Wenbo Zhan

Wenbo Zhan
University of Aberdeen | ABDN · School of Engineering

PhD

About

40
Publications
5,133
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
446
Citations

Publications

Publications (40)
Article
Most of the computational models of drug transport in vascular tumours assume a uniform distribution of blood vessels through which anti-cancer drugs are delivered. However, it is well known that solid tumours are characterized by dilated microvasculature with non-uniform diameters and irregular branching patterns. In this study, the effect of hete...
Article
Full-text available
The effectiveness of anticancer treatments is often hampered by the serious side effects owing to toxicity of anticancer drugs and their undesirable uptake by healthy cells in vivo. Thermosensitive liposome-mediated drug delivery has been developed as part of research efforts aimed at improving therapeutic efficacy while reducing the associated sid...
Article
Full-text available
Effective delivery of therapeutic agents to tumour cells is essential to the success of most cancer treatment therapies except for surgery. The transport of drug in solid tumours involves multiple biophysical and biochemical processes which are strongly dependent on the physicochemical properties of the drug and biological properties of the tumour....
Article
Full-text available
Although convection-enhanced delivery can successfully bypass the blood-brain barrier, its clinical performance remains disappointing. This is primarily attributed to the heterogeneous intratumoral environment, particularly the tumor microvasculature. This study investigates the combined convection-enhanced delivery of antiangiogenic drugs and lipo...
Article
Full-text available
Delivering therapeutic agents into the brain via convection-enhanced delivery (CED), a mechanically controlled infusion method, provides an efficient approach to bypass the blood-brain barrier and deliver drugs directly to the targeted focus in the brain. Mathematical methods based on Darcy's law have been widely adopted to predict drug distributio...
Article
Full-text available
Gas hydrate contains abundant methane gas, which is considered to be a promising energy resource to mitigate the influence of climate change in the future. Understanding the effect of fluids-solid-hydrate spatial distribution on elastic properties of hydrate-bearing sediments benefits the well-log interpretation. We constructed 4-D hydrate-bearing...
Article
Full-text available
Purpose Tissue hydraulic permeability of brain tumours can vary considerably depending on the tissue microstructure, compositions in interstitium and tumour cells. Its effects on drug transport and accumulation remain poorly understood. Methods Mathematical modelling is applied to predict the drug delivery outcomes in tumours with different tissue...
Article
Full-text available
Purpose: Brain disorders have become a serious problem for healthcare worldwide. Nanoparticle-based drugs are one of the emerging therapies and have shown great promise to treat brain diseases. Modifications on particle size and surface charge are two efficient ways to increase the transport efficiency of nanoparticles through brain-blood barrier;...
Article
Nanoparticles have been extensively studied to improve drug delivery outcomes, however, their use in topical delivery remains controversial. Although the feasibility to cross the human skin barrier has been demonstrated in experiments, the risk of low drug concentration in deep tissue still limits the application. In this study, multiphysics modell...
Article
In recent years, combination therapy has emerged as the cornerstone of clinical practice in treating glioblastoma multiforme. However, their ability to trigger and leverage the body's adaptive immunity has rarely been studied. Tumour heterogeneity, the presence of the blood-brain barrier, and an immunosuppressive tumor microenvironment play a cruci...
Conference Paper
Convection-enhanced delivery (CED) is a promising drug delivery technique for treating brain diseases. With the aim to bypass the blood-brain barrier which can successfully reduce over 98% of drug bioavailability in brain in routine pharmacotherapy, CED has been developed to directly infuse drugs into lesion through a tuned catheter [1]. This devel...
Article
Light irradiation is considered an ideal non-invasive stimulus that enables precise tumour treatment with flexible, facile, and spatiotemporal control. Photodynamic therapy (PDT) is an important clinically relevant therapeutic modality that has proven to compensate for the reduced therapeutic efficacy of conventional chemotherapy. However, oxygen c...
Article
Full-text available
The flow dynamics of binary particle mixtures in the fluidized bed needs to be monitored in order to optimize the related industrial processes. In this paper, electrostatic sensing and high-speed imaging are applied to measure the velocities of polyethylene and sand particles in the binary particle mixtures in fluidization. Experimental studies wer...
Article
Full-text available
Focused ultrasound (FUS) coupled with microbubbles (MB) has been found as a promising approach to disrupt the blood-brain barrier (BBB). However, how this disruption affects drug transport remains unclear. In this study, drug transport in the combination therapy of liposomes and FUS-MB induced BBB disruption (BBBD) is investigated based on a multip...
