Wiebke Duettmann

Wiebke Duettmann
Charité Universitätsmedizin Berlin | Charité · Medical Department, Division of Nephrology and Internal Intensive Care Medicine

About

33
Publications
1,568
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99
Citations
Citations since 2017
33 Research Items
99 Citations
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Publications

Publications (33)
Preprint
Full-text available
Artificial Intelligence-based decision support systems (AI-DSS) to improve hemodialysis therapy are currently under development. However, the influence of AI-DSS on shared decision making (SDM) in hemodialysis patients has not been studied so far. We performed a Wizard of Oz experiment, using a sham AI-DSS suggesting ultrafiltration volume at the b...
Article
Full-text available
Introduction Artificial intelligence–driven decision support systems (AI–DSS) have the potential to help physicians analyze data and facilitate the search for a correct diagnosis or suitable intervention. The potential of such systems is often emphasized. However, implementation in clinical practice deserves continuous attention. This article aims...
Article
Full-text available
Background: High numbers of unknown classifications and inconsistent methodologies in previous studies make the interpretation of causes leading to graft loss difficult. In addition, data on a holistic view looking at both death with a functioning graft (DWF) and death-censored graft failure (DCGF) are sparse. Methods: In this single-center stud...
Article
Full-text available
Patient care after kidney transplantation requires integration of complex information to make informed decisions on risk constellations. Many machine learning models have been developed for detecting patient outcomes in the past years. However, performance metrics alone do not determine practical utility. We present a newly developed clinical decis...
Article
Full-text available
Background Remote patient management (RPM) in heart failure (HF) patients has been investigated in several prospective randomized trials. The Telemedical Interventional Management in Heart Failure II (TIM-HF2)-trial showed reduced all-cause mortality and hospitalizations in heart failure (HF) patients using remote patient management (RPM) vs. usual...
Preprint
Full-text available
Background: In the information extraction and natural language processing domain, accessible datasets are crucial to reproduce and compare results. Publicly available implementations and tools can serve as benchmark and facilitate the development of more complex applications. However, in the context of clinical text processing the number of accessi...
Preprint
Full-text available
Patient care after kidney transplantation requires integration of complex information to make informed decisions on risk constellations. Many machine learning models have been developed for detecting patient outcomes in the past years. However, performance metrics alone do not determine practical utility. Often, the actual performance of medical pr...
Article
Full-text available
Background Transplant glomerulopathy (TG) may indicate different disease entities including chronic AMR (antibody-mediated rejection). However, AMR criteria have been frequently changed, and long-term outcomes of allografts with AMR and TG according to Banff 2017 have rarely been investigated. Methods 282 kidney allograft recipients with biopsy-pr...
Article
Full-text available
Background: Antiviral drugs have shown little impact in patient infected with acute respiratory coronavirus 2 (SARS-CoV-2). Especially for immunocompromised persons positive for SARS-CoV-2, novel treatments are warranted. Recently, the U.S. FDA has granted an emergency use authorization (EUA) to two monoclonal antibodies (mAb) targeting the viral s...
Article
Full-text available
The Banff 2017 report permits the diagnosis of pure chronic antibody-mediated rejection (cAMR) in absence of microcirculation inflammation. We retrospectively investigated renal allograft function and long-term outcomes of 67 patients with cAMR, and compared patients who received antihumoral therapy (cAMR-AHT, n = 21) with patients without treatmen...
Poster
Full-text available
Expert survey with strategic evaluation of approach and usability of a prototype ("digital platform as a solution for improving communication in the context of waiting list management"). Usability testing of the transplant module of the "comjoodoc" platform, which enables data exchange between dialysis and transplant centers. Overall, the approach...
Article
Full-text available
