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Publications (85)
The neonatal hepatitis B vaccination (HBVac) was implemented 35 years ago in Taiwan, but many vaccinees exhibit inadequate long-term vaccine-induced seroprotective hepatitis B surface antibody (anti-HBs) levels. We investigated the association of the human leukocyte antigen (HLA) alleles (DPA1, DPB1, DQA1, and DQB1) with the long-term immunological...
Aims/hypothesis
An elevated fasting glucose level in non-diabetic individuals is a key predictor of type 2 diabetes. Genome-wide association studies (GWAS) have identified hundreds of SNPs for fasting glucose but most of their functional roles in influencing the trait are unclear. This study aimed to identify the mediation effects of DNA methylatio...
Patients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation carriers and 419 non-mutation carriers from 75 pedigrees coll...
Genetic variations in DNA base excision repair (BER) genes may affect tumor sensitivity to chemotherapy and radiotherapy. Thus, we investigated the effects of single-nucleotide polymorphisms (SNPs) in key BER pathway genes on clinical outcomes in male patients who received concurrent chemoradiotherapy (CCRT). Seven SNPs from XRCC1, OGG1, APEX1, and...
Background:
High disease burden suggests the desirability to identify high-risk Asian never-smoking females (NSFs) who may benefit from low-dose computed tomography (LDCT) screening. In North America, one is eligible for LDCT screening if one satisfies the U.S. Preventive Services Task Force (USPSTF) criteria or has model-estimated six-year risk >...
Background: The nucleotide excision repair (NER) pathway plays a major role in the repair of DNA damaged by exogenous agents including chemo-and radiotherapeutic agents. Thus, we investigate the association between key potentially functional single nucleotide polymorphisms (SNPs) in the NER pathway and clinical outcomes in oral squamous cell carcin...
We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-re...
Background: The nucleotide excision repair (NER) pathway plays a major role in the repair of DNA damaged by exogenous agents including chemo-and radiotherapeutic agents. Thus, we investigate the association between key potentially functional single nucleotide polymorphisms (SNPs) in the NER pathway and clinical outcomes in oral squamous cell carcin...
Background:
We aimed to investigate the association between single-nucleotide polymorphisms (SNP) in mismatch repair (MMR) pathway genes and survival in patients with oral squamous cell carcinoma (OSCC) who received adjuvant concurrent chemoradiotherapy (CCRT).
Methods:
Using the Sequenom iPLEX MassARRAY system, five SNPs in four major MMR genes...
Figure S1. Linkage disequilibrium analysis between SNPs in MSH3 (rs12515548 and rs26279). The numbers in the squares indicate pairwise D' (left) or R 2 (right) values and the corresponding shades of red or black represents the degree of linkage disequilibrium between pairs of SNPs.
Purpose
To study the association between chronic hepatitis B virus (HBV) and age‐related macular degeneration (AMD).
Methods
Data used in this retrospective, frequency‐matched cohort study were acquired from the Longitudinal Health Insurance Database 2000, which includes medical claims and registration files for 1 000 000 enrolees in the Taiwan Na...
The nucleotide excision repair (NER) pathway plays a major role in the repair of DNA damaged by exogenous agents, such as chemotherapeutic and radiotherapeutic agents. Thus, we investigated the association between key potentially functional single nucleotide polymorphisms (SNPs) in the NER pathway and clinical outcomes in oral squamous cell carcino...
Background/aim:
Epidermal growth factor receptor (EGFR), mothers against decapentaplegic homolog 7 (SMAD7) and transforming growth factor betta (TGFB) are crucial for colorectal cancer (CRC) tumorigenesis. This study investigated whether polymorphisms in EGFR, SMAD7, and TGFB are associated with CRC risk in patients with Lynch syndrome.
Materials...
The SORBS1 gene plays an important role in insulin signaling. We aimed to examine whether common single-nucleotide polymorphisms (SNPs) of SORBS1 are associated with prevalence and incidence of diabetes, age at onset of diabetes, and the related traits of glucose homeostasis. A total of 1135 siblings from 492 ethnic Chinese families were recruited...
Chromosome 12q23-q24 has been linked to triglyceride (TG) levels by previous linkage studies, and it contains the Insulin-like growth factor 1 (IGF1) gene. We investigated the association between IGF1 and TG levels using two independent samples collected in Taiwan. First, based on 954 siblings in 397 families from the Stanford Asian Pacific Program...
Supplementary figure and tables.
Background
DNA repair genes are crucial for maintaining genomic stability by preventing mutagenesis and carcinogenesis. The present retrospective cohort study aimed at investigating whether MLH1, APEX1, MUTYH, OGG1, NUDT1, XRCC5, XPA, and ERCC2 single nucleotide polymorphisms (SNPs) are associated with colorectal cancer (CRC) in Chinese population...
Objective
Both adenomyosis and endometriosis are characterized by the presence of ectopic endometrial glands and stroma and have been suggested to share some characteristics with malignant tumors. Although accumulating evidence indicates that endometriosis is associated with some cancer types, the cancer risks in patients with adenomyosis have been...
