Wendie Zhou

• Master of Medicine
• PhD Student at Peking University

Providing the necessary supportive environment is important for promoting healthy ageing and ensuring the well-being of older adults. However, whether social support could buffer the detrimental effect of reversible cognitive frailty (RCF) on health outcomes among older adults has not been empirically examined. To examine the moderating effect of t...

Subjective support-focused cognitive behavioral therapy (SS-CBT) could increase subjective support among (pre)frail community-dwelling older adults, however, the underlying mechanisms remain unclear. We conducted a randomized controlled trial, in which the SS-CBT group (n = 50) received SS-CBT once a week for eight weeks and the wait-list control g...

Objectives: To investigate whether baseline depressive symptoms impacted the effectiveness of an exercise intervention among (pre)frail older adults. Methods: This is a subanalysis of a stepped-wedge cluster randomized trial implementing an exercise intervention, with an application of the integration of the Health Belief Model, Theory of Planne...

This study aims to elucidate the methodology and compare the accuracy of different blood biomarkers for diagnosing ischemic stroke (IS). We reviewed 29 articles retrieved from PubMed, MEDLINE, Web of Science, and CINAHL Plus with Full Text. Among these, 23 articles involving 3,494 participants were suitable for meta-analysis. The pooled area under...

Purpose Two-sample Mendelian randomization methods were used to explore the causal effects of cognitive reserve proxies, such as educational attainment, occupational attainment, and physical activity (PA), on biological (leukocyte telomere length), phenotypic (sarcopenia-related features), and functional (frailty index and cognitive performance) ag...

This study aimed to develop and validate prediction models for incident reversible cognitive frailty (RCF) based on social-ecological predictors. Older adults aged ≥60 years from China Health and Retirement Longitudinal Study (CHARLS) 2011–2013 survey were included as training set ( n = 1230). The generalized linear mixed model (GLMM), eXtreme Grad...

Aim Reversible cognitive frailty (RCF) is an ideal target to prevent asymptomatic cognitive impairment and dependency. This study aimed to develop and validate prediction models for incident RCF. Methods A total of 1230 older adults aged ≥60 years from China Health and Retirement Longitudinal Study 2011–2013 survey were included as the training se...

Aim Systematic reviews on interventions for informal caregivers of community‐dwelling frail older adults were published over a decade ago and they mistook frailty for other severe age‐related conditions like disability and dementia. Therefore, this study aimed to systematically synthesize these interventions supporting these caregivers identified b...

Background Functional ability is the important prerequisite to live independently and achieve aging in place, which depends on the complex interaction of intrinsic and extrinsic factors. Identifying the trends and influencing factors of functional ability would contribute to the accurate assessment and intervention of geriatric health. This study a...

Frailty may increase the risk of adverse outcomes and the presence of comorbidities in hypertension. Understanding the prevalence of frailty in older adults with hypertension is of great importance, whereas estimates of the prevalence of frailty in this population vary greatly. A systematic review and meta-analysis was conducted to estimate the poo...

Objective: Ischemic Stroke (IS) causes mortality and disability globally. Early IS diagnosis is crucial for the successful treatment of suspected stroke. Blood biomarkers have been proposed as approaches that achieve acceptable sensitivity and specificity in distinguishing between stroke and mimic stroke to provide proper early treatment. This syst...

Background Stroke is the leading cause of mortality. This study aimed to investigate the association between stroke, comorbidities, and activity of daily living (ADL) among older adults in the United States. Methods Participants were 1165 older adults aged 60 and older from two waves (2016 and 2018) of the Health and Retirement Study who had a str...

Objective: To determine how the COVID-19 pandemic impacts patients with chronic disease medication adherence. Methods: Four electronic databases, PubMed, MEDLINE, Web of Science, and CINAHL Plus Full Text, were searched for literature between 2019 and 2021. Abstracts and later full texts were independently screened by the authors of this review...

Aim The study aimed to investigate the effect of early mobilization combined with early nutrition (EMN) on intensive care unit-acquired weakness (ICU-AW) in intensive care unit (ICU) settings compared with early mobilization (EM) or routine care. Methods A prospective, dual-center, randomized controlled trial was conducted. The control group under...

Objective To evaluate the existing evidence of a machine learning-based classification system that stratifies patients with stroke. Methods The authors carried out a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations for a review article. PubMed, MEDLINE, Web of Science, and...

Objectives This study aimed to identify the difficulties that caregivers of chronically ill patients experienced during the COVID-19 pandemic and to provide directions for future studies. Methods Five electronic databases, including PubMed, Web of Science, CINAHL Plus Full Text, EMBASE, and Scopus, were systematically searched from January 2019 to...

Objective: It is reported that age and sex have been identified as potential risk factors for severe outcomes and the distribution of coronavirus disease (COVID-19), although the specifics of these relationships are unclear. Furthermore, little is known about the relationship between age, sex, COVID-19, and population density in Thailand. This stud...

Background Stroke is a principal cause of mortality and disability globally. Numerous studies have contributed to the knowledge base regarding self-management interventions among chronic disease patients, but there are few such studies for patients with stroke. Therefore, it is necessary to analyze self-management interventions among stroke patient...

Objective: To determine whether there is a relationship between the extent of human travel and the number of COVID-19 cases in Thailand. Materials and Methods: The data set on monthly COVID-19 in Thailand between January and July 2020 were retrieved from the Ministry of Public Health, Thailand. Data regarding people’s travel in Thailand during the...

Background Poor physical functioning (PF) is a common issue among critically ill patients. It was suggested that reasonable nutrition accelerates PF recovery. However, the details and types of nutritional interventions on the PF of different intensive care unit (ICU) patients at present have not been well analyzed yet. This study aimed to systemati...

Introduction: Intensive care unit-acquired weakness (ICU-AW) occurs in 25% to 100% of critically ill patients, and is associated with prolonged mechanical ventilation, extended ICU stay, and total hospital stay, increased hospital costs, higher risk of death, impaired physical function, and decreased quality of life. However, there are not any cur...

Objectives We aimed to develop and validate a postoperative delirium (POD) prediction model for patients admitted to the intensive care unit (ICU). Design A prospective study was conducted. Setting The study was conducted in the surgical, cardiovascular surgical and trauma surgical ICUs of an affiliated hospital of a medical university in Heilong...