Wilfredo Alejandro González-Arriagada

Wilfredo Alejandro González-Arriagada
Universidad de Valparaíso (Chile) | CINV · School of Dentistry

MSc; PhD

About

118
Publications
25,090
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400
Citations
Introduction
Associate Professor, Universidad de Valparaíso Oral and Maxillofacial Pathologist, El Carmen Hospital, Maipú Director of Research Office Director of Master of Dental Sciences Director of Specialty in Oral and Maxillofacial Pathology
Additional affiliations
January 2009 - March 2014
University of Campinas
Position
  • PhD
January 2007 - August 2019
Universidad de Valparaíso (Chile)
Position
  • Professor (Assistant)
March 2005 - present
Universidad de Valparaíso (Chile)
Position
  • Professor (Assistant)

Publications

Publications (118)
Article
Full-text available
Background Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies,...
Article
T regulatory cells (Tregs) suppressive function can have a detrimental effect on immune responses against tumor cells. Within the Treg cells subset, a new non-classical population has been reported, which express high levels of CD49b molecule and, depending on their activation status, can also express the canonical Tregs transcription factor Foxp3....
Preprint
Background Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies,...
Article
Optogenetics is a molecular biological technique involving transfection of cells with photosensitive proteins and the subsequent study of their biological effects. The aim of this study was to evaluate the effect of blue light on the survival of HeLa cells, transfected with channelrhodopsin-2 (ChR2). HeLa wild-type cells were transfected with a pla...
Preprint
The poor prognosis of head and neck cancer (HNC) is associated with the presence of metastasis within the lymph nodes (LNs). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN-negative or -positive tissues, saliva, and blood cells, reveals insights into the biology and potential metastasis b...
Article
Full-text available
Near-infrared spectroscopy (NIRS) is a non-ionizing optical technique that can be used to quantify proteins, carbohydrates, fats, and other organic and biological substances. The aim of this study was to determine the ability of NIRS to identify different concentrations of L-fucose and L-proline solutions by utilizing different NIR spectral regions...
Article
Background The communication between cancer cells and lymphatic fibroblasts is important for the implantation of lymph node metastasis and chemokines play a fundamental role. CCR5 is one of the main chemokine receptors associated to regional lymph node metastasis; however, the mechanisms of the CCL5/CCR5 axis in oral squamous cell carcinoma (OSCC)...
Article
Objective To report the clinicopathologic features of acquired oral syphilis cases in South American countries. Materials and Methods Clinical data were retrospectively collected from the records of 18 oral diagnostic services in Argentina, Brazil, Chile, Colombia, Venezuela, Uruguay, and Peru. Serologies of non-treponemal and treponemal tests wer...
Article
Background Plasma cell neoplasms are characterized by the proliferation of a single clone of plasma cells with production of a monoclonal immunoglobulin. They can manifest as a single lesion (plasmacytoma) or as multiple lesions (multiple myeloma). Methods Paraffin-embedded tissue blocks of patients microscopically diagnosed with plasma cell neopl...
Article
Full-text available
The oral squamous cell carcinoma (OSCC), which has a high morbidity rate, affects patients worldwide. Changes in SPINK7 in precancerous lesions could promote oncogenesis. Our aim was to evaluate SPINK7 as a potential molecular biomarker which predicts OSCC stages, compared to: HER2, TP53, RB1, NFKB and CYP4B1. This study used oral biopsies from thr...
Article
Full-text available
Statement of problem Established restorative protocols for patients after head and neck radiotherapy are lacking, increasing the failure rates of dental adhesive restorations. Purpose The purpose of this systematic review and meta-analysis was to analyze the evidence regarding the impact of head and neck radiotherapy on the longevity of dental adh...
Article
Background Trophoblast cell surface antigen 2 (TROP2) has unclear clinical role in oral squamous cell carcinomas (OSCC). Here, we investigated the association of TROP2 immunoexpression with clinicopathological parameters and survival of OSCC patients. Subjects and Methods Cancer‐specific survival (CSS) and disease‐free survival (DFS) were assessed...
Article
Full-text available
Oral leukoplakia is the most prevalent potentially malignant disorder of the oral cavity. To evaluate its potential for malignancy, appropriate documentation of the biological parameters is crucial, allowing the patients' progression to be assessed. We hypothesized a lack of standardization in the parameters employed for the prognostic study of ora...
Article
Objective Identifying markers that influence oral squamous cell carcinoma (OSCC) prognosis is a fundamental strategy to improve the overall survival of patients. Markers such as eukaryotic translation elongation factor 1δ (EEF1D), fascin, N-terminal propeptide of type I collagen (PINP), and cancer-associated fibroblasts (CAFs) have been noticed in...
Article
Introducción: Para los trastornos temporomandibulares (TTM) el tratamiento de primera línea es el conservador, éste incluye a la terapia convencional, además se ha descrito el uso de la estimulación nerviosa eléctrica transcutánea (TENS). El objetivo de este estudio fue determinar la respuesta terapéutica del TENS como complemento a la terapia conv...
Article
Introducción: Para los trastornos temporomandibulares (TTM) el tratamiento de primera línea es el conservador, éste incluye a la terapia convencional, además se ha descrito el uso de la estimulación nerviosa eléctrica transcutánea (TENS). El objetivo de este estudio fue determinar la respuesta terapéutica del TENS como complemento a la terapia conv...
Preprint
Full-text available
The oral squamous cell carcinoma (OSCC) affects patients worldwide with a high morbidity rate. Changes of SPINK7 in precancerous lesions could promote oncogenesis. Our aim was to evaluate SPINK7 as a potential molecular biomarker predictive of OSCC stages, compared with: HER2, TP53, RB1, NFKB and CYP4B1. Oral biopsies from patients with dysplasia (...