Cancer-free survival (CFS) curves in endometriosis and endometriosis-free cohorts.
(A) CFS curves for endometrial cancer. (B) CFS curves for ovarian cancer.
(TIF)
The proportion of women affected by adenomyosis or endometriosis in each stratum of birth year in LHID2000.
(XLSX)
Distribution of cancer types in the endometriosis cohort.
(XLSX)
Thyroid cancer-free survival curves in endometriosis and endometriosis-free cohorts.
(TIF)
Comparisons of demographic characteristics and comorbidities between endometriosis and endometriosis-free cohorts.
(XLSX)
Comparison of the distributions of cancer-free survival between endometriosis and endometriosis-free cohorts.
(XLSX)
Ovarian cancer-free survival curves in adenomyosis and adenomyosis-free cohorts.
(TIF)
Background
In this study, the long-term efficacy of hepatitis B virus (HBV) vaccination was assessed using seroprevalence and an age–period–cohort (APC) model of HBV seromarkers among university entrants 30 years after the introduction of the national neonatal HBV vaccination program in Taiwan.
Methods
In total, data of 17,611 university entrants...
Background:
Oral verrucous hyperplasia is commonly observed in the oral cavity of betel quid chewers and is a potential malignant disorder. However, the prognostic factors and genetic alterations of oral verrucous hyperplasia are unclear.
Methods:
We calculate the survival rate and prognostic factors using a Kaplan-Meier analysis and Cox proport...
Background:
Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. This study attempted to elucidate the role of the BDNF variant rs6265 in emotional symptoms following mild traumatic brain injury (mTBI).
Methods:
To...
C-reactive protein (CRP) encoded by CRP gene is a reflection of systemic inflammation. Many studies associated CRP level with diabetes and glucose levels, but the association of CRP gene with these traits is unclear. We conducted a cross-sectional study consisting of 945 siblings from 330 families collected by the Stanford Asian Pacific Program in...
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, can lead to long-term joint damage, chronic pain, and loss of motor function in the hands, and may share some common genetic factors with other autoimmune disorders, such as ankylosing spondylitis (AS). Many single-nucleotide polymorphisms (SNPs) were reported by genome-wide a...
Cytochrome P450 (CYP), glutathione-S-transferase (GST), and N-acetyltransferase (NAT) are crucial for metabolism and clearance of xenobiotics. This study investigated whether CYP, GST, and NAT single nucleotide polymorphisms (SNPs) are associated with colorectal cancer (CRC) in patients with Lynch syndrome. The interaction between these SNPs and ci...
Long noncoding RNAs (lncRNAs) have been implicated in hypoxia/HIF-1-associated cancer progression through largely unknown mechanisms. Here we identify MIR31HG as a hypoxia-inducible lncRNA and therefore we name it LncHIFCAR (long noncoding HIF-1α co-activating RNA); we describe its oncogenic role as a HIF-1α co-activator that regulates the HIF-1 tr...
List of human cancer-associated lncRNAs included in screening
Primers used for PCR in the present study
Supplementary Figures and Supplementary Tables
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight k...
Background and Aim
TP53 encodes p53, which has a crucial role in modulating genes that regulate defense against cancer development. This study investigated whether TP53 polymorphisms are associated with colorectal cancer (CRC) in patients with Lynch syndrome and whether TP53 interacts with lifestyle factors to modify CRC risk.
Methods
We identifie...
Interaction between TP53 polymorphisms and lifestyle factors and CRC risk among MMR germline mutation carriers.
(DOCX)
Background
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major causes of chronic hepatitis infection (CHI). This longitudinal cohort study investigated the association of CHI with hepatic and extrahepatic cancer development in Taiwan.
Methods
Patients with HBV infection and HCV infection were identified from the Taiwan National Healt...
[This corrects the article DOI: 10.1371/journal.pone.0161958.].
Rationale:
Patients of NSCLC with mutated EGFR are relatively sensitive to EGFR-TKI treatment and have longer progression-free survival (PFS) when treated with EGFR-TKI, compared with platinum-based chemotherapy. However, many advanced NSCLC patients with mutated EGFR do not response to first-line EGFR-TKI treatment and still have shorter PFS.
Ob...
Objective
The association between Sjögren’s syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV infections.
Materials and Methods
We identifi...
Essential hypertension is a complex disease involving multiple genetic and environmental factors. A human gene containing a sorbin homology domain and 3 SH3 domains in the C-terminal region, termed SORBS1, plays a significant role in insulin signaling. We previously found a significant association between the T228A polymorphism and insulin resistan...
Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility
loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian
non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Pha...
Objective:
Ankylosing spondylitis (AS) is a form of chronic inflammatory spondyloarthritis (SpA) that causes pain and stiffness in spines or joints. Human leukocyte antigen B27 (HLA-B27) and B60 (HLA-B60) have been reported as major genetic risk factors of AS. In addition, rs13202464, located on major histocompatibility complex (MHC) region, showe...
