Wendy Wattigney

Wendy Wattigney
U.S. Department of Health and Human Services | HHS · Centers for Disease Control and Prevention (CDC)

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86
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9,953
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Citations since 2017
0 Research Items
1609 Citations
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2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300

Publications

Publications (86)
Article
Full-text available
Toluene diisocyanate (TDI) is a well-known cause of occupational asthma, but we know little about the potential for exposure and health effects among residents who live near facilities that release TDI. In the mid-1990's, the North Carolina Department of Health and Human Services and the Agency for Toxic Substances and Disease Registry investigated...
Article
To describe how the Hazardous Substances Emergency Events Surveillance (HSEES) program identifies leading causes of uncontrolled ammonia releases and targets activities aimed at reducing the frequency of these incidents. Ammonia incidents reported to HSEES nationally were examined. HSEES programs in state health departments conducted and evaluated...
Article
Because of their small size and ongoing organ development, children may be more susceptible than adults to the harmful effects of toxic chemicals. The objective of the study reported here was to identify frequent locations, released substances, and factors contributing to short-term chemical exposures associated with adverse health consequences exp...
Article
As society continues to focus on the importance of academic achievement, the physical environment of schools should be addressed as 1 of the critical factors that influence academic outcomes. The School Health Policies and Programs Study (SHPPS) 2006 provides, for the first time, a comprehensive look at the extent to which schools have health-promo...
Article
Since September 11, 2001, concern about potential terrorist attacks has increased in the United States. To reduce morbidity and mortality from outbreaks of illness from the intentional release of chemical agents, we examine data from the Toxic Exposure Surveillance System (TESS). TESS, a national system for timely collection of reports from US pois...
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To examine the public health consequences of acute hazardous substance releases resulting from the improper mixing of chemicals. Data from the Agency for Toxic Substances and Disease Registry's Hazardous Substances Emergency Events Surveillance system for 1996-2001 events were analyzed. "Private households" was the most frequent industry classifica...
Article
The Hazardous Substances Emergency Events Surveillance (HSEES) system is a comprehensive, state-based surveillance system of hazardous substance releases and public health consequences. Maintained by the Agency for Toxic Substances and Disease Registry (ATSDR) since 1990, the system captures information on acute releases of hazardous substances tha...
Article
Trends in hypertension-related mortality for groups by race/ethnicity, sex, and age have not been examined previously. National multiple-cause mortality files for 1980-1998 were analyzed for adult decedents with hypertension listed as one of 20 conditions causing death. Racial/ethnic comparisons of hypertension-related death were performed using ag...
Article
Trends in hypertension-related mortality for groups by race/ethnicity, sex, and age have not been examined previously. National multiple-cause mortality files for 1980–1998 were analyzed for adult decedents with hypertension listed as one of 20 conditions causing death. Racial/ethnic comparisons of hypertension-related death were performed using ag...
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Releases of hazardous materials can cause substantial morbidity and mortality. To reduce and prevent the public health consequences (victims or evacuations) from uncontrolled or illegally released hazardous substances, a more comprehensive analysis is needed to determine risk factors for hazardous materials incidents. Hazardous Substances Emergency...
Article
Atrial fibrillation, the most common sustained disturbance of heart rhythm, is associated with a 5-fold increase in the incidence of ischemic stroke. The National Hospital Discharge Survey was used to estimate the annual number and prevalence of hospitalizations with atrial fibrillation among men and women 35 years of age or older. From 1985 throug...
Article
Stroke is the third-leading cause of death and a leading cause of disability in adults in the United States. In recent years, leaders in the stroke care community identified a national registry as a critical tool to monitor the practice of evidence-based medicine for acute stroke patients and to target areas for continuous quality of care improveme...
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The authors used death certificate data to evaluate national trends in the reporting of atrial fibrillation as an underlying or contributory cause of death for groups defined by age (45 years or older), sex, and race (Black vs. White) and to examine comorbidity. The multiple-causes mortality files from 1980 through 1998 were analyzed for decedents,...
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Full-text available
Vaccination at 6 months of age followed by routine revaccination is recommended when exposure of infants to measles is likely. Dade County, Florida, began this early two-dose schedule during a large epidemic in 1986-1987 (i.e., 22% of cases occurred in infants aged 6-11 months). This schedule was continued routinely in high-risk areas. The effect o...
