hypoxia. Aims To determine socio-demographic determinants of BNP in children with pneumonia. To determine the socio-economic determinants of BNP in childr...
Article
Full-text available
Background: Lack of physical activity contributes to overweight and obesity. It is recommended that children accumulate at least one hour of moderate to vigorous intensity physical activity daily. Objective: The level of physical activity, body mass index (BMI) and blood pressure (BP) were evaluated in pupils attending private primary schools....
Article
Full-text available
Aim: To determine the electrocardiography (ECG) and echocardiography findings in adolescent school children. Study Design: A cross sectional descriptive study. Place and Duration of Study: Selected secondary school in Benin City, Nigeria. The study was conducted between May and June 2016. Methods: Subjects were overweight and obese school children...
Article
Full-text available
Background: A pre-anaesthestic echocardiogram (echo) is requested for most non-cardiac surgeries to identify possible cardiac structural anomalies. Objective: To describe the prevalence and spectrum of structural cardiac abnormalities seen in various non-cardiac conditions. Methods: We carried out a retrospective review of pre-anaesthetic echo...
Article
Full-text available
Background Paediatric cardiac services in Nigeria have been perceived to be inadequate but no formal documentation of availability and distribution of facilities and services has been done. Objective: To evaluate and document the currently available paediatric cardiac services in Nigeria. Methods In this questionnaire-based, cross-sectional descri...
Article
Background: The introduction of a new vaccine into an immunization programme may affect the immunization system negatively or positively. The aim of this study is to determine the effect of the introduction of the pentavalent vaccine as replacement for DTP and Hepatitis B vaccines on timeliness, completion of the schedule and dropout rates among c...
Article
Full-text available
Introduction: Group A β-haemolytic Streptococcus (GAS), a gram-positive bacterium also known as Streptococcus pyogenes, causes pyoderma, pharyngitis and invasive disease. Repeated GAS infections may lead to autoimmune diseases such as acute post-streptococcal glomerulonephritis, acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Invasiv...
Article
Background: Severe malaria anemia is a major cause of childhood heart failure in malaria endemic countries. The resulting hypoxic-ischemic injuries may cause myocardial damage detectable by electrocardiogram (ECG) and elevated troponin T (cTnT) levels. Objective: Evaluate the ECG changes and cTnT levels in children with severe malaria anemia com...
Conference Paper
Full-text available
A 16-year-old boy whose diabetes mellitus was diagnosed 3 months previously in a private hospital but was not placed on medication. The presenting complaints were fast breathing for 24 hours, weakness for 2 hours, and unresponsiveness to calls for 0.5 hours. His father was obese with type 2 diabetes mellitus and died 8 months earlier from cardiac a...
Article
The human immunodeficiency virus (HIV) infection is a multi-systemic illness and often leads to acquired immunodeficiency syndrome (AIDS) in untreated cases. In children, neurologic manifestations are common. HIV encephalopathy is a neurological dysfunction arising from direct HIV infection of the brain. It ranges between 30% to 50% in untreated ca...
Article
Full-text available
Background: The rising prevalence of cardiovascular diseases in the population has increased the demand for cardiovascular imaging procedures (specifically echocardiography) in our center. Aim: To determine the percentage of appropriate indications for echocardiography. Materials and methods: This was a prospective study conducted over a perio...
Article
Full-text available
Background Human immunodeficiency virus (HIV) infection and Plasmodium falciparum malaria are 2 of the gravest health threats in sub-Saharan Africa. Multiple repeat infections with the malaria parasite as seen in endemic areas are necessary to develop specific malaria immunity. HIV is an immunosuppressive virus and in children aged <5 years, develo...
Article
Full-text available
Introduction: Acquired heart diseases (AHD) are not uncommon in children. The current multi-center study aims to provide a more representative data of AHD in Nigeria. Methods: Over 42 months, children referred for echocardiographic evaluation who had confirmed AHD in three centers in Nigeria were recruited. The data was collected on biodata and typ...
Article
Full-text available
Background: Determination of abnormal blood pressure (BP) in children is dependent on comparison with normal percentile values. The commonly used National Institute of Health (NIH) standard is generated from childrenoutside of Africa.Objective: To develop BP percentile values for Nigerian childrenbased on BP cuff width 40% to 50% of arm circumferen...
Article
Immunity to diphtheria has been noted to wane with age such that previous studies have shown that a significant proportion of females with characteristics comparable to those of Nigerian women of reproductive age have inadequate levels of immunity to diphtheria. Thus, it is envisaged that Nigerian newborns may inherit inadequate levels of immunity...
