William Seiple

William Seiple
New York University | NYU · Department of Ophthalmology

PhD

About

144
Publications
17,392
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
4,849
Citations
Citations since 2017
12 Research Items
1113 Citations
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200

Publications

Publications (144)
Article
This paper investigates the tools and practices used by Orientation and Mobility (O&M) specialists in instructing people who are blind or have low vision in concepts, skills, and techniques for safe and independent travel. Based on interviews with experienced instructors who practice in different O&M settings we find that a shortage of qualified sp...
Article
This paper describes the interface and testing of an indoor navigation app - ASSIST - that guides blind & visually impaired (BVI) individuals through an indoor environment with high accuracy while augmenting their understanding of the surrounding environment. ASSIST features personalized interfaces by considering the unique experiences that BVI ind...
Article
Vision loss and blindness are significant causes of disability. Patient activation has been previously unstudied in individuals with vision loss. Among our 146 participants, visual acuities for 38.3 percent were better than 20/70, 43.2 percent had acuities between 20/70 and 20/400, and 12.3 percent had acuities of <20/400. Participants with lower P...
Article
Importance Patients with vision loss who are hospitalized for common illnesses are often not identified as requiring special attention. This perception, however, may affect the outcomes, resource use, and costs for these individuals. Objective To assess whether the mean hospitalization lengths of stay, readmission rates, and costs of hospitalizati...
Chapter
Blind & visually impaired (BVI) individuals and those with Autism Spectrum Disorder (ASD) each face unique challenges in navigating unfamiliar indoor environments. In this paper, we propose an indoor positioning and navigation system that guides a user from point A to point B indoors with high accuracy while augmenting their situational awareness....
Article
Significance: This research is significant because, although vision-related quality of life (VRQoL) is improved after vision rehabilitation (VR), patients with certain characteristics respond less positively on VRQoL measures, and this should inform future care. Purpose: The purposes of this study were to evaluate how two VRQoL questionnaires co...
Article
Full-text available
Purpose: This study surveys current low vision rehabilitation practice methodologies among French practitioners and it describes their opinions about the utility of using virtual reality as a tool for low vision rehabilitation training in patients with age-related macular degeneration.Methods: An online questionnaire was distributed between October...
Article
Full-text available
Significance: Systematic lighting assessments should be part of low vision evaluations. The LuxIQ has gained popularity as an assessment tool, but its reliability has not been examined independently and is necessary for evidence-based vision rehabilitation. Purpose: Besides magnification, improved lighting levels are a common intervention in rea...
Article
There is an immediate need for noninvasive therapies to improve the functional abilities of persons blinded by traumatic injury. The BrainPort Vision Pro, an updated hands-free oral electronic vision device, enables perception of visual information using the tongue as a substitute for the eye. Purpose: The purpose of this study was to evaluate th...
Article
Significance: Fundus-guided perimetry is a common clinical tool used to measure visual field sensitivities. Comparisons between perimeters are often made despite relative differences in hardware parameters. We directly compared two perimeters using Weber contrast, which allowed us to assess the clinical gain associated with the extended stimulus r...
Article
Full-text available
Objective: We sought to determine under what conditions brighter lighting improves reading performance. Method: Thirteen participants with typical sight and 9 participants with age-related macular degeneration (AMD) read sentences ranging from 0.0 to 1.3 logMAR under luminance levels ranging from 3.5 to 696 cd/m². Results: At the dimmest lumin...
Article
Purpose To examine whether individuals with Stargardt disease macular dystrophy (STGD) change the location of fixation with instruction. Design Case-control study. Participants Thirteen normally sighted and 37 STGD participants. Methods Using an Optos scanning laser ophthalmoscopy/OCT microperimeter (Optos plc, Dunfermline, UK), fixation was mea...
Poster
Full-text available
Purpose: Optimal lighting is an essential component of low vision rehabilitation. The LuxIQ assessment tool provides a new opportunity for systematic evaluation of lighting needs; however, to date, this tool has not been evaluated for its ability to provide consistent and repeatable data. The goal of this study was to compare test and re-test data...
Article
Full-text available
Introduction This study was conducted to evaluate the functional performance of the BrainPort V100 device, an FDA-cleared sensory-substitution system, in persons who are profoundly blind (that is, have some or no light perception). Methods This was a prospective, single-arm, multicenter clinical investigation. Participants received 10 hours of dev...
Article
Full-text available
Background. Parkinson's disease (PD) progressively affects dopaminergic neurotransmission and may affect retinal dopaminergic functions and structures. Objective. This 2-year randomized, open-label, parallel-group, flexible-dose study, NCT00144300, evaluated ophthalmologic safety profiles of immediate-release (IR) pramipexole and ropinirole in pati...
