Wilhelmus J Kwanten

Wilhelmus J Kwanten
University of Antwerp | UA · Laboratory of experimental medicine and pediatrics (LEMP)

MD, PhD

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37
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Publications

Publications (37)
Article
Background & Aims Portal hypertension (PH) is the strongest predictor of hepatic decompensation and death in patients with cirrhosis. However, its discriminatory accuracy in patients with non-alcoholic fatty liver disease (NAFLD) has been challenged as hepatic vein catheterization may not reflect the real portal vein pressure as accurately as in pa...
Article
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Background and aims To evaluate the association between muscle mass and fatty infiltration and biopsy-assessed NAFLD in patients with obesity. Materials and Methods At inclusion (n=184) and 12 months after a dietary intervention (n=15) or a bariatric surgery (n=24), we evaluated NAFLD with liver biopsy, skeletal muscle mass index with computed tom...
Article
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Monitoring the progression of non-alcoholic fatty liver disease is hindered by a lack of suitable non-invasive imaging methods. Here, we show that the endogenous pigment lipofuscin displays strong near-infrared and shortwave-infrared fluorescence when excited at 808 nm, enabling label-free imaging of liver injury in mice and the discrimination of p...
Article
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Background and Aims: Non-alcoholic steatohepatitis (NASH) is a multisystem condition, involving the liver, adipose tissue, and immune system. Regulatory T (Treg) cells are a subset of T cells that exert an immune-controlling effect. Previously, a reduction of Treg cells in the visceral adipose tissue (VAT) was shown to be associated with a more sev...
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Background & Aims Non-alcoholic steatohepatitis (NASH) is a multisystem condition, implicating liver and adipose tissue. Whereas the general involvement of the innate and adaptive immune system has been established, we aimed to define the exact role of the functionally diverse T-cell subsets in NASH pathogenesis through diet reversal and immunologi...
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Purpose of Review In non-alcoholic fatty liver disease (NAFLD), an increased portal pressure is observed before signs of cirrhosis or even inflammation or fibrosis are histologically present. This review describes the differences between the mechanisms of cirrhotic portal hypertension (PHT) and PHT in non-cirrhotic NAFLD. Recent Findings The incre...
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Non-alcoholic fatty liver disease (NAFLD) constitutes a spectrum of disease states characterized by hepatic steatosis and is closely associated to obesity and the metabolic syndrome. In non-alcoholic steatohepatitis (NASH), additionally, inflammatory changes and hepatocellular damage are present, representing a more severe condition, for which the...
Article
Sarcopenia, described as the loss of muscle mass and/or strength, is gaining importance as it can be increasingly related to many chronic diseases. It is also associated with chronic liver disease, and recently it has been more frequently linked to non‐alcoholic fatty liver disease (NAFLD) in particular. Both sarcopenia and NAFLD are subject to com...
Article
Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of disease ranging from steatosis to steatohepatitis (NASH) and fibrosis, but the underlying pathophysiological mechanisms remain largely unknown. As there is currently no approved pharmacological therapy and the prevalence of NAFLD keeps increasing, understanding of its pathophysiology is...
Article
Treatment-related side effects are a major clinical problem in cancer treatment. They lead to reduced compliance to therapy as well as increased morbidity and mortality. Well-known are the sequelae of chemotherapy on the heart, especially in childhood cancer survivors. Therefore, measures to mitigate the adverse events of cancer therapy may improve...
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Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease. The presence of portal hypertension has been demonstrated in NAFLD prior to development of inflammation or fibrosis, and is a result of extrahepatic and intrahepatic factors, principally driven by vascular dysfunction. An increased intrahepatic vascular r...
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Non-Alcoholic Fatty Liver Disease (NAFLD) is highly prevalent and associated with considerable liver-related and non-liverrelated morbidity and mortality. There is, however, a lot of uncertainty on how to handle NAFLD in clinical practice. The current guidance document, compiled under the aegis of the Belgian Association for the Study of the Liver...
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Nonalcoholic fatty liver disease prevalence is soaring with the obesity pandemic, but the pathogenic mechanisms leading to the progression toward active nonalcoholic steatohepatitis (NASH) and fibrosis, major causes of liver-related death, are poorly defined. To identify key components during the progression toward NASH and fibrosis, we investigate...
Article
Conclusion: We identified autophagy as a pivotal cell response determining the efficiency of AAV's intracellular processing in hepatocytes and thus the outcome of liver-directed gene therapy using AAV vectors, and showed in a proof-of-principle study how this newly identified virus-host-interaction can be employed to enhance efficacy of this vecto...
Chapter
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the Western world. The first stage of NAFLD includes macrovesicular fat accumulation without inflammation or fibrosis, and is referred to as non-alcoholic fatty liver (NAFL or simple steatosis). In some patients, simple steatosis progresses to non-alcoholic ste...
Chapter
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https://www.intechopen.com/books/autophagy-in-current-trends-in-cellular-physiology-and-pathology/autophagy-in-non-alcoholic-fatty-liver-disease-nafld-
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BACKGROUND & AIMS Autophagy and the unfolded protein response (UPR) are key cellular homeostatic mechanisms and are both involved in liver diseases, including non-alcoholic fatty liver disease (NAFLD). Although increasing but conflicting results link these mechanisms to lipid metabolism, their role and potential crosstalk herein has been poorly inv...
Article
Non-alcoholic fatty liver disease (NAFLD) has become one of the most frequent chronic liver diseases in the Western society and its prevalence is likely to rise even further. An increasing body of evidence shows that NAFLD is not only a potentially progressive liver disease, but also has systemic consequences. More specifically, evidence points out...
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http://www.wjgnet.com/1007-9327/full/v20/i23/7325.htm || Autophagy is a mechanism involved in cellular homeostasis under basal and stressed conditions delivering cytoplasmic content to the lysosomes for degradation to macronutrients. The potential role of autophagy in disease is increasingly recognised and investigated in the last decade. Nowadays...
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Non-alcoholic fatty liver disease can progress to steatohepatitis and fibrosis, and is also associated with impaired liver regeneration. The pathophysiology remains elusive. We recently showed that severe steatosis is associated with an increase in portal pressure, suggesting liver flow impairment. The objective of this study is to directly assess...
Article
Acute appendicitis is the most frequent cause of an acute abdomen. It is important to recognize it on time to prevent complications. This study gives an overview of a structured approach based on current literature. Diagnosing acute appendicitis is not always easy and is mainly based on anamnesis and physical examination. The characteristic present...

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