Wiep van der Toorn

Wiep van der Toorn
Freie Universität Berlin | FUB · Institute of Computer Science

About

7
Publications
633
Reads
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48
Citations

Publications

Publications (7)
Preprint
Full-text available
Nanopore direct RNA sequencing (dRNA-seq) enables unique insights into (epi-)transcriptomics. However, applications are currently limited by the lack of accurate and cost-effective sample multiplexing. We introduce WarpDemuX, an ultra-fast and highly accurate adapter-barcoding and demultiplexing approach. WarpDemuX enhances speed and accuracy by fa...
Preprint
Full-text available
Nanopore direct RNA sequencing (dRNA-seq) enables unique insights into (epi-)transcriptomics. However, applications are currently limited by the lack of accurate and cost-effective sample multiplexing. We introduce WarpDemuX, an ultra-fast and highly accurate adapter-barcoding and demultiplexing approach. WarpDemuX enhances speed and accuracy by fa...
Article
Full-text available
Background Direct RNA sequencing (dRNA-seq) on the Oxford Nanopore Technologies (ONT) platforms can produce reads covering up to full-length gene transcripts, while containing decipherable information about RNA base modifications and poly-A tail lengths. Although many published studies have been expanding the potential of dRNA-seq, its sequencing a...
Preprint
Full-text available
Motivation: Direct RNA sequencing (dRNA-seq) on the Oxford Nanopore Technology platforms has become increasingly popular in recent years, with promising outlook to transform the field of epitranscriptomics. Reads produced from dRNA-seq can cover up to full-length gene transcripts while containing decipherable information about RNA base modification...
Article
Full-text available
Non-pharmaceutical interventions (NPIs) remain decisive tools to contain SARS-CoV-2. Strategies that combine NPIs with testing may improve efficacy and shorten quarantine durations. We develop a stochastic within-host model of SARS-CoV-2 that captures temporal changes in test sensitivities, incubation- and infectious periods. We use the model to si...
Article
Full-text available
While large-scale vaccination campaigns against SARS-CoV-2 are rolled out at the time of writing, non-pharmaceutical interventions (NPIs), including the isolation of infected individuals, and quarantine of exposed individuals remain central measures to contain the spread of SARS-CoV-2. Strategies that combine NPIs with innovative SARS-CoV-2 testing...
Preprint
Full-text available
While large-scale vaccination campaigns against SARS-CoV-2 are rolled out at the time of writing, non-pharmaceutical interventions (NPIs), including the isolation of infected individuals, and quarantine of exposed individuals remain central measures to contain the spread of SARS-CoV-2. Strategies that combine NPIs with innovative SARS-CoV-2 testing...

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