Wen Zhang

Wen Zhang
Icahn School of Medicine at Mount Sinai | MSSM · Department of Genetics and Genomic Sciences

PhD

About

135
Publications
24,050
Reads
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1,705
Citations
Introduction
My interests focus on computational genetics, bioinformatics, optimal control and computational scientific problems. I like researching and pipeline development.
Additional affiliations
July 2017 - July 2020
Annals of Human Genetics
Position
  • Editor
June 2017 - present
Applied mathematics
Position
  • Editorial Member
June 2017 - present
International Journal of Computing Science and Mathematics
Position
  • Editor

Publications

Publications (135)
Article
Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are exp...
Preprint
Full-text available
Schizophrenia is a highly heritable psychiatric disorder with a complex genetic risk architecture that reflects the additive impact of hundreds of risk variants. While many schizophrenia-associated risk variants are thought to regulate the expression of target genes in a cell-type-specific manner, the mechanisms by which the effect of these myriad...
Preprint
Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood psychiatric disorder, with a major genetic component. Here we present a GWAS meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loci, which is more than twice the number previously reported. Fine-mapping...
Article
Objectives We developed a computer-aided diagnosis system called ECRCCAD using standard white-light endoscopy (WLE) for predicting conventional adenomas with high-grade dysplasia (HGD) to optimise the patients' management decisions during colonoscopy. Methods Pretraining model was used to fine-tune the model parameters by transfer learning. 2,397...
Article
Full-text available
Background Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has been associated with neurological and neuropsychiatric illness in many individuals. We sought to further our understanding of the relationship between brain tropism, neuro-inflammation, and host immune response in ac...
Article
Full-text available
Speech sound disorders (SSD) manifest as difficulties in phonological memory and awareness, oral motor function, language, vocabulary, reading, and spelling. Families enriched for SSD are rare, and typically display a cluster of deficits. We conducted a genome-wide association study (GWAS) in 435 children from 148 families in the Cleveland Family S...
Preprint
Full-text available
Background Recent efforts have identified genetic loci that are associated with coronavirus disease 2019 (COVID-19) infection rates and disease outcome severity. Translating these genetic findings into druggable genes and readily available compounds that reduce COVID-19 host susceptibility is a critical next step. Methods We integrate COVID-19 gene...
Preprint
Full-text available
Enhancer RNAs (eRNAs) constitute an important tissue- and cell-type-specific layer of the regulome. Identification of risk variants for neuropsychiatric diseases within enhancers underscores the importance of understanding the population-level variation of eRNAs in the human brain. We jointly analyzed cell type-specific transcriptome and regulome d...
Article
Introduction: As we know, the majority of colorectal cancers are thought to evolve from colorectal adenomas. In this study, we explored the use of Computer-aided diagnosis (CAD) in the detection of colorectal polyps and the estimation of their sizes, which is important for the diagnosis and management of colorectal cancer. Materials and methods:...
Article
Traditional Chinese medicine (TCM) had demonstrated effectiveness in the prevention and control of COVID-19. Statistics showed that Ephedra and Glycyrrhiza were frequently used in the treatment of COVID-19. We hypothesized that the Ephedra-Glycyrrhiza drug pair is a potential choice for the treatment of COVID-19. Here, 112 active compounds were ide...
Preprint
Speech sound disorders (SSD) manifest as difficulties in phonological memory and awareness, oral motor function, language, vocabulary, reading and spelling. Families enriched for SSD are rare, and typically display a cluster of deficits. We conducted a genome-wide association study (GWAS) in 435 children from 148 families in the Cleveland Family Sp...
Preprint
Full-text available
Much is still unknown about the neurobiology of Alzheimer's disease (AD). To better understand AD, we generated 636 ATAC-seq libraries from cases and controls to construct detailed genome-wide chromatin accessibility maps of neurons and non-neurons from two AD-affected brain regions, the entorhinal cortex and superior temporal gyrus. By analyzing a...
Preprint
Full-text available
In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between brain tropism, neuroinflammation and host immune response has not been well characterized. We analyzed 68,557 single-nucleus transcriptomes from three brain regions (dorsolateral prefrontal cortex, medul...
