Wilfried Gyselaers

Wilfried Gyselaers
Hasselt University · Physiology Research Group (FYSIO)

About

175
Publications
31,248
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2,945
Citations
Citations since 2017
73 Research Items
2279 Citations
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20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500

Publications

Publications (175)
Article
Background: As by definition, mean arterial pressure equals the product of cardiac output (CO) and total vascular resistance (TPR), we hypothesized that, irrespective of thresholds to define hypertension, a CO-TPR imbalance might exist in first-trimester normotensive pregnancies with altered risks for adverse gestational outcomes. Methods: A sta...
Article
Full-text available
PurposeThis study aimed to investigate Doppler characteristics of maternal internal jugular veins in uncomplicated pregnancies vs. those affected by hypertensive disorders.Materials and methodsVenous pulse transit time and venous impedance index were measured at three different locations (right proximal, right distal, left proximal) of internal jug...
Article
Full-text available
The gold standard to measure intra-abdominal pressure (IAP) is intra-vesical measurement via the urinary bladder. However, this technique is restricted in ambulatory settings because of the risk of iatrogenic urinary tract infections. Rectal IAP measurements (IAPrect) may overcome these limitations, but requires validation. This validation study co...
Article
Full-text available
Introduction Following the detection of fetal growth restriction, there is no consensus about the criteria that should trigger delivery in the late preterm period. The consequences of inappropriate early or late delivery are potentially important yet practice varies widely around the world, with abnormal findings from fetal heart rate monitoring in...
Article
Standardized combined Doppler-electrocardiogram assessment was performed longitudinally at three different locations of internal jugular veins between 12 wk of gestation and 6 wk postnatally in 24 uncomplicated pregnancies. All images were classified as typical or non-typical based on the presence of the physiologic deflections A, X, H and C. Linea...
Article
Gestational hypertension and preeclampsia are the 2 main types of hypertensive disorders in pregnancy. Noninvasive maternal cardiovascular function assessment, which helps obtain information from all the components of circulation, has shown that venous hemodynamic dysfunction is a feature of preeclampsia but not of gestational hypertension. Venous...
Article
Female heart disease has for a long time been an underrecognized problem in the field of cardiology. With an ever-growing number of these patients getting pregnant, cardiac dysfunction during pregnancy is an increasingly large medical problem. Previous work has shown that maternal heart disease may have an adverse effect on pregnancy outcome in bot...
Article
The opinion on the mechanisms underlying the pathogenesis of preeclampsia still divides scientists and clinicians. This common complication of pregnancy has long been viewed as a disorder linked primarily to placental dysfunction, which is caused by abnormal trophoblast invasion, however, evidence from the previous 2 decades has triggered and suppo...
Article
Full-text available
Background Up to now, 3 epidemiological studies have shown clear inverse associations between prenatal acrylamide exposure and birth size. In addition to studying the association between acrylamide and birth size, we investigated the interaction between acrylamide and polymorphisms in acrylamide-metabolising genes, with the aim of probing the causa...
Article
Full-text available
Background The micronutrient iodine is essential for a healthy intrauterine environment and is required for optimal fetal growth and neurodevelopment. Evidence linking urinary iodine concentrations, which mainly reflects short-term iodine intake, to gestational diabetes mellitus (GDM) is inconclusive. Although the placental concentrations would bet...
Article
Full-text available
Background Observational data from the retrospective, non-randomized Pregnancy REmote MOnitoring I (PREMOM I) study showed that remote monitoring (RM) may be beneficial for prenatal observation of women at risk for gestational hypertensive disorders (GHD) in terms of clinical outcomes, health economics, and stakeholder perceptions. PREMOM II is a p...
Article
Full-text available
We investigate the relationship between maternal cardiovascular (CV) function and fetal Doppler changes in healthy pregnancies and those with pre-eclampsia (PE), small for gestational age (SGA) or fetal growth restriction (FGR). This was a three-centre prospective study, where CV assessment was performed using inert gas rebreathing, continuous Dopp...
Article
Full-text available
Background To investigate the possibility of using maternal biophysical parameters only in screening for the different types of gestational hypertensive diseases. Methods A total of 969 pregnant women were randomly screened in first and second trimester, of which 8 developed Early-onset Preeclampsia, 29 Late-onset Preeclampsia, 35 Gestational Hype...
Preprint
Background Up to now, 3 epidemiological studies have shown clear inverse associations between prenatal acrylamide exposure and birth size. In addition to studying the association between acrylamide and birth size, we investigated the interaction between acrylamide and polymorphisms in acrylamide-metabolising genes, with the aim of probing the causa...