Article
Purpose: It has been reported that patients with macular disease have difficulties with face perception. Some of this difficulty may be caused by the sensory and perceptual consequences of using peripheral retina. However, strong correlations have not always been found between performance on face tasks and clinical measure of function. Based on th...
Article
To assess the influences of stimulus parameters (physics) on measures of visual field sensitivity (psychophysics). Subjects' thresholds were measured on three different clinically available perimeters: the Humphrey Field Analyzer (HFA), the Nidek MP1 (MP1), and the Opko OCT/SLO (OSLO). On all machines, visual field testing was done with a 10-2 spat...
Article
Full-text available
Visual field assessment is a key part of optometry and ophthalmology practice. However, in people with non-central or unsta-ble fixation, it is not possible to relate defects on a visual field map to a specific retinal loca-tion. Microperimetry (or fundus related perimetry) is a technique that images the reti-na during visual field testing, enablin...
Article
To investigate the relationship between depression and quantitative measures of visual function, we recruited 18 subjects with central scotomas from macular degeneration who were enrolled in a reading rehabilitation program. Psychological batteries and reading assessments were administered prior to rehabilitation; reading assessments and a measure...
Article
Full-text available
To establish normative values for macular light sensitivity and to determine the intrasession fluctuation of perimetric responses using the OPKO/OTI microperimeter. A total of 32 visually normal subjects participated in the study. A standardized grid pattern was used for testing, which consisted of 28 points arranged concentrically in three circles...
Article
To investigate a relationship between the inner segment-outer segment (IS-OS) junctional layer integrity and the overlying retinal sensitivity assessed by Spectral OCT/SLO (spectral-domain optical coherence tomography) and microperimetry testing in patients with dry and wet forms of age-related macular degeneration (AMD). Spectral-domain optical co...
Article
To quantify the effects of three vision rehabilitation training approaches on improvements in reading performance. Thirty subjects with AMD participated in the training portion of the study. The median age of the subjects was 79 years (range, 54-89 years). The three training modules were: Visual Awareness and Eccentric Viewing (module 1), Control o...
Article
Recent advances in OCT technology now provide unprecedented near-histological views of retinal structure in the clinic. OCT instruments provide expanded knowledge about sites of disease action and a method for evaluation of treatments. Recently, OCT technology has been coupled with microperimetry utilizing the system's integrated live scanning lase...
Article
To investigate the combination of 3D optical coherence tomography (OCT) retinal thickness measurements and superimposed scanning laser ophthalmoscopy (SLO) microperimetry obtained using a Spectral OCT/SLO and to test the correlation between retinal thickness and retinal sensitivity in retinal diseases grouped according to anatomic locations. Patien...
Article
Full-text available
The aim was to correlate retinal sensitivity as determined by scanning laser ophthalmoscope microperimetry (SLO-MP) in glaucomatous eyes with paracentral visual field (VF) defects detected by standard automated perimetry (SAP). Twenty eyes with glaucomatous optic neuropathy and an SAP VF defect involving the central 16 test points (at least one poi...
Article
To examine if vision in subjects with macular heterotopia (MH) secondary to retinopathy of prematurity (ROP) is related to anatomical macular structure. Six subjects with MH who were between 18 years and 65 years of age and three age-matched subjects with normal vision were recruited for the study. Vision and macular structure of the better eye of...
Article
Full-text available
The field of electrodiagnostics is rapidly expanding.Improved computing power has expanded our abilityto control stimuli and to analyze the biologic signalselicited by them. Similar trends are also affectingother areas ranging from biochemistry and geneticsto imaging of the retina and brain. Natural, fertileareas of study are the overlap of these f...
Article
To investigate the location and fixation stability of preferred retinal locations (PRLs) in patients with macular disease, and the relationship among areas of abnormal fundus autofluorescence, the PRL and visual sensitivity. Fifteen patients (15 eyes) were studied. Seven had Stargardt disease, 1 bull's eye maculopathy, 5 age-related macular degener...
Article
To test whether choroideremia carriers have a mosaic pattern of retinal dysfunction, as noted in carriers of X-linked recessive retinitis pigmentosa and X-linked retinoschisis. Prospective observational case series. Seven obligate choroideremia carriers (age range, 18-72) with visual acuity (VA) of 20/25 or better were recruited into the study. The...