Article
Full-text available
The availability of high-quality RNA-sequencing and genotyping data of post-mortem brain collections from consortia such as CommonMind Consortium (CMC) and the Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) Consortium enable the generation of a large-scale brain cis-eQTL meta-analysis. Here we generate cerebral cortical eQTL fr...
Article
In the article, we present several new bounds for the the complete elliptic integrals K (r) = | 0π /²(1−r² sin² θ )⁻1/²dθ and E (r) = | 0π /² (1−r² sin² θ )¹/²dθ , and find an asymptotic expansion for K (r) as r → 1, which are the refinements and improvements of the previously well-known results.
Article
In the article, we prove that the inequality Γ(x + 1) < x2 + p x + p holds for all x ∈ (0, 1) if and only if p > p0, where Γ(x) = | 0∞ tx−¹ e−t dt is the gamma function, p0 = [x0 Γ(x0 + 1) − x²0 ] /[1 − Γ(x0 + 1)] = 1.755 ··· , x0 = 0.192 ··· is the unique solution of the equation ψ (x + 1) = [1 − Γ(x + 1)][2 − Γ(x)]/[(1 − x)Γ(x + 1)] on the interv...
Preprint
Colorectal cancer (CRC) is the third in incidence and mortality of cancer. Screening with colonoscopy has been shown to reduce mortality by 40-60%. Challenge for screening indistinguishable precancerous and noninvasive lesion using conventional colonoscopy was still existing. We propose to establish a propagable artificial intelligence assisted hig...
Article
In this paper, we present the best possible parameters α 1 , α 2 , α 3 and β 1 , β 2 , β 3 such that the double inequalities C α 1 (a, b)G 1−α 1 (a, b) < T (a, b) < C β 1 (a, b)G 1−β 1 (a, b), α 2 C(a, b) + (1 − α 2)G(a, b) < T (a, b) < β 2 C(a, b) + (1 − β 2)G(a, b), α 3 G(a, b) + 1 − α 3 C(a, b) < 1 T (a, b) < β 3 G(a, b) + 1 − β 3 C(a, b) hold f...
Article
In the aritcle, we prove that the double inequalities αA(a, b)+(1−α)G(a, b) < T [A(a, b), G(a, b)] < βA(a, b) + (1 − β)G(a, b) and G[λa + (1 − λ)b, λb + (1 − λ)a] < T [A(a, b), G(a, b)] < G[µa + (1 − µ)b, µb + (1 − µ)a] hold for all a, b > 0 with a = b if and only if α ≤ 1/2, β ≥ 2/π, λ ≤ (1 − 1 − 4/π 2)/2 and µ ≥ 1/2 − √ 2/4 if α, β ∈ R and λ, µ ∈...
Article
In the article, we find the best possible parameters α 1 , α 2 , α 3 , β 1 , β 2 and β 3 such that the double inequalities A α 1 (a, b)H 1−α 1 (a, b) < T Q(a, b) < β 1 A(a, b) + (1 − β 1)H(a, b), [α 2 A(a, b) + (1 − α 2)H(a, b)]A(a, b) L(a, b) < T Q(a, b) < [β 2 A(a, b) + (1 − β 2)H(a, b)]A(a, b) L(a, b) , [α 3 L(a, b) + (1 − α 3)H(a, b)]A(a, b) <...
Article
In the article, we prove that α = 3, β = log 4/(π/2 − log 4) = 7.51371 · · · , γ = 1/4 and δ = 1 + log 2 − π/2 = 0.122351 · · · are the best possible constants such that the double inequalities β + 1 β + r 2 log 4 r < K(r) < α + 1 α + r 2 log 4 r , 1 + 1 2 log 4 r − γ r 2 < E(r) < 1 + 1 2 log 4 r − δ r 2 hold for all r ∈ (0, 1), where r = √ 1 − r 2...
Article
In the article, we present several monotonicity properties and bounds for the complete elliptic integral of the first kind. As applications, we find sharp bounds for the arithmetic-geometric mean.