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Rates of physical inactivity and poor nutrition, which are 2 of the most important modifiable risk factors for cardiovascular disease in women, are substantial. Even so, studies of interventions designed to improve lifestyle behaviors in women have been limited and often confined to particular geographical areas. To evaluate the effect of Choose to...
Article
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The elimination of wild-virus-associated poliomyelitis in the Western Hemisphere in 1991 and rapid progress in global polio eradication efforts changed the risk-benefit ratio associated with the exclusive use of oral poliovirus vaccine (OPV) for routine immunization. These changes, plus the November 1987 development of an enhanced-potency inactivat...
Article
To estimate the incidence of pertussis, a prospective study was done among members of a managed care organization in Minneapolis/St. Paul, Minnesota. Of 212 patients 10–49 years old enrolled from January 1995 through December 1996, 8 were found to be culture positive, 10 were found to be positive by polymerase chain reaction assay, 13 had a ⩾2-fold...
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Reported cases of pertussis have increased in the United States, with peaks occurring every few years. Bordetella pertussis isolates collected in Cincinnati from 1989 to 1996 were analyzed with pulsed-field gel electrophoresis (PFGE), to evaluate trends. Among 496 isolates, 30 PFGE profiles were identified; 32% were CYXXI-010, the profile that pred...
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During the Russian diphtheria epidemic of the 1990s, adults had an unexpectedly high rate of disease. A retrospective, matched case-control study was done to measure the effectiveness of one, two, or three or more doses of diphtheria toxoid against diphtheria among 40- to 49-year-old Russians. Thirty-nine diphtheria case-patients and 117 controls w...
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A measles epidemic occurred in Romania with 32,915 cases and 21 deaths reported between November 1996 and June 1998, despite high vaccination coverage since the early 1980s. Most cases were unvaccinated children aged <2 years and vaccinated school-aged children. A case-control study among preschool children and a cohort study among primary-school c...
Article
Black-white differences in serum triglycerides and high-density lipoprotein (HDL) cholesterol concentrations are known. However, the metabolic basis for these differences is not clear. This study determined the magnitude of postprandial triglyceride concentrations, lipoprotein lipase and hepatic triglyceride lipase activities in postheparin plasma,...
Article
Secular trends in onset of menarche and obesity were examined 14 years apart in two biracial (black-white) cohorts of girls aged 8 to 17 under study for cardiovascular risk. The first cohort (N=1,190, 64% white) was examined in 1978-1979, the second (N=1,164, 57% white) in 1992-1994. The second cohort was heavier in terms of body weight and Rohrer...
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We assessed the pattern of acquisition and loss of Helicobacter pylori infection in a cohort of 212 children from a biracial community with a homogeneous socioeconomic class. The children were followed over 12 years (1973–1974 to 1985–1986) from childhood to young adulthood. H. pylori status was assessed by the presence of serum IgG antibodies to H...
Article
To determine the association of serum levels of lipoprotein (a) (Lp(a)) with coronary artery disease (CAD) in relation to other risk factor variables in black and white women. Retrospective case-control study. Community of Bogalusa, Louisiana and Cardiac Catheterization Laboratory at the Medical Center of Louisiana, New Orleans, USA. The study incl...
Article
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In adults, cardiovascular risk factors reinforce each other in their effect on cardiovascular events. However, information is scant on the relation of multiple risk factors to the extent of asymptomatic atherosclerosis in young people. We performed autopsies on 204 young persons 2 to 39 years of age, who had died from various causes, principally tr...
Article
Although the association between parental coronary artery disease (CAD) and its risk factors in the offspring is known, the timing and the course of development of risk factors from childhood to adulthood in the offspring is not known. To examine the association between parental CAD and longitudinal changes in risk factor profile from childhood to...
Article
Mortality from coronary heart disease is relatively low in Japan compared with other developed countries and has remained low despite an increasing standard of living and an apparent increase in mean plasma cholesterol concentration in adults over the past three decades. Important differences in childhood plasma lipoprotein profile might contribute...
Article
Cross-sectional and longitudinal associations of serum lipids and lipoproteins with oral contraceptive (OC) use were examined among white and black women aged 18-27 years in 1985-86 and 1988-1991 in the Bogalusa Heart Study, a study of cardiovascular disease in a Southern community. Analyses of covariance. In 1985-1986, white OC users had significa...
Article
To examine sibling aggregation of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein (apo) B and apo A-I in white versus black school-aged children. Study subjects included 790 full sibships representing 1305 sibpairs aged 5 to 17 years from a biracial community. Intraclass correlation coeffici...