Background: Transplant glomerulopathy (TG) is one of the main causes of post-transplant proteinuria (PU). The features and possible risk factors for proteinuria in TG patients are uncertain. Methods: We investigated all patients who had biopsy-proven TG from 2000 to 2018 in our center. The clinical and histological data were compared between two gr...
Article
Background and Aims Patients with chronic kidney disease suffer often from cardiovascular diseases, especially high blood pressure and its complications such as stroke and heart attack. After kidney transplantation, this condition persists and can in addition harm the graft. However, outpatient care surveillance is not ideal to treat high blood pre...
Article
Background Few studies have thoroughly investigated the causes of kidney graft loss (GL), despite its importance. Methods A novel approach assigns each persistent and relevant decline in renal function over the lifetime of a renal allograft to a standardized category, hypothesizing that singular or multiple events finally lead to GL. An adjudicati...
Article
The MACCS (Medical Assistant for Chronic Care Service) platform enables secure sharing of key medical information between patients after kidney transplantation and physicians. Patients provide information such as vital signs, well-being, and medication intake via smartphone apps. The information is transferred directly into a database and electroni...
Article
Full-text available
Background: The number of patients returning to dialysis after graft failure increases. Surprisingly, little is known about the clinical and immunological outcomes of this cohort. Methods: We retrospectively analyzed 254 patients after kidney allograft loss between 1997-2017 and report clinical outcomes such as mortality, relisting, retransplant...
Article
Full-text available
Proteinuria and transplant glomerulopathy (TG) are common in kidney transplantation. To date, there is limited knowledge regarding proteinuria in different types of TG and its relationship to allograft survival. A retrospective cohort analysis of TG patients from indication biopsies was performed to investigate the relationship of proteinuria, hist...
Article
Purpose of review: Although a widely recognized and complex pathophysiological condition, sarcopenic obesity remains less appreciated and may elude diagnosis and workup in both kidney transplant waitlisted candidates and kidney transplant recipients. The lack of consensus definition, and practical diagnostic tools for evaluating waitlisted candida...
Preprint
UNSTRUCTURED The Covid-19 pandemic has put new demands on the medical systems worldwide. The pressure of taking far-reaching decisions within multiply limited resources under the constraint that personal contact must be minimized has evoked the question if technical support in the form of Artificial Intelligence (AI) could help leverage these chall...
Article
Full-text available
eHealth (“electronic” Health) is a new field in medicine that has the potential to change medical care, increase efficiency, and reduce costs. In this review, we analyzed the current status of eHealth in transplantation by performing a PubMed search over the last 5 years with a focus on clinical studies for post‐transplant care. We retrieved 463 ma...
Conference Paper
Tools and resources to automatically process clinical text are very limited, particularly outside the English speaking world. As many relevant patient information within electronic health records are described in unstructured text, this is a clear drawback. In order to slightly overcome this problem, we present information extraction models for Ger...
Article
Full-text available
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 denotes a global health issue. Data regarding COVID-19 incidence in kidney transplant recipients (KTR) are sparse. From 19 March to 19 May 2020, we performed a systematic screening for COVID-19 in KTR. Tests included serum analysis for SARS-CoV-2 antibodies using S protein-based...
Chapter
Patienten nach erfolgreicher Nierentransplantation müssen meist einen komplizierten Medikationsplan einnehmen und im Alltag verschiedene Vorgaben beachten. Nicht jedem gelingt dies, was zu kurz-oder langfristigem Verlust der Transplantatfunktion mit der dann notwendigen Wiedereinleitung der Dialyse führen kann. Die Dialyse erzeugt hohe Kosten für d...
Chapter
Für die Digitalisierung im Gesundheitswesen braucht es innovative Projekte zur Optimierung veralteter Arbeitsprozesse. Das Medical Allround Care Service Solutions (MACSS) stellt prototypisch eine neuartige Smart-Health-Serviceplattform für eine integrierte Versorgung chronisch kranker Patienten zur Verfügung, die eine bidirektionale Kommunikation z...

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Projects

Projects (2)
Project
- Development and Implementation of AI based algorithms in kidney transplantation