Article
In the article, we present several monotonicity properties and bounds for the complete elliptic integral of the first kind. As applications, we find sharp bounds for the arithmeticgeometric mean.
Article
In the article, we find the best possible parameters 1 , 1 , 2 and 2 on the interval OE0; 1=2 such that the double inequalities H.a; bI 1 / < ˛A.a; b/ C .1 ˛/T .a; b/ < H.a; bI 1 /; G.a; bI 2 / < ˛A.a; b/ C .1 ˛/T .a; b/ < G.a; bI 2 / hold for all ˛ 2 OE0; 1 and a; b > 0 with a ¤ b, where A.a; b/ D .a C b/=2, T .a; b/ D 2 R =2 0 a cos 2  b sin 2...
Article
Full-text available
Background: The enhancing incidence of carbapenem-resistant Klebsiella pneumoniae (CRKP)-mediated infections in Mengchao Hepatobiliary Hospital of Fujian Medical University in 2017 is the motivation behind this investigation to study gene phenotypes and resistance-associated genes of emergence regarding the CRKP strains. In current study, seven in...
Preprint
Ba ckgrou nd The enhancing incidence of carbapenem-resistant Klebsiella pneumoniae (CRKP)-mediated infections in Mengchao Hepatobiliary Hospital of Fujian Medical University in 2017 is the motivation behind this investigation to study gene phenotypes and resistance-associated genes of emergence regarding the CRKP strains. In current study, seven in...
Preprint
Background The enhancing incidence of carbapenem-resistant Klebsiella pneumoniae (CRKP)-mediated infections in Mengchao Hepatobiliary Hospital of Fujian Medical University in 2017 is the motivation behind this investigation to study gene phenotypes and resistance-associated genes of emergence regarding the CRKP strains. In current study, seven inpa...
Preprint
The enhancing incidence of carbapenem-resistant Klebsiella pneumoniae (CRKP)-mediated infections in Mengchao Hepatobiliary Hospital of Fujian Medical University in 2017 is the motivation behind this investigation to study gene phenotypes and resistance-associated genes of emergence regarding the CRKP strains. In current study, seven inpatients are...
Preprint
Objective Artificial intelligence (AI) has undeniable values in detection, characterization, and monitoring of tumors during cancer imaging. However, major AI explorations in digestive endoscopy have not been systematically planned, and more important, most AI productions are based on Single-center Studies (ScSs). ScSs result in data scarcity, redu...
Article
Despite the progresses of genome-wide association studies (GWASs) in revealing genetic mechanisms of human complex traits, the basis through which most identified risk variants function are highly unknown and need further investigations as well as discoveries. Recent advancements of transcriptome predictions put the transcriptome-wide association s...
Article
Full-text available
We establish the monotonicity and convexity properties for several special functions involving the generalized elliptic integrals, and present some new analytic inequalities.
Article
Full-text available
Transcriptome-wide association studies integrate gene expression data with common risk variation to identify gene-trait associations. By incorporating epigenome data to estimate the functional importance of genetic variation on gene expression, we generate a small but significant improvement in the accuracy of transcriptome prediction and increase...
Preprint
The enhancing incidence of carbapenem-resistant Klebsiella pneumoniae (CRKP)-mediated infections in Mengchao Hepatobiliary Hospital of Fujian Medical University in 2017 promoted this investigation to study gene phenotypes and resistance genes of emergence regarding the CRKP strains. In current study, seven inpatients are enrolled in the hospital wi...
Article
Full-text available
In the article, we present several monotonicity theorems and inequalities for the modular equation functions ma(r)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$m_{a}(...
Article
This mini-review gives the development of computational drug repositioning using big data from perspective of genetic study. The reverse profile principle is utilized to reposition drug hits by investigating gene expression, genotyping and GWAS data. Several big data sets are introduced, which are remarkable references that utilized for the genetic...
Article
Full-text available
This mini-review gives the development of computational drug repositioning using big data from perspective of genetic study. The reverse profile principle is utilized to reposition drug hits by investigating gene expression, genotyping and GWAS data. Several big data sets are introduced, which are remarkable references that utilized for the genetic...
