William Supple

William Supple
StarPower LifeSciences Inc. · Development

Doctor of Philosophy

About

18
Publications
628
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1,412
Citations
Introduction
Investigation and discovery of ynergistic components that affect StarPower LifeScience's proprietary vitamin D analog. Senolytics, aging, inflammation, cardiovascular disease, developmental and neurodegenerative conditions, muscle composition, muscle spindle physiology, autoimmune disease. Primary focus is mitigation of autoimmune disease resulting from chronic inflammation caused by vitamin D deficiency in humans. Vitamin D deficiency is the most widespread public health crisis.

Publications

Publications (18)
Article
This study sought to determine whether electrical stimulation of the amygdaloid central nucleus (ACe) produces cholinergically mediated neocortical arousal manifested in the suppression of frontal cortex delta wave (1-4 Hz) activity. Stimulation in both anesthetized and conscious rabbits produced a suppression of delta activity that was accompanied...
Article
The anatomical connections between the midline cerebellum and the pontine parabrachial nucleus (PBN) were investigated in the rabbit using anterograde and retrograde axonal transport techniques. Small injections (20-50 nl) of cholera toxin conjugated to horseradish peroxidase (CT-HRP) or wheat germ agglutinin conjugated HRP (WGA-HRP) into the corte...
Article
This study sought to determine whether electrical stimulation of the amygdaloid central nucleus (ACe) produces cholinergically mediated neocortical arousal manifested in the suppression of frontal cortex delta wave (1-4 Hz) activity. Stimulation in both anesthetized and conscious rabbits produced a suppression of delta activity that was accompanied...
Article
Full-text available
The effects of lesions of the cerebellum on the acquisition and retention of aversive Pavlovian conditioned bradycardia were examined in rabbits. Lesions of the anterior cerebellar vermis severely attenuated the acquisition of simple conditioned bradycardia without disrupting baseline heart rate (HR), or unconditioned HR responses. Also, lesions of...
Article
Extracellular single-unit recordings of Purkinje cells in the anterior cerebellar vermis (ACV) of the rabbit found evidence of short-latency (20-30 ms) differential responses to discriminatively-conditioned auditory stimuli during Pavlovian fear conditioning procedures. These differential unit responses appeared to be a function of learning as diff...
Article
Intricate anatomical connections exist between the cerebellar vermis and the hypothalamus. This study examined the effects of electrical microstimulation of the hypothalamus on Purkinje cell activity in the anterior cerebellar vermis (ACV) in the awake rabbit. Single-pulse stimulation of the hypothalamus evoked robust, short-latency modifications o...
Article
Full-text available
Three experiments assessed the effects of damage to the medial cerebellum on long-term habituation (LTH) of the acoustic startle response. Experiment 1 replicated previous results. Lesions of the cerebellar vermis blocked LTH without affecting initial response levels or short-term habituation (STH). The lesions did not disrupt LTH of a simultaneous...
Chapter
To achieve a more complete understanding of the neural substrates of learning and memory, several goals must be attained. Clearly, identifying critical brain areas that participate in the acquisition, storage, and retrieval of information would be necessary. Having identified these areas, it would then be necessary to determine the exact manner in...
Article
The effects of lesions of the cerebellum on the acquisition of heart rate (HR) conditioned responses (CRs) were examined in rats. Large lesions of the cerebellar vermis severely attenuated the acquisition of differentially conditioned bradycardic responses in restrained rats without affecting unconditioned HR responses to the tone conditioned stimu...
Article
The effects of lesions of the cerebellar vermis on the acquisition of heart-rate conditioning in rats was examined. Lesions of the vermis severely attenuated the acquisition of conditioned bradycardic responses in a simple conditioning procedure in restrained rats. Importantly, the vermal lesions did not affect resting heart-rate, unconditioned hea...
Article
Recent evidence suggests that the amygdaloid central nucleus (ACE) may contribute significantly to Pavlovian fear-conditioned bradycardic responses during the presentation of conditioned emotional stimuli. Because the medial component of the medial geniculate nucleus (MGm) is a major source of input to the region of the ACE, the extracellular singl...
Article
In a series of independent experiments, we showed that lesions of the vermis of the cerebellum in rats blocked the hyperdefensiveness induced by lesions of the ventromedial hypothalamus (VMH), attenuated spontaneous mouse killing, and reduced unconditioned freezing and other signs of fear in the presence of a cat. The vermal lesions did not signifi...
Article
The cerebellar vermis has extensive anatomical connections with many brain stem and forebrain structures which have been implicated in emotional or affective behavior. Previous reports indicate that lesions of the vermis in a variety of experimental animals result in altered emotional behavior. The studies reported here attempted to clarify the nat...
Article
Full-text available
The acoustic startle response in rats shows both short-term habituation, which recovers in seconds or minutes, and long-term habituation, which is effectively permanent. Lesions of the cerebellar vermis significantly attenuated long-term habituation without affecting the short-term process or altering initial response levels. In this response syste...

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Project (1)
Project
Role of vitamin D 25(OHD) status in adverse outcome cytokine storm.