Article
To determine whether retinal dysfunction in obligate carriers of the Bardet-Biedl syndrome (BBS) could be observed in local electroretinographic responses obtained with the multifocal electroretinogram (mfERG). Six obligate carriers of the BBS were examined for the study. Examination of each carrier included an ocular examination and mfERG testing...
Article
Shinoda and colleagues hypothesized that patients with cone dystrophy (CD) might suffer from a selective ON-system deficit, based on the local nature of the disease [Shinoda, K, Ohde, H, Inoue, R, Ishida, S, Mashima, Y, & Oguchi, Y (2002). ON-pathway disturbance in two siblings. Acta Ophthalmologica Scandinavica, 80, 219-223]. The purpose of the cu...
Article
To investigate possible adverse effects of a yellow-tinted intraocular lens (IOL) on scotopic sensitivity and hue discrimination. Departments of Ophthalmology, Columbia University and New York University School of Medicine, New York, New York, USA. Nine patients with a yellow-tinted IOL in 1 eye and a colorless ultraviolet IOL in the fellow eye and...
Article
Full-text available
To determine whether retinal dysfunction in obligate carriers of X-linked retinoschisis (XLRS) could be observed in local electroretinographic responses obtained with the multifocal electroretinogram (mfERG). Nine obligate carriers of XLRS (mean age, 46.2 years) were examined for the study. Examination of each carrier included an ocular examination...
Article
Full-text available
To quantify the extent of visual function losses in patients with North Carolina Macular Dystrophy (NCMD) and to demonstrate the importance of accounting for eccentric fixation when making comparisons with normal data. Five patients with NCMD who were from a single family were examined. Multifocal electroretinograms (mfERGs) and psychophysical asse...
Article
This chapter discusses the electrophysiologic findings in a broad group of retinopathies that are labeled as acquired rather than inherited. Labeling a disease acquired may be artificial and reflects our current knowledge about the disease. For the diseases discussed in this chapter, a brief description of the clinical findings is given and then th...
Article
Full-text available
To evaluate the contrast response of the visual system in retinitis pigmentosa (RP) under conditions designed to emphasize the parvocellular (PC) and magnocellular (MC) pathways. Visual evoked potentials (VEPs) were measured in 10 patients with RP and in 10 age-equivalent control subjects with normal visual acuity and color vision, by using an arra...
Article
Full-text available
To determine whether training oculomotor control, without direct practice in reading sentences, could increase reading speed in patients with age-related macular degeneration (AMD). Sixteen patients with AMD participated in the study (age range, 65-87 years; mean, 77). The training program consisted of a series of exercises that were designed to al...
Article
Previous studies indicated abnormal development of fixation toward the optic nerve head in patients with the inherited retinal disease North Carolina macular dystrophy (NCMD). The implication of this development on functional vision and structural characteristics has not been described. The anatomical characteristics of five NCMD-affected individua...
Article
To identify clinical vision measures that are associated with the driving performance of glaucoma patients who have visual field loss and visual acuity better than 20/100 and to compare the driving performance of glaucoma patients with the driving performance of a group of age- and sex-equivalent individuals without eye disease. Forty patients with...
Article
We examined the effects of inter-modal attention and mental arithmetic on Humphrey visual field sensitivity and multifocal visual evoked potential (mfVEP) amplitude. Four normally sighted subjects (ages ranging from 24 to 58 years) participated in this study. Monocular visual field sensitivity was measured under two conditions: (1) standard testing...
Article
(1) To compare the outcomes of orientation and mobility and driving training with Fresnel prisms and the Gottlieb Visual Field Awareness System for patients with homonymous hemianopsia, and (2) To determine whether the patients continue to use the optical enhancement devices at a 2-year follow-up point. Patients with homonymous hemianopsia were pro...
Article
To evaluate acuity and multifocal electroretinogram (mfERG) responses from the macula in affected and unaffected fellow eyes of patients with macular holes. We tested 10 eyes with macular hole and 10 fellow eyes from 11 patients. We measured local visual acuity thresholds at 27 discrete locations within 21 degrees diameter using the Functional Fund...
Article
We examined the reliability of Humphrey visual field thresholds and multifocal electroretinogram (mfERG) amplitudes and timing in a group of patients with Retinitis Pigmentosa (RP). Eight patients with RP and seven control subjects were tested five times: at baseline (visit #0), at three weekly follow-up visits (visits #1 - #3), and at three months...
Article
The purpose of this study was to investigate atypical multifocal ERG (mfERG) responses for patients with diseases that can affect the photoreceptors. MfERGS were obtained from seven patients with retinitis pigmentosa (RP), three with progressive cone dystrophy (CD) and eight with diabetic retinopathy (DR). Both first- and second-order kernel respon...