Article
Full-text available
Cannabis, a psychoactive drug widely used for medicinal, recreational, and religious purposes, can have detrimental effects on several body systems, including the respiratory, cardiovascular, and central nervous systems. The use of cannabis in cigarette form can produce a series of oral alterations, including periodontitis, caries, xerostomia, a de...
Article
Full-text available
Background/purpose Temporomandibular disorders (TMD) are common conditions that involve the temporomandibular joints (TMJs), jaw muscles, or both, and can cause alteration in the mandibular kinematics. The aim of this study was to assess the relationship between mandibular kinematics and temporomandibular joint disorders (TMJD) as a clinical tool f...
Preprint
Full-text available
Background. The oral squamous cell carcinoma (OSCC) affects more than 300,000 patients annually worldwide with a high morbidity rate (37.8%). Several tumor biomarkers have been suggested to anticipate outcome but results were poor. Changes of SPINK7 and associated proteins in precancerous oral lesions could lead to genomic instability and promote o...
Article
Full-text available
Today, we face difficulty in generating new hypotheses and understanding oral lichen planus due to the large amount of biomedical information available. In this research, we have used an integrated bioinformatics approach assimilating information from data mining, gene ontologies, protein–protein interaction and network analysis to predict candidat...
Article
Purpose: The main goal of this study was to evaluate the impact of different ionizing radiation doses on the mineral (carbonate/phosphate ratio, crystallinity index [CI]) and organic (amide III/phosphate, amide I sub-band ratios) structures, as well as the microhardness, of enamel and dentin, along with their influence on the bonding strength stabi...
Article
The ageing of population is increasing, and a great percentage of these patients wear removable prostheses, and can suffer denture stomatitis, a condition that has been associated with candidiasis. Aims: To evaluate in vitro the effectiveness of Copper Sulfate against Candida albicans in samples of heat-polymerized acrylic resin, compared to nystat...
Article
Infectious mononucleosis (IM) is a very common disease, and although in most instances, the patient develops an asymptomatic infection, other patients progress into an array of signs and symptoms that tend to be characteristic of the pathological process, guiding the clinician into choosing the right laboratory examinations under the suspicion of t...
Article
Background: MiRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level and have been associated with malignant transformation of oral epithelial precursor lesions such as oral leukoplakia. The aim was to perform a scoping review of the contemporary literature about the different roles of miRNAs during the mali...
Article
Background: Radiotherapy is widely used in contemporary head and neck cancer treatment protocols. The ability of head and neck radiotherapy (HNRT) to cause direct radiogenic destruction to the teeth is one of the most controversial topics in the field of oral oncology. Therefore, this systematic review aimed to investigate ionising radiation as an...
Article
Objectives Radiation-related caries is an important collateral effect in patients with head and neck cancer subjected to radiotherapy, with rapidly progressive, asymptomatic and ample lesions, associated to direct and indirect effects of radiation. The present study has the aim of determine the alterations of the immunoexpression of collagen IV and...
Article
Objectives MicroRNAs play an important role in the development and progression of head and neck squamous cell carcinomas (HNSCC). In the current study, we compared the expression levels of microRNAs in primary HNSCC with and without cervical lymph node metastasis and determined their clinicopathological significance. The expression levels of miR-26...
Conference Paper
Alhough lymph node measasis is he main prognosic facor in paiens wih head and neck squamous cell carcinoma (HNSCC), he molecular signals involved in his process are poorly characerized and no molecular markers are currenly used in clinical pracice. Recenly, cancer is being viewed as an ecosysem, in which umor cells cooperae wih each oher and hos ce...
Conference Paper
Alhough lymph node measasis is he main prognosic facor in paiens wih head and neck squamous cell carcinoma (HNSCC), he molecular signals involved in his process are poorly characerized and no molecular markers are currenly used in clinical pracice. Recenly, cancer is being viewed as an ecosysem, in which umor cells cooperae wih each oher and hos ce...
Article
Full-text available
Background Diverse studies have evidenced that chemokines can play a critical role in pathogenesis of oral squamous cell carcinoma (SCC). The main chemokines involved in oral carcinogenesis, tumor invasion and metastasis are CCR4, CCR5, CCR7 and CXCR4, and our aim was to evaluate the prognostic value of the immunoexpression of these chemokines in S...
Article
Full-text available
Background: Breast cancer is a malignant disease that represents an important public health burden. The description of new molecular markers can be important to diagnosis, classifica�tion, and treatment. Transient receptor potential vanilloid 1 (TRPV1) polymodal channel is expressed in different neoplastic tissues and cell lines of breast cancer...
Article
Full-text available
The analysis of the salivary metabolomic profile may offer an early phase approach to assess the changes associated with a wide range of diseases including head and neck cancer. The aim of the present study was to investigate the potential of nuclear magnetic resonance (NMR) spectroscopy for detecting the salivary metabolic changes associated with...
Article
Full-text available
Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological and molecular characteristics limiting the standard tumor-node-metastasis prognosis classification. Therefore, defining biological signatures that allow assessing the prognostic outcomes for OSCC patients would be of great clinical significance. Using histopa...