Wietje Nolte

Wietje Nolte
Saxon State Office for Environment, Agriculture and Geology · Agriculture

Dr. agr.

About

15
Publications
2,072
Reads
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151
Citations
Introduction
Wietje Nolte currently works at the Saxon State Office for Environment, Agriculture and Geology (LfULG) in Germany. Her major interest is in equine genetics and currently Wietje is part of a research group working towards the implementation of genomic selection and the change of the method for parentage control in German warmblood horses.
Additional affiliations
August 2018 - November 2018
The Commonwealth Scientific and Industrial Research Organisation
Position
  • Researcher
January 2017 - December 2019
Leibniz Institute for Farm Animal Biology
Position
  • PhD Student
Education
January 2017 - June 2021
University of Rostock
Field of study
  • Animal Breeding and Livestock Genetics
October 2014 - November 2016
University of Rostock
Field of study
  • Livestock Science
September 2010 - July 2014
Hogeschool Van Hall Larenstein
Field of study
  • Animal Husbandry

Publications

Publications (15)
Article
Full-text available
The study of selection signatures helps to find genomic regions that have been under selective pressure and might host genes or variants that modulate important phenotypes. Such knowledge improves our understanding of how breeding programmes have shaped the genomes of livestock. In this study, 942 stallions were included from four, exemplarily chos...
Article
Full-text available
Background: Genomic regions associated with divergent livestock feed efficiency have been found predominantly outside protein coding sequences. Long non-coding RNAs (lncRNA) can modulate chromatin accessibility, gene expression and act as important metabolic regulators in mammals. By integrating phenotypic, transcriptomic, and metabolomic data with...
Article
Full-text available
Long non-coding RNAs (lncRNAs) can influence transcriptional and translational processes in mammalian cells and are associated with various developmental, physiological and phenotypic conditions. However, they remain poorly understood and annotated in livestock species. We combined phenotypic, metabolomics and liver transcriptomic data of bulls div...
Article
Long non-coding RNAs (lncRNAs) hold gene regulatory potential, but require substantial further functional annotation in livestock. Applying two metabogenomic approaches by combining transcriptomic and metabolomic analyses, we aimed to identify lncRNAs with potential regulatory function for divergent nutrient partitioning of lactating crossbred cows...
Conference Paper
Seit über zwei Jahrzehnten wird die Abstammungskontrolle für Pferde in Deutschland über das von der International Society for Animal Genetics empfohlene Abstammungspanel mit Mikrosatelliten (MS) durchgeführt. Im Rahmen der geplanten Einführung der genomischen Selektion beim deutschen Warmblutpferd soll in naher Zukunft die Umstellung auf ein SNP-ba...
Conference Paper
In equine parentage control, the current common practice is the use of an internationally agreed upon microsatellite (MS) marker panel. In German horse breeding the goal is to transition to a SNP-based parentage control system. To facilitate the change from one method to another, an intermediate solution is the imputation of MS markers based on SNP...
Article
Full-text available
Reliability of genomic predictions is influenced by the size and genetic composition of the reference population. For German Warmblood horses, compilation of a reference population has been enabled through the cooperation of five German breeding associations. In this study, preliminary data from this joint reference population were used to genetica...
Thesis
The majority of the mammalian genomeconsists of genomic elements that do not code for a protein, including the class of long non-coding RNA (lncRNA), whose role in phenotypic modulationin livestock remains largely unknown. In this dissertation, an integrative approach was used to analyse the transcriptome, phenome and metabolome of bulls (N = 24) a...
Article
Full-text available
High ambient temperature has multiple potential effects on the organism such as hyperthermia, endotoxemia, and/or systemic inflammation. However, it is often difficult to discriminate between cause and consequence of phenotypic effects, such as the indirect influence of heat stress via reduced food intake. Lactating dairy cows are a particularly se...
Data
Breed specific significant integrated Haplotype Score (iHS) signals (-log10(p-value) ≥ 4.0) in Trakehner, Holsteiner, Hanoverian and Oldenburger. (DOC)
Data
Breed specific Runs of Homozygosity (ROH) in Holsteiner, Hanoverian, Oldenburger and Trakehner. ROH were shared by at least 33 percent of all individuals (N = 942) in the sample set. (DOC)
Conference Paper
Full-text available
In modern livestock production systems resource efficiency and nutrient transformation play a crucial role for optimal animal husbandry and economic success. Animals expressing divergent metabolic phenotypes under identical environmental conditions have conjectured genetic differences, many of which may be found outside protein coding regions. Whil...
Conference Paper
Genetische Diversität ist der Grundstein für jegliche Selektion und Zuchtfortschritt. Daher ist detaillierte Kenntnis der gegenwärtigen Populationsstruktur und ihrer Entwicklung fundamental für die erfolgreiche Konzeption und Implementierung von Zuchtprogrammen. Insbesondere der Inzuchtkoeffizient (F) und die effektive Populationsgröße (Ne) geben E...

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Cited By

Projects

Projects (4)
Project
Validation and establishment of a breeding value estimation for the breed Saxon-Thuringian heavy warmblood in the breeding area Saxony/Thuringia taking into account new traits, e.g. aptitude for driving.
Project
The goal of this project is to assess structure, practices and management of private as well as professional horse farms in Saxony (Germany) with particular focus on grassland management.
Project
Despite the revolution in functional genome analysis a wide gap in understanding associations between the (epi)genome and complex phenotypes of interest currently remains and impedes efficient use of annotated genomes for precision breeding. The BovReg consortium will provide a comprehensive map of functionally active genomic features in cattle and how their (epi)genetic variation in beef and dairy breeds translates into phenotypes. This constitutes key knowledge for biology-driven genomic prediction needed by scientific and industry livestock communities. The BovReg brings together a critical mass of experts in ruminant research and beyond encompassing bioinformatics, molecular and quantitative genetics, animal breeding, reproductive physiology, ethics and social science. BovReg is embedded in the global and European activities on the Functional Annotation of Animal Genomes (FAANG). This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 815668.