Article
Full-text available
This study identifies clinical vision measures or retinal structural measures associated with the driving performance of diabetic retinopathy patients. Twenty-five licensed drivers with diabetic retinopathy (median age, 53 years; range, 34-72 years) completed clinical tests (visual acuity, letter contrast sensitivity, and Humphrey 30-2 visual field...
Article
Full-text available
Multidimensional psychophysical and electrophysical maps of the central retina are essential for assessing the functioning of the diseased retina. In this study, grating acuity, contrast sensitivity, duration for letter identification, multifocal electroretinograms, and Humphrey visual field thresholds were measured at equivalent positions througho...
Article
Full-text available
To determine the extent of rod and cone photoreceptor dysfunction in patients with cone dystrophy using psychophysical and electrophysiological tests. Ten patients with cone dystrophy participated. Rod and cone system psychophysical thresholds were measured as a function of retinal eccentricity. Bright-flash full-field electroretinograms were obtai...
Article
Full-text available
To determine the influence of age on local electroretinographic responses in humans. Multifocal electroretinograms (mfERGs) were obtained from 62 normally sighted subjects ranging in age from 21 to 81 years. A stimulus array of 103 scaled hexagons was used to measure electrical signals within a retinal area approximately 46 degrees in diameter. Com...
Article
purpose. To determine the influence of age on local electroretinographic responses in humans. methods. Multifocal electroretinograms (mfERGs) were obtained from 62 normally sighted subjects ranging in age from 21 to 81 years. A stimulus array of 103 scaled hexagons was used to measure electrical signals within a retinal area approximately 46° in di...
Article
A body of clinical and laboratory evidence suggests that tinted spectacle lenses may have an effect on visual performance. The aim of this study was to quantify the effects of spectacle lens tint on the visual performance of 25 subjects with cataracts. Cataracts were scored based on best-corrected acuity and by comparison with the Lens Opacity Clas...
Article
To determine the extent of electrophysiologic dysfunction in patients with central serous chorioretinopathy (CSC). Prospective observational case series. Six patients with unilateral CSC (mean age, 40 years) were recruited into the study. Six patients with CSC underwent multifocal electroretinogram (mfERG) testing on both their clinically affected...
Article
Full-text available
To compare the patterns of local cone and rod system impairment in patients with progressive cone dystrophy (CD) using psychophysical and electrophysiological techniques. Local cone system function was assessed by measuring cone system thresholds (visual fields) and cone-mediated multifocal electroretinograms (mfERGs). Rod system function was asses...
Article
To determine the manner in which attention is distributed among numerous locations in the visual space, we used a multifocal recording technique that allowed simultaneous recordings of evoked cortical activity from 12 visual field areas out to 23.6 degrees. We found that multifocal visual evoked potential (mfVEP) amplitude was larger when a region...
Article
Full-text available
To evaluate quantitatively the effects of tinted spectacle lenses on visual performance in individuals without visual pathology. Twenty-five subjects were assessed by measuring contrast sensitivity with and without glare. Gray, brown, yellow, green, purple, and blue lens tints were evaluated. Measurements were repeated with each lens tint and with...
Article
To examine whether a mosaic pattern of retinal dysfunction in obligate carriers of X-linked retinitis pigmentosa (XLRP) could be observed in local electroretinographic responses obtained with the multifocal electroretinogram (mfERG). Prospective observational case series. Five obligate carriers of XLRP (mean age, 53.2 years) were recruited into the...
Article
The multifocal electroretinogram (mfERG) has been commonly used as a method for obtaining objective visual fields. Although qualitative comparisons have been good, quantitative comparisons between the results from mfERG and the results from Humphrey Visual Field Analyser (HVFA) have found variable degrees of agreement depending upon the mfERG respo...
Article
To test the hypothesis that the retinal pigment epithelial/photoreceptor complex is affected in patients with pigment dispersion syndrome and/or in patients with pigmentary glaucoma. Electro-oculograms were recorded from patients with pigment dispersion syndrome, pigmentary glaucoma, ocular hypertension, and primary open-angle glaucoma and from con...
Article
We examined whether lateral spread of adaptation can be observed in the electroretinogram in humans. Specifically, we tested whether the luminance level of a surrounding, nonmodulated annulus affects the multifocal electroretinogram (ERG) response of a modulated central area. Multifocal electroretinograms were recorded in response to an array of 37...