Article
Full-text available
Particle transfer across the placenta has been suggested but to date, no direct evidence in real-life, human context exists. Here we report the presence of black carbon (BC) particles as part of combustion-derived particulate matter in human placentae using white-light generation under femtosecond pulsed illumination. BC is identified in all screen...
Article
Elevated blood pressure (BP) in early life may lead to cardiovascular morbidity and mortality in later life. Air pollution exposure has been associated with increased BP in adults and children, but the contribution of prenatal air pollution exposure has rarely been assessed. In addition, we are not aware of any study on neonatal BP and maternal res...
Article
Background: Obesity is a major risk factor for cardiovascular diseases. In this study, we aimed to investigate the maternal circulatory differences during pregnancy between obese and normal weight women. Materials and methods: The functioning of the maternal circulation (arteries, veins, heart and body fluid) was assessed by ECG-Doppler ultrasou...
Poster
Full-text available
Iodine is an essential trace element, used in the production of thyroid hormones, and plays a key role during the gestational period for optimal foetal growth and (neuro-)development. To this day, Europe still faces the public health problems of iodine deficiency. Previous studies indicate that the placental iodine levels are representative for the...
Article
Full-text available
BACKGROUND: Pregnancy-induced hypertension (PIH) is associated with high levels of morbidity and mortality in mothers, fetuses, and newborns. New technologies, such as remote monitoring (RM), were introduced in 2015 into the care of patients at risk of PIH in Ziekenhuis Oost-Limburg (Genk, Belgium) to improve both maternal and neonatal outcomes. In...
Article
Introduction: Telemonitoring of hypertension in pregnancy is becoming increasingly common. Several small studies have described the potential benefits of patient-led, remote monitoring; including fewer hospital visits, better blood pressure control and cost savings. Areas Covered: This review summarises the principles of prenatal remote monitoring...
Article
It is generally accepted today that there are two different types of preeclampsia: an early-onset or placental type and a late-onset or maternal type. In the latent phase, the first one presents with a low output/high resistance circulation eventually leading in the late second or early third trimester to an intense and acutely aggravating systemic...
Article
Full-text available
Objective: To assess the cost-effectiveness of treatment with nifedipine compared to atosiban in women with threatened preterm birth. Design: An economic analysis alongside a randomized clinical trial (the APOSTEL III study). Setting: Obstetric departments of twelve tertiary hospitals and seven secondary hospitals in the Netherlands and Belgiu...
Conference Paper
Full-text available
Preterm birth (PTB), or birth before the completion of 37 weeks of pregnancy, is the leading cause of neonatal morbidity and mortality and the second-leading cause of death in children under the age of five. The importance of early intervention to prevent and reduce the impact of PTB is clear. However, no solution is currently available to easily a...
Article
Background: A mobile health application is an exciting, fast-paced domain that is likely to improve prenatal care. Methods: In this narrative review, we summarise the use of mobile health applications in this setting with a special emphasis on both the benefits of remote monitoring devices and the potential pitfalls of their use, highlighting th...
Article
Full-text available
This review summarizes current knowledge from experimental and clinical studies on renal function and venous hemodynamics in normal pregnancy, in gestational hypertension (GH) and in two types of preeclampsia: placental or early-onset preeclampsia (EPE) and maternal or late-onset (LPE) preeclampsia, presenting at <34 weeks and ≥34 weeks respectivel...
Poster
Full-text available
Title* Early labour detection in laboratory and free-living conditions using combined electrohysterography and heart rate data Objective * Detection and management of complications such as preterm birth, could be improved by early labour detection. In our previous work, we showed that specific patterns in physiological data such as electrohysterogr...
Article
Background: Pregnancies complicated with small for gestational age (SGA) neonates are reported with maternal circulatory maladaptations. Objectives: We aimed to understand the pathophysiology of the maternal circulation in normotensive SGA pregnancies and to point out the trimestral differences from those with appropriate-to-large (non-SGA [NGA]...
Article
Full-text available
Objectives: Overwhelming clinical evidence exists on disturbed vascular and endothelial function in the pathophysiology of preeclampsia (PE). In a non-pregnant (NP) population, L-FMC (low-flow mediated constriction) provides insight in the 'resting' endothelial capacity in contrast to the gold standard of flow mediated dilatation (FMD), reflecting...
Article
Detection and management of complications such as preterm birth, could be improved by early labour detection. In our previous work, we showed that specific patterns in physiological data such as electrohysterography (EHG) and heart rate (HR) could be used to build predictive statistical models able to detect labour. In this work we highlight how ph...