Article
The relationship of dyslipidemias between young offspring and their parents was examined to evaluate its usefulness in predicting lipid disorders among parents and children. Young offspring ages 5-17 years and their parents were studied in a community-based sample of 477 families. The dyslipidemias were defined as: (1) isolated high low-density lip...
Article
LEARNING OUTCOME: To describe ethnic and gender differences in serum cholesteryl ester fatty acids in young adults. The composition of fatty acids in serum cholesteryl esters (CE) was analyzed by gas chromatography in 106 young adults (x age=26.5yrs.) (43 males, 63 females; 63 whites, 43 blacks). A total of 97.4% of the fatty acids in serum CE were...
Article
There is evidence that bilirubin functions as an endogenous tissue protector by its antioxidant and anti-complement actions, properties that are relevant to atherogenesis. Serum bilirubin distribution and its relation to cardiovascular risk were examined in 4156 individuals aged 5-30 years from a biracial (black white) community. Bilirubin levels s...
Article
Positive parental history of coronary artery disease (CAD) (myocardial infarction, angina, angioplasty, bypass surgery) reported by 371 of 1,930 black and white adults aged 18 to 31 years in 1988 to 1991 in the Bogalusa Heart Study was verified by interviewing parents or next-of-kin. Error rates in reporting information concerning parental CAD and...
Article
Epidemiologic surveys from different parts of the developed world are showing increases in asthma prevalence; the causes are not known. To describe trends in prevalence of childhood asthma measured across serial cross-sectional surveys of the school age population of Bogalusa, Louisiana. The Bogalusa Heart Study is a long-term epidemiologic study o...
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The hypothesis that birth weight predicts blood pressure inversely at age 7 through 11 years was examined in 1,446 white children and black children in Washington Parish, Louisiana. Two data sets of the Bogalusa Heart Study were merged: 1) newborn cohort participants (n = 233), initially examined at birth, 1973-1974, and reexamined in 1984-1985 at...
Article
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The relation between birth weight and serum lipid concentrations at age 7 through 11 years was examined in a sample of 1,411 black children and white children in Washington Parish, Louisiana. Two data sets of the Bogalusa Heart Study were merged: 1) newborn cohort participants (n = 225) initially examined at birth, 1973-1974, and reexamined in 1984...
Article
The influence of apolipoprotein (apo) E polymorphism on the tracking of serum lipoprotein variables over a 6-year follow-up period was examined in 442 individuals aged 5-15 years at baseline. The apo E phenotype-specific differences in total cholesterol and low-density lipoprotein (LDL) cholesterol levels persisted in the study cohort at baseline a...
Article
Cigarette smoking among adolescents continues to be a major public health problem in the United States. Smoking trends from 1976–1977 to 1992–1994 were examined in the Bogalusa Heart Study, an investigation of cardiovascular disease risk factors among black and white, male and female adolescents in a semirural town in the southern United States. Ag...
Article
To compare the body mass index (BMI) (weight/height2) and the Ponderal index (PI) (weight/height3) in childhood as predictors of adult overweight in a biracial group of children. Prospective, 15-y follow-up. 835 children aged 10-15 y at baseline. Weight in kg and height in m. Overweight, defined as a BMI greater than 27 kg/m2 in young adults. Overa...
Article
Apolipoprotein (apo) E is an important genetic determinant of serum lipoprotein concentrations and coronary artery disease risk. Multiple cardiovascular risk factors in addition to lipoproteins were examined by apoE phenotype in a random subsample (n = 746) of 8-17-year old children from a total community. The apoE2 group (n = 58) carrying E2/2 and...
Article
To examine the usefulness of childhood low-density lipoprotein cholesterol (LDL-C) measurement for predicting future dyslipidemia and other cardiovascular risk in adulthood. A longitudinal cohort over 15 years was identified from a community study of the natural course of arteriosclerosis: 1169 individuals (34% black), aged 5 to 14 years, were incl...
Article
The Dinamap 845XT automatic blood pressure monitor, Dinamap 8100 (an update model), and two mercury sphygmomanometers were compared in 417 school-aged children examined in the spring of 1992 as part of the Bogalusa Heart Study. This study was conducted in the nearby community of Franklinfen, Louisiana, to verify data obtained as part of a cross-sec...
