William Marcondes Facchinatto

William Marcondes Facchinatto
University of Aveiro | UA

PhD in Physical Chemistry

About

24
Publications
2,387
Reads
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223
Citations
Citations since 2017
22 Research Items
219 Citations
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Introduction
Detachable experience in the preparation of synthetic and biopolymers, as well as the production of nanocomposites and biomaterials by different methods used in industry and academia. Skillful, and in continuous improvement, regarding the writing of relevant results in high-impact scientific papers. Communicative and motivated with excellent competence in leadership and team development.
Education
March 2016 - April 2021
University of São Paulo (USP)
Field of study
  • Nuclear Magnetic Resonance studies of macromolecules for distinct applications
March 2014 - February 2016
University of São Paulo (USP)
Field of study
  • Preparation of biopolymers for biofarmaceutical applications
February 2009 - December 2013
University of São Paulo (USP)
Field of study
  • Synthesis and characterization of polymeric materials for opto-electronic devices

Publications

Publications (24)
Article
Although the Amazonian fruit pupunha (Bactris gasipaes) is rich in phenolic compounds, it is rarely consumed. Application could be expanded by transforming it into products with a longer shelf life. Therefore, the objective of this study was to produce pupunha flour (PF) from fruits harvested at different locations, characterize the flours using va...
Article
Full-text available
Multidrug-resistant bacteria represent a global health and economic burden that urgently calls for new technologies to combat bacterial antimicrobial resistance. Here, we developed novel nanocomposites (NCPs) based on chitosan that display different degrees of acetylation (DAs), and conjugated polymer cyano-substituted poly(p-phenylene vinylene) (C...
Article
Full-text available
Poly(p-anisidine) (PPA) is a polyaniline derivative presenting a methoxy (–OCH3 ) group at the para position of the phenyl ring. Considering the important role of conjugated polymers in novel technological applications, a systematic, combined experimental and theoretical investigation was performed to obtain more insight into the crystallization pr...
Preprint
Full-text available
We systematically investigated the effect of β-chitin (BCH) particle size on the preparation of nanocrystals/nanowhiskers (CWH) by acid hydrolysis. Regardless this variable, CWH aqueous suspension exhibited outstanding stability and the average degree of acetylation remained nearly constant after the acid treatment. In contrast, the morphology, dim...
Preprint
Full-text available
Chitosans with different average degrees of acetylation and weight molecular weight were analyzed by time-domain NMR relaxometry using the recently proposed pulse sequence named Rhim and Kessemeier-Radiofrequency Optimized Solid-Echo (RK-ROSE) to acquire 1 H NMR signal of solid-state materials. The NMR signal decay was composed of faster (tenths of...
Preprint
Full-text available
Vulvovaginal candidiasis (VVC) represents a considerable health burden for women. Despite the availability of a significant array of antifungal drugs and topical products, the management of the infection is not always effective, and new approaches are needed. Here, we explored cationic N -(2-hydroxy)-propyl-3-trimethylammonium, O- palmitoyl chitosan...
Preprint
Full-text available
Methoxypoly(ethyleneglycol)-graft-chitosan (PEG-g-Ch) was prepared by grafting polyethyleneglycol into chitosans (Ch) exhibiting different average degree of deacetylation (60 % < < 95 %). 1 H NMR showed that PEG-g-Ch derivatives presented high average degree of N-substitution (≈ 40 %) and such derivatives exhibited full water solubility at 1.0 < pH...
Preprint
Full-text available
The aim of this work was to investigate the potential of a new 3,6-O,O'-dimyristoyl derivative amphiphilic chitosan (DMCh), in improving the solubility of camptothecin (CPT), a hydrophobic anticancer drug, and its potential oral delivery. FTIR, 1 H NMR and solid-state 13 C NMR spectroscopy were used to characterize DMCh and to determine its average...
Preprint
Full-text available
We propose a novel approach relied on high-resolution solid-state 13 C NMR spectroscopy to quantify the crystallinity index of chitosans (Ch) prepared with variable average degrees of acetylation (̅̅̅̅) from 5% to 60% and average weight molecular weight (̅) ranged in 0.15×10 6 g mol-1-1.2×10 6 g mol-1. The Dipolar Chemical Shift Correlation J o u r...
Article
We systematically investigated the effect of β-chitin (BCH) particle size on the preparation of nanocrystals/nanowhiskers (CWH) by acid hydrolysis. Regardless this variable, CWH aqueous suspension exhibited outstanding stability and the average degree of acetylation remained nearly constant after the acid treatment. In contrast, the morphology, dim...