Article
Background: The Pregnancy Remote Monitoring (PREMOM) study enrolled pregnant women at increased risk of developing hypertensive disorders of pregnancy and investigated the effect of remote monitoring in addition to their prenatal follow-up. Objective: The objective of this study was to investigate the perceptions and experiences of remote monitorin...
Article
Full-text available
Objectives To evaluate body water volumes and cardiac output in each trimester of pregnancies complicated with hypertension and/or poor fetal growth, relative to uncomplicated pregnancy. Methods In this semi-longitudinal cohort study, a standardised non-invasive maternal hemodynamics assessment in first, second or third trimester was performed in...
Data
Details on patient’s demographics and impedance measurements of volumes and cardiac output. (PDF)
Article
Background: In 2015, we performed a cost analysis of a prenatal remote monitoring (RM) program compared with conventional care (CC) for women diagnosed with gestational hypertensive disorders (GHD). Introduction: We investigated where the cost savings were distributed by dividing our patient population into three subgroups, according to the gest...
Article
Intrathoracic impedance was remotely monitored from preconception to postpartum in a woman with an implantable cardioverter defibrillator. At 6 and 20 weeks, two significant changes were recorded, suggestive for thoracic fluid accumulation. After normal outcome, postpartum intrathoracic impedance returned to preconception values. The obtained resul...
Preprint
BACKGROUND Pregnancy-induced hypertension (PIH) is associated with high levels of morbidity and mortality in mothers, fetuses, and newborns. New technologies, such as remote monitoring (RM), were introduced in 2015 into the care of patients at risk of PIH in Ziekenhuis Oost-Limburg (Genk, Belgium) to improve both maternal and neonatal outcomes. In...
Article
Background: Pregnancy-induced hypertension (PIH) is associated with high levels of morbidity and mortality in mothers, fetuses, and newborns. New technologies, such as remote monitoring (RM), were introduced in 2015 into the care of patients at risk of PIH in Ziekenhuis Oost-Limburg (Genk, Belgium) to improve both maternal and neonatal outcomes. I...
Article
Full-text available
Background During normal pregnancy, placental oxidative stress (OS) is present during all three trimesters and is necessary to obtain normal cell function. However, if OS reaches a certain level, pregnancy complications might arise. In preeclampsia (PE), a dangerous pregnancy specific hypertensive disorder, OS induced in the ischemic placenta cause...
Preprint
Normal reference ranges of maternal impedance cardiography, bioimpedance spectrum analysis and venous combined ECG-Doppler sonography, as applied in the protocol for Maternal Cardiovascular Profiling published as10.17504/protocols.io.tffejjn
Preprint
A maternal cardiovascular profile was assessed in every pregnant woman combining three non-invasive techniques to obtain information about arteries, veins, heart and body fluid content (Table 1). A standardized protocol was used as reported in previous studies, as enlisted below.
Poster
Full-text available
In this study, we present a hidden Markov model approach to pre-eclampsia (PE) diagnosis using the Viterbi algorithm. We aim at identifying PE in high-risk pregnancies monitored in hospital settings. The proposed model uses daily blood pressure measurements collected using commercially available sensors, starting at 20 weeks of gestational age. An...
Preprint
Full-text available
BACKGROUND The Pregnancy Remote Monitoring (PREMOM) study enrolled pregnant women at increased risk of developing hypertensive disorders of pregnancy and investigated the effect of remote monitoring in addition to their prenatal follow-up. OBJECTIVE The objective of this study was to investigate the perceptions and experiences of remote monitoring...
Article
Full-text available
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Article
Full-text available
Background: Remote monitoring in obstetrics is relatively new; some studies have shown its effectiveness for both mother and child. However, few studies have evaluated the economic impact compared to conventional care, and no cost analysis of a remote monitoring prenatal follow-up program for women diagnosed with gestational hypertensive diseases...
Article
Full-text available
Objectives: In 2015, we showed the value of a remote monitoring (RM) follow-up program for women diagnosed with gestational hypertensive disorders (GHDs) compared with women who received conventional care (CC). We want to confirm or refute the conclusions drawn in 2015, by including data from 2016. Study design: A two year retrospective study in...
Article
Full-text available
Background: HIF1α, miR-210 and its downstream targets ISCU, COX-10, RAD52 and PTEN are all part of the placental hypoxia-responsive network. Tight regulation of this network is required to prevent development of maternal-fetal complications such as fetal growth restriction. HIF1α expression is increased in preeclamptic placentae, but little is kno...