Article
Full-text available
Troponin T (cTnT) and Creatinine Kinase Isoenzyme (CK-MB) are both markers of myocardial injuries. However, CK-MB is also elevated in acute kidney injury. The diagnostic value of both cTnT and cardiac CK-MB in combined myocardial and acute kidney injuries (AKI) in asphyxiated neonates was evaluated. 40 asphyxiated infants and 40 non-asphyxiated con...
Article
Full-text available
The control of hepatitis B infection involves several strategies of which the most effective is vaccination. Schedules which include a birth dose (which can prevent vertical transmission when administered within 24 hours of birth) are recommended for use in countries with a high rate of vertical transmission. Nigeria is highly endemic for hepatitis...
Article
Full-text available
Cardiac rhabdomyoma (CR) is a rare tumor commonly associated with tuberous sclerosis. They are often detected prenatally or in early infancy. The case of a Nigerian human immunodeficiency virus (HIV)-exposed neonate with CR who presented with supraventricular tachycardia and cardiovascular collapse is presented. The infant was born to a mother on h...
Article
Full-text available
Background: Pericardial effusion (PE) is best detected with echocardiography. In settings where echocardiography is unavailable, other methods are relied on to diagnose PE. Objective: To evaluate the clinical, radiologic, and electrocardiographic (ECG) correlates of PE in children with echocardiographically detected PE. Methods: Children referred f...
Article
Full-text available
Delay in receipt of immunization may result in a child being susceptible to vaccine preventable diseases for prolonged periods. Identification of factors which contribute to delay in receipt of immunization will help in developing targeted interventions. This study examined prospectively factors contributing to delay in the commencement of infant i...
Article
Full-text available
Some children with congenital heart diseases (CHD) may have increased pulmonary blood flow that causes recurrent bronchopneumonia and congestive heart failure. Serum zinc is reduced in children with pneumonia and patients on diuretics. To evaluate the serum zinc level of children with CHD and their controls without CHD. The subjects were 41 childre...
Article
Full-text available
Pneumonia is a common cause of childhood morbidity and mortality globally. Some congenital heart disease (CHD) may predispose their sufferer to bronchopneumonia. To evaluate the contribution of CHD to pneumonia in children seen in a tertiary hospital. Over a year, consecutive children diagnosed radiologically with pneumonia were evaluated echocardi...
Article
Full-text available
Background: Group A streptococcus (GAS) is a major cause of mortality in man. Regular disease surveillance can be achieved through evaluation of throat carriage. Objectives: To evaluate GAS throat carriage amongst nursery and primary schools pupils in Benin City, Nigeria. Method: This cross sectional study was carried out between September and Nove...
Article
Full-text available
Objective: To compare the weight for age, the serum albumin and vitamin A of children with congenital heart disease (CHD) with those of age and sex matched controls without CHD. Methods: Consecutive children diagnosed to have CHD by echocardiography who were afebrile two weeks prior were recruited. Subjects who had bronchopneumonia were noted. Thei...
Article
Full-text available
Congenital heart disease (CHD) is among the leading causes of morbidity and mortality in childhood. We report on the spectrum of echocardiographically diagnosed CHD from three different centers across Nigeria. Over a period of 42 months, children who were referred for echocardiographic evaluation in the centers located in three large metropolitan c...
Article
Full-text available
Intrapericardial diaphragmatic hernia is uncommon condition in which abdominal content herniate into the pericardium. It is mostly of traumatic origin, sometimes it is congenital. Radiologically, the condition may be suspected when the bowel loops are seen. However, diaphragmatic hernia may simulate acute gastrothorax, pneumotocelles and pneumothor...
Article
Objectives: To evaluate immunologic response to antiretroviral treatment (ART) among HIV-infected Nigerian children (<36 months old) and to assess its association with early infant feeding pattern and nutritional status at treatment initiation. Design: Mixed prospective and retrospective cohort study. Methods: One hundred fifty HIV-infected ch...
Article
Full-text available
Pharyngitis is a common reason for presentation in the hospital by children. Although Group A streptococcus is the most important cause of and reason for antibiotic treatment of pharyngitis, viral aetiology is the commonest. The knowledge that GAS cause the non suppurative sequalae of rheumatic fever and less so, acute glomerulonephritis perhaps dr...
Article
Full-text available
Access to highly active anti-retroviral therapy (HAART) has improved the prognosis of Nigerian children infected with the human immunodeficiency virus (HIV); thus, more children are surviving. Long-term exposure to HAART is potentially nephrotoxic. We therefore aimed at assessing the prevalence of renal disease in Nigerian children infected with HI...
Article
Full-text available
Objective: To determine the prevalence of RHD among primary school pupils in Egor Local Government Area (LGA) of Edo State of Nigeria. Design: A cross sectional study Setting: The study was carried out among selected primary pupils in three public and six private schools in Egor LGA, (the smallest governmental unit) in mid-Western Nigeria. Subjects...