Article
To determine the correlation between the aesthetics of lens tints preferred for cosmesis and lens tints preferred for viewing. Thirty-five subjects (mean age: 25; 49% male, 51% female) with no significant ocular pathology participated in the study. Median visual acuity was 20/20. Color vision testing was performed on each subject using Ishihara pla...
Article
Purpose: To determine the correlation between the aesthetics of lens tints preferred for cosmesis and lens tints preferred for viewing. Methods: Thirty-five subjects (mean age: 25; 49% male, 51% female) with no significant ocular pathology participated in the study. Median visual acuity was 20/20. Color vision testing was performed on each subject...
Article
In the current study, we measured threshold duration required to perform the tasks of letter identification, letter detection, grating orientation discrimination, and symmetry detection of targets presented as a function of retinal eccentricity. Targets were presented in the nasal visual field on the horizontal meridian at eccentricities ranging fr...
Article
Full-text available
To compare local cone and rod system function in patients with retinitis pigmentosa (RP) using electrophysiological and psychophysical techniques. Cone-mediated multifocal electroretinograms (M-ERGs), cone system threshold visual fields, rod-mediated M-ERGs, and rod system threshold visual fields were measured in seven patients with RP. All the pat...
Article
To investigate the functioning in daily task performance of individuals with retinitis pigmentosa (RP). Goals were (1) to quantify the relationships among clinical tests of vision, self-reports, and evaluations of actual task performance to predict difficulty in these tasks; and (2) to validate self-report questionnaire data about daily task perfor...
Article
To evaluate the nature and extent of retinal dysfunction in the macular and surrounding areas that occurs in patients with diabetes with clinically significant macular edema (CSME). Eleven patients were evaluated before focal laser treatment. Multifocal electroretinogram (ERG) and full-field ERG techniques were used to assess the effects of diabeti...
Article
Full-text available
To assess the effects of focal photocoagulation on retinal function in the macular and perimacular areas in patients with diabetes who have clinically significant macular edema. Eleven patients were assessed after focal laser treatment. Multifocal electroretinogram (ERG) and full-field ERG techniques were used to evaluate the effects of treatment o...
Article
Full-text available
This article describes the experimental protocol used to instruct fifteen patients with peripheral visual field loss due to retinitis pigmentosa, choroideremia, or Usher's syndrome Type II how to effectively use bioptic amorphic lenses. The factors that contributed to the successful use of these lenses, as well as difficulties the patients encounte...
Article
Electroretinograms to high-intensity flashes were obtained to determine the extent of rod and cone photoreceptor and postreceptor dysfunction in patients with primary open-angle glaucoma. Full-field flash electroretinograms were obtained using brief high-intensity flashes. Dark-adapted (rod-dominated) and light-adapted (cone-dominated) electroretin...
Article
Full-text available
1) To evaluate a vision rehabilitation program aimed at training persons with central vision loss to use a bioptic telescope for improving life skills, including driving and 2) to compare the outcomes of subjects who are given bioptic telescopes and training, with subjects who are prescribed telescopic lenses without training. Twenty-five subjects...
Article
Full-text available
Contributions to the multifocal electroretinogram (ERG) from the inner retina (i.e. ganglion and amacrine cells) were identified by recording from monkeys before and after intravitreal injections of n-methyl dl aspartate (NMdlA) and/or tetrodotoxin (TTX). Components similar in waveform to those removed by the drugs were identified in the human mult...
Article
To test the effectiveness of a bioptic form of a peripheral vision-enhancement lens in patients with retinitis pigmentosa (RP), choroideremia, and Usher's syndrome Type II. Fifteen patients with peripheral visual field loss were trained in the use of the amorphic lenses for driving and other everyday activities for a 3-month period. A cross-over st...
Article
To assess the feasibility of obtaining reliable multifocal rod electroretinograms (ERGS) and to compare them to full-field ERGs. Multifocal rod ERGs were recorded using a stimulus array of 61 hexagons. The minimum number of dark, blank frames between flashes was varied from 0 (a minimum of 13.3 msec between flashes) to 21 (a minimum of 293 msec bet...
Article
Full-text available
To assess local retinal function in patients with retinitis pigmentosa (RP), multi-focal ERGs and local thresholds (static visual fields) were obtained on eight RP patients with visual acuities of or better. All eight patients showed multi-focal responses with normal timing within the central 5 deg. However, there were few responses with normal tim...
Article
Full-text available
To determine whether the rod and cone photoreceptors are affected in patients with diabetic retinopathy. Twelve patients with diabetes and varying levels of retinopathy and nine age-similar control observers participated in this study. Two-color (500 versus 650 nm) dark-adapted thresholds were measured as a function of retinal eccentricity. Full-fi...