Article
Full-text available
Carbon nanofibers (CNF) are highly electric conductor materials that can be produced from petroleum-based polymers by different methods, such as electrospinning and solution blowing (SBS). In this work, we studied the production of CNF by SBS from lignin. The nanofibers were characterized by XRD, FTIR, Raman and 13C solid state NMR spectroscopies,...
Thesis
Full-text available
The main objective of this Thesis is to control the preparative condition for investigating the properties of chemically modified chitosans and the potential application of these materials in different fields of knowledge. For such a goal, different high- and low-NMR techniques were applied in order to elucidate intrinsic characteristics of chitins...
Preprint
Full-text available
Two samples of N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan (DPCat) with different average degrees of quaternization named as DPCat35 (DQ = 35%) and DPCat80 (DQ =80%),weresuccessfullysyn-thesized by reacting glycidyltrimethylammonium chloride (GTMAC) with O-palmitoyl chitosan (DPCh) derivative (DS = 12%). Such amphiphilic derivati...
Article
Two samples of N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan (DPCat) with different average degrees of quaternization named as DPCat35 (DQ¯ = 35%) and DPCat80 (DQ¯ = 80%), were successfully synthesized by reacting glycidyltrimethylammonium chloride (GTMAC) with O-palmitoyl chitosan (DPCh) derivative (DS¯ = 12%). Such amphiphilic de...
Article
Vulvovaginal candidiasis (VVC) represents a considerable health burden for women. Despite the availability of a significant array of antifungal drugs and topical products, the management of the infection is not always effective, and new approaches are needed. Here, we explored cationic N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan...
Article
Chitosans with different average degrees of acetylation and weight molecular weight were analyzed by time-domain NMR relaxometry using the recently proposed pulse sequence named Rhim and Kessemeier - Radiofrequency Optimized Solid-Echo (RK-ROSE) to acquire ¹H NMR signal of solid-state materials. The NMR signal decay was composed of faster (tenths o...
Article
We propose a novel approach relied on high-resolution solid-state ¹³C NMR spectroscopy to quantify the crystallinity index of chitosans (Ch) prepared with variable average degrees of acetylation ( DA¯) from 5% to 60% and average weight molecular weight (M¯w) ranged in 0.15 × 10⁶ g mol⁻¹-1.2 × 10⁶ g mol⁻¹. The Dipolar Chemical Shift Correlation (DIP...
Article
This study evaluated the effect of amylases on the formation, and characteristics of retrograded starches using sweet potato (SPS), cassava (CAS) and high amylose maize (HAS) starches. The starches were gelatinized, hydrolyzed with fungal or maltogenic α-amylase, de-branched and retrograded. The modified starches were then analyzed for digestibilit...
Article
Full-text available
N-acetyl-d-glucosamine (GlcNAc) is an important amino-monosaccharide with great potential for biotechnological applications. It has traditionally been produced by the chemical hydrolysis of chitin, despite certain industrial and environmental drawbacks, including acidic wastes, low yields and high costs. Therefore, enzymatic production has gained a...
Article
Methoxypoly(ethyleneglycol)-graft-chitosan (PEG-g-Ch) was prepared by grafting polyethyleneglycol into chitosans (Ch) exhibiting different average degree of deacetylation (60% < DD¯ < 95%). ¹H NMR showed that PEG-g-Ch derivatives presented high average degree of N-substitution (DS¯ ≈ 40%) and such derivatives exhibited full water solubility at 1.0...
Chapter
Full-text available
Some chemical modifications aiming to introduce a new functionality, to improve and/or develop a given property of chitosan are addressed. Given the great number of possible reactions, focus is put only on some representative chitosan derivatives, exploring examples of those exhibiting anionic, cationic, amphiphilic and hydrophilic character, as we...
Article
The aim of this work was to investigate the potential of a new 3,6-O,O’-dimyristoyl derivative amphiphilic chitosan (DMCh), in improving the solubility of camptothecin (CPT), a hydrophobic anticancer drug, and its potential oral delivery. FTIR, ¹H NMR and solid-state ¹³C NMR spectroscopy were used to characterize DMCh and to determine its average d...
Article
Full-text available
Polyalkylthiophenes are applied in the form of thin films as active layers in organic devices. The main properties defined in the synthetic procedure that can affect the film formation are the molar mass and regioregularity degree (the content of head-to-tail, HT, linkages). These properties can be varied, at principle, by changing the conditions o...

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