Article
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RESEARCHERS RECORDED BLOOD PRESSURE LEVELS of children and adolescents in the Bogalusa Heart Study (black and white populations) and in the Brooks Country Study (Hispanic population). Hispanic children had smaller stature, while whites and Hispanics tended to be fatter than blacks in childhood. In Bogalusa, black boys showed higher blood pressure l...
Article
Overweight in adolescence is considered an important predictor of long-term morbidity and mortality. The impact of adolescent overweight on adult overweight and related multiple cardiovascular risk factors was examined in a biracial (black-white) cohort (N = 783) who participated in two cross-sectional surveys as adolescents aged 13 to 17 years and...
Article
The Bogalusa Heart Study now establishes that precursors of adult cardiovascular diseases begin in childhood. The clearest evidence comes from autopsy studies that show coronary atherosclerotic lesions occur in early life and are strongly associated with very-low-density lipoprotein cholesterol, systolic and diastolic blood pressure, and obesity, a...
Article
Obesity is a determinant of cardiovascular risk factors in childhood, adolescence, and adulthood. Since the inception of the Bogalusa Heart Study, various anthropometric measures of body size and mass have been obtained. Attention is given to identifying the distribution for various obesity measures, secular trends in obesity, clustering of obesity...
Article
In a study of 8,276 black and white children and young adults, adverse risk factors associated with a parental history of cardiovascular disease intensified with the aging of the offspring, and susceptibility to certain cardiovascular diseases by race was also more apparent. This history can be an important surrogate measure for cardiovascular risk...
Article
The use of fourth phase Korotkoff sound (K4) versus fifth phase Korotkoff sound (K5) for the determination of diastolic blood pressure (DBP) has been a subject of controversy since the indirect method of determining arterial blood pressure was described. Using data from the Bogalusa Heart Study, we evaluated the differences between K4 and K5 (K4 –...
Article
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The Collaborative Pathology Study is one of the most impressive programs of the Bogalusa Heart Study. Attempts are made to obtain complete and uniform necropsy coverage of all decreased young people who may have been examined in the Bogalusa Heart Study. Since 1978, autopsy specimens have been collected from 190 deaths, representing 65% of all know...
Article
The Bogalusa Heart Study, a long-term epidemiologic investigation of the early natural history of atherosclerosis, was conducted for the first time in 1973-1974 on children from birth through the age of 14 in a biracial (black-white) population. The emergence of clinically recognizable abnormalities (obesity, hypertension, and hyperlipidemia) was s...
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Histologic features of arterial intima have been quantified at autopsy by morphometric methods in 66 individuals aged 6-30 years, in whom cardiovascular risk factors had been measured prospectively prior to death. Measures of serum cholesterol were found to correlate significantly with the extent of foam cell infiltration seen in paraffin sections...
Article
To assess whether circulating insulin is a major contributor to adverse lipid profiles during the transition from adolescence to young adulthood. The association between fasting insulin levels and serum lipid and lipoprotein levels was examined in a cross-sectional survey of 4136 young individuals aged 5 to 30 years from a biracial community. Fasti...
Article
Although cardiovascular risk factors relate to family history of cardiovascular disease, it is not clear how the relation changes from children to young adults. As part of a community study for cardiovascular health, parental history of diseases was obtained from 8276 offspring 5 to 31 years old, 36% black and 64% white. Between 5- to 10-year-old c...
Article
Cardiovascular risk factors are known to persist over time and to cluster both in childhood and adulthood. Less is known about the persistence of clustering of multiple cardiovascular risk factors comprising adverse levels of systolic blood pressure, the ratio of total cholesterol to high-density lipoprotein cholesterol, and plasma insulin from chi...
Article
Epidemiological studies of BPs in children and young adults over the past 20 years have contributed considerably to understanding the early onset of primary hypertension. Observations from autopsies and echocardiographic studies, together with long-term BP studies, of children clearly indicate that primary hypertension begins in early childhood. Al...
Article
The influence of apolipoprotein (apo) E polymorphism on the association between body fatness and concentrations of serum lipoprotein variables was studied in a random subsample (n = 892) of 8- to 17-year-old children from a total community. Covariates (age, race, and sex)-adjusted mean values of percent body fat, ponderal index (wt/ht3), and subsca...
Article
Although postmortem lipid levels have been used as surrogates for levels during life, it is uncertain whether atherosclerotic lesions are related similarly to antemortem and postmortem lipid values. In a sample of 23 children and young adults who had been examined for cardiovascular disease risk factors and subsequently died from violent causes, we...