Article
In the article, we prove that the double inequality π 2 J(r ′ ) − 51 π − 160 160 r 16 < E(r) < π 2 J(r ′ ) − 5 π 3 × 2 31 r 16 holds for all r ∈ (0, 1), where E(r) = ! π/ 2 0 " 1 − r 2 sin 2 (t ) dt is the complete elliptic integral of the second kind, r ′ = (1 − r 2 ) 1 / 2 and J(r ) = 51 r 2 + 20 r √ r + 50 r + 20 √ r + 51 16( 5 r + 2 √ r + 5)
Article
2020, The Author(s). The availability of high-quality RNA-sequencing and genotyping data of post-mortem brain collections from consortia such as CommonMind Consortium (CMC) and the Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) Consortium enable the generation of a large-scale brain cis-eQTL meta-analysis. Here we generate cere...
Article
In the article, we present a monotonicity property involving the zero-balanced hyper-geometric function F(a,b;a + b;x) for all a,b > 0 , and establish several sharp inequalities for F(a,b;a + b;x) in the first quadrant of ab-plane, which are the generalizations of the previously results.
Preprint
Full-text available
Transcriptome-wide association studies integrate gene expression data with common risk variation to identify gene-trait associations. By incorporating epigenome data to estimate the functional importance of genetic variation on gene expression, we improve the accuracy of transcriptome prediction and the power to detect significant expression-trait...
Article
In the article, we present a monotonicity property involving the zero-balanced hypergeometric function F(a,b;a+b;x) for all a,b > 0, and establish several sharp inequalities for F(a,b;a+b;x) in the first quadrant of ab-plane, which are the generalizations of the previously results.
Article
We establish the monotonicity and convexity properties for several special functions involving the generalized elliptic integrals, and present some new analytic inequalities.
Article
Full-text available
In the article, we present several quadratic transformation inequalities for Gaussian hypergeometric function and find the analogs of duplication inequalities for the generalized Grötzsch ring function.
Poster
Poster for the 10th Annual Neuroscience Retreat
Article
Motivation: Most genetic variants implicated in complex diseases by genome-wide association studies (GWAS) are non-coding, making it challenging to understand the causative genes involved in disease. Integrating external information such as quantitative trait locus (QTL) mapping of molecular traits (e.g., expression, methylation) is a powerful app...
Article
In the article, we prove that the double inequalities [Formula presented][Formula presented]<K(r)<[Formula presented][Formula presented], [Formula presented]L(1,r)<AGM(1,r)<[Formula presented]L(1,r) hold for all r∈(0,1) if and only if p≥π/2=1.570796⋯ and q≤89/69=1.289855⋯ where K(r)=∫0π/2(1−r²sin²⁡t)−1/2dt is the complete elliptic integral of the f...
Preprint
Full-text available
Motivation Most genetic variants implicated in complex diseases by genome-wide association studies (GWAS) are non-coding, making it challenging to understand the causative genes involved in disease. Integrating external information such as quantitative trait locus (QTL) mapping of molecular traits (e.g., expression, methylation) is a powerful appro...
Article
Full-text available
In the article, we find the best possible parameters p and q on the interval (7/5,(7? ? 20)/(5? ? 15)) such that the double inequality 1 ? ? (p)e? px² ? (1 ? ? (p))e?? (p)x² < erf(x) < 1 ? ? (q)e?qx² ? (1 ? ? (q))e?? (q)x² holds for all x > 0, where erf(x) =²?0x e?t² dt is the error function, ? (p) = 4[(7? ? 20) ? 5(? ? 3) p]/[? (15 p² ? 40 p + 28)...
Data
In the article, we present the best possible parameters a, b on the interval (0, ∞) such that the Gautschi double inequality [(x p + a) 1/p − x]/a < e x p ∞ x e −t p dt < [(x p + b) 1/p − x]/b holds for all x > 0 and p ∈ (0, 1). As applications, we find new bounds for the incomplete gamma function Γ(a, x) = ∞ x t a−1 e −t dt .