Article
An important risk factor for congenital malaria is cord blood malaria parasitaemia. We report on the effect of malaria prevention methods [intermittent preventive treatment (IPT) and insecticide-treated nets (ITNs)] on cord blood malaria parasitaemia, as well as the effect of cord blood malaria parasitaemia on the anthropometry of term normal birth...
Article
Full-text available
Paediatricians are required to attend all Caesarian sections, yet most neonates so delivered do not require complex resuscitations necessitating a paediatrician's presence. All Caesarean sections in the University of Benin Teaching Hospital from January to December 2009 were prospectively studied. The socio-demographic characteristics, indication a...
Article
Full-text available
Introduction: This study evaluated the cardiovascular responses to blood transfusion in children with anemic heart failure using mostly clinical parameters. Materials and methods: Consecutive patients with anemic heart failure presenting to a children's emergency room and requiring blood transfusion were assessed for heart rate (HR), respiratory...
Article
Objective: To evaluate heart failure in patients with pneumonia. Setting: The paediatric wards of a tertiary hospital in Nigeria. Subjects: One hundred and four patients were studied. Results: The mean age was 10.3 ± 11.0 months and 53(51.0%) were males. Of the 104, 41(39.4%) also had Congestive Cardiac Failure (CCF). All 41(100%) patients with CCF...
Article
Full-text available
Heart rate (HR) measurement is an important means of evaluating clinical status of newborns. Differences in HR between caucasian and negroid infants have been reported. Clinical estimation of HR is less accurate than estimates using devices. To establish the normal HR of term negroid newborns in the early days of life using an oscillometric device....
Article
In caucasian newborns, troponin T (cTnT) is a specific marker for myocardial injury in perinatal asphyxia. This is the first such study in negroid neonates. To evaluate myocardial injury in a group of asphyxiated African newborns and determine the influence of mode of delivery on cTnT levels. Serum cTnT and clinical parameters in 40 asphyxiated and...
Article
Febrile convulsion is one of the most common childhood neurological disorders. The underlying mechanism remains unclear; however, some reports have suggested that low serum zinc levels may be implicated in its pathogenesis. This case-control study was carried out to determine the serum zinc levels in Nigerian children with febrile convulsions in co...
Article
Febrile convulsion is one of the most common childhood neurological disorders. The underlying mechanism remains unclear; however, some reports have suggested that low serum zinc levels may be implicated in its pathogenesis. This case-control study was carried out to determine the serum zinc levels in Nigerian children with febrile convulsions in co...
Article
Full-text available
Univentricular heart is an uncommon congenital heart disease. While early surgical intervention increases chances of survival, there are reports of individuals with uncorrected univentricular heart living into adulthood in western literature. In this report we present two cases of Nigerian adolescents, 12 and 16 years with different types of univen...
Article
Full-text available
This study was carried out to determine the prevalence of asymptomatic bacteriuria in HIV positive children and to identify the causative organisms. We studied 155 Human Immunodeficiency Virus (HIV) infected children aged 10 months to 17 years attending the Paediatric HIV clinics of the University of Benin Teaching Hospital. Children who were febri...
Article
Full-text available
Background. Nigeria has one of the world's largest burdens of children living with HIV and is highly endemic for hepatitis B. This study set out to determine the prevalence of hepatitis B and C infections among HIV-infected children and to identify the factors associated with these co-infections. Method. We studied 155 HIV-infected children. Inform...
Article
Full-text available
INTRODUCTION: Diphtheria had been a major of cause of childhood mortality until the advent of an effective vaccine. Even in Nigeria with low to moderate coverage with the third dose of DPT the number of reported cases of diphtheria had been reducing. However, in a recent report we noted an increase in the incidence of diphtheria. The mainstay of ma...
Article
Full-text available
Background: Health care workers are important in the promotion, protection and support of breast feeding. Their ability to do this may be influenced by their knowledge, personal experiences and work. Patients and Method: The breast feeding experience of 36 female medical doctors who had babies within the preceding two years and had resumed work wa...
Article
Full-text available
To evaluated the economic burden to families of managing chronic heart failure in children with congenital heart disease. This longitudinal study was conducted over a year. The families of children with congenital heart disease who were being managed for chronic heart failure in the clinic were recruited for the study. With the aid of a structured...
Article
Full-text available
Neonatal morbidity and mortality rates reflect a nation's socio-economic status, the efficiency and effectiveness of health care services. This important indicator is useful in planning for improved healthcare delivery. A four year review of neonatal outcome was therefore conducted in the special care baby Unit (SCBU) of University of Benin Teachin...
Article
Full-text available
This paper presents the successful management of 750 grammes low birth weight baby using kangaroo mother care in the hospital and at home. The baby had suffered a variety of morbidities associated with prematurity in the early neonatal period.