Article
Full-text available
Branched endografts have been developed to treat complex pathology in the aortic arch and ascending aorta. This study aims to evaluate the haemodynamic performance of a double-branched thoracic endograft by detailed comparison of flow patterns and wall shear stress in the aorta and supra-aortic branches before and after stent-graft implantation. Pr...
Article
Convection enhanced delivery is an effective alternative to routine delivery methods to overcome the blood brain barrier. However, its treatment efficacy remains disappointing in clinic owing to the rapid drug elimination in tumour tissue. In this study, multiphysics modelling is employed to investigate the combination delivery of anti-angiogenic a...
Article
Full-text available
Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Here, the responses of six differe...
Article
Full-text available
Systemic toxicity and insufficient drug accumulation at the tumour site are main barriers in chemotherapy. Thermosensitive liposomes (TSL) combined with high intensity focused ultrasound (HIFU) has emerged as a potential solution to overcome these barriers through targeted drug delivery and localised release. Owing to the multiple physical and bioc...
Article
Surface modified PLGA nanoparticles were fabricated via nanoprecipitation for obtaining therapeutic concentration of paclitaxel (PTX) in brain tumor. The cellular uptake and cytotoxicity of NPs were evaluated on C6 glioma cells in vitro and BALB/c mice were used to study the brain penetration and bio-distribution upon intravenous administration. Re...
Article
Convection enhanced delivery is promising to overcome the blood brain barrier. However, the treatment is less efficient in clinic due to the rapid elimination of small molecular drugs in brain tumours. In this study, numerical simulation is applied to investigate the convection enhanced delivery of liposome encapsulated doxorubicin under various co...
Article
Convection enhanced delivery (CED) of chemotherapeutic drugs can successfully bypass the blood-brain barrier (BBB). However, the treatment efficacy is significantly variable in clinic owing to the absence of proper drugs and the lack of understanding on the local drug transport. In this study, mathematical modelling is employed to investigate the s...
Article
Full-text available
PurposeConvection enhanced delivery (CED) is a promising method of anticancer treatment to bypass the blood–brain barrier. This paper is aimed to study drug transport under different CED operating conditions. Methods The convection enhanced delivery of chemotherapeutics to an intact and a remnant brain tumour after resection is investigated by mean...
Article
Full-text available
Drug transport and its uptake by tumour cells are strongly dependent on tumour properties, which vary in different types of solid tumours. By simulating the key physical and biochemical processes, a numerical study has been carried out to investigate the transport of anti-cancer drugs in 3-D tumour models of different sizes. The therapeutic efficac...
Article
Full-text available
Early diagnosis of low grade glioma has been a challenge to clinicians. Positron Emission Tomography (PET) using 18F-FDG as a radio-tracer has limited utility in this area because of the high background in normal brain tissue. Other radiotracers such as 18F-Fluorocholine (18F-FCH) could provide better contrast between tumor and normal brain tissue...
Conference Paper
Three different temperature control modes used in high intensity focused ultrasound (HIFU) heating of solid tumour are compared in this study. Results show that the control mode with an independent temperature monitor for each focused region is effective in achieving a rapid temperature rise and maintaining a stable temperature level in tumour.
Conference Paper
Background: The efficacy of anticancer therapy is often offset by serious side effects. This is largely due to toxicity of the chemotherapy drug and its undesirable uptake in vivo. Various attempts have been made to retain the anticancer effect while reducing toxicities, including continuous infusion and liposomal delivery of chemotherapy drugs. Si...
Article
A numerical study based on a gas–solid two-fluid model using body-fitted coordinates to predict the immersed tube erosion rate in a bubbling fluidized bed has been conducted. Computations have been performed at various s/D ratios (ratio of the spacing between two tube centers to the diameter of the tubes) for a bed into which one, two, three or fou...
Article
Energy and environmental issues have been the important problems in the world. Based on understanding the Clean Development Mechanism (CDM) and the features of all types of resources in Heilongjiang Province, this paper analyses the potential of CDM projects in four areas including new energy, renewable energy, energy conservation, fuel switch, rec...
Article
The inlet boundary condition is an important element of the hydrodynamic behavior of the bubbling fluidized bed. Based on the Euler-Euler gas-solid two-fluid model, numerical simulation of bubbling fluidized bed with jet center inlet was studied. Using the pulse and steady velocity inlet boundary conditions, the formation, grow-up and separation of...

Network

Cited By

Projects

Project (1)