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Publications (25)
Context: The development of novel and potent alpha-glucosidase inhibitors from natural sources holds immense promise for treating diabetes. Aims: To identify the isolated compound, determine its inhibitory potency, explore its molecular interactions with the alpha-glucosidase receptor, and understand the role of specific structural features in its...
Context: Molecularly imprinted polymers (MIPs) are promising materials with tailored binding sites that can selectively recognize and bind target molecules. The combined approach of molecular docking and molecular dynamics (MD) simulation provides valuable insights into the interactions between 3-hydroxybutyrate (3HB) and the designed MIPs, sheddin...
Introduction: Over 422 million people worldwide suffer from diabetes, causing 1.5 million fatalities annually. The existing medications have shortcomings, including poor glucose control and adverse effects. The present study aimed to create possible alpha-glucosidase inhibitors utilizing a curculigoside A derivative ligand-based model. Methods: A p...
Objective: The study aimed to investigate the interactions between twelve extracellular enzymes and nuclear factor erythroid 2–related factor 2 (Nrf2) in the active site. Methods: The Zdock web server was accessed to perform molecular docking simulations for predicting interactions between the extracellular enzymes and the active site of Nrf2. The...
Context: Water kefir is a fermented beverage that is typically made in the home by inoculating a sugar-rich solution with a microbial community (water kefir grains). Several studies on the metabolite content and hepatoprotective effects of water kefir have been published, but carbon tetrachloride (CCl4)-induced acute liver injury has not been studi...
The liver is extremely vulnerable to damage because of its role in metabolism. Toxin, metabolic syndrome, alcohol, microorganisms, and autoimmune diseases can be the cause of liver damage. While different etiologies can cause liver disease, pathophysiologically, there are similarities in the role of free radicals, inflammatory mediators, and gut mi...
Berbagai efek farmakologis telah dikaji terhadap ekstrak dan islolat dari Acalypha Indica L. terutama terkait dengan aktifitas anti kanker. Matrix metalloproteinases MMP9 merupakan contoh yang sangat baik dari kelompok proteinase terpenting yang terlibat dalam sel metastatic/kanker. MMP9 telah dikaitkan dengan berbagai macam penyakit, termasuk sist...
Objective: Tuberculosis (TB) is a major global issue, mainly owing to the emergence of antibiotic-resistant strains of the disease's causative agent, Mycobacterium tuberculosis. The current standard of treatment for tuberculosis entails a prolonged course of antibiotics with toxic side effects and is accompanied by low patient compliance. Therefore...
Primary Health Care (PHC) adalah kontak pertama individu, keluarga, atau masyarakat dengan sistem pelayanan kesehatan. PHC bertujuan untuk meningkatkan akses masyarakat terhadap pelayanan kesehatan yang berkualitas. Di Indonesia, PHC memiliki 3 (tiga) strategi utama, yaitu kerjasama multisektoral, partisipasi masyarakat, dan penerapan teknologi. Sa...
Hiperlipidemia merupakan salah satu faktor penyakit kardiovaskular dengan angka kematian di dunia cukup tinggi. Buah okra (Abelmoschus esculentus (L.) Moench) merupakan salah satu sayuran yang berpotensi dapat digunakan sebagai antihiperlipidemia. Tujuan dari penelitian ini untuk mengetahui efek antihiperlipidemia dan dosis optimal dari ekstrak air...
POTENTIAL DEVELOPMENT OF WOMAN FARMING GROUP IN THE UTILIZATION OF THE YARD FOR DRUG AND COSMETICS PLANTS USING VERTICAL GARDEN METHOD IN CIBIRU WETAN VILLAGE, BANDUNG REGENCY.
The village of Cibiru Wetan is largely a rice field and swidden area with hilly contours and insufficient water availability. One of the utilization of fields with a lack o...
Dengan diadakannya pelatihan pembuatan sabun cair pada ibu-ibu PKK di RW Pengoptimalan kegiatan ibu-ibu PKK Di RW 9 dan 17 Desa Cibiru Wetan Kecamatan Cileunyi Kabupaten Bandung diharapkanakan dapat meningkatkan kreatifitas masyarakat guna menunjang perekononian keluarga, melalui pelatihan ini masyarakat lebih punya pengetahuan mengenai peluang usa...
Diabetes mellitus is a heterogeneous group of disorders characterized by increasing blood glucose level caused by lack of insulin hormone. One of the plants that were often used as traditional medicine for diabetes in Indonesia was okra (Abelmoschus esculentus L.) fruit. The aim of this research was to evaluate the antidiabetes activity of okra fru...
Acne is an inflammatory disease in the skin triggered by the bacteria. Acne treatment can be done by using natural materials such as shiitake mushrooms (Lentinus edodes). The aims of this study were to determine the antibacterial activity of extracts and fractions of shiitake mushrooms with broth microdilution method, determine the value of equalit...
PARTNER VILLAGE IN FAMILY MEDICINE PLANT CULTIVATION TOWARDS CIBIRU WETAN VILLAGE AS A HERBAL CENTER.
The area of Cibiru Wetan Village is a farming area because besides the limited water supply, the land is hilly. With the initiative and participation of women farmer groups which had so many achievements and skills, it was necessary to explore the...
Acne is an inflammatory disease that occurs in the skin triggered by the bacteria acne treatment can be done by using natural materials that shiitake mushrooms (Lentinus edodes). This aims of this study were to determining the antibacterial activity of extracts and fractions shiitake mushrooms with broth microdilution method, determining the value...
BACKGROUND: Diabetes Mellitus (DM) is a heterogeneous group of disorders characterized by increasing blood glucose levels caused by insufficiency of insulin hormone production and activities. There are significant increases in DM case every year in Indonesia, as a consequent, alternative and better drug is needed to be developed. One of the plants...
Myrtaceae is one of the families that has been widely studied for its antioxidant activity, and many species belonging to this family have strong activity. Kupa (Syzygium polycephalum), belonging to Myrtaceae family, has not been studied in terms of both chemical and pharmacological effects. The aim of this study was to evaluate the antioxidant and...
Wound is a condition where there is damage to normal tissue structure and function. This tissue damage may be accompanied by infection or not. Wound can be treated with the help of medicines. The Dayak Tunjung community in East Kalimantan has been used karehau leaves as a traditional medicine to treat wounds. The aim of this research was to evaluat...
Objective: Inflammation is body reactions in response to tissue injury and infection. In 2011, non-steroidal anti-inflammatory drug (NSAID) was the highest demand drug in Indonesia. However, long-term treatment using NSAID can cause several side effects to cardiovascular and digestive system. This research aimed to investigate anti-inflammatory pro...
Objective: This research was to investigate the activity of Andrographis paniculata extract (APE) and Guazuma ulmifolia extract (GUE) in treating obesity integrated diabetic conditions. Methods: There were two stages of inductions: the first stage was a 42 d of high carbohydrate intake (obese with insulin resistance mice model), followed by second...