Article
The structural gene locus for apolipoprotein E (apo E) is polymorphic. The relative apo E allele frequencies and the influence of this polymorphism on serum lipoprotein concentrations were studied in 8- to 17-year-old black (n = 444) and white (n = 446) children from the community of Bogalusa, LA. The frequencies of the e2, e3, and e4 alleles for w...
Article
: It is now well-established that primary hypertension begins in early childhood. Epidemiology studies of pediatric populations show that tracking of blood pressure occurs; ie, levels of blood pressure taken in childhood are predictive of blood pressure levels in young adulthood. Anatomic studies provide further evidence. Observations at autopsy sh...
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Race and sex differences in aorta and coronary atherosclerotic lesions were studied in 150 persons aged 6 to 30 years. The intimal surface involvement with aorta fatty streaks was extensive, 0 to 71%, and greater in blacks than in whites (32 vs 20%, p less than 0.001). Coronary artery fatty streaks were more extensive in male than in female subject...
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With increasing age, the thoracic aorta shows progressive fibroplastic intimal thickening, which is thought to be pre-atheromatous. A similar progressive intimal thickening in the renal cortical arteries is the distinguishing feature of the nephrosclerosis which underlies essential hypertension. Therefore, the earliest detectable youthful precursor...
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With increasing age, the thoracic aorta shows progressive fibroplastic intimal thickening, which is thought to be pre-atheromatous. A similar progressive intimal thickening in the renal cortical arteries is the distinguishing feature of the nephrosclerosis which underlies essential hypertension. Therefore, the earliest detectable youthful precursor...
Article
The Heart Smart Family Health Promotion Program is a multidisciplinary, school-based program for cardiovascular risk reduction among high-risk children and their families. As a program that includes young adults at high risk, it is adaptable to a clinical practice. Nineteen fourth and fifth graders were selected as probands for elevated risk factor...
Article
Methods: Serum lipoprotein profiles in 4,231 individuals, ages 5-26 years, were studied cross-sectionally in a biracial community to describe the race- and gender-specific changes from adolescence into young adulthood. Results: White children and adolescents of both genders showed significantly higher covariates--adjusted triglycerides (9-11 mg/...
Article
Obesity is an important determinant of serum lipids and lipoproteins in adults. Since obesity begins early in life, the impact of obesity of serum lipid and lipoprotein levels was examined in 3311 children and young adults (ages 5 to 26 years) from a totally biracial community. Study subjects were grouped according to race, sex, and age categories...
Article
Serum lipids (total cholesterol and triglycerides) and lipoprotein cholesterol fractions (low density lipoprotein (LDL) cholesterol, very low density lipoprotein (VLDL) cholesterol, and high density lipoprotein (HDL) cholesterol) have been measured approximately every 3 years on children and young adults since 1973-1974 in Bogalusa, Louisiana, a co...
Article
The distributions of serum creatinine levels and their relationship with selected anthropometric and cardiovascular risk variables have been described in 3983 children and young adults, aged 5 to 26 years, obtained from a biracial population, Bogalusa, Louisiana. For both blacks and whites serum creatinine levels increased slowly with age, until 11...
Article
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Arterionephrosclerosis is diagnosed at autopsy by assessing the severity and extent of certain structural features in the renal cortical arteries seen in tissue sections. These features are characterized by fibrotic intimal thickening and medial shrinkage, a progressive change from the youthful muscular pattern to the elderly sclerotic pattern. Int...
Article
Serum apolipoprotein (apo) E levels and its relationship to lipids and lipoprotein cholesterol fractions were examined in a random subsample (n = 561) of children and adolescents (7 to 17 years of age) from a total biracial community. Mean (±SD) levels of apo E were higher in blacks (males 4.8 ± 1.8 mg/dL; females 5.2 ± 1.8 mg/dL) than in whites (m...
Article
Clinical experience of diagnostic and interventional procedures, including cardiac surgery, indicates a greater prevalence of coronary heart disease in white men than in other race-gender groups. Studies of children and young adults in the Bogalusa Heart Study have provided evidence that might account for this race-gender contrast. A variety of ant...
Article
Cholesterol and apolipoprotein (apo) B contents and their relationship within serum low density lipoprotein (LDL) were examined in 2018 children, ages 8 to 17 years, from a biracial community. The levels of LDL cholesterol and LDL apo B showed significant race-related differences (blacks greater than whites) in both boys and girls and gender-relate...

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