Recent evidence from several relatively small nested case-control studies in prospective cohorts shows an association between longer telomere length measured phenotypically in peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of 7 telomere-length associated gene...
To identify the genetic factors that influence overall survival in never smokers who have non-small cell lung cancer (NSCLC), we performed a consistency meta-analysis study utilizing genome-wide association approaches for overall survival in 327 never smoker NSCLC patients from the MD Anderson Cancer Center and 293 cases from the Mayo Clinic. We th...
LDL-C locus TOMM40-APOE-APOC4 exhibited seven signals in African Americans. Each SNP was colored according to its LD (r2) in PAGE consortium with the strongest SNP rs7412 (R176C) colored in purple.
(PDF)
Association at HDL-C locus LCAT in Europeans (A), East Asians (B), African Americans (C), and trans-ethnic meta-analysis (D). Index SNP rs3785100 (SLC12A4-E4G) is the variant showing the strongest evidence of association in trans-ethnic meta-analysis.
(PDF)
Association at LDL-C locus ABO in Europeans (A), East Asians (B), African Americans (C), and trans-ethnic meta-analysis (D). Index SNP rs2519093 is the variant showing the strongest evidence of association in trans-ethnic meta-analysis.
(PDF)
Association at TG locus APOA5 in Europeans (A), East Asians (B), African Americans (C), and trans-ethnic meta-analysis (D). The SNPs rs3741298, rs651821 (-3A>G), rs3135506 (S19W), and rs662799 that exhibited the smallest P values in Europeans, East Asians, African Americans, and the trans-ethnic meta-analysis are indicated.
(PDF)
Lead SNP at TG (A), HDL-C (B), and LDL-C (C) loci within each ancestry group and their relative significance compared to reported GWAS index SNPs.
(PDF)
SNPs with the strongest association at TG (A), HDL-C (B) and LDL-C (C) loci in combined trans-ethnic meta-analysis and their associations within ancestry groups.
(PDF)
Association at TG locus GCKR in Europeans (A), East Asians (B), African Americans (C), and trans-ethnic meta-analysis (D). Index SNP rs1260326 (P446L) is the variant showing the strongest evidence of association in trans-ethnic meta-analysis.
(PDF)
Association at HDL-C locus ABCA1 in Europeans (A), East Asians (B), African Americans (C), and trans-ethnic meta-analysis (D). Index SNP rs1883025 is the variant showing the strongest evidence of association in trans-ethnic meta-analysis.
(PDF)
Characteristics of the study samples.
(PDF)
Number of SNPs at each locus for analysis in each of the three ancestry groups.
(PDF)
LDL-C association with haplotypes consisting of the third (rs1038026) and the fourth (rs157588) signals at TOMM40-APOE-APOC4 cluster.
(PDF)
Genome-wide association studies (GWAS) have identified ∼100 loci associated with blood lipid levels, but much of the trait heritability remains unexplained, and at most loci the identities of the trait-influencing variants remain unknown. We conducted a trans-ethnic fine-mapping study at 18, 22, and 18 GWAS loci on the Metabochip for their associat...
To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hon...
RNA interference (RNAi) is an endogenous cellular process in which small double-stranded RNAs lead to the destruction of mRNAs with complementary nucleoside sequence. With the production of RNAi libraries, large-scale RNAi screening in human cells can be conducted to identify unknown genes involved in a biological pathway. One challenge researchers...
RNA interference (RNAi) is an endogenous cellular process in which small double-stranded RNAs lead to the destruction of mRNAs with complementary nucleoside sequence. With the production of RNAi libraries, large-scale RNAi screening in human cells can be conducted to identify unknown genes involved in a biological pathway. One challenge researchers...
A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10(-12)); however, this association did not achieve genome-wide significance (p ≤ 10(-7)) among never-smoking males or females. To determine if this as...
We present a model-free approach to the study of the number of false discoveries for large-scale simultaneous family-based association tests (FBATs) in which the set of discoveries is decided by applying a threshold to the test statistics. When the association between a set of markers in a candidate gene and a group of phenotypes is studied by a cl...
SNP graph of rs2736100 from (A) Illumina 610K (B) Illumina 370K based on Beadstudio Genotyping Module v3.
(1.47 MB TIF)
Lung cancer risk associated with rs2736100 among never-smoking females from East Asia, by histology, including two previously published studies.
(0.03 MB XLS)
Chromosome 5, 6, and 15 SNPs genotyped.
(0.04 MB XLS)
Risk of lung cancer associated with rs2736100 for never-smoking female adenocarcinoma cases and never-smoking female controls from East Asia.
(0.66 MB TIF)
Lung cancer risk associated with rs2736100 among never-smoking females from East Asia, by study center, including two previously published studies.
(0.04 MB XLS)
Lung cancer risk associated with chromosome 5 SNPs, among never-smoking females from East Asia.
(0.05 MB XLS)
Lung cancer risk associated with chromosome 6 SNPs, among never-smoking females from East Asia.
(0.07 MB XLS)
Lung cancer risk associated with chromosome 15 SNPs, among never-smoking females from East Asia.
(0.07 MB XLS)