Article
Full-text available
There is increasing evidence that the predisposition for development of chronic diseases arises at the earliest times of life. In this context, maternal pre-pregnancy weight might modify fetal metabolism and the child’s predisposition to develop disease later in life. The aim of this study is to investigate the association between maternal pre-preg...
Article
Background: The classification of hypertensive disorders of pregnancy (HDP) is based on the time at the onset of hypertension, proteinuria, and other associated complications. Maternal hemodynamic interrogation in HDP considers not only the peripheral blood pressure but also the entire cardiovascular system, and it might help to classify the diffe...
Article
Full-text available
Background Despite reported positive results of telemonitoring effectiveness in various health care domains, this new technology is rarely used in prenatal care. A few isolated investigations were performed in the past years but with conflicting results. Objective The aim of this review was to (1) assess whether telemonitoring adds any substantial...
Article
Full-text available
Background Fetal development largely depends on thyroid hormone availability and proper placental function with an important role played by placental mitochondria. The biological mechanisms by which thyroid hormones exert their effects on mitochondrial function are not well understood. We investigated the role of fetal thyroid hormones on placental...
Article
A standardized combined Doppler-electrocardiography technique was developed for measurement of the triphasic waveform characteristics in the internal jugular vein. Flow velocities at the A, X, V and Y peaks, the RR interval and the PA and RX times were measured. From these the venous impedance index ([X-A]/X) and the ratios PA/RR and RX/RR were cal...
Article
Introduction: Cardio-metabolic risk factors including insulin levels are at young age barely perceived as harmful, but over time these risk factors may track and lead to higher risk of metabolic syndrome. Studies showed that exposure to air pollution is associated with an increased risk of insulin resistance in childhood. We determined whether the...
Article
Full-text available
Background Although remote monitoring (RM) has proven its added value in various health care domains, little is known about the remote follow-up of pregnant women diagnosed with a gestational hypertensive disorders (GHD). Objective The aim of this study was to evaluate the added value of a remote follow-up program for pregnant women diagnosed with...
Article
Full-text available
Background: Despite reported early subclinical hypertension of women at risk, blood pressures at threshold 140/90 mm Hg are used today to guide prenatal care. We aim to investigate the most appropriate gestation-speci c threshold to measure early gestational blood pressures, allowing for a simple strati cation between pregnant women at low/high ris...
Article
Full-text available
The ENVIRONAGE birth cohort is supported by the European Research Council [ERC-2012-StG.310898], and by funds of the Flemish Scientific Research council [FWO, G.0.733.15.N]. Bianca Cox, Janneke Hogervorst and Karen Vrijens have a postdoctoral fellowship from the Research Foundation - Flanders (FWO).
Article
Full-text available
In this paper we propose a method combining electrohysterography (EHG) and heart rate (HR) data to detect labour. Labour detection may be helpful in providing just in time care and avoiding unnecessary antenatal visits. Given specific changes in physiological data such as EHG and HR highlighted from previous literature in correspondence of uterine...
Article
Full-text available
In this paper, we propose a method to improve accuracy of fetal kicks detection during pregnancy using a single wearable device placed on the abdomen. Monitoring fetal wellbeing is key in modern obstetrics as it is routinely used as a proxy to fetal movement. However, accurate, nonin-vasive, long-term monitoring of fetal movement is challenging, es...
Article
Full-text available
Background: Maternal smoking during pregnancy results in an increased risk of low birth weight through perturbations in the utero-placental exchange. Epigenetics and mitochondrial function in fetal tissues might be molecular signatures responsive to in utero tobacco smoke exposure. Methods: In the framework of the ENVIRONAGE birth cohort, we inv...
Article
Full-text available
Background: Newborn telomere length sets telomere length for later life. At birth, telomere length is highly variable among newborns and the environmental factors during in utero life for this observation remain largely unidentified. Obesity during pregnancy might reflect an adverse nutritional status affecting pregnancy and offspring outcomes, but...
Article
Full-text available
Background The maternal cardiovascular system adapts quickly when embryo implantation is recognized by the body. Those adaptations play an important role, as a normal cardiovascular adaptation is a requirement for a normal course of pregnancy. Disturbed adaptations predispose to potential hypertensive disorders further in pregnancy [1–3]. This repo...
Article
Objectives: Venous compliance is known to differ between uncomplicated and preeclamptic pregnancies and can be assessed using Doppler ultrasonography. The purpose of this report is to address some of the interfering conditions in order to illustrate some of the limitations of venous Doppler sonography. Methods: Five case reports of pregnant wome...